Published in Curr Top Microbiol Immunol on January 01, 2013
NF-kappaB regulation in the immune system. Nat Rev Immunol (2002) 15.80
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol (1999) 15.63
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science (2002) 14.50
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell (1995) 11.86
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science (1998) 10.53
TLR signaling. Semin Immunol (2007) 8.16
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity (1998) 7.35
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem (2000) 6.54
Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol (2007) 6.11
Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol (1993) 5.99
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95
NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77
Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci (2002) 5.28
Nod-like proteins in immunity, inflammation and disease. Nat Immunol (2006) 5.25
Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science (1990) 5.21
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev (2011) 5.02
A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science (2002) 4.49
Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages. Biochem Biophys Res Commun (1998) 4.44
The molecular ecology of legionellae. Trends Microbiol (1996) 4.12
Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J (2009) 3.98
Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo. Proc Natl Acad Sci U S A (1988) 3.85
CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri. EMBO Rep (2001) 3.55
Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc Natl Acad Sci U S A (1992) 3.32
The phosphothreonine lyase activity of a bacterial type III effector family. Science (2007) 3.18
The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture. Eur J Biochem (2001) 2.73
Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J Biol Chem (1992) 2.63
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature (2002) 2.60
Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer. J Bacteriol (2005) 2.48
RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. PLoS Pathog (2006) 2.44
Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med (1996) 2.42
IcmS-dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion system. Mol Microbiol (2005) 2.37
Comprehensive identification of protein substrates of the Dot/Icm type IV transporter of Legionella pneumophila. PLoS One (2011) 2.37
Legionella eukaryotic-like type IV substrates interfere with organelle trafficking. PLoS Pathog (2008) 2.33
TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol Life Sci (2008) 2.23
A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death. Proc Natl Acad Sci U S A (2006) 2.21
NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila. J Exp Med (2006) 2.06
Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions. Mol Microbiol (2008) 2.02
Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. Mol Microbiol (2000) 2.00
Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog (2009) 1.94
The Legionella IcmS-IcmW protein complex is important for Dot/Icm-mediated protein translocation. Mol Microbiol (2005) 1.89
Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science (2012) 1.87
IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J Immunol (2000) 1.82
Anti-apoptotic signalling by the Dot/Icm secretion system of L. pneumophila. Cell Microbiol (2006) 1.81
Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog (2011) 1.78
Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth. Mol Microbiol (1999) 1.77
A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium. J Cell Biol (1995) 1.77
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. PLoS Pathog (2008) 1.70
Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J (2003) 1.69
The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocation. PLoS Pathog (2007) 1.67
Control of NF-kappaB-dependent transcriptional responses by chromatin organization. Cold Spring Harb Perspect Biol (2009) 1.67
The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesis. Helicobacter (2010) 1.59
Characterization of an axenic strain of Hartmannella vermiformis obtained from an investigation of nosocomial legionellosis. J Protozool (1991) 1.56
Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity (2008) 1.54
Signal transduction during Fc receptor-mediated phagocytosis. J Leukoc Biol (2002) 1.52
The E Block motif is associated with Legionella pneumophila translocated substrates. Cell Microbiol (2010) 1.51
A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors. Proc Natl Acad Sci U S A (2009) 1.48
Protein kinase C-mediated regulation of the cell cycle. Front Biosci (2000) 1.34
Identification of a Gal/GalNAc lectin in the protozoan Hartmannella vermiformis as a potential receptor for attachment and invasion by the Legionnaires' disease bacterium. J Exp Med (1997) 1.28
Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. Cytokine (2009) 1.28
The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades. J Mol Evol (1999) 1.27
Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus. J Biol Chem (2004) 1.25
LnaB: a Legionella pneumophila activator of NF-kappaB. Cell Microbiol (2010) 1.23
Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS Pathog (2009) 1.19
Modulation of protein kinase signaling by protein phosphatases and inhibitors. Pharmacol Ther (2002) 1.15
Protein kinase C and toll-like receptor signaling. Enzyme Res (2011) 1.14
Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum. Mol Cell Biol (1994) 1.11
Temporal resolution of two-tracked NF-kappaB activation by Legionella pneumophila. Cell Microbiol (2009) 1.07
Activation of host mitogen-activated protein kinases by secreted Legionella pneumophila effectors that inhibit host protein translation. Infect Immun (2012) 1.01
Phagocytosis of wild-type Legionella pneumophila occurs through a wortmannin-insensitive pathway. Infect Immun (2001) 1.01
Induction of human β-defensin-2 in pulmonary epithelial cells by Legionella pneumophila: involvement of TLR2 and TLR5, p38 MAPK, JNK, NF-κB, and AP-1. Am J Physiol Lung Cell Mol Physiol (2010) 1.00
Increases in c-Jun N-terminal kinase/stress-activated protein kinase and p38 activity in monocyte-derived macrophages following the uptake of Legionella pneumophila. Infect Immun (2004) 0.97
Protein kinase LegK2 is a type IV secretion system effector involved in endoplasmic reticulum recruitment and intracellular replication of Legionella pneumophila. Infect Immun (2011) 0.96
Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase. PLoS One (2008) 0.96
Legionella pneumophila heat-shock protein-induced increase of interleukin-1 beta mRNA involves protein kinase C signalling in macrophages. Immunology (1996) 0.94
Role of protein kinase C-alpha in the control of infection by intracellular pathogens in macrophages. J Immunol (1999) 0.94
The Legionella pneumophila effector VipA is an actin nucleator that alters host cell organelle trafficking. PLoS Pathog (2012) 0.93
Immunological similarity between the 170 kD amoebic adherence glycoprotein and human beta 2 integrins. Lancet (1993) 0.93
Legionella pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol (2006) 0.93
Atypical protein kinase C in cell motility. Cell Mol Life Sci (2012) 0.93
Protein kinase C control of gene expression. Crit Rev Eukaryot Gene Expr (2001) 0.89
The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. Cell Host Microbe (2009) 0.89
Signal transduction during Legionella pneumophila entry into human monocytes. Infect Immun (1998) 0.88
Control of host cell phosphorylation by legionella pneumophila. Front Microbiol (2011) 0.87
PKC(alpha) and PKC(epsilon) differentially regulate Legionella pneumophila-induced GM-CSF. Eur Respir J (2009) 0.81
Live Legionella pneumophila induces MUC5AC production by airway epithelial cells independently of intracellular invasion. Can J Microbiol (2012) 0.78
Retracted Inhibition of Akt/GSK3beta signalling pathway by Legionella pneumophila is involved in induction of T-cell apoptosis. Biochem J (2010) 0.78
Legionella pneumophila invasion of MRC-5 cells induces tyrosine protein phosphorylation. Infect Immun (1999) 0.78
Signal transduction in the protozoan host Hartmannella vermiformis upon attachment to Legionella pneumophila. Microbes Infect (2000) 0.78
Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. Proc Natl Acad Sci U S A (2004) 4.27
Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe (2009) 3.86
The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity. Mol Microbiol (2003) 3.20
Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. Dev Cell (2006) 3.06
A bifunctional bacterial protein links GDI displacement to Rab1 activation. Science (2007) 2.60
RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. PLoS Pathog (2006) 2.44
Legionella pneumophila replication vacuole formation involves rapid recruitment of proteins of the early secretory system. Infect Immun (2004) 2.25
A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death. Proc Natl Acad Sci U S A (2006) 2.21
An open letter to Elias Zerhouni. Science (2005) 2.19
Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. J Exp Med (2006) 2.11
NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila. J Exp Med (2006) 2.06
Legionella pneumophila Dot/Icm translocated substrates: a sum of parts. Curr Opin Microbiol (2009) 2.01
Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science (2012) 1.87
The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (2012) 1.82
IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole. Infect Immun (2004) 1.76
The E Block motif is associated with Legionella pneumophila translocated substrates. Cell Microbiol (2010) 1.51
Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion. Proc Natl Acad Sci U S A (2011) 1.50
LidA, a translocated substrate of the Legionella pneumophila type IV secretion system, interferes with the early secretory pathway. Infect Immun (2005) 1.49
Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathways. Cell Microbiol (2008) 1.47
The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proc Natl Acad Sci U S A (2012) 1.47
Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila. Infect Immun (2004) 1.45
Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction. Infect Immun (2008) 1.40
Innate immune recognition of Yersinia pseudotuberculosis type III secretion. PLoS Pathog (2009) 1.38
Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun (2006) 1.36
E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates. Infect Immun (2010) 1.34
CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells. PLoS Pathog (2009) 1.24
LnaB: a Legionella pneumophila activator of NF-kappaB. Cell Microbiol (2010) 1.23
Towards a molecular understanding of human diseases using Dictyostelium discoideum. Trends Mol Med (2006) 1.22
Yersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1. PLoS Pathog (2005) 1.20
Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth. Infect Immun (2002) 1.19
Dictyostelium discoideum strains lacking the RtoA protein are defective for maturation of the Legionella pneumophila replication vacuole. Cell Microbiol (2005) 1.15
The DotL protein, a member of the TraG-coupling protein family, is essential for Viability of Legionella pneumophila strain Lp02. J Bacteriol (2005) 1.11
Experimental evolution of Legionella pneumophila in mouse macrophages leads to strains with altered determinants of environmental survival. PLoS Pathog (2012) 1.10
Growth of Yersinia pseudotuberculosis in mice occurs independently of Toll-like receptor 2 expression and induction of interleukin-10. Infect Immun (2007) 1.10
Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake. J Exp Med (2003) 1.08
IcmR-regulated membrane insertion and efflux by the Legionella pneumophila IcmQ protein. J Biol Chem (2003) 1.05
Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin. Infect Immun (2003) 1.05
Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes. PLoS Pathog (2012) 1.02
Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages. Cell Microbiol (2008) 1.01
Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants. Cell Microbiol (2007) 1.00
The polybasic region of Rac1 modulates bacterial uptake independently of self-association and membrane targeting. J Biol Chem (2008) 0.97
Bacterial pathogen manipulation of host membrane trafficking. Annu Rev Cell Dev Biol (2014) 0.97
Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission. Cell Host Microbe (2012) 0.95
Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). J Biol Chem (2010) 0.92
Disruption of RhoGDI and RhoA regulation by a Rac1 specificity switch mutant. J Biol Chem (2006) 0.91
The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. Cell Host Microbe (2009) 0.89
Non-vertebrate hosts in the analysis of host-pathogen interactions. Microbes Infect (2006) 0.88
Yersinia pseudotuberculosis virulence determinants invasin, YopE, and YopT modulate RhoG activity and localization. Infect Immun (2009) 0.87
Control of host cell phosphorylation by legionella pneumophila. Front Microbiol (2011) 0.87
Cdc42 interacts with the exocyst complex to promote phagocytosis. J Cell Biol (2013) 0.87
A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth. Infect Immun (2008) 0.85
Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake. Curr Opin Microbiol (2005) 0.85
Analyzing microbial disease at high resolution: following the fate of the bacterium during infection. Curr Opin Microbiol (2011) 0.84
The Legionella pneumophila EnhC protein interferes with immunostimulatory muramyl peptide production to evade innate immunity. Cell Host Microbe (2012) 0.83
Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure (2009) 0.81
IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure (2013) 0.77
Analysis of Legionella infection using RNAi in Drosophila cells. Methods Mol Biol (2013) 0.77
Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system. Infect Immun (2013) 0.76
QnAs with Ralph R. Isberg. Proc Natl Acad Sci U S A (2013) 0.75