PubRank

Kevin J Tracey

Author PubWeight™ 290.59‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2002 12.09
2 High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005 11.57
3 Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A 2003 7.14
4 The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 2005 6.86
5 Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 2004 6.38
6 HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol 2011 6.23
7 Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science 2011 5.87
8 Sepsis definitions: time for change. Lancet 2013 5.63
9 Endogenous HMGB1 regulates autophagy. J Cell Biol 2010 4.71
10 HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 2006 4.53
11 A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc Natl Acad Sci U S A 2010 3.80
12 Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med 2003 3.75
13 Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A 2002 3.68
14 Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med 2006 3.66
15 Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. Crit Care Med 2007 3.63
16 Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock. Crit Care Med 2005 3.58
17 Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Crit Care Med 2007 3.27
18 Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med 2006 3.26
19 Novel role of PKR in inflammasome activation and HMGB1 release. Nature 2012 3.13
20 The cytokine activity of HMGB1. J Leukoc Biol 2005 3.02
21 Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med 2005 3.01
22 HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology 2002 2.95
23 The "cytokine profile": a code for sepsis. Trends Mol Med 2005 2.89
24 Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. J Exp Med 2012 2.89
25 Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol 2010 2.88
26 Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med 2002 2.83
27 Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). Mol Med 2012 2.79
28 Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia. Proc Natl Acad Sci U S A 2008 2.58
29 Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am J Physiol Cell Physiol 2003 2.50
30 The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology 2006 2.47
31 High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin. J Leukoc Biol 2006 2.44
32 Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis. Crit Care Med 2007 2.41
33 Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol Cell Biol 2004 2.33
34 High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization. J Immunol 2004 2.32
35 Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med 2003 2.30
36 Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med 2006 2.27
37 Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo. Shock 2009 2.26
38 High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages. Anesthesiology 2014 2.24
39 IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism. J Immunol 2003 2.24
40 The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis. J Leukoc Biol 2013 2.22
41 Alarmins: awaiting a clinical response. J Clin Invest 2012 2.19
42 Recombinant HMGB1 with cytokine-stimulating activity. J Immunol Methods 2004 2.14
43 The cholinergic anti-inflammatory pathway. Brain Behav Immun 2005 2.13
44 Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol 2007 2.12
45 Targeting HMGB1 in inflammation. Biochim Biophys Acta 2009 2.11
46 ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem 2005 2.11
47 HMGB1 as a DNA-binding cytokine. J Leukoc Biol 2002 2.07
48 Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc Natl Acad Sci U S A 2006 2.06
49 Reflex principles of immunological homeostasis. Annu Rev Immunol 2012 2.04
50 The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J Infect Dis 2005 2.02
51 Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol 2007 2.02
52 The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol Med 2003 2.00
53 Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling. Mol Med 2008 1.97
54 Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J Vasc Surg 2002 1.89
55 Neural reflexes in inflammation and immunity. J Exp Med 2012 1.87
56 Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia. Shock 2006 1.80
57 Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis. Mol Med 2007 1.80
58 Lymphocyte-derived ACh regulates local innate but not adaptive immunity. Proc Natl Acad Sci U S A 2013 1.78
59 The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. Mol Med 2009 1.73
60 RR interval variability is inversely related to inflammatory markers: the CARDIA study. Mol Med 2007 1.71
61 Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Brain Behav Immun 2008 1.70
62 Rethinking inflammation: neural circuits in the regulation of immunity. Immunol Rev 2012 1.68
63 Drug discovery: a jump-start for electroceuticals. Nature 2013 1.66
64 A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol 2007 1.60
65 The vagus nerve and the inflammatory reflex--linking immunity and metabolism. Nat Rev Endocrinol 2012 1.59
66 Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol Med 2009 1.52
67 Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. J Leukoc Biol 2004 1.49
68 Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis. Crit Care Med 2010 1.47
69 The neurology of the immune system: neural reflexes regulate immunity. Neuron 2009 1.46
70 Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis. J Lipid Res 2005 1.43
71 Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2006 1.43
72 Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J Immunol 2006 1.42
73 IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. J Immunol 2007 1.41
74 EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages. Biochem Pharmacol 2011 1.41
75 The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J Nutr 2006 1.38
76 Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor. Arthritis Rheum 2008 1.34
77 HMGB1 mediates cognitive impairment in sepsis survivors. Mol Med 2012 1.33
78 JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation. Proc Natl Acad Sci U S A 2014 1.31
79 Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. Cytokine 2003 1.30
80 HMGB1 as a cytokine and therapeutic target. J Endotoxin Res 2002 1.30
81 High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis. Arthritis Rheum 2003 1.26
82 Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis. Mol Med 2012 1.26
83 A hepatic protein, fetuin-A, occupies a protective role in lethal systemic inflammation. PLoS One 2011 1.25
84 Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis. Am J Physiol Lung Cell Mol Physiol 2005 1.24
85 Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal. Proc Natl Acad Sci U S A 2002 1.23
86 Experimental therapeutic strategies for severe sepsis: mediators and mechanisms. Ann N Y Acad Sci 2008 1.20
87 A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen. Gut 2013 1.20
88 HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion. Cytokine 2002 1.19
89 Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro. J Immunol 2004 1.18
90 Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor. Ann N Y Acad Sci 2005 1.18
91 Regulation of HMGB1 release by inflammasomes. Protein Cell 2013 1.18
92 High Mobility Group Box Protein-1 correlates with renal function in chronic kidney disease (CKD). Mol Med 2008 1.17
93 HMGB1 as a potential therapeutic target. Novartis Found Symp 2007 1.17
94 Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis. Arthritis Res Ther 2012 1.17
95 Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b. J Immunol 2009 1.15
96 The inflammatory reflex and the role of complementary and alternative medical therapies. Ann N Y Acad Sci 2009 1.13
97 HMGB1 is a bone-active cytokine. J Cell Physiol 2008 1.13
98 Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]. J Immunol 2009 1.09
99 HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis. Rheum Dis Clin North Am 2004 1.09
100 High mobility group B1 protein suppresses the human plasmacytoid dendritic cell response to TLR9 agonists. J Immunol 2006 1.07
101 Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia. Virology 2009 1.07
102 Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation. J Immunol 2012 1.07
103 The effects of CpG DNA on HMGB1 release by murine macrophage cell lines. J Leukoc Biol 2005 1.05
104 Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. J Immunol 2008 1.05
105 Dendritic cell activating peptides induce distinct cytokine profiles. Int Immunol 2006 1.05
106 High-mobility group box-1 protein (HMGB1) is increased in antineutrophilic cytoplasmatic antibody (ANCA)-associated vasculitis with renal manifestations. Mol Med 2010 1.04
107 High Mobility Group Box-1 mediates hyperoxia-induced impairment of Pseudomonas aeruginosa clearance and inflammatory lung injury in mice. Am J Respir Cell Mol Biol 2012 1.04
108 HMGB1 in sepsis. Scand J Infect Dis 2003 1.03
109 HMGB1 in the immunology of sepsis (not septic shock) and arthritis. Adv Immunol 2004 1.03
110 Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage. Crit Care Med 2005 1.03
111 It takes nerve to dampen inflammation. Nat Immunol 2005 1.02
112 Aerobic exercise attenuates inducible TNF production in humans. J Appl Physiol (1985) 2007 1.01
113 Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway. J Endotoxin Res 2003 1.00
114 High mobility group box 1 (HMGB1). Crit Care Med 2005 1.00
115 Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner. Virology 2003 0.98
116 Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake. Biochem Pharmacol 2012 0.98
117 Targeting high mobility group box 1 as a late-acting mediator of inflammation. Crit Care Med 2003 0.98
118 3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin. Biochem J 2003 0.95
119 Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review. Expert Rev Clin Immunol 2014 0.94
120 Galantamine alleviates inflammation and other obesity-associated complications in high-fat diet-fed mice. Mol Med 2011 0.94
121 Peripheral administration of fetuin-A attenuates early cerebral ischemic injury in rats. J Cereb Blood Flow Metab 2009 0.93
122 Lipid unites disparate syndromes of sepsis. Nat Med 2004 0.93
123 Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors. J Neurosci 2011 0.93
124 α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex. Mol Med 2012 0.93
125 High-mobility group box 1 mediates persistent splenocyte priming in sepsis survivors: evidence from a murine model. Shock 2013 0.91
126 Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity. Proc Natl Acad Sci U S A 2011 0.91
127 Neural signaling in the spleen controls B-cell responses to blood-borne antigen. Mol Med 2012 0.90
128 Identification of pharmacological modulators of HMGB1-induced inflammatory response by cell-based screening. PLoS One 2013 0.89
129 High-mobility group box 1 protein is an inflammatory mediator in necrotizing enterocolitis: protective effect of the macrophage deactivator semapimod. Am J Physiol Gastrointest Liver Physiol 2005 0.89
130 HMGB1 activates replication of latent HIV-1 in a monocytic cell-line, but inhibits HIV-1 replication in primary macrophages. Cytokine 2006 0.88
131 From CNI-1493 to the immunological homunculus: physiology of the inflammatory reflex. J Leukoc Biol 2007 0.88
132 A novel inhibitor of inflammatory cytokine production (CNI-1493) reduces rodent post-hemorrhagic vasospasm. Neurocrit Care 2006 0.88
133 Globin attenuates the innate immune response to endotoxin. Shock 2002 0.87
134 Vagus nerve stimulation regulates hemostasis in swine. Shock 2010 0.87
135 Identification of pigment epithelium-derived factor as an adipocyte-derived inflammatory factor. Mol Med 2012 0.85
136 High-mobility group box 1 and the receptor for advanced glycation end products contribute to lung injury during Staphylococcus aureus pneumonia. Crit Care 2013 0.85
137 Is severe sepsis a neuroendocrine disease? Mol Med 2002 0.83
138 Mapping the immunological homunculus. Proc Natl Acad Sci U S A 2011 0.83
139 Human genetics: an inflammatory issue. Nature 2004 0.82
140 Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria. Malar J 2013 0.82
141 Pathogenic role of HMGB1 in SARS? Med Hypotheses 2004 0.80
142 Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock. J Infect Dis 2005 0.80
143 A new approach to rheumatoid arthritis: treating inflammation with computerized nerve stimulation. Cerebrum 2012 0.80
144 High mobility group box-1 as a therapeutic target downstream of tumor necrosis factor. J Infect Dis 2003 0.78
145 Green tea catechins quench the fluorescence of bacteria-conjugated Alexa fluor dyes. Inflamm Allergy Drug Targets 2013 0.78
146 RAGE does not contribute to renal injury and damage upon ischemia/reperfusion-induced injury. J Innate Immun 2011 0.78
147 A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage. Neurosurgery 2010 0.77
148 The gesture life of high mobility group box 1. Curr Opin Clin Nutr Metab Care 2003 0.76
149 Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate. PLoS One 2010 0.76
150 Sepsis definitions - Authors' reply. Lancet 2013 0.75
151 Editorial. Mol Med 2013 0.75
152 Bacteria and the neural code. N Engl J Med 2014 0.75