Published in Gastroenterology on September 01, 2002
Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med (2005) 6.86
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J (2003) 6.46
HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol (2011) 6.23
The enigma of sepsis. J Clin Invest (2003) 4.32
DAMPening inflammation by modulating TLR signalling. Mediators Inflamm (2010) 3.29
Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med (2006) 3.26
Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. J Cell Biol (2004) 2.75
Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med (2006) 2.27
High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal (2011) 2.19
Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1. J Leukoc Biol (2006) 2.17
Targeting HMGB1 in inflammation. Biochim Biophys Acta (2009) 2.11
Pathogenesis of malaria and clinically similar conditions. Clin Microbiol Rev (2004) 1.87
HMGB1 in health and disease. Mol Aspects Med (2014) 1.67
Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats. Crit Care Med (2009) 1.67
Potential role of high-mobility group box 1 in cystic fibrosis airway disease. Am J Respir Crit Care Med (2008) 1.62
A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol (2007) 1.60
Current trends in inflammatory and immunomodulatory mediators in sepsis. J Leukoc Biol (2012) 1.52
Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release. J Immunol (2007) 1.48
No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med (2008) 1.46
Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. J Leukoc Biol (2009) 1.45
Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis. World J Gastroenterol (2006) 1.44
The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J Nutr (2006) 1.38
Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis. Crit Care (2008) 1.34
A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS One (2007) 1.30
Therapeutic potential of HMGB1-targeting agents in sepsis. Expert Rev Mol Med (2008) 1.30
PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis. Nat Commun (2014) 1.29
Novel HMGB1-inhibiting therapeutic agents for experimental sepsis. Shock (2009) 1.29
Role of HMGB1 in cardiovascular diseases. Curr Opin Pharmacol (2006) 1.26
Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis. Mol Med (2012) 1.26
HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption. Microvasc Res (2010) 1.24
Novel insights for systemic inflammation in sepsis and hemorrhage. Mediators Inflamm (2010) 1.24
Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation. J Cell Mol Med (2008) 1.22
Pathophysiology and treatment of septic shock in neonates. Clin Perinatol (2010) 1.17
Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice. Br J Pharmacol (2011) 1.16
Scientific and clinical challenges in sepsis. Curr Pharm Des (2009) 1.14
Bench-to-bedside review: High-mobility group box 1 and critical illness. Crit Care (2007) 1.14
Neuropeptides rescue mice from lethal sepsis by down-regulating secretion of the late-acting inflammatory mediator high mobility group box 1. Am J Pathol (2008) 1.11
Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock. Ann Surg (2007) 1.06
Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. J Immunol (2008) 1.05
Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function. Infect Immun (2014) 1.01
Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats. World J Gastroenterol (2008) 0.98
Potential role of high mobility group box 1 in viral infectious diseases. Viral Immunol (2006) 0.98
Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases. J Cell Death (2010) 0.97
Anti-inflammatory role of fetuin-A in injury and infection. Curr Mol Med (2012) 0.96
Redox modulation of HMGB1-related signaling. Antioxid Redox Signal (2013) 0.94
Fetal cholinergic anti-inflammatory pathway and necrotizing enterocolitis: the brain-gut connection begins in utero. Front Integr Neurosci (2013) 0.94
High mobility group box 1 protein as a potential drug target for infection- and injury-elicited inflammation. Inflamm Allergy Drug Targets (2010) 0.92
Native versus recombinant high-mobility group B1 proteins: functional activity in vitro. Inflammation (2004) 0.92
More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines. Med Hypotheses (2005) 0.91
Mast cell stabilization improves survival by preventing apoptosis in sepsis. J Immunol (2010) 0.90
High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity. BMC Gastroenterol (2012) 0.89
Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis. Biochem Pharmacol (2013) 0.88
Anti-inflammatory resuscitation improves survival in hemorrhage with trauma. J Trauma (2009) 0.88
Nitric oxide and airway epithelial barrier function: regulation of tight junction proteins and epithelial permeability. Arch Biochem Biophys (2008) 0.86
CXCR4 antagonist AMD3100 modulates claudin expression and intestinal barrier function in experimental colitis. PLoS One (2011) 0.84
Activation of A431 human carcinoma cell motility by extracellular high-mobility group box 1 protein and epidermal growth factor stimuli. Biochem J (2005) 0.83
Neuropeptide modulators of high mobility group box 1 secretion as potential therapeutic agents for severe sepsis. Am J Pathol (2008) 0.82
The HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction. Antioxid Redox Signal (2015) 0.82
Meningococcal outer membrane protein NhhA triggers apoptosis in macrophages. PLoS One (2012) 0.81
HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity. BMC Gastroenterol (2014) 0.81
Extracellular high-mobility group box 1 is increased in patients with Behçet's disease with intestinal involvement. J Korean Med Sci (2011) 0.81
The cardioprotection induced by lipopolysaccharide involves phosphoinositide 3-kinase/Akt and high mobility group box 1 pathways. J Biomed Res (2010) 0.80
Helicobacter pylori Activates HMGB1 Expression and Recruits RAGE into Lipid Rafts to Promote Inflammation in Gastric Epithelial Cells. Front Immunol (2016) 0.80
Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1. J Cell Mol Med (2015) 0.80
Systems engineering medicine: engineering the inflammation response to infectious and traumatic challenges. J R Soc Interface (2010) 0.80
High mobility group box1 protein is involved in acute inflammation induced by Clostridium difficile toxin A. Acta Biochim Biophys Sin (Shanghai) (2016) 0.79
Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response. Crit Care (2013) 0.79
Local and systemic pathogenesis and consequences of regimen-induced inflammatory responses in patients with head and neck cancer receiving chemoradiation. Mediators Inflamm (2014) 0.78
Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1. Int J Clin Exp Med (2008) 0.78
Sequestering HMGB1 via DNA-conjugated beads ameliorates murine colitis. PLoS One (2014) 0.78
Immune-modulating therapy in acute pancreatitis: fact or fiction. World J Gastroenterol (2014) 0.78
Inhibition of histone deacetylase 6 restores intestinal tight junction in hemorrhagic shock. J Trauma Acute Care Surg (2016) 0.77
Calcium/Calmodulin-Dependent Protein Kinase is Involved in the Release of High Mobility Group Box 1 Via the Interferon-β Signaling Pathway. Immune Netw (2012) 0.77
High-mobility-group box chromosomal protein 1 as a new target for modulating stress response. Surg Today (2010) 0.77
Total parenteral-nutrition-mediated dendritic-cell activation and infiltration into the small intestine in a rat model. J Anesth (2010) 0.77
A Novel Role for Programmed Cell Death Receptor Ligand-1 (PD-L1) in Sepsis-Induced Intestinal Dysfunction. Mol Med (2016) 0.77
High-mobility group box 1 impairs airway epithelial barrier function through the activation of the RAGE/ERK pathway. Int J Mol Med (2016) 0.77
Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications. Mucosal Immunol (2016) 0.77
Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction. J Mol Med (Berl) (2016) 0.77
Plasma high-mobility group box 1 as an indicator of surgical stress. Surg Today (2011) 0.76
Gut Microbiota and Immunity: Possible Role in Sudden Infant Death Syndrome. Front Immunol (2015) 0.76
Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases. J Cell Death (2010) 0.75
Increased of serum high-mobility group box chromosomal protein 1 correlated with intestinal mucosal barrier injury in patients with severe acute pancreatitis. World J Emerg Surg (2014) 0.75
Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries. J Inflamm (Lond) (2016) 0.75
Low doses of celecoxib attenuate gut barrier failure during experimental peritonitis. Lab Invest (2013) 0.75
HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis. Int J Inflam (2017) 0.75
8th Annual Toronto Critical Care Medicine Symposium, 30 October-1 November 2003, Toronto, Ontario, Canada. Crit Care (2004) 0.75
Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity. Infect Immun (2015) 0.75
Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation. Oncotarget (2016) 0.75
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90
Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature (2002) 12.09
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol (2005) 11.57
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med (2005) 6.86
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med (2004) 6.38
HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol (2011) 6.23
Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science (2011) 5.87
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Sepsis definitions: time for change. Lancet (2013) 5.63
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23
Endogenous HMGB1 regulates autophagy. J Cell Biol (2010) 4.71
HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock (2006) 4.53
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA (2002) 4.09
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc Natl Acad Sci U S A (2010) 3.80
Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med (2003) 3.75
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A (2002) 3.68
Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med (2006) 3.66
Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. Crit Care Med (2007) 3.63
Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock. Crit Care Med (2005) 3.58
Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Crit Care Med (2007) 3.27
Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med (2006) 3.26
Novel role of PKR in inflammasome activation and HMGB1 release. Nature (2012) 3.13
The cytokine activity of HMGB1. J Leukoc Biol (2005) 3.02
Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med (2005) 3.01
The "cytokine profile": a code for sepsis. Trends Mol Med (2005) 2.89
Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. J Exp Med (2012) 2.89
Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol (2010) 2.88
Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med (2002) 2.83
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). Mol Med (2012) 2.79
Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia. Proc Natl Acad Sci U S A (2008) 2.58
Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am J Physiol Cell Physiol (2003) 2.50
The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology (2006) 2.47
High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin. J Leukoc Biol (2006) 2.44
Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis. Crit Care Med (2007) 2.41
Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol Cell Biol (2004) 2.33
High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization. J Immunol (2004) 2.32
Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med (2006) 2.27
Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo. Shock (2009) 2.26
High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages. Anesthesiology (2014) 2.24
IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism. J Immunol (2003) 2.24
The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis. J Leukoc Biol (2013) 2.22
Alarmins: awaiting a clinical response. J Clin Invest (2012) 2.19
Recombinant HMGB1 with cytokine-stimulating activity. J Immunol Methods (2004) 2.14
The cholinergic anti-inflammatory pathway. Brain Behav Immun (2005) 2.13
Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol (2007) 2.12
Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12
Targeting HMGB1 in inflammation. Biochim Biophys Acta (2009) 2.11
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med (2005) 2.11
ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem (2005) 2.11
A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med (2012) 2.07
HMGB1 as a DNA-binding cytokine. J Leukoc Biol (2002) 2.07
Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc Natl Acad Sci U S A (2006) 2.06
Reflex principles of immunological homeostasis. Annu Rev Immunol (2012) 2.04
Targeting mitochondria. Acc Chem Res (2008) 2.03
The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J Infect Dis (2005) 2.02
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol (2007) 2.02
Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000. Crit Care Med (2003) 2.01
The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol Med (2003) 2.00
Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling. Mol Med (2008) 1.97
Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin (2005) 1.95
Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J Vasc Surg (2002) 1.89
Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit Care Med (2004) 1.88
Neural reflexes in inflammation and immunity. J Exp Med (2012) 1.87