Published in Acta Crystallogr D Biol Crystallogr on May 12, 2006
Gene cooption and convergent evolution of oxygen transport hemoglobins in jawed and jawless vertebrates. Proc Natl Acad Sci U S A (2010) 1.07
Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells. PLoS One (2012) 0.80
Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences. Biochim Biophys Acta (2016) 0.78
Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts. Front Physiol (2015) 0.77
Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells. Proc Jpn Acad Ser B Phys Biol Sci (2016) 0.75
Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection. Hepatology (2014) 2.83
Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol (2004) 2.47
Transgenic silkworms produce recombinant human type III procollagen in cocoons. Nat Biotechnol (2002) 2.42
1.25 A resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms. J Mol Biol (2006) 1.93
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. Proc Natl Acad Sci U S A (2006) 1.91
Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice. J Hepatol (2010) 1.56
Specific damage induced by X-ray radiation and structural changes in the primary photoreaction of bacteriorhodopsin. J Mol Biol (2002) 1.52
Successful in vivo propagation of factor IX-producing hepatocytes in mice: potential for cell-based therapy in haemophilia B. Thromb Haemost (2008) 1.49
Structural basis of biological N2O generation by bacterial nitric oxide reductase. Science (2010) 1.44
Suppression of type I collagen production by microRNA-29b in cultured human stellate cells. Biochem Biophys Res Commun (2009) 1.41
MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. Gut (2012) 1.40
Suppression of hepatic stellate cell activation by microRNA-29b. Biochem Biophys Res Commun (2011) 1.39
Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis. Lab Invest (2004) 1.38
Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties. J Inorg Biochem (2002) 1.37
A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease. J Gastroenterol (2010) 1.32
In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver. J Pharm Sci (2007) 1.31
Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut (2006) 1.31
Localization of oxidized phosphatidylcholine in nonalcoholic fatty liver disease: impact on disease progression. Hepatology (2006) 1.31
BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2. Am J Physiol Lung Cell Mol Physiol (2005) 1.28
Light-dependent regulation of structural flexibility in a photochromic fluorescent protein. Proc Natl Acad Sci U S A (2008) 1.28
Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology (2003) 1.24
Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo. Hepatology (2011) 1.23
Tolerance of the Rieske-type [2Fe-2S] cluster in recombinant ferredoxin BphA3 from Pseudomonas sp. KKS102 to histidine ligand mutations. Biochem J (2005) 1.23
Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studies. J Biol Chem (2003) 1.22
Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver. Am J Pathol (2002) 1.22
Inflammation and fibrogenesis in steatohepatitis. J Gastroenterol (2012) 1.21
NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single turnover cycle. J Biol Chem (2004) 1.20
Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages. Microb Pathog (2006) 1.20
Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation. J Cell Physiol (2011) 1.19
Structure of PAS-linked histidine kinase and the response regulator complex. Structure (2009) 1.19
Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis B virus. Hepatology (2005) 1.15
The crystal structures of the ferric and ferrous forms of the heme complex of HmuO, a heme oxygenase of Corynebacterium diphtheriae. J Biol Chem (2003) 1.15
Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways. J Biol Chem (2003) 1.13
Density functional theory study on a missing piece in understanding of heme chemistry: the reaction mechanism for indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase. J Am Chem Soc (2008) 1.13
Single lymphocyte analysis with a microwell array chip. Cytometry A (2007) 1.12
Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif. Antimicrob Agents Chemother (2006) 1.11
Proteome analysis of human vitreous proteins. Mol Cell Proteomics (2003) 1.11
Separation of a phosphorylated histidine protein using phosphate affinity polyacrylamide gel electrophoresis. Anal Biochem (2006) 1.09
Treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for 'middle'? J Gastroenterol (2013) 1.08
Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3. Biochemistry (2008) 1.08
Identification of vitamin A-free cells in a stellate cell-enriched fraction of normal rat liver as myofibroblasts. Histochem Cell Biol (2006) 1.08
Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice. Hepatology (2003) 1.08
Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Proc Natl Acad Sci U S A (2007) 1.07
Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice. Gastroenterology (2005) 1.06
Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population. BMC Gastroenterol (2012) 1.04
Direct observation of photolysis-induced tertiary structural changes in hemoglobin. Proc Natl Acad Sci U S A (2003) 1.04
Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice. J Hepatol (2009) 1.03
Expression of human cytochromes P450 in chimeric mice with humanized liver. Drug Metab Dispos (2004) 1.03
Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor. J Gen Virol (2010) 1.03
Mapping of phosphorylated proteins on two-dimensional polyacrylamide gels using protein phosphatase. Proteomics (2002) 1.03
A fibroin secretion-deficient silkworm mutant, Nd-sD, provides an efficient system for producing recombinant proteins. Insect Biochem Mol Biol (2005) 1.02
Induction of microRNA-214-5p in human and rodent liver fibrosis. Fibrogenesis Tissue Repair (2012) 1.02
Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy: evaluation of both HBsAg-positive and HBsAg-negative cohorts. J Gastroenterol (2011) 1.02
Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning. J Atheroscler Thromb (2009) 1.02
The structural basis for the exo-mode of action in GH74 oligoxyloglucan reducing end-specific cellobiohydrolase. J Mol Biol (2007) 1.02
Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. Am J Pathol (2011) 1.02
Impaired liver regeneration in mice by lipopolysaccharide via TNF-alpha/kallikrein-mediated activation of latent TGF-beta. Gastroenterology (2002) 1.01
Structural characterization of a thiazoline-containing chromophore in an orange fluorescent protein, monomeric Kusabira Orange. Biochemistry (2008) 1.01
Proteome analysis of gelatin-bound urinary proteins from patients with bladder cancers. Eur Urol (2005) 1.01
Chimeric mice with humanized liver. Toxicology (2007) 1.01
Real-time tissue elastography as a tool for the noninvasive assessment of liver stiffness in patients with chronic hepatitis C. J Gastroenterol (2010) 1.00
Separation of phosphoprotein isotypes having the same number of phosphate groups using phosphate-affinity SDS-PAGE. Proteomics (2008) 1.00
Real-time analysis of ligand-induced cell surface and intracellular reactions of living mast cells using a surface plasmon resonance-based biosensor. Anal Biochem (2002) 0.99
Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver. Histochem Cell Biol (2005) 0.99
Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan. J Hepatobiliary Pancreat Sci (2014) 0.99
Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin. Biochemistry (2005) 0.99
Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. Lab Invest (2009) 0.99
The generation of germline transgenic silkworms for the production of biologically active recombinant fusion proteins of fibroin and human basic fibroblast growth factor. Biomaterials (2006) 0.98
Generation of a transgenic silkworm that secretes recombinant proteins in the sericin layer of cocoon: production of recombinant human serum albumin. J Biotechnol (2006) 0.98
Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice. Gut (2013) 0.98
Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans. Biochemistry (2003) 0.98
Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice. J Hepatol (2005) 0.98
Humanization of excretory pathway in chimeric mice with humanized liver. Toxicol Sci (2007) 0.98
Transplantation of engineered chimeric liver with autologous hepatocytes and xenobiotic scaffold. Ann Surg (2013) 0.98
Platelet count for predicting fibrosis in nonalcoholic fatty liver disease. J Gastroenterol (2011) 0.97
Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis. World J Gastroenterol (2006) 0.97
Structural basis of human cytoglobin for ligand binding. J Mol Biol (2004) 0.96