Published in Biochemistry on March 04, 2008
Conformational plasticity and structure/function relationships in cytochromes P450. Antioxid Redox Signal (2010) 1.40
Diversity of P450 enzymes in the biosynthesis of natural products. Nat Prod Rep (2012) 1.34
Crystal structures of cytochrome P450 105P1 from Streptomyces avermitilis: conformational flexibility and histidine ligation state. J Bacteriol (2008) 1.10
Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis. J Biol Chem (2010) 1.04
Cytochrome P450-mediated metabolism of vitamin D. J Lipid Res (2013) 1.00
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. Proc Natl Acad Sci U S A (2015) 0.95
Structure of cytochrome P450 PimD suggests epoxidation of the polyene macrolide pimaricin occurs via a hydroperoxoferric intermediate. Chem Biol (2010) 0.95
Structural evidence for enhancement of sequential vitamin D3 hydroxylation activities by directed evolution of cytochrome P450 vitamin D3 hydroxylase. J Biol Chem (2010) 0.81
Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T. J Biol Chem (2014) 0.80
Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin. Int J Mol Sci (2012) 0.80
Crystallization and preliminary X-ray diffraction studies of vitamin D3 hydroxylase, a novel cytochrome P450 isolated from Pseudonocardia autotrophica. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.79
CYP105-diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces. J Appl Microbiol (2014) 0.78
Virtual Screening Analysis and In-vitro Xanthine Oxidase Inhibitory Activity of Some Commercially Available Flavonoids. Iran J Pharm Res (2013) 0.77
Systemic Control of Bone Homeostasis by FGF23 Signaling. Curr Mol Biol Rep (2016) 0.77
Crystal Structure of Cytochrome P450 (CYP105P2) from Streptomyces peucetius and Its Conformational Changes in Response to Substrate Binding. Int J Mol Sci (2016) 0.76
N-Heterocyclic Carbene Capture by Cytochrome P450 3A4. Mol Pharmacol (2016) 0.75
In-silico and In-vitro based studies of Streptomyces peucetius CYP107N3 for oleic acid epoxidation. BMB Rep (2012) 0.75
Identification of a vitamin D3-specific hydroxylase genes through actinomycetes genome mining. J Ind Microbiol Biotechnol (2013) 0.75
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics (2005) 2.98
1.25 A resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms. J Mol Biol (2006) 1.93
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. Proc Natl Acad Sci U S A (2006) 1.91
Cloning and characterization of the goadsporin biosynthetic gene cluster from Streptomyces sp. TP-A0584. Microbiology (2005) 1.55
Specific damage induced by X-ray radiation and structural changes in the primary photoreaction of bacteriorhodopsin. J Mol Biol (2002) 1.52
Structural basis of biological N2O generation by bacterial nitric oxide reductase. Science (2010) 1.44
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A (2009) 1.40
Activation of a Rac GTPase by the NLR family disease resistance protein Pit plays a critical role in rice innate immunity. Cell Host Microbe (2010) 1.38
Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties. J Inorg Biochem (2002) 1.37
Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers. Drug Metab Dispos (2009) 1.34
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol (2005) 1.33
Light-dependent regulation of structural flexibility in a photochromic fluorescent protein. Proc Natl Acad Sci U S A (2008) 1.28
Tolerance of the Rieske-type [2Fe-2S] cluster in recombinant ferredoxin BphA3 from Pseudomonas sp. KKS102 to histidine ligand mutations. Biochem J (2005) 1.23
Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studies. J Biol Chem (2003) 1.22
Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells. J Biol Chem (2003) 1.21
NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single turnover cycle. J Biol Chem (2004) 1.20
Structure of PAS-linked histidine kinase and the response regulator complex. Structure (2009) 1.19
Cross-sectional anatomic configurations of peripapillary atrophy evaluated with spectral domain-optical coherence tomography. Invest Ophthalmol Vis Sci (2009) 1.19
The crystal structures of the ferric and ferrous forms of the heme complex of HmuO, a heme oxygenase of Corynebacterium diphtheriae. J Biol Chem (2003) 1.15
Density functional theory study on a missing piece in understanding of heme chemistry: the reaction mechanism for indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase. J Am Chem Soc (2008) 1.13
Separation of a phosphorylated histidine protein using phosphate affinity polyacrylamide gel electrophoresis. Anal Biochem (2006) 1.09
Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Proc Natl Acad Sci U S A (2007) 1.07
The fungal hydrophobin RolA recruits polyesterase and laterally moves on hydrophobic surfaces. Mol Microbiol (2005) 1.06
Metabolism of vitamin D by human microsomal CYP2R1. Biochem Biophys Res Commun (2004) 1.06
The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases. Drug Metab Dispos (2008) 1.05
Linezolid-induced optic neuropathy. Am J Ophthalmol (2005) 1.05
Direct observation of photolysis-induced tertiary structural changes in hemoglobin. Proc Natl Acad Sci U S A (2003) 1.04
1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis. Clin J Am Soc Nephrol (2013) 1.04
The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages. Toxicol Sci (2009) 1.03
Structural characterization of a thiazoline-containing chromophore in an orange fluorescent protein, monomeric Kusabira Orange. Biochemistry (2008) 1.01
Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka. Chromosome Res (2012) 1.01
The roles of cytochrome P450 enzymes in prostate cancer development and treatment. Anticancer Res (2012) 1.01
Fusion of SPECT and multidetector CT images for accurate localization of pelvic sentinel lymph nodes in prostate cancer patients. J Nucl Med Technol (2005) 1.00
Separation of phosphoprotein isotypes having the same number of phosphate groups using phosphate-affinity SDS-PAGE. Proteomics (2008) 1.00
Pre-germinated brown rice could enhance maternal mental health and immunity during lactation. Eur J Nutr (2007) 0.99
Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin. Biochemistry (2005) 0.99
Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans. Biochemistry (2003) 0.98
Structural basis of human cytoglobin for ligand binding. J Mol Biol (2004) 0.96
YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase. J Biol Chem (2003) 0.96
Solution structure of the C-terminal transcriptional activator domain of FixJ from Sinorhizobium meliloti and its recognition of the fixK promoter. Biochemistry (2005) 0.96
Chondrosarcoma of the nasal septum: A case report. Auris Nasus Larynx (2009) 0.95
Observation of a calcium-binding site in the gamma-class carbonic anhydrase from Pyrococcus horikoshii. Acta Crystallogr D Biol Crystallogr (2008) 0.94
Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus. Nat Struct Mol Biol (2012) 0.94
Crystal structure of H2O2-dependent cytochrome P450SPalpha with its bound fatty acid substrate: insight into the regioselective hydroxylation of fatty acids at the alpha position. J Biol Chem (2011) 0.93
Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1. J Biol Chem (2005) 0.93
Escherichia coli cytosolic glycerophosphodiester phosphodiesterase (UgpQ) requires Mg2+, Co2+, or Mn2+ for its enzyme activity. J Bacteriol (2007) 0.93
The signaling pathway in histidine kinase and the response regulator complex revealed by X-ray crystallography and solution scattering. J Mol Biol (2006) 0.93
A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism. J Biol Chem (2010) 0.93
Peroxide-utilizing biocatalysts: structural and functional diversity of heme-containing enzymes. Curr Opin Chem Biol (2004) 0.92
Insight into functional diversity of cytochrome P450 in the white-rot basidiomycete Phanerochaete chrysosporium: involvement of versatile monooxygenase. Biochem Biophys Res Commun (2011) 0.92
Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms. Drug Metab Dispos (2007) 0.92
ONIOM study on a missing piece in our understanding of heme chemistry: bacterial tryptophan 2,3-dioxygenase with dual oxidants. J Am Chem Soc (2010) 0.92
Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate cancer. Anticancer Res (2009) 0.91
Experimental application of pulsed laser-induced water jet for endoscopic submucosal dissection: mechanical investigation and preliminary experiment in swine. Dig Endosc (2012) 0.91
Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis. Biosci Biotechnol Biochem (2011) 0.90
Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase. Drug Metab Dispos (2011) 0.90
Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam. Biochemistry (2003) 0.90
Interaction of bisphenol A with human UDP-glucuronosyltransferase 1A6 enzyme. Environ Toxicol (2008) 0.90
Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet. Drug Metab Dispos (2007) 0.89
Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli. FEBS J (2008) 0.89
Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D(3) analogs. J Steroid Biochem Mol Biol (2012) 0.89
Excited states of fluorescent proteins, mKO and DsRed: chromophore-protein electrostatic interaction behind the color variations. J Phys Chem B (2010) 0.89
Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats. Mol Pharmacol (2006) 0.89
Metabolism of sesamin by cytochrome P450 in human liver microsomes. Drug Metab Dispos (2010) 0.88
Structural basis of the signal transduction in the two-component system. Adv Exp Med Biol (2008) 0.88
Hydrogen peroxide dependent monooxygenations by tricking the substrate recognition of cytochrome P450BSbeta. Angew Chem Int Ed Engl (2007) 0.88
Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1. Biochemistry (2004) 0.88
Transient intermediates from Mn(salen) with sterically hindered mesityl groups: interconversion between MnIV-phenolate and MnIII-phenoxyl radicals as an origin for unique reactivity. Inorg Chem (2008) 0.88
Crystal structure and spectroscopic studies of a stable mixed-valent state of the hemerythrin-like domain of a bacterial chemotaxis protein. Inorg Chem (2011) 0.88
Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine in humans. Drug Metab Dispos (2007) 0.87
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes. J Pharm Sci (2010) 0.87
Design of lambda Cro fold: solution structure of a monomeric variant of the de novo protein. J Mol Biol (2005) 0.87
Laughter lowered the increase in postprandial blood glucose. Diabetes Care (2003) 0.86
Hybrid respiration in the denitrifying mitochondria of Fusarium oxysporum. J Biochem (2003) 0.86
Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells. J Steroid Biochem Mol Biol (2011) 0.86
Interaction between mitochondrial CYP27B1 and adrenodoxin: role of arginine 458 of mouse CYP27B1. Biochemistry (2006) 0.86
Evaluation of mutagenic activities of leachates in landfill sites by micronucleus test and comet assay using goldfish. Mutat Res (2006) 0.86
CYP24A1 as a potential target for cancer therapy. Anticancer Agents Med Chem (2014) 0.86
Molecular dynamics simulations reveal proton transfer pathways in cytochrome C-dependent nitric oxide reductase. PLoS Comput Biol (2012) 0.85
Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1. Biochem Biophys Res Commun (2004) 0.85
Enzymatic reaction of hydrogen peroxide-dependent peroxygenase cytochrome P450s: kinetic deuterium isotope effects and analyses by resonance Raman spectroscopy. Biochemistry (2002) 0.85
Theoretical and experimental studies of the conversion of chromopyrrolic acid to an antitumor derivative by cytochrome P450 StaP: the catalytic role of water molecules. J Am Chem Soc (2009) 0.85
Crystal structure of VioE, a key player in the construction of the molecular skeleton of violacein. J Biol Chem (2008) 0.85
Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES. Biochem Biophys Res Commun (2004) 0.85