Published in J Mol Biol on May 30, 2006
Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER. Acta Crystallogr D Biol Crystallogr (2012) 3.05
Structure of the haptoglobin-haemoglobin complex. Nature (2012) 1.40
Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance. Nat Genet (2010) 1.17
Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin. J Biol Chem (2010) 1.15
Effects of macromolecular crowding on protein conformational changes. PLoS Comput Biol (2010) 1.15
Heme on innate immunity and inflammation. Front Pharmacol (2014) 1.15
Hemoglobin variants: biochemical properties and clinical correlates. Cold Spring Harb Perspect Med (2013) 1.09
Unsuspected pathway of the allosteric transition in hemoglobin. Proc Natl Acad Sci U S A (2011) 1.04
Iron L-edge X-ray absorption spectroscopy of oxy-picket fence porphyrin: experimental insight into Fe-O2 bonding. J Am Chem Soc (2013) 1.03
Hemoglobin dynamics in red blood cells: correlation to body temperature. Biophys J (2008) 1.02
Solution structure of poly(ethylene) glycol-conjugated hemoglobin revealed by small-angle X-ray scattering: implications for a new oxygen therapeutic. Biophys J (2007) 1.00
Nitrosyl hydride (HNO) as an O2 analogue: long-lived HNO adducts of ferrous globins. Biochemistry (2009) 0.98
Preliminary time-of-flight neutron diffraction study of human deoxyhemoglobin. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.96
WAXS studies of the structural diversity of hemoglobin in solution. J Mol Biol (2011) 0.96
Molecular dynamics simulations of hemoglobin A in different states and bound to DPG: effector-linked perturbation of tertiary conformations and HbA concerted dynamics. Biophys J (2007) 0.94
Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases. Front Pharmacol (2012) 0.94
A comparative NMR study of the polypeptide backbone dynamics of hemoglobin in the deoxy and carbonmonoxy forms. Biochemistry (2007) 0.94
Probing the oxyferrous and catalytically active ferryl states of Amphitrite ornata dehaloperoxidase by cryoreduction and EPR/ENDOR spectroscopy. Detection of compound I. J Am Chem Soc (2010) 0.92
Blocking the gate to ligand entry in human hemoglobin. J Biol Chem (2010) 0.92
The role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly. Antioxid Redox Signal (2010) 0.92
Kinetic-dynamic model for conformational control of an electron transfer photocycle: mixed-metal hemoglobin hybrids. J Phys Chem B (2008) 0.90
Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus. J Biol Chem (2014) 0.90
Interfacial and distal-heme pocket mutations exhibit additive effects on the structure and function of hemoglobin. Biochemistry (2008) 0.89
Modulating distal cavities in the α and β subunits of human HbA reveals the primary ligand migration pathway. Biochemistry (2011) 0.89
Structural transition temperature of hemoglobins correlates with species' body temperature. Eur Biophys J (2007) 0.88
Deer mouse hemoglobin exhibits a lowered oxygen affinity owing to mobility of the E helix. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.87
α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide. J Biol Chem (2012) 0.87
New look at hemoglobin allostery. Chem Rev (2015) 0.87
Structure of human R-state aquomethemoglobin at 2.0 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.87
Spontaneous quaternary and tertiary T-R transitions of human hemoglobin in molecular dynamics simulation. PLoS Comput Biol (2010) 0.86
Mass spectrometry evidence for cisplatin as a protein cross-linking reagent. Anal Chem (2011) 0.85
Studying and polishing the PDB's macromolecules. Biopolymers (2012) 0.83
Structures and oxygen affinities of crystalline human hemoglobin C (β6 Glu->Lys) in the R and R2 quaternary structures. J Biol Chem (2011) 0.83
Insights into the solution structure of human deoxyhemoglobin in the absence and presence of an allosteric effector. Biochemistry (2007) 0.83
Differential control of heme reactivity in alpha and beta subunits of hemoglobin: a combined Raman spectroscopic and computational study. J Am Chem Soc (2014) 0.83
Reverse engineering the cooperative machinery of human hemoglobin. PLoS One (2013) 0.82
An investigation of the distal histidyl hydrogen bonds in oxyhemoglobin: effects of temperature, pH, and inositol hexaphosphate. Biochemistry (2010) 0.82
Modeling of peroxide activation in artemisinin derivatives by serial docking. J Mol Model (2009) 0.81
Stability of peroxide antimalarials in the presence of human hemoglobin. Antimicrob Agents Chemother (2009) 0.81
Water-mediated variability in the structure of relaxed-state haemoglobin. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.80
Kinetic spectroscopy of heme hydration and ligand binding in myoglobin and isolated hemoglobin chains: an optical window into heme pocket water dynamics. Phys Chem Chem Phys (2010) 0.79
Reaction trajectory revealed by a joint analysis of protein data bank. PLoS One (2013) 0.79
Identification and functional and spectral characterization of a globin-coupled histidine kinase from Anaeromyxobacter sp. Fw109-5. J Biol Chem (2011) 0.79
Collective dynamics underlying allosteric transitions in hemoglobin. PLoS Comput Biol (2013) 0.79
Ambidentate H-bonding of NO and O2 in heme proteins. J Inorg Biochem (2012) 0.79
X-ray absorption spectroscopic investigation of the electronic structure differences in solution and crystalline oxyhemoglobin. Proc Natl Acad Sci U S A (2013) 0.79
The Monod-Wyman-Changeux allosteric model accounts for the quaternary transition dynamics in wild type and a recombinant mutant human hemoglobin. Proc Natl Acad Sci U S A (2012) 0.79
Conservation of the three-dimensional structure in non-homologous or unrelated proteins. Hum Genomics (2012) 0.78
Unlocking the binding and reaction mechanism of hydroxyurea substrates as biological nitric oxide donors. J Chem Inf Model (2012) 0.78
Carboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase. Anesth Analg (2013) 0.78
An order-disorder transition plays a role in switching off the root effect in fish hemoglobins. J Biol Chem (2010) 0.78
Molecular modeling of the human hemoglobin-haptoglobin complex sheds light on the protective mechanisms of haptoglobin. PLoS One (2013) 0.78
Structure of fully liganded Hb ζ2β2s trapped in a tense conformation. Acta Crystallogr D Biol Crystallogr (2013) 0.78
Real-time tracking of CO migration and binding in the α and β subunits of human hemoglobin via 150-ps time-resolved Laue crystallography. Chem Phys (2013) 0.78
Methemoglobin Formation and Characterization of Hemoglobin Adducts of Carcinogenic Aromatic Amines and Heterocyclic Aromatic Amines. Chem Res Toxicol (2016) 0.78
An Origin of Cooperative Oxygen Binding of Human Adult Hemoglobin: Different Roles of the α and β Subunits in the α2β2 Tetramer. PLoS One (2015) 0.77
Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia. J Biol Inorg Chem (2013) 0.77
Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family. Nat Commun (2015) 0.77
Visualizing the Bohr effect in hemoglobin: neutron structure of equine cyanomethemoglobin in the R state and comparison with human deoxyhemoglobin in the T state. Acta Crystallogr D Struct Biol (2016) 0.76
α-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond. J Biol Chem (2013) 0.76
Autoxidation and oxygen binding properties of recombinant hemoglobins with substitutions at the αVal-62 or βVal-67 position of the distal heme pocket. J Biol Chem (2013) 0.76
Differences in coordination states of substituted tyrosine residues and quaternary structures among hemoglobin M probed by resonance Raman spectroscopy. J Biol Inorg Chem (2009) 0.76
Hemoglobin Kirklareli (α H58L), a New Variant Associated with Fe Deficiency and Increased CO Binding. J Biol Chem (2016) 0.75
Non-site-specific allosteric effect of oxygen on human hemoglobin under high oxygen partial pressure. Sci Rep (2014) 0.75
Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case. Biomed Res Int (2017) 0.75
Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation. J Struct Biol (2016) 0.75
Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α₂β₂(Pro100Leu)). Protein Sci (2012) 0.75
The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Role of β/δ101Gln in regulating the effect of temperature and allosteric effectors on oxygen affinity in woolly mammoth hemoglobin. Biochemistry (2013) 0.75
Conformational stability and crystal packing: polymorphism in Neurospora crassa CAT-3. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.75
Protonation states of histidine and other key residues in deoxy normal human adult hemoglobin by neutron protein crystallography. Acta Crystallogr D Biol Crystallogr (2010) 0.75
Alteration of the α1β2/α2β1 subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice. PLoS One (2017) 0.75
Spectroscopic studies of the cytochrome P450 reaction mechanisms. Biochim Biophys Acta (2017) 0.75
Phthalide Derivatives from Angelica Sinensis Decrease Hemoglobin Oxygen Affinity: A New Allosteric-Modulating Mechanism and Potential Use as 2,3-BPG Functional Substitutes. Sci Rep (2017) 0.75
The structural basis for an essential subunit interaction in influenza virus RNA polymerase. Nature (2008) 2.74
Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Crit Care (2012) 2.02
The accuracy of a continuous blood glucose monitor during surgery. Anesth Analg (2008) 1.92
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. Proc Natl Acad Sci U S A (2006) 1.91
Airway obstruction caused by nasal airway. Anesth Analg (2006) 1.80
Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase. EMBO J (2009) 1.78
Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli. J Biol Chem (2005) 1.76
Crystal structure of elongation factor P from Thermus thermophilus HB8. Proc Natl Acad Sci U S A (2004) 1.65
Using a stool for stabilization of a dental chair when CPR is required. Resuscitation (2010) 1.57
Specific damage induced by X-ray radiation and structural changes in the primary photoreaction of bacteriorhodopsin. J Mol Biol (2002) 1.52
Limited tolerance towards folded elements during secretion of the autotransporter Hbp. Mol Microbiol (2007) 1.52
Crystal structures of the liganded and unliganded nickel-binding protein NikA from Escherichia coli. J Biol Chem (2003) 1.52
Cardiac output by PulseCO is not interchangeable with thermodilution in patients undergoing OPCAB. Can J Anaesth (2005) 1.51
Structural basis of biological N2O generation by bacterial nitric oxide reductase. Science (2010) 1.44
Tracheobronchomalacia-like lung collapse during three separate trials of general anesthesia. Anesth Analg (2006) 1.41
Neutron structure analysis using the IBARAKI biological crystal diffractometer (iBIX) at J-PARC. Acta Crystallogr D Biol Crystallogr (2010) 1.41
Dental mirror is a relief for difficult endotracheal intubation. Anesth Analg (2006) 1.39
Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties. J Inorg Biochem (2002) 1.37
Light-dependent regulation of structural flexibility in a photochromic fluorescent protein. Proc Natl Acad Sci U S A (2008) 1.28
Tolerance of the Rieske-type [2Fe-2S] cluster in recombinant ferredoxin BphA3 from Pseudomonas sp. KKS102 to histidine ligand mutations. Biochem J (2005) 1.23
Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studies. J Biol Chem (2003) 1.22
Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle. J Virol (2012) 1.21
NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single turnover cycle. J Biol Chem (2004) 1.20
Interactions of FliJ with the Salmonella type III flagellar export apparatus. J Bacteriol (2003) 1.20
Structure of PAS-linked histidine kinase and the response regulator complex. Structure (2009) 1.19
Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance. Nat Genet (2010) 1.17
The crystal structures of the ferric and ferrous forms of the heme complex of HmuO, a heme oxygenase of Corynebacterium diphtheriae. J Biol Chem (2003) 1.15
Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics. Biochemistry (2006) 1.13
Density functional theory study on a missing piece in understanding of heme chemistry: the reaction mechanism for indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase. J Am Chem Soc (2008) 1.13
Mutational analysis of the substrate specificity of Escherichia coli penicillin binding protein 4. Biochemistry (2009) 1.11
Autotransporter passenger proteins: virulence factors with common structural themes. J Mol Med (Berl) (2010) 1.10
Crystal structure of the conserved protein TT1542 from Thermus thermophilus HB8. Protein Sci (2003) 1.09
Separation of a phosphorylated histidine protein using phosphate affinity polyacrylamide gel electrophoresis. Anal Biochem (2006) 1.09
Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3. Biochemistry (2008) 1.08
Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Proc Natl Acad Sci U S A (2007) 1.07
A novel intein-like autoproteolytic mechanism in autotransporter proteins. J Mol Biol (2010) 1.07
Direct observation of photolysis-induced tertiary structural changes in hemoglobin. Proc Natl Acad Sci U S A (2003) 1.04
Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain. J Neurosci (2011) 1.04
The structure of the Haemophilus influenzae HMW1 pro-piece reveals a structural domain essential for bacterial two-partner secretion. J Biol Chem (2007) 1.01
Crystal structure of the GTP-binding protein Obg from Thermus thermophilus HB8. J Mol Biol (2004) 1.01
Structural characterization of a thiazoline-containing chromophore in an orange fluorescent protein, monomeric Kusabira Orange. Biochemistry (2008) 1.01
The effects of vasodilation on cardiac output measured by PiCCO. J Cardiothorac Vasc Anesth (2008) 1.00
Separation of phosphoprotein isotypes having the same number of phosphate groups using phosphate-affinity SDS-PAGE. Proteomics (2008) 1.00
The nature of the TRAP-Anti-TRAP complex. Proc Natl Acad Sci U S A (2009) 0.99
Incidence and risk factors of postoperative delirium in cervical spine surgery. Spine (Phila Pa 1976) (2009) 0.99
Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin. Biochemistry (2005) 0.99
Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. J Biol Chem (2003) 0.98
Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans. Biochemistry (2003) 0.98
Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms. J Mol Biol (2012) 0.98
Effects of a protease inhibitor, ulinastatin, on coagulation and fibrinolysis in abdominal surgery. J Anesth (2006) 0.97
Structural basis of human cytoglobin for ligand binding. J Mol Biol (2004) 0.96
YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase. J Biol Chem (2003) 0.96
Solution structure of the C-terminal transcriptional activator domain of FixJ from Sinorhizobium meliloti and its recognition of the fixK promoter. Biochemistry (2005) 0.96
Protonation states of buried histidine residues in human deoxyhemoglobin revealed by neutron crystallography. J Am Chem Soc (2007) 0.96
Appearance of differentiated cells derived from polar body nuclei in the silkworm, Bombyx mori. Front Physiol (2013) 0.95
Sedation guidelines for midazolam infusion during combined spinal and epidural anesthesia. J Clin Anesth (2004) 0.95
[Anesthetic management for a patient with multiple sclerosis at exacerbation stage under general anesthesia]. Masui (2003) 0.95
Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus. Nat Struct Mol Biol (2012) 0.94
Observation of a calcium-binding site in the gamma-class carbonic anhydrase from Pyrococcus horikoshii. Acta Crystallogr D Biol Crystallogr (2008) 0.94
Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae. J Mol Biol (2009) 0.93
Crystal structure of H2O2-dependent cytochrome P450SPalpha with its bound fatty acid substrate: insight into the regioselective hydroxylation of fatty acids at the alpha position. J Biol Chem (2011) 0.93
Escherichia coli cytosolic glycerophosphodiester phosphodiesterase (UgpQ) requires Mg2+, Co2+, or Mn2+ for its enzyme activity. J Bacteriol (2007) 0.93
The signaling pathway in histidine kinase and the response regulator complex revealed by X-ray crystallography and solution scattering. J Mol Biol (2006) 0.93
A conserved aromatic residue in the autochaperone domain of the autotransporter Hbp is critical for initiation of outer membrane translocation. J Biol Chem (2010) 0.93
A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism. J Biol Chem (2010) 0.93
Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Acta Crystallogr D Biol Crystallogr (2002) 0.92
Peroxide-utilizing biocatalysts: structural and functional diversity of heme-containing enzymes. Curr Opin Chem Biol (2004) 0.92
Dynamic allostery in the ring protein TRAP. J Mol Biol (2007) 0.92
ONIOM study on a missing piece in our understanding of heme chemistry: bacterial tryptophan 2,3-dioxygenase with dual oxidants. J Am Chem Soc (2010) 0.92
R-state haemoglobin with low oxygen affinity: crystal structures of deoxy human and carbonmonoxy horse haemoglobin bound to the effector molecule L35. J Mol Biol (2005) 0.92
Efficacy of a heat and moisture exchanger in inhalation anesthesia at two different flow rates. J Anesth (2007) 0.91
Compositional stability of a salivary bacterial population against supragingival microbiota shift following periodontal therapy. PLoS One (2012) 0.91
Stress hormone changes in general anesthesia of long duration: isoflurane-nitrous oxide vs sevoflurane-nitrous oxide anesthesia. J Clin Anesth (2005) 0.91
Effects of vasodilation on cardiac output measured by PulseCO. J Clin Monit Comput (2007) 0.90
Direct determination of protonation states of histidine residues in a 2 A neutron structure of deoxy-human normal adult hemoglobin and implications for the Bohr effect. J Mol Biol (2010) 0.90
Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam. Biochemistry (2003) 0.90
Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis. Biosci Biotechnol Biochem (2011) 0.90
Crystal structures of the catalytic domains of pseudouridine synthases RluC and RluD from Escherichia coli. Biochemistry (2004) 0.90
Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli. FEBS J (2008) 0.89
Role of domains within the autotransporter Hbp/Tsh. Acta Crystallogr D Biol Crystallogr (2010) 0.89
Excited states of fluorescent proteins, mKO and DsRed: chromophore-protein electrostatic interaction behind the color variations. J Phys Chem B (2010) 0.89
Novel mechanisms of pH sensitivity in tuna hemoglobin: a structural explanation of the root effect. J Biol Chem (2004) 0.89
Hydrogen peroxide dependent monooxygenations by tricking the substrate recognition of cytochrome P450BSbeta. Angew Chem Int Ed Engl (2007) 0.88
Transient intermediates from Mn(salen) with sterically hindered mesityl groups: interconversion between MnIV-phenolate and MnIII-phenoxyl radicals as an origin for unique reactivity. Inorg Chem (2008) 0.88
Structural basis of the signal transduction in the two-component system. Adv Exp Med Biol (2008) 0.88
Crystal structure and spectroscopic studies of a stable mixed-valent state of the hemerythrin-like domain of a bacterial chemotaxis protein. Inorg Chem (2011) 0.88
Crystal structure of a novel polyisoprenoid-binding protein from Thermus thermophilus HB8. Protein Sci (2005) 0.87
Design of lambda Cro fold: solution structure of a monomeric variant of the de novo protein. J Mol Biol (2005) 0.87
Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils. Clin Chim Acta (2002) 0.87
Rounding up: Engineering 12-membered rings from the cyclic 11-mer TRAP. Structure (2006) 0.87
Hybrid respiration in the denitrifying mitochondria of Fusarium oxysporum. J Biochem (2003) 0.86
Urinary fatty acids and liver-type fatty acid binding protein in diabetic nephropathy. Nephron Clin Pract (2009) 0.86
Urinary liver type fatty acid binding protein in diabetic nephropathy. Clin Chim Acta (2013) 0.86
Crystal structure of unliganded TRAP: implications for dynamic allostery. Biochem J (2011) 0.86
Roles of human liver type fatty acid binding protein in kidney disease clarified using hL-FABP chromosomal transgenic mice. Nephrology (Carlton) (2011) 0.86
Intersubunit linker length as a modifier of protein stability: crystal structures and thermostability of mutant TRAP. Protein Sci (2008) 0.85