Published in Cancer Res on May 15, 2006
Pancreatic cancer. Annu Rev Pathol (2008) 6.96
The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics (2008) 3.11
Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer. J Cell Physiol (2010) 1.81
Macrophage inhibitory cytokine 1: a new prognostic marker in prostate cancer. Clin Cancer Res (2009) 1.51
Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality. Aging Cell (2010) 1.29
Growth-differentiation factor-15 is a robust, independent predictor of 11-year mortality risk in community-dwelling older adults: the Rancho Bernardo Study. Circulation (2011) 1.25
Growth differentiation factor 15 in erythroid health and disease. Curr Opin Hematol (2010) 1.21
TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator. PLoS One (2013) 1.12
Anorexia-cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15. Int J Obes (Lond) (2015) 1.08
Unique features of the transcriptional response to model aneuploidy in human cells. BMC Genomics (2014) 1.06
Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15. J Cachexia Sarcopenia Muscle (2012) 1.02
RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis. Mol Biol Cell (2011) 1.00
A prospective study of macrophage inhibitory cytokine-1 (MIC-1/GDF15) and risk of colorectal cancer. J Natl Cancer Inst (2014) 1.00
Clinical and genetic correlates of growth differentiation factor 15 in the community. Clin Chem (2012) 0.99
GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective. J Diabetes Res (2015) 0.99
Macrophage inhibitory cytokine 1 (MIC-1/GDF15) as a novel diagnostic serum biomarker in pancreatic ductal adenocarcinoma. BMC Cancer (2014) 0.99
A digest on the role of the tumor microenvironment in gastrointestinal cancers. Cancer Microenviron (2010) 0.97
The novel biomarker growth differentiation factor 15 in heart failure with normal ejection fraction. Eur J Heart Fail (2010) 0.95
Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells. Blood (2013) 0.95
The role of NAG-1/GDF15 in the inhibition of intestinal polyps in APC/Min mice by sulindac. Cancer Prev Res (Phila) (2011) 0.94
Growth differentiation factor-15: a new biomarker in cardiovascular disease. Herz (2009) 0.93
The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract. PLoS One (2014) 0.93
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice. PLoS One (2012) 0.93
Adaptive induction of growth differentiation factor 15 attenuates endothelial cell apoptosis in response to high glucose stimulus. PLoS One (2013) 0.93
Macrophage inhibitory cytokine-1 regulates melanoma vascular development. Am J Pathol (2010) 0.91
SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas. J Biol Chem (2011) 0.91
Association of serum level of growth differentiation factor 15 with liver cirrhosis and hepatocellular carcinoma. PLoS One (2015) 0.91
RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability. J Biol Chem (2013) 0.90
Potentials of plasma NGAL and MIC-1 as biomarker(s) in the diagnosis of lethal pancreatic cancer. PLoS One (2013) 0.89
GDF-15: a novel serum marker for metastases in uveal melanoma patients. Graefes Arch Clin Exp Ophthalmol (2011) 0.88
Inhibitory Effects of Salinomycin on Cell Survival, Colony Growth, Migration, and Invasion of Human Non-Small Cell Lung Cancer A549 and LNM35: Involvement of NAG-1. PLoS One (2013) 0.87
The H6D variant of NAG-1/GDF15 inhibits prostate xenograft growth in vivo. Prostate (2011) 0.86
Macrophage inhibitory factor 1 acts as a potential biomarker in patients with esophageal squamous cell carcinoma and is a target for antibody-based therapy. Cancer Sci (2014) 0.86
Change of body weight and macrophage inhibitory cytokine-1 during chemotherapy in advanced gastric cancer: what is their clinical significance? PLoS One (2014) 0.85
Protective Effects of Liposomal N-Acetylcysteine against Paraquat-Induced Cytotoxicity and Gene Expression. J Toxicol (2011) 0.85
Growth-differentiation factor-15 and functional outcome after acute ischemic stroke. J Neurol (2012) 0.83
Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes. PLoS One (2011) 0.83
Opposing effects of PI3K/Akt and Smad-dependent signaling pathways in NAG-1-induced glioblastoma cell apoptosis. PLoS One (2014) 0.79
Prolonged NF-κB activation by a macrophage inhibitory cytokine 1-linked signal in enteropathogenic Escherichia coli-infected epithelial cells. Infect Immun (2013) 0.79
Association of macrophage inhibitory cytokine-1 with nutritional status, body composition and bone mineral density in patients with anorexia nervosa: the influence of partial realimentation. Nutr Metab (Lond) (2010) 0.79
Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI. PLoS One (2015) 0.79
Plasma Inflammatory Markers and Risk of Advanced Colorectal Adenoma in Women. Cancer Prev Res (Phila) (2015) 0.78
Expression of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) inversely correlates with tumor progression in gastric adenomas and carcinomas. J Cancer Res Clin Oncol (2008) 0.77
Macrophage inhibitory cytokine 1 biomarker serum immunoassay in combination with PSA is a more specific diagnostic tool for detection of prostate cancer. PLoS One (2015) 0.77
MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma. Br J Cancer (2015) 0.76
Increased serum levels of GDF-15 associated with mortality and subclinical atherosclerosis in patients on maintenance hemodialysis. Herz (2014) 0.76
Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer. J Cell Mol Med (2016) 0.76
Assessment of selected cytokines, proteins, and growth factors in the peritoneal fluid of patients with ovarian cancer and benign gynecological conditions. Onco Targets Ther (2015) 0.76
Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci (2016) 0.76
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice. PLoS One (2015) 0.76
From Inflammation to Prostate Cancer: The Role of Inflammasomes. Adv Urol (2016) 0.76
ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial. Trials (2017) 0.75
The effect of full length and mature NAG-1 protein overexpression on cytotoxicity of celecoxib, tamoxifen and doxorubicin in HT1080. Daru (2010) 0.75
NSAID-activated gene 1 mediates pro-inflammatory signaling activation and paclitaxel chemoresistance in type I human epithelial ovarian cancer stem-like cells. Oncotarget (2016) 0.75
Plasma growth differentiation factor 15 predicts first-ever stroke in hypertensive patients. Medicine (Baltimore) (2016) 0.75
First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15. PLoS One (2017) 0.75
Bleomycin-Induced Pulmonary Changes on Restaging Computed Tomography Scans in Two Thirds of Testicular Cancer Patients Show No Correlation With Fibrosis Markers. Oncologist (2016) 0.75
Effect of bexarotene on differentiation of glioblastoma multiforme compared with ATRA. Clin Exp Metastasis (2016) 0.75
NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development. J Clin Invest (2017) 0.75
Femtosecond protein nanocrystallography-data analysis methods. Opt Express (2010) 4.64
Single mimivirus particles intercepted and imaged with an X-ray laser. Nature (2011) 4.63
Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci (2005) 4.54
GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res (2006) 2.85
Signaling microdomains define the specificity of receptor-mediated InsP(3) pathways in neurons. Neuron (2002) 2.75
Effects of task-specific locomotor and strength training in adults who were ambulatory after stroke: results of the STEPS randomized clinical trial. Phys Ther (2007) 2.62
KCNQ/M currents in sensory neurons: significance for pain therapy. J Neurosci (2003) 2.40
Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage. Lancet (2004) 2.39
Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci U S A (2003) 2.31
Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med (2007) 2.20
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci (2003) 2.08
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels. J Neurosci (2005) 2.05
The increasing incidence of small thyroid cancers: where are the cases coming from? Laryngoscope (2010) 2.01
Serum markers in patients with resectable pancreatic adenocarcinoma: macrophage inhibitory cytokine 1 versus CA19-9. Clin Cancer Res (2006) 1.93
Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem (2010) 1.93
Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J Invest Dermatol (2005) 1.86
Probing the regulation of M (Kv7) potassium channels in intact neurons with membrane-targeted peptides. J Neurosci (2006) 1.83
Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity. J Invest Dermatol (2008) 1.76
Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers. Clin Cancer Res (2004) 1.74
Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A (2008) 1.74
MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. Clin Cancer Res (2003) 1.71
The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. J Biol Chem (2003) 1.64
Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem (2002) 1.57
Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1. Oncogene (2002) 1.52
How leaders create and use networks. Harv Bus Rev (2007) 1.51
Macrophage inhibitory cytokine 1: a new prognostic marker in prostate cancer. Clin Cancer Res (2009) 1.51
Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium. J Neurosci (2003) 1.47
SEM imaging of liquid jets. Micron (2008) 1.46
The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism. Growth Factors (2011) 1.46
Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study. Lancet (2002) 1.46
Gating of the polycystin ion channel signaling complex in neurons and kidney cells. FASEB J (2004) 1.43
Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation. Mol Cancer Ther (2003) 1.41
Mortality among hourly motor vehicle manufacturing workers. J Occup Environ Med (2003) 1.41
Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4. FEBS J (2005) 1.39
The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome. Cancer Res (2005) 1.32
Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells. Cancer Res (2003) 1.31
Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality. Aging Cell (2010) 1.29
Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis. Clin Cancer Res (2006) 1.23
High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40). J Immunol (2009) 1.22
Junctional signaling microdomains: bridging the gap between the neuronal cell surface and Ca2+ stores. Neuron (2002) 1.21
GDF-15 contributes to proliferation and immune escape of malignant gliomas. Clin Cancer Res (2010) 1.20
The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins? FEBS Lett (2010) 1.20
Stepping over obstacles to improve walking in individuals with poststroke hemiplegia. J Rehabil Res Dev (2004) 1.19
Gait parameters associated with responsiveness to treadmill training with body-weight support after stroke: an exploratory study. Phys Ther (2009) 1.17
Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling. Cancer Res (2009) 1.16
Altered trunk position sense and its relation to balance functions in people post-stroke. J Neurol Phys Ther (2008) 1.16
Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome. Int J Cancer (2009) 1.16
Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction. Arthritis Rheum (2007) 1.15
Role of mitochondrial dysfunction in cardiac glycoside toxicity. J Mol Cell Cardiol (2010) 1.14
Reduction of ischemia/reperfusion injury with bendavia, a mitochondria-targeting cytoprotective Peptide. J Am Heart Assoc (2012) 1.14
TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator. PLoS One (2013) 1.12
Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of prostate cancer bone metastases. Cancer Epidemiol Biomarkers Prev (2007) 1.12
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease. Nephrol Dial Transplant (2011) 1.12
Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets. PLoS One (2012) 1.12
Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors. Proc Natl Acad Sci U S A (2006) 1.11
Serum macrophage inhibitory cytokine-1 (MIC-1/GDF15): a potential screening tool for the prevention of colon cancer? Cancer Epidemiol Biomarkers Prev (2011) 1.11
Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland. J Biol Chem (2008) 1.11
Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. J Mol Cell Cardiol (2012) 1.11
CLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia. J Neurosci (2008) 1.09
A pre-initiation complex at the 3'-end of genes drives antisense transcription independent of divergent sense transcription. Nucleic Acids Res (2011) 1.09
Exercise increases SOCS-3 expression in rat skeletal muscle: potential relationship to IL-6 expression. J Physiol (2006) 1.09
Characterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells. J Biol Chem (2002) 1.09
Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation. J Biol Chem (2003) 1.08
Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss. Prostate (2009) 1.06
Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise. Am J Physiol Heart Circ Physiol (2007) 1.06
Functional organization of PLC signaling microdomains in neurons. Trends Neurosci (2004) 1.05