Published in Nat Genet on May 21, 2006
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Neonatal diabetes mellitus. Endocr Rev (2008) 2.64
Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus. J Clin Invest (2008) 2.36
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab (2012) 2.22
Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man. Cell Metab (2014) 1.66
Neonatal diabetes mellitus: a disease linked to multiple mechanisms. Orphanet J Rare Dis (2007) 1.61
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes (2008) 1.56
Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Mol Cell Biol (2009) 1.52
Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment. Curr Diab Rep (2011) 1.52
Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3. Diabetes (2011) 1.47
Wolcott-Rallison syndrome. Orphanet J Rare Dis (2010) 1.45
Management of diabetes mellitus in infants. Nat Rev Endocrinol (2011) 1.40
Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proc Natl Acad Sci U S A (2010) 1.36
GATA6 mutations cause a broad phenotypic spectrum of diabetes from pancreatic agenesis to adult-onset diabetes without exocrine insufficiency. Diabetes (2012) 1.36
Wolcott-Rallison syndrome is the most common genetic cause of permanent neonatal diabetes in consanguineous families. J Clin Endocrinol Metab (2009) 1.35
GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet (2013) 1.19
Neonatal diabetes mellitus: a model for personalized medicine. Trends Endocrinol Metab (2010) 1.18
Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Mol Cell Biol (2009) 1.18
Permanent diabetes during the first year of life: multiple gene screening in 54 patients. Diabetologia (2011) 1.15
The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res (2009) 1.13
Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell (2010) 1.13
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet (2013) 1.12
Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1). Nucleic Acids Res (2008) 1.11
Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions. Mol Cell Biol (2008) 1.10
Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease. Histol Histopathol (2010) 1.04
Genetically engineered pig models for human diseases. Annu Rev Anim Biosci (2013) 1.01
Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes. PLoS One (2011) 1.01
A polycystin-centric view of cyst formation and disease: the polycystins revisited. Kidney Int (2015) 1.01
Exome sequencing and genetic testing for MODY. PLoS One (2012) 1.00
Genomic analysis of fibrolamellar hepatocellular carcinoma. Hum Mol Genet (2014) 0.99
Distribution and effects of nonsense polymorphisms in human genes. PLoS One (2008) 0.99
X-chromosome gene dosage and the risk of diabetes in Turner syndrome. J Clin Endocrinol Metab (2009) 0.97
Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes. Dev Biol (2011) 0.95
Gli-similar proteins: their mechanisms of action, physiological functions, and roles in disease. Vitam Horm (2012) 0.95
Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Mol Med (2012) 0.95
Long non-coding RNAs as regulators of the endocrine system. Nat Rev Endocrinol (2015) 0.93
Many faces of monogenic diabetes. J Diabetes Investig (2014) 0.89
The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice. Diabetologia (2011) 0.89
Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nat Genet (2016) 0.89
Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2). J Biol Chem (2010) 0.89
Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused. J Biol Chem (2011) 0.88
Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes. Cell Stem Cell (2016) 0.87
Glis3 regulates neurogenin 3 expression in pancreatic β-cells and interacts with its activator, Hnf6. Mol Cells (2012) 0.87
The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Mol Endocrinol (2013) 0.87
The pancreatic β cell and type 1 diabetes: innocent bystander or active participant? Trends Endocrinol Metab (2013) 0.86
Revealing transcription factors during human pancreatic β cell development. Trends Endocrinol Metab (2014) 0.85
A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS). Am J Med Genet A (2012) 0.84
Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions. BMC Evol Biol (2010) 0.84
Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies. BMC Med Genet (2008) 0.83
Frequency and spectrum of Wolcott-Rallison syndrome in Saudi Arabia: a systematic review. Libyan J Med (2013) 0.82
Polycystic kidney disease in the medaka (Oryzias latipes) pc mutant caused by a mutation in the Gli-Similar3 (glis3) gene. PLoS One (2009) 0.82
TRANSCRIPTION FACTOR GLI-SIMILAR 3 (GLIS3): IMPLICATIONS FOR THE DEVELOPMENT OF CONGENITAL HYPOTHYROIDISM. J Endocrinol Diabetes Obes (2014) 0.81
Expanding the Clinical Spectrum Associated With GLIS3 Mutations. J Clin Endocrinol Metab (2015) 0.81
The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. PLoS One (2016) 0.81
Pathogenesis of the metabolic syndrome: insights from monogenic disorders. Mediators Inflamm (2013) 0.80
Distribution and function of polycystin-2 in mouse retinal ganglion cells. Neuroscience (2011) 0.80
Meta-analysis of genome-wide association study of homeostasis model assessment β cell function and insulin resistance in an East Asian population and the European results. Mol Genet Genomics (2014) 0.78
The Endocrine Pancreas: insights into development, differentiation and diabetes. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.78
Next generation sequencing in endocrine practice. Mol Genet Metab (2015) 0.78
The role of pancreatic imaging in monogenic diabetes mellitus. Nat Rev Endocrinol (2011) 0.78
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet (2016) 0.78
Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev (2016) 0.78
MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research. Eur J Endocrinol (2015) 0.78
Genetic variation of fasting glucose and changes in glycemia in response to 2-year weight-loss diet intervention: the POUNDS LOST trial. Int J Obes (Lond) (2016) 0.77
Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy. Oncotarget (2016) 0.77
Long noncoding RNA variations in cardiometabolic diseases. J Hum Genet (2016) 0.77
4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice. NMR Biomed (2015) 0.77
Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions. PLoS One (2014) 0.77
Molecular diagnosis of maturity onset diabetes of the young in India. Indian J Endocrinol Metab (2013) 0.76
Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis. Genes (Basel) (2017) 0.75
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology. F1000Res (2016) 0.75
Editing genetics, stem cells are prophetic, what's the best way to model cells of diabetics? Stem Cell Investig (2016) 0.75
Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic β Cell Differentiation and Function. Endocrinology (2016) 0.75
Extended clinical features associated with novel Glis3 mutation: a case report. BMC Endocr Disord (2017) 0.75
Infantile onset diabetes mellitus in developing countries - India. World J Diabetes (2016) 0.75
Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease. Stem Cell Investig (2016) 0.75
Intolerable secretion and diabetes in tolerant transgenic mice, revisited. Nat Genet (2016) 0.75
HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PLoS One (2015) 0.75
Alteration of GLIS3 gene expression pattern in patients with breast cancer. Adv Biomed Res (2016) 0.75
Long Noncoding RNAs in Metabolic Syndrome Related Disorders. Mediators Inflamm (2016) 0.75
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells. Mol Metab (2017) 0.75
Can non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes? J Clin Endocrinol Metab (2017) 0.75
Congenital hypothyroidism: insights into pathogenesis and treatment. Int J Pediatr Endocrinol (2017) 0.75
Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver. Nat Immunol (2017) 0.75
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science (2009) 8.80
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol (2002) 5.36
The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol (2006) 3.84
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57
A retrospective, multinational, multicenter study on the natural history of infantile-onset Pompe disease. J Pediatr (2006) 3.45
A review of the Constant score: modifications and guidelines for its use. J Shoulder Elbow Surg (2008) 3.23
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol (2002) 3.22
BioMart Central Portal: an open database network for the biological community. Database (Oxford) (2011) 3.03
Pompe disease diagnosis and management guideline. Genet Med (2006) 3.03
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol (2003) 3.01
Chinese hamster ovary cell-derived recombinant human acid alpha-glucosidase in infantile-onset Pompe disease. J Pediatr (2006) 2.97
Incremental value of continuous glucose monitoring when starting pump therapy in patients with poorly controlled type 1 diabetes: the RealTrend study. Diabetes Care (2009) 2.84
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab (2007) 2.76
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science (2005) 2.51
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes (2008) 2.51
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum Mol Genet (2007) 2.50
Scapular notching in reverse shoulder arthroplasty. J Shoulder Elbow Surg (2008) 2.49
Translational control and the unfolded protein response. Antioxid Redox Signal (2007) 2.47
Towards a new developmental synthesis: adaptive developmental plasticity and human disease. Lancet (2009) 2.35
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci (2013) 2.35
A variant in the CD209 promoter is associated with severity of dengue disease. Nat Genet (2005) 2.31
A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone. Nat Genet (2004) 2.30
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab (2006) 2.21
Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem (2010) 2.14
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes (2009) 2.02
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem (2004) 2.00
Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J Pathol (2013) 1.86
Genetics of type 1 diabetes: what's next? Diabetes (2010) 1.80
Large genomic rearrangements in the hepatocyte nuclear factor-1beta (TCF2) gene are the most frequent cause of maturity-onset diabetes of the young type 5. Diabetes (2005) 1.79
A comparison of hemiarthroplasty and total shoulder arthroplasty in the treatment of primary glenohumeral osteoarthritis: results of a multicenter study. J Shoulder Elbow Surg (2003) 1.76
Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics. PLoS Pathog (2013) 1.75
Arbovirus high fidelity variant loses fitness in mosquitoes and mice. Proc Natl Acad Sci U S A (2011) 1.73
Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. J Biol Chem (2010) 1.72
R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation. Heart Rhythm (2010) 1.71
PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance. J Clin Endocrinol Metab (2012) 1.68
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc Natl Acad Sci U S A (2008) 1.66
Contribution of clinical tests to the diagnosis of rotator cuff disease: a systematic literature review. Joint Bone Spine (2008) 1.65
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. Gastroenterology (2011) 1.63
PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis. Biochem J (2006) 1.61
Arbovirus-derived piRNAs exhibit a ping-pong signature in mosquito cells. PLoS One (2012) 1.58
Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia. Blood (2008) 1.56
Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014) 1.55
Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia. Genes Chromosomes Cancer (2008) 1.55
The proximal biceps as a pain generator and results of tenotomy. Sports Med Arthrosc (2008) 1.54
Neonatal Bacterial Meningitis: 444 Cases in 7 Years. Pediatr Infect Dis J (2011) 1.53
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest (2012) 1.52
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem (2007) 1.52
Problems, complications, reoperations, and revisions in reverse total shoulder arthroplasty: a systematic review. J Shoulder Elbow Surg (2011) 1.52
Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes (2004) 1.50
Arthrogryposis, renal tubular acidosis and cholestasis (ARC) syndrome: two new cases and review. Clin Dysmorphol (2005) 1.47
Premedication for neonatal endotracheal intubation: results from the epidemiology of procedural pain in neonates study. Pediatr Crit Care Med (2013) 1.47
A predictive computational model of the dynamic 3D interphase yeast nucleus. Curr Biol (2012) 1.46
Wolcott-Rallison syndrome. Orphanet J Rare Dis (2010) 1.45
SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update). Nucleic Acids Res (2012) 1.45
Percutaneous screw fixation of acetabular roof fractures by radiologists under CT and fluoroscopy guidance. AJR Am J Roentgenol (2013) 1.44
Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs. Diabetes (2011) 1.44
Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle (2010) 1.43
Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children. Physiol Genomics (2006) 1.43
Using BioMart as a framework to manage and query pancreatic cancer data. Database (Oxford) (2011) 1.43
PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. J Cell Physiol (2008) 1.41
Fine mapping of quantitative trait loci affecting female fertility in dairy cattle on BTA03 using a dense single-nucleotide polymorphism map. Genetics (2008) 1.36
Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritis. PLoS Genet (2009) 1.36
The reverse total shoulder arthroplasty. J Bone Joint Surg Am (2007) 1.35
Disruption of a long distance regulatory region upstream of SOX9 in isolated disorders of sex development. J Med Genet (2011) 1.34
A novel hypomorphic PDX1 mutation responsible for permanent neonatal diabetes with subclinical exocrine deficiency. Diabetes (2009) 1.34
S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer. Cancer Res (2007) 1.33
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology (2013) 1.32
Coxsackievirus B3 mutator strains are attenuated in vivo. Proc Natl Acad Sci U S A (2012) 1.32
Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance. N Engl J Med (2011) 1.31
PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway. Diabetes (2010) 1.31
GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. J Biol Chem (2009) 1.29
Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations. J Clin Endocrinol Metab (2004) 1.29
XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes. Mol Cell (2012) 1.24
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep (2012) 1.24
RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila. Nat Immunol (2013) 1.24
In silico reconstruction of viral genomes from small RNAs improves virus-derived small interfering RNA profiling. J Virol (2011) 1.24
Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. Mol Ther (2009) 1.23
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice. BMC Cell Biol (2007) 1.23
eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiol Genomics (2009) 1.22
Grammont's idea: The story of Paul Grammont's functional surgery concept and the development of the reverse principle. Clin Orthop Relat Res (2011) 1.22
Aetiological diagnosis of male sex ambiguity: a collaborative study. Eur J Pediatr (2002) 1.22
Pseudohypoaldosteronisms, report on a 10-patient series. Nephrol Dial Transplant (2008) 1.21
Genetic determination and linkage mapping of Plasmodium falciparum malaria related traits in Senegal. PLoS One (2008) 1.20
Online resources of cancer data: barriers, benefits and lessons. Brief Bioinform (2010) 1.19
Schimke immunoosseous dysplasia: suggestions of genetic diversity. Hum Mutat (2007) 1.19
GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet (2013) 1.19
Neonatal infection and 5-year neurodevelopmental outcome of very preterm infants. Pediatrics (2013) 1.18
Patterns of loosening of polyethylene keeled glenoid components after shoulder arthroplasty for primary osteoarthritis: results of a multicenter study with more than five years of follow-up. J Bone Joint Surg Am (2012) 1.18
EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood (2013) 1.17
Complications of unconstrained shoulder prostheses. J Shoulder Elbow Surg (2011) 1.16
Cdc48p is required for the cell cycle commitment point at Start via degradation of the G1-CDK inhibitor Far1p. J Cell Biol (2003) 1.15
Prosthetic replacement in the treatment of osteoarthritis of the shoulder: early results of 268 cases. J Shoulder Elbow Surg (2002) 1.15