Published in Science on March 18, 2005
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96
Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77
tRNA biology charges to the front. Genes Dev (2010) 4.07
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab (2008) 3.45
Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab (2008) 3.03
ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab (2009) 2.49
Nutrient-sensing mechanisms and pathways. Nature (2015) 2.46
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Adv Nutr (2012) 2.27
Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A (2009) 2.22
Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states. Cell Cycle (2011) 2.15
Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. J Biol Chem (2009) 1.64
Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR. Biochem J (2013) 1.46
Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science (2013) 1.46
Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan. Cell Metab (2017) 1.40
Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast. PLoS Genet (2008) 1.37
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Mol Cell (2014) 1.36
Transfer RNA and human disease. Front Genet (2014) 1.35
Nutrient-sensing mechanisms across evolution. Cell (2015) 1.30
The transcription factor network associated with the amino acid response in mammalian cells. Adv Nutr (2012) 1.27
MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. J Biol Chem (2008) 1.23
Homeostatic regulation of protein intake: in search of a mechanism. Am J Physiol Regul Integr Comp Physiol (2012) 1.21
Deprivation of protein or amino acid induces C/EBPbeta synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription. Biochem J (2008) 1.18
Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells. Physiol Genomics (2010) 1.15
Microcephaly and simplified gyral pattern of the brain associated with early onset insulin-dependent diabetes mellitus. Neurogenetics (2006) 1.12
The dilemmas of the gourmet fly: the molecular and neuronal mechanisms of feeding and nutrient decision making in Drosophila. Front Neurosci (2013) 1.11
The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature (2016) 1.08
Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway. PLoS One (2010) 1.07
Neural and metabolic regulation of macronutrient intake and selection. Proc Nutr Soc (2012) 1.04
Brain responses to high-protein diets. Adv Nutr (2012) 1.00
Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence. Biochem J (2005) 1.00
tRNAs: cellular barcodes for amino acids. FEBS Lett (2010) 0.99
Consolidation and translation regulation. Learn Mem (2012) 0.99
Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system. Mol Endocrinol (2011) 0.99
Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium. Amino Acids (2010) 0.99
The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. J Nutr (2010) 0.99
Odor concentration invariance by chemical ratio coding. Front Syst Neurosci (2008) 0.98
Feeding regulation in Drosophila. Curr Opin Neurobiol (2014) 0.98
The structure of the PERK kinase domain suggests the mechanism for its activation. Acta Crystallogr D Biol Crystallogr (2011) 0.98
The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation. J Cell Biol (2014) 0.94
l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells. Cancer Res (2014) 0.93
Protein-dependent regulation of feeding and metabolism. Trends Endocrinol Metab (2015) 0.92
Remodeling of lipid metabolism by dietary restriction of essential amino acids. Diabetes (2013) 0.92
eIF5 is a dual function GAP and GDI for eukaryotic translational control. Small GTPases (2010) 0.92
S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid. Diabetes (2012) 0.91
The anterior piriform cortex is sufficient for detecting depletion of an indispensable amino acid, showing independent cortical sensory function. J Neurosci (2011) 0.91
Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism. Cell Rep (2015) 0.90
The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment. Am J Physiol Endocrinol Metab (2013) 0.90
Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia. Invest New Drugs (2011) 0.89
A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2. Mol Cell Biol (2008) 0.89
An upstream ORF with non-AUG start codon is translated in vivo but dispensable for translational control of GCN4 mRNA. Nucleic Acids Res (2011) 0.87
Leucine acts in the brain to suppress food intake but does not function as a physiological signal of low dietary protein. Am J Physiol Regul Integr Comp Physiol (2014) 0.87
Yeast Gcn4p stabilization is initiated by the dissociation of the nuclear Pho85p/Pcl5p complex. Mol Biol Cell (2006) 0.86
Diverse roles for the Drosophila fructose sensor Gr43a. Fly (Austin) (2013) 0.86
Threonine-deficient diets induced changes in hepatic bioenergetics. Am J Physiol Gastrointest Liver Physiol (2009) 0.84
Defining meal requirements for protein to optimize metabolic roles of amino acids. Am J Clin Nutr (2015) 0.83
Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila. Development (2014) 0.83
GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. Am J Physiol Endocrinol Metab (2014) 0.83
GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling. Am J Physiol Cell Physiol (2012) 0.83
Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming. Cell Cycle (2012) 0.83
Vaccinology in the era of high-throughput biology. Philos Trans R Soc Lond B Biol Sci (2015) 0.83
Adipose transplant for inborn errors of branched chain amino acid metabolism in mice. Mol Genet Metab (2013) 0.82
Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction. Diabetes (2016) 0.82
Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2. J Biol Chem (2011) 0.82
Hypothalamic eIF2α signaling regulates food intake. Cell Rep (2014) 0.82
Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency. Funct Integr Genomics (2008) 0.81
The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal. Mol Neurobiol (2012) 0.81
Dietary indispensable amino acids profile affects protein utilization and growth of Senegalese sole larvae. Fish Physiol Biochem (2016) 0.80
Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells. PLoS Genet (2014) 0.79
IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth. J Biol Chem (2013) 0.79
Commensal bacteria and essential amino acids control food choice behavior and reproduction. PLoS Biol (2017) 0.78
The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin. Pharmacol Biochem Behav (2009) 0.78
Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo. PLoS Genet (2015) 0.77
No protein intake compensation for insufficient indispensable amino acid intake with a low-protein diet for 12 days. Nutr Metab (Lond) (2014) 0.77
High Leucine Diets Stimulate Cerebral Branched-Chain Amino Acid Degradation and Modify Serotonin and Ketone Body Concentrations in a Pig Model. PLoS One (2016) 0.77
General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice. J Biol Chem (2013) 0.77
Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet. PLoS One (2014) 0.76
GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat. PLoS One (2013) 0.76
The amino acid sensor GCN2 biases macronutrient selection during aging. Eur J Nutr (2011) 0.76
Selective amino acid restriction therapy (SAART): a non-pharmacological strategy against all types of cancer cells. Oncoscience (2015) 0.76
Dietary protein-induced hepatic IGF-1 secretion mediated by PPARγ activation. PLoS One (2017) 0.75
Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2. Cell Rep (2016) 0.75
Drosophila FIT is a protein-specific satiety hormone essential for feeding control. Nat Commun (2017) 0.75
A global characterization of the translational and transcriptional programs induced by methionine restriction through ribosome profiling and RNA-seq. BMC Genomics (2017) 0.75
Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast. Assay Drug Dev Technol (2009) 0.75
Enantiomer-specific selection of amino acids. Amino Acids (2013) 0.75
Effects of essential amino acid deficiency: down-regulation of KCC2 and the GABAA receptor; disinhibition in the anterior piriform cortex. J Neurochem (2013) 0.75
Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in Caenorhabditis elegans. Genetics (2017) 0.75
The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet. PLoS One (2017) 0.75
GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis. Am J Physiol Endocrinol Metab (2013) 0.75
Central Amino Acid Sensing in the Control of Feeding Behavior. Front Endocrinol (Lausanne) (2016) 0.75
L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors. Mol Ther Oncolytics (2015) 0.75
IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. BMC Biol (2016) 0.75
CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid. Int J Obes (Lond) (2014) 0.75
The widespread occurrence of tRNA-derived fragments in Saccharomyces cerevisiae. FEBS Open Bio (2016) 0.75
Concentration-dependent linkage of dietary methionine restriction to the components of its metabolic phenotype. Obesity (Silver Spring) (2017) 0.75
Nutrient Sensing: Another Chemosensitivity of the Olfactory System. Front Physiol (2017) 0.75
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol (2002) 5.36
Pseudoreplication is a pseudoproblem. J Comp Psychol (2009) 3.91
The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol (2006) 3.84
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol (2002) 3.22
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol (2003) 3.01
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat Genet (2006) 2.95
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab (2007) 2.76
Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition. J Biol Chem (2005) 2.53
Translational control and the unfolded protein response. Antioxid Redox Signal (2007) 2.47
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci (2013) 2.35
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Adv Nutr (2012) 2.27
Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. J Biol Chem (2008) 2.25
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab (2006) 2.21
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. J Biol Chem (2002) 2.16
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem (2011) 2.12
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem (2004) 2.00
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Mol Biol Cell (2011) 1.73
Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. J Biol Chem (2010) 1.72
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc Natl Acad Sci U S A (2008) 1.66
Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. J Biol Chem (2009) 1.64
PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis. Biochem J (2006) 1.61
Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab (2013) 1.58
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem (2007) 1.52
Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response. J Biol Chem (2010) 1.51
Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes (2004) 1.50
GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation. Biochem J (2005) 1.48
Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol Endocrinol Metab (2002) 1.48
DNA Methyltransferase protein synthesis is reduced in CXXC finger protein 1-deficient embryonic stem cells. DNA Cell Biol (2009) 1.44
Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame. J Biol Chem (2001) 1.41
PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. J Cell Physiol (2008) 1.41
The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells. Mol Immunol (2007) 1.39
Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii. J Biol Chem (2008) 1.34
The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats. J Nutr (2009) 1.32
A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem J (2007) 1.32
Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control. Biochem J (2004) 1.31
PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway. Diabetes (2010) 1.31
GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. J Biol Chem (2009) 1.29
Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. J Biol Chem (2006) 1.29
Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses. Mol Cell Biol (2002) 1.28
The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes (2007) 1.28
Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes (2002) 1.28
Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. Biochem J (2006) 1.27
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep (2012) 1.24
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice. BMC Cell Biol (2007) 1.23
eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiol Genomics (2009) 1.22
Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii. Proc Natl Acad Sci U S A (2010) 1.21
Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. J Biol Chem (2004) 1.20
Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J Biol Chem (2010) 1.20
Methods for analyzing eIF2 kinases and translational control in the unfolded protein response. Methods Enzymol (2011) 1.17
The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver. Int J Biochem Cell Biol (2004) 1.17
Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe. Genetics (2004) 1.17
Rats rapidly reject diets deficient in essential amino acids. J Nutr (2003) 1.16
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Mol Biol Cell (2013) 1.13
Tryptophan catabolism generates autoimmune-preventive regulatory T cells. Transpl Immunol (2006) 1.12
PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology (2003) 1.11
Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. PLoS One (2008) 1.10
Mechanisms of food intake repression in indispensable amino acid deficiency. Annu Rev Nutr (2007) 1.10
Feeding meals containing soy or whey protein after exercise stimulates protein synthesis and translation initiation in the skeletal muscle of male rats. J Nutr (2007) 1.09
PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice. PLoS One (2009) 1.05
Expansion and evolution of insect GMC oxidoreductases. BMC Evol Biol (2007) 1.05
Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation. BMC Cell Biol (2009) 1.04
Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast. Eukaryot Cell (2005) 1.04
Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. Am J Physiol Endocrinol Metab (2003) 1.04
Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats. Am J Physiol Endocrinol Metab (2011) 1.04
Diets deficient in indispensable amino acids rapidly decrease the concentration of the limiting amino acid in the anterior piriform cortex of rats. J Nutr (2004) 1.02
Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster. J Exp Biol (2004) 1.02
IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem (2005) 1.00
Ligand-induced 5-HT3 receptor internalization in enteric neurons in rat ileum. Gastroenterology (2006) 1.00
Localization and activation of glucagon-like peptide-2 receptors on vagal afferents in the rat. Endocrinology (2007) 0.99
Stress response pathways in protozoan parasites. Cell Microbiol (2008) 0.99
The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. J Nutr (2010) 0.99
Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin. J Biol Chem (2013) 0.98
Phosphorylation of eIF2alpha is involved in the signaling of indispensable amino acid deficiency in the anterior piriform cortex of the brain in rats. J Nutr (2004) 0.98
PERK in beta cell biology and insulin biogenesis. Trends Endocrinol Metab (2010) 0.98
Site-directed mutagenesis of the active site of diacylglycerol kinase alpha: calcium and phosphatidylserine stimulate enzyme activity via distinct mechanisms. Biochem J (2003) 0.97
Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. J Biol Chem (2008) 0.97
Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol (2011) 0.95