Published in Genes Dev on April 01, 1991
DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5). Mol Cell Biol (1995) 2.69
Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev (1999) 2.54
Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. Proc Natl Acad Sci U S A (1992) 2.42
The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J (1992) 2.36
Pax3 modulates expression of the c-Met receptor during limb muscle development. Proc Natl Acad Sci U S A (1996) 2.35
Sequence analysis and expression patterns divide the maize knotted1-like homeobox genes into two classes. Plant Cell (1994) 2.33
Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. EMBO J (1992) 2.32
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol Cell Biol (1995) 2.28
Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins. Mol Cell Biol (1993) 2.12
Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Mol Cell Biol (1992) 2.11
The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J (1995) 1.89
The oncogenic potential of Pax genes. EMBO J (1993) 1.88
Drosophila female sexual behavior induced by sterile males showing copulation complementation. Proc Natl Acad Sci U S A (2000) 1.64
A clinico-genetic study of renal coloboma syndrome in children. Pediatr Nephrol (2007) 1.59
Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies. Am J Hum Genet (1999) 1.53
Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol Cell Biol (1993) 1.48
Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8. EMBO J (1997) 1.46
The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain. Proc Natl Acad Sci U S A (1991) 1.44
A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant. Proc Natl Acad Sci U S A (1993) 1.44
C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8. EMBO J (1996) 1.43
Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. Mol Cell Biol (1996) 1.40
DNA-binding specificity of the cut repeats from the human cut-like protein. Mol Cell Biol (1995) 1.39
Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein. Proc Natl Acad Sci U S A (1994) 1.37
Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease. Pigment Cell Melanoma Res (2008) 1.35
Characterization of quail Pax-6 (Pax-QNR) proteins expressed in the neuroretina. Mol Cell Biol (1993) 1.33
Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site. Mol Cell Biol (1995) 1.31
Further delineation of renal-coloboma syndrome in patients with extreme variability of phenotype and identical PAX2 mutations. Am J Hum Genet (1997) 1.29
An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity. Mol Cell Biol (1996) 1.26
Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor. Mol Cell Biol (1998) 1.24
Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency. Proc Natl Acad Sci U S A (1998) 1.22
Eye evolution: common use and independent recruitment of genetic components. Philos Trans R Soc Lond B Biol Sci (2009) 1.20
The second STE12 homologue of Cryptococcus neoformans is MATa-specific and plays an important role in virulence. Proc Natl Acad Sci U S A (2001) 1.19
Synergistic activation of transcription is mediated by the N-terminal domain of Drosophila fushi tarazu homeoprotein and can occur without DNA binding by the protein. Mol Cell Biol (1993) 1.12
Identification of a novel downstream binding protein implicated in late-phase-specific activation of the adenovirus major late promotor. Nucleic Acids Res (1992) 1.11
A LIM motif is present in a pollen-specific protein. Plant Cell (1992) 1.08
Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition. Proc Natl Acad Sci U S A (1998) 1.05
Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains. Nucleic Acids Res (1994) 1.03
The origin, molecular regulation and therapeutic potential of myogenic stem cell populations. J Anat (2009) 1.03
Comparative study of Pax2 expression in glial cells in the retina and optic nerve of birds and mammals. J Comp Neurol (2010) 0.95
Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity. Proc Natl Acad Sci U S A (1995) 0.95
Further elucidation of the genomic structure of PAX3, and identification of two different point mutations within the PAX3 homeobox that cause Waardenburg syndrome type 1 in two families. Am J Hum Genet (1995) 0.95
Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. Am J Pathol (1995) 0.94
DNA-binding specificity of the S8 homeodomain. Nucleic Acids Res (1993) 0.91
Homeobox-containing gene transiently expressed in a spatially restricted pattern in the early sea urchin embryo. Proc Natl Acad Sci U S A (1995) 0.90
Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter. Biochem J (1999) 0.90
Transcriptional activities of the Pax6 gene eyeless regulate tissue specificity of ectopic eye formation in Drosophila. Dev Biol (2009) 0.88
Mutation of a single lysine residue severely impairs the DNA recognition and regulatory functions of the VZV gene 62 transactivator protein. Nucleic Acids Res (1994) 0.88
Functional analysis of the homeodomain protein SIX5. Nucleic Acids Res (2000) 0.88
Exocrine pancreas transcription factor 1 binds to a bipartite enhancer element and activates transcription of acinar genes. Mol Cell Biol (1991) 0.86
Formation of the spinal network in zebrafish determined by domain-specific pax genes. J Comp Neurol (2011) 0.84
WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis. Neoplasia (2008) 0.84
Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube. PLoS Genet (2013) 0.83
The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2. Biochem J (2003) 0.83
Differential induction of Pax genes by NGF and BDNF in cerebellar primary cultures. J Cell Biol (1994) 0.82
A hypofunctional PAX1 mutation causes autosomal recessively inherited otofaciocervical syndrome. Hum Genet (2013) 0.82
A novel pax-like protein involved in transcriptional activation of cyst wall protein genes in Giardia lamblia. J Biol Chem (2010) 0.81
Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase. Mol Biol Cell (2010) 0.81
SUMOylation of Pax7 is essential for neural crest and muscle development. Cell Mol Life Sci (2012) 0.81
An intron 9 containing splice variant of PAX2. J Transl Med (2009) 0.81
Pax3 and Tbx5 specify whether PDGFRα+ cells assume skeletal or cardiac muscle fate in differentiating embryonic stem cells. Stem Cells (2014) 0.81
Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila. Dev Biol (2009) 0.80
Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism. Biochem J (1999) 0.80
Functional association between eyegone and HP1a mediates wingless transcriptional repression during development. Mol Cell Biol (2012) 0.77
The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function. Protein Cell (2014) 0.76
The RED domain of Paired is specifically required for Drosophila accessory gland maturation. Open Biol (2015) 0.75
Pax3 isoforms in sensory neurogenesis: expression and function in the ophthalmic trigeminal placode. Dev Dyn (2014) 0.75
Retracted Functional conservation of the Drosophila gooseberry gene and its evolutionary alleles. PLoS One (2012) 0.75
Overexpression of A-myb induces basic fibroblast growth factor-dependent proliferation of chicken neuroretina cells. J Virol (1997) 0.75
Survival of patients with breast cancer attending Bristol Cancer Help Centre. Lancet (1990) 7.04
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A (1980) 6.31
Mutations in RPE65 cause Leber's congenital amaurosis. Nat Genet (1997) 4.48
A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell (1989) 4.05
The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature (1986) 3.61
Modulation of Dengue virus infection in human cells by alpha, beta, and gamma interferons. J Virol (2000) 3.61
A new class of angiotensin-converting enzyme inhibitors. Nature (1980) 3.03
Identification of a Stat gene that functions in Drosophila development. Cell (1996) 2.90
High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA. Cell (1995) 2.78
Cooperative dimerization of paired class homeo domains on DNA. Genes Dev (1993) 2.66
Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations. Cell (1995) 2.63
Infection of human cells by dengue virus is modulated by different cell types and viral strains. J Virol (2000) 2.49
Application of molecular typing techniques in the 1998 dengue epidemic in Nicaragua. Am J Trop Med Hyg (1999) 2.20
Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus. Nat Genet (1999) 2.04
The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters. Nature (1989) 1.98
The mouse Engrailed-1 gene and ventral limb patterning. Nature (1996) 1.98
Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila. Cell (1994) 1.97
Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake. Study of Osteoporotic Fractures Research Group. Ann Intern Med (2000) 1.94
Interferon inhibits dengue virus infection by preventing translation of viral RNA through a PKR-independent mechanism. Virology (2001) 1.87
Cooperative interactions between paired domain and homeodomain. Development (1996) 1.84
Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system. Curr Biol (1998) 1.83
PCR detection and identification of Leishmania parasites in clinical specimens in Ecuador: a comparison with classical diagnostic methods. J Parasitol (1999) 1.80
Simplified polymerase chain reaction detection of new world Leishmania in clinical specimens of cutaneous leishmaniasis. Am J Trop Med Hyg (1998) 1.76
Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors. Genes Dev (1997) 1.69
The transmission of refractive errors within eskimo families. Am J Optom Arch Am Acad Optom (1969) 1.66
Risk factors associated with recent transmission of tuberculosis: systematic review and meta-analysis. Int J Tuberc Lung Dis (2009) 1.54
A new rhodopsin in R8 photoreceptors of Drosophila: evidence for coordinate expression with Rh3 in R7 cells. Development (1997) 1.49
Two-step process for photoreceptor formation in Drosophila. Nature (2001) 1.47
A developmentally regulated microsomal protein specific for the pigment epithelium of the vertebrate retina. J Neurosci Res (1993) 1.45
Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed. Mol Cell Biol (1989) 1.43
The homeodomain: a new face for the helix-turn-helix? Bioessays (1992) 1.42
Maternal and Infant Services: examination of access in a culturally diverse community. J Paediatr Child Health (2003) 1.42
A new visualization approach for identifying mutations that affect differentiation and organization of the Drosophila ommatidia. Development (2001) 1.39
Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development (1996) 1.38
A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer. Nature (1999) 1.37
Engrailed, a homeodomain protein, can repress in vitro transcription by competition with the TATA box-binding protein transcription factor IID. Proc Natl Acad Sci U S A (1990) 1.35
Training senior house officers. BMJ (1997) 1.35
The reliability and validity of doctor-recorded morbidity data in active data collection systems. Scand J Prim Health Care (1998) 1.31
Binding site-dependent direct activation and repression of in vitro transcription by Drosophila homeodomain proteins. Cell (1990) 1.30
Beta-cell function improved by supplementing basal insulin secretion in mild diabetes. Br Med J (1976) 1.28
The hypothermia of hypoglycemia. Studies with 2-deoxy-D-glucose in normal human subjects and mice. N Engl J Med (1972) 1.28
Population bottlenecks and patterns of human polymorphism. Mol Biol Evol (1999) 1.28
An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res (1992) 1.26
Inhaled benzo(a)pyrene impairs long-term potentiation in the F1 generation rat dentate gyrus. Cell Mol Biol (Noisy-le-grand) (2004) 1.26
Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proc Natl Acad Sci U S A (1996) 1.25
In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product. Development (1996) 1.24
Widespread atypical cutaneous Leishmaniasis caused by Leishmania (L.) Chagasi in Nicaragua. Am J Trop Med Hyg (1999) 1.23
Subacute infantile mountain sickness. J Pathol (1988) 1.22
Structural basis of Hox specificity. Nat Struct Biol (1999) 1.20
Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade. Cell (1993) 1.17
Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead. Mech Dev (1995) 1.16
Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance. Antimicrob Agents Chemother (2000) 1.16
A green fluorescent protein enhancer trap screen in Drosophila photoreceptor cells. Mech Dev (2000) 1.13
MMPI diagnosis of black psychiatric patients. Am J Psychiatry (1979) 1.12
Homeodomain proteins. Cooperating to be different. Curr Biol (1995) 1.10
Bicoid-independent formation of thoracic segments in Drosophila. Science (2000) 1.10
A conserved regulatory element present in all Drosophila rhodopsin genes mediates Pax6 functions and participates in the fine-tuning of cell-specific expression. Mech Dev (2001) 1.09
Response of myocardial connective tissue to development of experimental hypertrophy. Am J Physiol (1969) 1.08
Photoreceptor subtype specification: from flies to humans. Semin Cell Dev Biol (2001) 1.08
The WASp-like protein scar regulates macropinocytosis, phagocytosis and endosomal membrane flow in Dictyostelium. J Cell Sci (2001) 1.08
Paracetamol use, availability, and knowledge of toxicity among British and American adolescents. Arch Dis Child (1996) 1.06
Evolution of color vision. Curr Opin Neurobiol (1999) 1.06
Use of thalidomide in patients with myeloma and renal failure may be associated with unexplained hyperkalaemia. Br J Haematol (2003) 1.05
Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition. Proc Natl Acad Sci U S A (1998) 1.05
Early degenerative joint disease simulating impingement syndrome: arthroscopic findings. Arthroscopy (1992) 1.04
A functional homologue of goosecoid in Drosophila. Development (1996) 1.03
A normative reference database study for Pronosco X-posure System. J Clin Densitom (2001) 1.03
buttonhead does not contribute to a combinatorial code proposed for Drosophila head development. Development (1997) 1.01
Phosphorylation of bicoid on MAP-kinase sites: contribution to its interaction with the torso pathway. Development (2000) 0.98
Long-term results of local recurrence after breast conservation treatment for invasive breast cancer. Int J Radiat Oncol Biol Phys (2001) 0.98
The effect of skin disease on self image [proceedings]. Br J Dermatol (1978) 0.97
Pulmonary haemodynamics of the yak, cattle, and cross breeds at high altitude. Thorax (1986) 0.96
Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development. Development (1998) 0.96
Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications. J Biol Chem (1983) 0.96
Twelve months of nightly zolpidem does not lead to rebound insomnia or withdrawal symptoms: a prospective placebo-controlled study. J Psychopharmacol (2011) 0.95
Is neutrophil elastase associated with elastic tissue in emphysema? J Clin Pathol (1988) 0.95
Acetaminophen overdose as a suicidal gesture: a survey of adolescents' knowledge of its potential for toxicity. J Am Acad Child Adolesc Psychiatry (1992) 0.95
A randomized clinical trial of inpatient family intervention. V. Results for affective disorders. J Affect Disord (1990) 0.93
Glycosylation causes an apparent block in translation of immunoglobulin heavy chain. J Biol Chem (1981) 0.93
Effect of propranolol and metoprolol on parathyroid hormone and calcitonin secretions in uraemic patients. Br Med J (1980) 0.92
Factor V deficiency and antenatal intraventricular haemorrhage. Arch Dis Child (1984) 0.91
Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development (1998) 0.91
Bicoid functions without its TATA-binding protein-associated factor interaction domains. Proc Natl Acad Sci U S A (1999) 0.90
Pulmonary blood vessels and endocrine cells in subacute infantile mountain sickness. Respir Med (1989) 0.90
The mirage called choice. Health Care Anal (1995) 0.89
A controlled evaluation of inpatient family intervention. I. Preliminary results of the six-month follow-up. Arch Gen Psychiatry (1985) 0.89
Sensitive assay for biologically active fragment of human parathyroid hormone. Lancet (1977) 0.89
Bacterial immunoabsorbent columns. Appl Microbiol (1969) 0.89
A randomized clinical trial of inpatient family intervention, III: Effects at 6-month and 18-month follow-ups. Am J Psychiatry (1988) 0.88
Nested restriction site-specific PCR to detect and type hepatitis C virus (HCV): a rapid method to distinguish HCV subtype 1b from other genotypes. J Clin Microbiol (2001) 0.87
Identification and characterization of Nasonia Pax genes. Insect Mol Biol (2010) 0.87
Reinventing a common strategy for patterning the eye. Cell (2001) 0.87
Re-entrant activity in a presubiculum-subiculum circuit generates epileptiform activity in vitro. Brain Res (1999) 0.87
Tandem high-dose chemotherapy supported by hematopoietic progenitor cells yields prolonged survival in stage IV breast cancer. Bone Marrow Transplant (1996) 0.87
Arthroscopic distal clavicle excision. Technique and early results. Clin Orthop Relat Res (1994) 0.87
Vitamin-D deficiency in the osteomalacia of chronic renal failure. Lancet (1976) 0.86
Agreement in symptoms of anxiety and depression between patients and GPs: the influence of ethnicity. Fam Pract (2001) 0.86
Diagnosis of insulinomas by suppression tests. Lancet (1974) 0.86