Published in Cell on September 08, 1995
MMDB: 3D structure data in Entrez. Nucleic Acids Res (2000) 6.93
Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR. EMBO J (2002) 2.53
Protein-DNA binding specificity predictions with structural models. Nucleic Acids Res (2005) 2.45
Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA. EMBO J (1997) 1.75
PAX6 mutations: genotype-phenotype correlations. BMC Genet (2005) 1.65
The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator. EMBO J (1998) 1.64
Connecting protein structure with predictions of regulatory sites. Proc Natl Acad Sci U S A (2007) 1.46
Differences in water release for the binding of EcoRI to specific and nonspecific DNA sequences. Proc Natl Acad Sci U S A (1996) 1.45
What drives proteins into the major or minor grooves of DNA? J Mol Biol (2006) 1.45
Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease. Pigment Cell Melanoma Res (2008) 1.35
The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain. Mol Cell Biol (1999) 1.35
The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes Dev (2000) 1.35
A molecular code dictates sequence-specific DNA recognition by homeodomains. EMBO J (1996) 1.34
Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution. EMBO J (1997) 1.31
Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proc Natl Acad Sci U S A (1996) 1.25
Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor. Mol Cell Biol (1998) 1.24
Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens. Int J Dev Biol (2004) 1.20
Homeodomain revisited: a lesson from disease-causing mutations. Hum Genet (2005) 1.18
Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus. Genetics (2001) 1.13
Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells. PLoS One (2006) 1.09
Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition. Proc Natl Acad Sci U S A (1998) 1.05
The Arabidopsis zinc finger-homeodomain genes encode proteins with unique biochemical properties that are coordinately expressed during floral development. Plant Physiol (2006) 1.03
Compound heterozygosity for mutations in PAX6 in a patient with complex brain anomaly, neonatal diabetes mellitus, and microophthalmia. Am J Med Genet A (2009) 1.02
The yeast a1 and alpha2 homeodomain proteins do not contribute equally to heterodimeric DNA binding. Mol Cell Biol (1999) 0.99
The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions. Nucleic Acids Res (2005) 0.99
Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Dis Model Mech (2008) 0.97
Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. PLoS One (2013) 0.96
Testing water-mediated DNA recognition by the Hin recombinase. EMBO J (2002) 0.96
The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Nucleic Acids Res (2007) 0.95
Target selectivity of bicoid is dependent on nonconsensus site recognition and protein-protein interaction. Mol Cell Biol (2000) 0.95
Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13. Mol Cell Biol (2004) 0.94
Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. Proc Natl Acad Sci U S A (1998) 0.93
Protein and drug interactions in the minor groove of DNA. Nucleic Acids Res (2002) 0.92
The SKN-1 amino-terminal arm is a DNA specificity segment. Mol Cell Biol (1999) 0.92
Siamois and Twin are redundant and essential in formation of the Spemann organizer. Dev Biol (2011) 0.90
Homeodomain-DNA interactions of the Pho2 protein are promoter-dependent. Nucleic Acids Res (1997) 0.88
Protein and DNA contact surfaces that mediate the selective action of the Phox1 homeodomain at the c-fos serum response element. Mol Cell Biol (1997) 0.87
Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless. EMBO J (2010) 0.84
A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency. Hum Genet (2010) 0.83
Quantitative measurement of water diffusion lifetimes at a protein/DNA interface by NMR. J Biomol NMR (2001) 0.82
Functional analysis of Waardenburg syndrome-associated PAX3 and SOX10 mutations: report of a dominant-negative SOX10 mutation in Waardenburg syndrome type II. Hum Genet (2011) 0.82
Gene regulation by PAX6: structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204. Mol Vis (2014) 0.81
Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers. J Biol Chem (2009) 0.81
Crystallization and preliminary X-ray analysis of the Pax6 paired domain bound to the Pax6 gene enhancer. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.81
Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control. Arch Biochem Biophys (2009) 0.81
A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected]. PLoS Genet (2014) 0.81
Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning. PLoS One (2011) 0.80
Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila. Dev Biol (2009) 0.80
Single-base pair differences in a shared motif determine differential Rhodopsin expression. Science (2015) 0.80
Structure solution of DNA-binding proteins and complexes with ARCIMBOLDO libraries. Acta Crystallogr D Biol Crystallogr (2014) 0.79
Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant. Biochemistry (2012) 0.79
DNA targeting and cleavage by an engineered metalloprotein dimer. J Biol Inorg Chem (2011) 0.77
Three enhancements to the inference of statistical protein-DNA potentials. Proteins (2012) 0.77
Transcription of follicle-stimulating hormone subunit genes is modulated by porcine LIM homeobox transcription factors, LHX2 and LHX3. J Reprod Dev (2016) 0.77
Physical basis of the inducer-dependent cooperativity of the Central glycolytic genes Repressor/DNA complex. Nucleic Acids Res (2010) 0.77
In the TTF-1 homeodomain the contribution of several amino acids to DNA recognition depends on the bound sequence. Nucleic Acids Res (1996) 0.76
Several cis-regulatory elements control mRNA stability, translation efficiency, and expression pattern of Prrxl1 (paired related homeobox protein-like 1). J Biol Chem (2013) 0.75
Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA. FEBS J (2011) 0.75
New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA. Sci Rep (2017) 0.75
Meis: New friends of Pax. Neurogenesis (Austin) (2014) 0.75
Cell Type-Specific Epigenomic Analysis Reveals a Uniquely Closed Chromatin Architecture in Mouse Rod Photoreceptors. Sci Rep (2017) 0.75
Molecular analysis of the PAX6 gene for aniridia and congenital cataracts in Tunisian families. Hum Genome Var (2014) 0.75
Interaction between Pax6 and its novel mutant in Bufo raddei Strauch. Mol Vis (2011) 0.75
An affinity-structure database of helix-turn-helix: DNA complexes with a universal coordinate system. BMC Bioinformatics (2015) 0.75
Water and protein movements in ligand-receptor interactions. J Biol Phys (2002) 0.75
Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation. Nat Commun (2017) 0.75
Isolation and expression analysis of a Pax group III gene from the crustacean Cherax destructor. Dev Genes Evol (2005) 0.75
Crystallographic R factor refinement by molecular dynamics. Science (1987) 15.90
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science (2000) 9.29
Crystal structure of the Src family tyrosine kinase Hck. Nature (1997) 7.66
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell (1994) 6.54
Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp. Cell (1992) 5.77
Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell (1993) 5.47
Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell (1996) 5.38
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell (1998) 5.27
Molecular dynamics and protein function. Proc Natl Acad Sci U S A (2005) 4.70
The structural basis of the activation of Ras by Sos. Nature (1998) 4.50
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature (1992) 4.46
Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature (1997) 4.26
A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell (1989) 4.05
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell (1996) 3.88
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell (1998) 3.79
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature (1995) 3.77
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol Cell (1999) 3.73
The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature (1986) 3.61
X-ray structure and refinement of carbon-monoxy (Fe II)-myoglobin at 1.5 A resolution. J Mol Biol (1986) 3.49
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell (1999) 3.47
Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK. Science (1997) 3.31
Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation. Cell (2001) 3.25
Identification of a Stat gene that functions in Drosophila development. Cell (1996) 2.90
The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol Cell (2001) 2.87
Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III. Cell (2001) 2.68
Cooperative dimerization of paired class homeo domains on DNA. Genes Dev (1993) 2.66
Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations. Cell (1995) 2.63
Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha. Structure (2000) 2.57
Structures of Src-family tyrosine kinases. Curr Opin Struct Biol (1997) 2.56
Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III. Cell (2001) 2.39
The paired box encodes a second DNA-binding domain in the paired homeo domain protein. Genes Dev (1991) 2.35
Crystal structure of the DsbA protein required for disulphide bond formation in vivo. Nature (1993) 2.27
Thermal expansion of a protein. Biochemistry (1987) 2.25
Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis. J Mol Biol (1994) 2.23
Effect of anisotropy and anharmonicity on protein crystallographic refinement. An evaluation by molecular dynamics. J Mol Biol (1986) 2.16
Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III. Cell (1997) 2.16
Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol Cell (2001) 2.12
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J (1995) 2.10
Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I. Cell (1996) 2.09
Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage. J Mol Biol (2000) 2.02
Structure of the amino-terminal protein interaction domain of STAT-4. Science (1998) 2.00
The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters. Nature (1989) 1.98
Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila. Cell (1994) 1.97
Cooperative interactions between paired domain and homeodomain. Development (1996) 1.84
Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell (1998) 1.77
Convergent evolution of similar function in two structurally divergent enzymes. Nature (1991) 1.77
Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure (1995) 1.76
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange. J Biol Chem (2001) 1.71
Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors. Genes Dev (1997) 1.69
Challenges at the frontiers of structural biology. Trends Cell Biol (1999) 1.62
A new rhodopsin in R8 photoreceptors of Drosophila: evidence for coordinate expression with Rh3 in R7 cells. Development (1997) 1.49
Crystal structure of an archaebacterial DNA polymerase. Structure (1999) 1.49
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J (1997) 1.48
Two-step process for photoreceptor formation in Drosophila. Nature (2001) 1.47
Temperature dependence of the structure and dynamics of myoglobin. A simulation approach. J Mol Biol (1990) 1.46
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure (1994) 1.43
Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed. Mol Cell Biol (1989) 1.43
The homeodomain: a new face for the helix-turn-helix? Bioessays (1992) 1.42
The influence of the proliferating cell nuclear antigen-interacting domain of p21(CIP1) on DNA synthesis catalyzed by the human and Saccharomyces cerevisiae polymerase delta holoenzymes. J Biol Chem (1997) 1.42
Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand. J Biol Chem (2000) 1.41
A new visualization approach for identifying mutations that affect differentiation and organization of the Drosophila ommatidia. Development (2001) 1.39
Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development (1996) 1.38
Engrailed, a homeodomain protein, can repress in vitro transcription by competition with the TATA box-binding protein transcription factor IID. Proc Natl Acad Sci U S A (1990) 1.35
A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases. J Mol Biol (2000) 1.30
Binding site-dependent direct activation and repression of in vitro transcription by Drosophila homeodomain proteins. Cell (1990) 1.30
Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue. J Biol Chem (1998) 1.28
Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proc Natl Acad Sci U S A (1996) 1.25
In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product. Development (1996) 1.24
Structural basis of Hox specificity. Nat Struct Biol (1999) 1.20
Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade. Cell (1993) 1.17
Clamp loader structure predicts the architecture of DNA polymerase III holoenzyme and RFC. Curr Biol (2001) 1.16
Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead. Mech Dev (1995) 1.16
Mode of peptidoglycan synthesis in Salmonella typhimurium: single-strand insertion. J Bacteriol (1988) 1.14
A green fluorescent protein enhancer trap screen in Drosophila photoreceptor cells. Mech Dev (2000) 1.13
Homeodomain proteins. Cooperating to be different. Curr Biol (1995) 1.10
Bicoid-independent formation of thoracic segments in Drosophila. Science (2000) 1.10
Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction. Proc Natl Acad Sci U S A (1991) 1.09
A conserved regulatory element present in all Drosophila rhodopsin genes mediates Pax6 functions and participates in the fine-tuning of cell-specific expression. Mech Dev (2001) 1.09
Photoreceptor subtype specification: from flies to humans. Semin Cell Dev Biol (2001) 1.08
Crystallization of proliferating cell nuclear antigen (PCNA) from Saccharomyces cerevisiae. J Mol Biol (1994) 1.07
Evolution of color vision. Curr Opin Neurobiol (1999) 1.06
Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition. Proc Natl Acad Sci U S A (1998) 1.05
A functional homologue of goosecoid in Drosophila. Development (1996) 1.03
A new human hereditary amyloidosis: the result of a stop-codon mutation in the apolipoprotein AII gene. Genomics (2001) 1.02
Crystallization of DsbA, an Escherichia coli protein required for disulphide bond formation in vivo. J Mol Biol (1993) 1.02
buttonhead does not contribute to a combinatorial code proposed for Drosophila head development. Development (1997) 1.01
Phosphorylation of bicoid on MAP-kinase sites: contribution to its interaction with the torso pathway. Development (2000) 0.98
Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications. J Biol Chem (1983) 0.96
Captopril enhances insulin responsiveness of forearm muscle tissue in non-insulin-dependent diabetes mellitus. Eur J Clin Invest (1987) 0.95
Thermus thermophilis dnaX homolog encoding gamma- and tau-like proteins of the chromosomal replicase. J Biol Chem (1997) 0.94
Effect of propranolol and metoprolol on parathyroid hormone and calcitonin secretions in uraemic patients. Br Med J (1980) 0.92
Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development (1998) 0.91
Bicoid functions without its TATA-binding protein-associated factor interaction domains. Proc Natl Acad Sci U S A (1999) 0.90
Sensitive assay for biologically active fragment of human parathyroid hormone. Lancet (1977) 0.89
The sliding clamp of DNA polymerase III holoenzyme encircles DNA. Mol Biol Cell (1992) 0.88
Reinventing a common strategy for patterning the eye. Cell (2001) 0.87
Identification and characterization of Nasonia Pax genes. Insect Mol Biol (2010) 0.87
Biochemical characterization of a neuroserpin variant associated with hereditary dementia. Am J Pathol (2001) 0.87
Cholecalcin (a 9-kDa cholecalciferol-induced calcium-binding protein) messenger RNA. Distribution and induction by calcitriol in the rat digestive tract. Eur J Biochem (1985) 0.86