Published in Genes Dev on November 01, 1993
DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5). Mol Cell Biol (1995) 2.69
A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol (1994) 2.42
Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. Mol Cell Biol (1996) 2.32
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol Cell Biol (1995) 2.28
A transcription factor-based mechanism for mouse heterochromatin formation. Nat Struct Mol Biol (2012) 2.15
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev (2000) 2.13
Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol Cell Biol (1997) 2.04
The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID. J Virol (1994) 2.01
GRAS proteins form a DNA binding complex to induce gene expression during nodulation signaling in Medicago truncatula. Plant Cell (2009) 2.00
Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo. EMBO J (1998) 1.97
Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins. EMBO J (1994) 1.77
Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein Roaz. Mol Cell Biol (1998) 1.75
Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A (2008) 1.68
A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos. EMBO J (1999) 1.67
The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins. Genes Dev (1997) 1.66
Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence. PLoS Genet (2008) 1.59
Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins. Mol Cell Biol (1996) 1.58
Siamois is required for formation of Spemann's organizer. Proc Natl Acad Sci U S A (1997) 1.57
Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes Dev (2001) 1.50
Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol (1996) 1.48
Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Mol Cell Biol (1999) 1.45
A regulatory network to segregate the identity of neuronal subtypes. Dev Cell (2008) 1.41
Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. Mol Cell Biol (1996) 1.40
Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein. Proc Natl Acad Sci U S A (1994) 1.37
The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes Dev (2000) 1.35
A molecular code dictates sequence-specific DNA recognition by homeodomains. EMBO J (1996) 1.34
Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site. Mol Cell Biol (1995) 1.31
Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B. Mol Cell Biol (2004) 1.29
An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity. Mol Cell Biol (1996) 1.26
Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proc Natl Acad Sci U S A (1996) 1.25
Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes. Nucleic Acids Res (1994) 1.24
Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor. Mol Cell Biol (1998) 1.24
Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs. Dev Cell (2012) 1.23
Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo. Proc Natl Acad Sci U S A (2005) 1.22
The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes. Mol Cell Biol (1995) 1.20
Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens. Int J Dev Biol (2004) 1.20
Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. EMBO J (2002) 1.20
Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina. Proc Natl Acad Sci U S A (2006) 1.15
Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus. Genetics (2001) 1.13
Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function. Development (2010) 1.11
Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif. Nucleic Acids Res (1996) 1.10
Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus. Genetics (2008) 1.09
Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition. Proc Natl Acad Sci U S A (1998) 1.05
The ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500). J Med Genet (2000) 1.03
Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains. Nucleic Acids Res (1994) 1.03
The Drosophila gap gene network is composed of two parallel toggle switches. PLoS One (2011) 1.00
The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions. Nucleic Acids Res (2005) 0.99
Regulation of Dlx3 gene expression in visceral arches by evolutionarily conserved enhancer elements. Proc Natl Acad Sci U S A (2003) 0.99
An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene. Mol Cell Biol (2000) 0.99
Cooperative interaction of CI protein regulates lysogeny of Lactobacillus casei by bacteriophage A2. J Virol (1999) 0.99
Pax gene diversity in the basal cnidarian Acropora millepora (Cnidaria, Anthozoa): implications for the evolution of the Pax gene family. Proc Natl Acad Sci U S A (2000) 0.97
Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins. Mol Cell Biol (1995) 0.96
Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proc Natl Acad Sci U S A (2010) 0.96
Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity. Proc Natl Acad Sci U S A (1995) 0.95
Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. Proc Natl Acad Sci U S A (1998) 0.93
Dominant negative dimerization of a mutant homeodomain protein in Axenfeld-Rieger syndrome. Mol Cell Biol (2003) 0.93
Precise cis-regulatory control of spatial and temporal expression of the alx-1 gene in the skeletogenic lineage of s. purpuratus. Dev Biol (2011) 0.91
A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord. Proc Natl Acad Sci U S A (1997) 0.91
A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX. Am J Hum Genet (2012) 0.90
Siamois and Twin are redundant and essential in formation of the Spemann organizer. Dev Biol (2011) 0.90
Corepressors TLE1 and TLE3 interact with HESX1 and PROP1. Mol Endocrinol (2010) 0.89
A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein. Mol Cell Biol (2000) 0.89
Transcriptional activities of the Pax6 gene eyeless regulate tissue specificity of ectopic eye formation in Drosophila. Dev Biol (2009) 0.88
Functional analysis of the homeodomain protein SIX5. Nucleic Acids Res (2000) 0.88
Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor. Front Cell Neurosci (2015) 0.87
Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless. EMBO J (2010) 0.84
The incidence of deafness is non-randomly distributed among families segregating for Waardenburg syndrome type 1 (WS1). J Med Genet (1997) 0.83
DNA-binding sequence specificity of DUX4. Skelet Muscle (2016) 0.83
ARX regulates cortical intermediate progenitor cell expansion and upper layer neuron formation through repression of Cdkn1c. Cereb Cortex (2013) 0.82
Genome-wide view of TGFβ/Foxh1 regulation of the early mesendoderm program. Development (2014) 0.82
Characterization of Cer-1 cis-regulatory region during early Xenopus development. Dev Genes Evol (2011) 0.82
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity. PLoS One (2011) 0.81
Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells. Stem Cells (2009) 0.81
Occupancy of tissue-specific cis-regulatory modules by Otx2 and TLE/Groucho for embryonic head specification. Nat Commun (2014) 0.81
Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila. Dev Biol (2009) 0.80
Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning. PLoS One (2011) 0.80
Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding. Mol Cell Biol (1999) 0.80
Homeobox gene Prx3 expression in rodent brain and extraneural tissues. Proc Natl Acad Sci U S A (1997) 0.80
Identification and expression of Hop, an atypical homeobox gene expressed late in lens fiber cell terminal differentiation. Mol Vis (2007) 0.79
Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant. Biochemistry (2012) 0.79
PAX3 and FOXD3 Promote CXCR4 Expression in Melanoma. J Biol Chem (2015) 0.78
NPPB and ACAN, two novel SHOX2 transcription targets implicated in skeletal development. PLoS One (2014) 0.78
A Track Record on SHOX: From Basic Research to Complex Models and Therapy. Endocr Rev (2016) 0.78
Solution NMR structures of homeodomains from human proteins ALX4, ZHX1, and CASP8AP2 contribute to the structural coverage of the Human Cancer Protein Interaction Network. J Struct Funct Genomics (2014) 0.76
Characterization of a novel HESX1 mutation in a pediatric case of septo-optic dysplasia. Clin Case Rep (2017) 0.75
Cell Type-Specific Epigenomic Analysis Reveals a Uniquely Closed Chromatin Architecture in Mouse Rod Photoreceptors. Sci Rep (2017) 0.75
A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy. Oncotarget (2014) 0.75
Several cis-regulatory elements control mRNA stability, translation efficiency, and expression pattern of Prrxl1 (paired related homeobox protein-like 1). J Biol Chem (2013) 0.75
A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell (1989) 4.05
The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature (1986) 3.61
A strain-driven morphotropic phase boundary in BiFeO3. Science (2009) 2.95
Identification of a Stat gene that functions in Drosophila development. Cell (1996) 2.90
High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA. Cell (1995) 2.78
Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations. Cell (1995) 2.63
The paired box encodes a second DNA-binding domain in the paired homeo domain protein. Genes Dev (1991) 2.35
The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters. Nature (1989) 1.98
Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila. Cell (1994) 1.97
Cooperative interactions between paired domain and homeodomain. Development (1996) 1.84
Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors. Genes Dev (1997) 1.69
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development (1996) 1.65
Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance. Mol Cell Biol (1990) 1.63
A new rhodopsin in R8 photoreceptors of Drosophila: evidence for coordinate expression with Rh3 in R7 cells. Development (1997) 1.49
Two-step process for photoreceptor formation in Drosophila. Nature (2001) 1.47
The papillomavirus E2 protein: a factor with many talents. Trends Biochem Sci (1991) 1.44
Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed. Mol Cell Biol (1989) 1.43
The homeodomain: a new face for the helix-turn-helix? Bioessays (1992) 1.42
Functional analysis of the papilloma virus E2 trans-activator in Saccharomyces cerevisiae. Genes Dev (1989) 1.40
A new visualization approach for identifying mutations that affect differentiation and organization of the Drosophila ommatidia. Development (2001) 1.39
Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development (1996) 1.38
Engrailed, a homeodomain protein, can repress in vitro transcription by competition with the TATA box-binding protein transcription factor IID. Proc Natl Acad Sci U S A (1990) 1.35
Binding site-dependent direct activation and repression of in vitro transcription by Drosophila homeodomain proteins. Cell (1990) 1.30
Several different upstream promoter elements can potentiate transactivation by the BPV-1 E2 protein. EMBO J (1991) 1.25
Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proc Natl Acad Sci U S A (1996) 1.25
In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product. Development (1996) 1.24
Sequence interval within the PEST motif of Bicoid is important for translational repression of caudal mRNA in the anterior region of the Drosophila embryo. EMBO J (1999) 1.20
Structural basis of Hox specificity. Nat Struct Biol (1999) 1.20
Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade. Cell (1993) 1.17
Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead. Mech Dev (1995) 1.16
A green fluorescent protein enhancer trap screen in Drosophila photoreceptor cells. Mech Dev (2000) 1.13
Homeodomain proteins. Cooperating to be different. Curr Biol (1995) 1.10
Bicoid-independent formation of thoracic segments in Drosophila. Science (2000) 1.10
A conserved regulatory element present in all Drosophila rhodopsin genes mediates Pax6 functions and participates in the fine-tuning of cell-specific expression. Mech Dev (2001) 1.09
Photoreceptor subtype specification: from flies to humans. Semin Cell Dev Biol (2001) 1.08
Two DNA-bound E2 dimers are required for strong transcriptional activation and for cooperation with cellular factors in most cells. New Biol (1991) 1.06
Evolution of color vision. Curr Opin Neurobiol (1999) 1.06
Mechanisms for the adsorption of substituted nitrobenzenes by smectite clays. Environ Sci Technol (2001) 1.06
Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition. Proc Natl Acad Sci U S A (1998) 1.05
Control of papillomavirus gene expression. Biochim Biophys Acta (1990) 1.05
A functional homologue of goosecoid in Drosophila. Development (1996) 1.03
buttonhead does not contribute to a combinatorial code proposed for Drosophila head development. Development (1997) 1.01
Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway. Development (2001) 1.00
Phosphorylation of bicoid on MAP-kinase sites: contribution to its interaction with the torso pathway. Development (2000) 0.98
A partition-limited model for the plant uptake of organic contaminants from soil and water. Environ Sci Technol (2001) 0.97
Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications. J Biol Chem (1983) 0.96
Evidence for an oncogenic role of AHI-1 in Sezary syndrome, a leukemic variant of human cutaneous T-cell lymphomas. Leukemia (2006) 0.95
Effect of propranolol and metoprolol on parathyroid hormone and calcitonin secretions in uraemic patients. Br Med J (1980) 0.92
Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development (1998) 0.91
Persistence of Hunchback in the terminal region of the Drosophila blastoderm embryo impairs anterior development. Development (2000) 0.90
Bicoid functions without its TATA-binding protein-associated factor interaction domains. Proc Natl Acad Sci U S A (1999) 0.90
Sensitive assay for biologically active fragment of human parathyroid hormone. Lancet (1977) 0.89
Characterization of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis from eastern China. J Appl Microbiol (2008) 0.87
Identification and characterization of Nasonia Pax genes. Insect Mol Biol (2010) 0.87
Reinventing a common strategy for patterning the eye. Cell (2001) 0.87
Cholecalcin (a 9-kDa cholecalciferol-induced calcium-binding protein) messenger RNA. Distribution and induction by calcitriol in the rat digestive tract. Eur J Biochem (1985) 0.86
High bicoid levels render the terminal system dispensable for Drosophila head development. Development (2000) 0.85
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Orthorhombic BiFeO3. Phys Rev Lett (2012) 0.85
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Spectroscopic study of nitroaromatic-smectite sorption mechanisms. Environ Sci Technol (2001) 0.83
Signal transduction in the early Drosophila embryo: when genetics meets biochemistry. Trends Biochem Sci (1994) 0.82
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Structure of chicken calcitonin predicted by partial nucleotide sequence of its precursor. FEBS Lett (1985) 0.81
Neither the homeodomain nor the activation domain of Bicoid is specifically required for its down-regulation by the Torso receptor tyrosine kinase cascade. Development (1996) 0.81
Synthesis, molecular cloning, and restriction analysis of DNA complementary to vitamin D-dependent calcium-binding protein mRNA from rat duodenum. J Biol Chem (1983) 0.80
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Primary Translation product of mRNA coding for rat duodenal vitamin D-dependent calcium-binding protein. FEBS Lett (1981) 0.78
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Munster, a novel paired-class homeobox gene specifically expressed in the Drosophila larval eye. Mech Dev (1999) 0.78
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Characterisation of rat 9-kDa cholecalcin (CaBP) messenger RNA using a complementary DNA. Absence of homology with 28-kDa cholecalcin mRNA. Eur J Biochem (1985) 0.77
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Genetic and Non-Genetic Factors in Pigmentation of Neurospora Crassa. Genetics (1952) 0.76
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Rat duodenal calcium-binding protein messenger RNA: induction by 1,25-dihydroxyvitamin D3. J Steroid Biochem (1983) 0.75
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Rapid increase of calcitonin-specific mRNA after acute hypercalcemia. Eur J Biochem (1984) 0.75
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Propranolol therapy for secondary hyperparathyroidism in uraemia. Lancet (1978) 0.75