Published in Am J Respir Crit Care Med on May 25, 2006
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation (2010) 2.85
Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest (2012) 2.59
Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest (2008) 2.49
Pathology of pulmonary hypertension. Clin Chest Med (2007) 2.34
Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertension. AIDS (2008) 2.12
Pathogenic mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol (2007) 1.85
Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol (2010) 1.33
Pathogenesis of HIV and the lung. Curr HIV/AIDS Rep (2013) 1.06
Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques. Am J Physiol Lung Cell Mol Physiol (2009) 1.05
Immune and inflammatory mechanisms in pulmonary arterial hypertension. Prog Cardiovasc Dis (2012) 1.03
Enhanced pulmonary arteriopathy in simian immunodeficiency virus-infected macaques exposed to morphine. Am J Respir Crit Care Med (2012) 1.03
Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling. Respir Res (2011) 1.03
Effect of cocaine on human immunodeficiency virus-mediated pulmonary endothelial and smooth muscle dysfunction. Am J Respir Cell Mol Biol (2010) 1.02
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J Exp Med (2014) 1.01
Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension. Am J Respir Cell Mol Biol (2012) 0.97
Dysfunctional intracellular trafficking in the pathobiology of pulmonary arterial hypertension. Am J Respir Cell Mol Biol (2007) 0.96
HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. J Surg Res (2009) 0.96
Pulmonary vascular lesions are common in SIV- and SHIV-env-infected macaques. AIDS Res Hum Retroviruses (2010) 0.95
Human immunodeficiency virus transgenic rats exhibit pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2011) 0.93
Pulmonary hypertension associated with HIV infection: pulmonary vascular disease: the global perspective. Chest (2010) 0.93
Dependence of Golgi apparatus integrity on nitric oxide in vascular cells: implications in pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol (2011) 0.93
HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway. Nucleic Acids Res (2014) 0.92
Human Immunodeficiency Virus nef signature sequences are associated with pulmonary hypertension. AIDS Res Hum Retroviruses (2012) 0.91
Pathogenesis of HIV-associated pulmonary hypertension: potential role of HIV-1 Nef. Proc Am Thorac Soc (2011) 0.89
HIV-1/cocaine induced oxidative stress disrupts tight junction protein-1 in human pulmonary microvascular endothelial cells: role of Ras/ERK1/2 pathway. PLoS One (2014) 0.87
Contributors to diffusion impairment in HIV-infected persons. Eur Respir J (2013) 0.85
Noninfectious pulmonary complications of human immunodeficiency virus infection. Am J Med Sci (2014) 0.84
Protein trafficking dysfunctions: Role in the pathogenesis of pulmonary arterial hypertension. Pulm Circ (2011) 0.83
HIV-1, reactive oxygen species, and vascular complications. Free Radic Biol Med (2012) 0.83
Pulmonary Arterial Hypertension among HIV-Infected Children: Results of a National Survey and Review of the Literature. Front Pediatr (2015) 0.82
Human immunodeficiency virus and pulmonary arterial hypertension. ISRN Cardiol (2013) 0.82
Diagnosis and treatment of pulmonary arterial hypertension and atrial fibrillation in an adult chimpanzee (Pan troglodytes). J Am Assoc Lab Anim Sci (2008) 0.82
Hemodynamic and histologic characterization of a swine (Sus scrofa domestica) model of chronic pulmonary arterial hypertension. Comp Med (2011) 0.82
HIV related pulmonary arterial hypertension: epidemiology in Africa, physiopathology, and role of antiretroviral treatment. AIDS Res Ther (2015) 0.81
Animal Models of Pulmonary Hypertension: Matching Disease Mechanisms to Etiology of the Human Disease. J Pulm Respir Med (2014) 0.80
Injection drug use as a "second hit" in the pathogenesis of HIV-associated pulmonary hypertension. Am J Respir Crit Care Med (2012) 0.79
Human immunodeficiency virus-1 transgene expression increases pulmonary vascular resistance and exacerbates hypoxia-induced pulmonary hypertension development. Pulm Circ (2013) 0.79
Human immunodeficiency virus-associated pulmonary arterial hypertension. Clin Chest Med (2013) 0.79
Maintaining lung health with longstanding HIV. Curr Opin Infect Dis (2016) 0.79
HIV inhibits endothelial reverse cholesterol transport through impacting subcellular Caveolin-1 trafficking. Retrovirology (2015) 0.77
Genomics of pulmonary arterial hypertension: implications for therapy. Heart Fail Clin (2010) 0.76
Cocaine enhances HIV-1 gp120-induced lymphatic endothelial dysfunction in the lung. Physiol Rep (2015) 0.76
The complexity of HIV persistence and pathogenesis in the lung under antiretroviral therapy: challenges beyond AIDS. Viral Immunol (2014) 0.76
Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension. PLoS One (2016) 0.75
Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus. J Med Primatol (2014) 0.75
Infections in the immunosuppressed host. Ann Am Thorac Soc (2014) 0.75
Effect of Cocaine on Pulmonary Vascular Remodeling and Hemodynamics in Human Immunodeficiency Virus-Transgenic Rats. Am J Respir Cell Mol Biol (2016) 0.75
Heart-lung interaction via infection. Ann Am Thorac Soc (2014) 0.75
Human immunodeficiency virus, herpes virus infections, and pulmonary vascular disease. Pulm Circ (2013) 0.75
Prevalence and hospital discharge status of human immunodeficiency virus-associated pulmonary arterial hypertension in the United States. Pulm Circ (2015) 0.75
Risk of echocardiographic pulmonary hypertension in individuals with human immunodeficiency virus-hepatitis C virus coinfection. Ann Am Thorac Soc (2014) 0.75
Challenges in the development of chronic pulmonary hypertension models in large animals. Pulm Circ (2017) 0.75
Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell (1991) 13.69
Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med (1995) 8.15
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature (1998) 6.94
Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med (2006) 6.06
The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR. Biochemistry (1996) 3.41
Expression of human herpesvirus 8 in primary pulmonary hypertension. N Engl J Med (2003) 3.00
Pathologic assessment of vasculopathies in pulmonary hypertension. J Am Coll Cardiol (2004) 2.93
Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med (1995) 2.76
Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells. Nat Immunol (2006) 2.71
A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. Curr Biol (1998) 2.43
Primary pulmonary hypertension in HIV infection. Chest (1991) 2.40
Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection. J Virol (2000) 2.04
Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J (2004) 1.74
Soluble Nef antigen of HIV-1 is cytotoxic for human CD4+ T cells. FEBS Lett (1996) 1.56
Platelet-derived growth factor expression in primary pulmonary hypertension: comparison of HIV seropositive and HIV seronegative patients. Eur Respir J (1998) 1.51
Induction of AIDS in rhesus monkeys by a recombinant simian immunodeficiency virus expressing nef of human immunodeficiency virus type 1. J Virol (1999) 1.47
Prognostic factors for survival in human immunodeficiency virus-associated pulmonary arterial hypertension. Am J Respir Crit Care Med (2003) 1.46
Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection. Hum Pathol (1997) 1.46
Arteriopathy in macaques infected with simian immunodeficiency virus. Lab Invest (1992) 1.43
Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension. Am J Respir Crit Care Med (2004) 1.40
Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors. J Virol (2004) 1.39
HIV-associated primary pulmonary hypertension. A case control study. Swiss HIV Cohort Study. Am J Respir Crit Care Med (1997) 1.35
Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease. J Virol (1998) 1.30
Characterization of Nef-CXCR4 interactions important for apoptosis induction. J Virol (2004) 1.24
Primary pulmonary hypertension in association with human immunodeficiency virus infection. A possible viral etiology for some forms of hypertensive pulmonary arteriopathy. Am Rev Respir Dis (1992) 1.23
Role of molecular mimicry to HIV-1 peptides in HIV-1-related immunologic thrombocytopenia. Blood (2005) 1.20
Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J Virol (2003) 1.11
The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1. J Biol Chem (1996) 1.11
Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases. J Virol (2005) 1.02
SIV/HIV Nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques. Virology (1999) 1.02
Membranoproliferative glomerulonephritis and plexogenic pulmonary arteriopathy in a homosexual man with acquired immunodeficiency syndrome. Hum Pathol (1987) 1.02
The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes. Virology (1999) 0.98
Antiretroviral drug studies in nonhuman primates: a valid animal model for innovative drug efficacy and pathogenesis experiments. AIDS Rev (2005) 0.98
Evidence for vascular remodeling in the lungs of macaques infected with simian immunodeficiency virus/HIV NEF recombinant virus. Chest (2005) 0.96
Pathogenesis of SIV pneumonia: selective replication of viral genotypes in the lung. Virology (2001) 0.96
Role of human immunodeficiency virus in primary pulmonary hypertension--case reports. Angiology (1998) 0.91
Pulmonary hypertension. Am J Respir Crit Care Med (2005) 0.90
Hemodynamic and echocardiographic evaluation of the stumptailed macaque: a potential nonhuman primate model for pulmonary vascular disease. J Med Primatol (1987) 0.84
Pulmonary hypertension in a murine model of the acquired immunodeficiency syndrome. Am J Respir Crit Care Med (1994) 0.84
Pulmonary lymphoid cell activation and cytokine expression in murine AIDS-associated interstitial pneumonitis. Am J Respir Cell Mol Biol (1997) 0.82
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32
Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys. Nature (2008) 6.17
Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol (2004) 5.79
Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys. Nature (2012) 5.49
Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity. Nature (2006) 4.59
Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D. J Virol (2007) 4.54
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med (2005) 4.31
Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med (2005) 4.31
Retracted Expression of concern: Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med (2008) 3.93
Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A (2008) 3.86
Potential effects of aggressive decongestion during the treatment of decompensated heart failure on renal function and survival. Circulation (2010) 3.78
Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol (2009) 3.75
Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med (2013) 3.65
Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo. Circ Res (2006) 3.63
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am J Respir Crit Care Med (2004) 3.59
Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation (2004) 3.51
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys. Nat Med (2010) 3.44
Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med (2011) 3.28
Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation (2004) 3.28
Diabetic cardiomyopathy: the search for a unifying hypothesis. Circ Res (2006) 3.27
Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am J Respir Crit Care Med (2004) 3.19
The cancer paradigm of severe pulmonary arterial hypertension. Am J Respir Crit Care Med (2008) 3.09
Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol Rev (2007) 3.03
Expression of human herpesvirus 8 in primary pulmonary hypertension. N Engl J Med (2003) 3.00
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest (2009) 2.96
Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function and prolongs survival in the spontaneously hypertensive, heart failure-prone rat. Circ Heart Fail (2008) 2.93
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood (2007) 2.93
The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest (2009) 2.92
Endothelial dysfunction in pulmonary hypertension. Circulation (2004) 2.82
Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure. Circulation (2009) 2.73
Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail (2006) 2.69
Modern age pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med (2012) 2.68
Magnitude and phenotype of cellular immune responses elicited by recombinant adenovirus vectors and heterologous prime-boost regimens in rhesus monkeys. J Virol (2008) 2.66
Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants. Nat Immunol (2005) 2.60
Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol (2003) 2.59
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A (2008) 2.53
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nat Med (2010) 2.53
Human pulmonary chimerism after hematopoietic stem cell transplantation. Am J Respir Crit Care Med (2003) 2.50
Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting. Am J Cardiol (2007) 2.49
Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy. Am J Physiol Renal Physiol (2007) 2.46
Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proc Natl Acad Sci U S A (2007) 2.44
Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation (2010) 2.43
Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis. Am J Respir Crit Care Med (2004) 2.42
An animal model of autoimmune emphysema. Am J Respir Crit Care Med (2004) 2.40
Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys. J Virol (2010) 2.39
Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS. J Virol (2009) 2.37
Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination. J Immunol (2008) 2.35
Vascular endothelial growth factor in the lung. Am J Physiol Lung Cell Mol Physiol (2006) 2.25
Gene microarray analysis of peripheral blood cells in pulmonary arterial hypertension. Am J Respir Crit Care Med (2004) 2.22
Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. Am J Respir Crit Care Med (2010) 2.20
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res (2007) 2.19
Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol (2005) 2.13
Idiopathic pulmonary fibrosis and pulmonary hypertension: connecting the dots. Am J Respir Crit Care Med (2007) 2.11
The Biomedical Resource Ontology (BRO) to enable resource discovery in clinical and translational research. J Biomed Inform (2010) 2.10
Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension. Am J Respir Crit Care Med (2010) 2.09
Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure. J Am Coll Cardiol (2011) 2.09
Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol (2007) 2.08
Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med (2008) 2.08
Molecular pathogenesis of emphysema. J Clin Invest (2008) 2.03
Idiopathic pleuroparenchymal fibroelastosis: description of a novel clinicopathologic entity. Chest (2004) 2.00
Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circ Res (2003) 2.00
Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. J Pharmacol Exp Ther (2006) 1.98
Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. Am J Pathol (2008) 1.90
Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem (2005) 1.88
International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations. Vaccine (2011) 1.88
Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol (2006) 1.88
Oxidative stress in severe pulmonary hypertension. Am J Respir Crit Care Med (2003) 1.85
Apoptosis and emphysema: the missing link. Am J Respir Cell Mol Biol (2003) 1.82
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med (2012) 1.81
Ontogeny of CD24 in the human kidney. Kidney Int (2010) 1.81
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc Natl Acad Sci U S A (2011) 1.81
alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. Am J Pathol (2006) 1.81
Plasma and lipids from stored platelets cause acute lung injury in an animal model. Transfusion (2003) 1.79
Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells. Am J Pathol (2010) 1.79
Aging and cigarette smoke: fueling the fire. Am J Respir Crit Care Med (2006) 1.76
A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes (2002) 1.75
Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J (2004) 1.74
Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure. Am J Physiol Lung Cell Mol Physiol (2002) 1.73
Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells. FASEB J (2005) 1.72
A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema. Am J Respir Crit Care Med (2006) 1.72
Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury. Crit Care Med (2011) 1.68
Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation (2013) 1.68
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med (2010) 1.67
Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe (2013) 1.66
Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med (2013) 1.66