Published in Osteoarthritis Cartilage on June 02, 2006
Developments in the scientific understanding of osteoarthritis. Arthritis Res Ther (2009) 2.22
Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage (2011) 1.89
A current review of molecular mechanisms regarding osteoarthritis and pain. Gene (2013) 1.48
Value of biomarkers in osteoarthritis: current status and perspectives. Ann Rheum Dis (2013) 1.40
Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers. Arthritis Res Ther (2009) 1.30
Novel fast semi-automated software to segment cartilage for knee MR acquisitions. Osteoarthritis Cartilage (2006) 1.24
Cartilage repair: past and future--lessons for regenerative medicine. J Cell Mol Med (2009) 1.24
The future of blood-based biomarkers for Alzheimer's disease. Alzheimers Dement (2013) 1.22
Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities. Arthritis Res Ther (2011) 1.22
First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis. PLoS One (2010) 1.20
Molecular serum markers of liver fibrosis. Biomark Insights (2012) 1.20
Prognostic biomarkers in osteoarthritis. Curr Opin Rheumatol (2013) 1.18
Biomarkers for osteoarthritis: current position and steps towards further validation. Best Pract Res Clin Rheumatol (2014) 1.17
Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum (2011) 1.16
Diagnosis of osteoarthritis: imaging. Bone (2011) 1.13
Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms? Arthritis Rheum (2011) 1.10
Functional articular cartilage repair: here, near, or is the best approach not yet clear? Nat Rev Rheumatol (2013) 1.09
Global metabolic profiling of human osteoarthritic synovium. Osteoarthritis Cartilage (2011) 1.08
Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. BMC Musculoskelet Disord (2011) 1.06
Osteoarthritis year 2010 in review: biochemical markers. Osteoarthritis Cartilage (2011) 1.02
Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis. Ann Rheum Dis (2012) 1.01
Animal models of osteoarthritis: challenges of model selection and analysis. AAPS J (2013) 1.01
Serological muscle loss biomarkers: an overview of current concepts and future possibilities. J Cachexia Sarcopenia Muscle (2012) 0.99
Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis--the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation. BMC Musculoskelet Disord (2010) 0.95
Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage (2011) 0.94
A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials. Curr Drug Targets (2010) 0.94
Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans. Eur J Appl Physiol (2010) 0.93
Collagen biomarkers for arthritis applications. Biomark Insights (2007) 0.93
Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis. Osteoarthritis Cartilage (2009) 0.93
Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study. Osteoarthritis Cartilage (2008) 0.92
Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis. Osteoarthritis Cartilage (2011) 0.91
Whither osteoarthritis biomarkers? Osteoarthritis Cartilage (2009) 0.91
OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis. Osteoarthritis Cartilage (2015) 0.91
Animal models of osteoarthritis: classification, update, and measurement of outcomes. J Orthop Surg Res (2016) 0.90
Cytokines as biochemical markers for knee osteoarthritis. World J Orthop (2015) 0.90
Lumbar spine radiographic features and demographic, clinical, and radiographic knee, hip, and hand osteoarthritis. Arthritis Care Res (Hoboken) (2012) 0.90
Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. Osteoarthritis Cartilage (2009) 0.90
Trajectory of cartilage loss within 4 years of knee replacement--a nested case-control study from the osteoarthritis initiative. Osteoarthritis Cartilage (2014) 0.90
Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis. Arthritis Res Ther (2011) 0.89
Biomarkers: in combination they may do better. Arthritis Res Ther (2009) 0.89
Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning. BMC Musculoskelet Disord (2013) 0.89
Low-Grade Inflammation in Symptomatic Knee Osteoarthritis: Prognostic Value of Inflammatory Plasma Lipids and Peripheral Blood Leukocyte Biomarkers. Arthritis Rheumatol (2015) 0.89
Raman spectroscopy of synovial fluid as a tool for diagnosing osteoarthritis. J Biomed Opt (2009) 0.88
Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee. Osteoarthritis Cartilage (2008) 0.88
Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis. BMC Musculoskelet Disord (2011) 0.87
Indian hedgehog in synovial fluid is a novel marker for early cartilage lesions in human knee joint. Int J Mol Sci (2014) 0.87
Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family. Arthritis Rheum (2010) 0.85
3D superimposition and understanding temporomandibular joint arthritis. Orthod Craniofac Res (2015) 0.84
Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis. Int J Rheumatol (2009) 0.84
Can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on epidemiology and phenotype of osteoarthritis. Drugs Aging (2015) 0.84
Novel cardiac-specific biomarkers and the cardiovascular continuum. Biomark Insights (2012) 0.83
Reference intervals of serum hyaluronic acid corresponding to the radiographic severity of knee osteoarthritis in women. BMC Musculoskelet Disord (2013) 0.83
Diagnostic index of three-dimensional osteoarthritic changes in temporomandibular joint condylar morphology. J Med Imaging (Bellingham) (2015) 0.82
Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project. J Rheumatol (2014) 0.82
Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis. Arthritis Res Ther (2010) 0.82
The current and future status of biomarkers in osteoarthritis. J Rheumatol (2014) 0.82
Will posttranslational modifications of brain proteins provide novel serological markers for dementias? Int J Alzheimers Dis (2012) 0.81
Biomarkers of (osteo)arthritis. Biomarkers (2015) 0.81
Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study. Arthritis Res Ther (2009) 0.81
Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes. BMC Cardiovasc Disord (2010) 0.81
Towards the identification of early stage osteoarthritis. Clin Cases Miner Bone Metab (2014) 0.81
Pre-Osteoarthritis: Definition and Diagnosis of an Elusive Clinical Entity. Cartilage (2015) 0.81
Republished: Value of biomarkers in osteoarthritis: current status and perspectives. Postgrad Med J (2014) 0.80
Magnetic Capture of a Molecular Biomarker from Synovial Fluid in a Rat Model of Knee Osteoarthritis. Ann Biomed Eng (2015) 0.80
Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints. Can J Vet Res (2014) 0.79
Correlation between μCT imaging, histology and functional capacity of the osteoarthritic knee in the rat model of osteoarthritis. J Transl Med (2015) 0.79
Association between serum and urine biomarkers and lumbar spine individual radiographic features: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage (2012) 0.79
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty. Drugs Aging (2015) 0.78
Correlation of bone morphogenetic protein-2 levels in serum and synovial fluid with disease severity of knee osteoarthritis. Med Sci Monit (2015) 0.78
Perspectives on next steps in classification of oro-facial pain - Part 3: biomarkers of chronic oro-facial pain - from research to clinic. J Oral Rehabil (2015) 0.78
Diagnosis of Osteoarthritis by Cartilage Surface Smoothness Quantified Automatically from Knee MRI. Cartilage (2011) 0.78
Diagnostic index of 3D osteoarthritic changes in TMJ condylar morphology. Proc SPIE Int Soc Opt Eng (2015) 0.77
Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: how markers of β-cell loss may assist. J Transl Med (2012) 0.77
Fell-Muir lecture: cartilage 2010 - the known unknowns. Int J Exp Pathol (2010) 0.76
Personalized medicine for osteoarthritis: where are we now? Ther Adv Musculoskelet Dis (2013) 0.76
Soluble biomarkers development in osteoarthritis: from discovery to personalized medicine. Biomarkers (2015) 0.76
ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis Cartilage (2015) 0.75
A 12-week randomized, double-blind, placebo-controlled multicenter study of choline-stabilized orthosilicic acid in patients with symptomatic knee osteoarthritis. BMC Musculoskelet Disord (2017) 0.75
Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair. Sci Rep (2017) 0.75
Neo-epitope Peptides as Biomarkers of Disease Progression for Muscular Dystrophies and Other Myopathies. J Neuromuscul Dis (2016) 0.75
Impact of physical activity and mechanical loading on biomarkers typically used in osteoarthritis assessment: current concepts and knowledge gaps. Ther Adv Musculoskelet Dis (2016) 0.75
Biomarkers in osteoarthritis. HSS J (2012) 0.75
Current Trends in Cartilage Science: An Impression from the ICRS World Conference 2012. Cartilage (2013) 0.75
3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease. Osteoarthritis Cartilage (2014) 0.75
The Need for Predictive, Prognostic, Objective and Complementary Blood-Based Biomarkers in Osteoarthritis (OA). EBioMedicine (2016) 0.75
Review of Soluble Biomarkers of Osteoarthritis: Lessons From Animal Models. Cartilage (2016) 0.75
The minor collagens in articular cartilage. Protein Cell (2017) 0.75
The effect of vigorous running and cycling on serum COMP, lubricin, and femoral cartilage thickness: a pilot study. Eur J Appl Physiol (2016) 0.75
Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: The Johnston County Osteoarthritis Project. Osteoarthritis Cartilage (2017) 0.75
Medial femur T2 Z-scores predict the probability of knee structural worsening over 4-8 years: Data from the osteoarthritis initiative. J Magn Reson Imaging (2017) 0.75
Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med (2000) 11.12
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med (1995) 11.08
Body weight and mortality among women. N Engl J Med (1995) 11.04
OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage (2008) 10.99
Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol (1989) 10.98
Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet (1998) 10.11
Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol (1994) 9.90
Aspirin and the risk of colorectal cancer in women. N Engl J Med (1995) 9.59
No hiding place: on the discomforts of researching the contemporary policy process. J Soc Policy (1990) 8.97
Evidence based policymaking. BMJ (1995) 8.08
OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage (2010) 7.52
Cyclooxygenase in biology and disease. FASEB J (1998) 7.17
Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med (1999) 6.17
A prospective study of family history and the risk of colorectal cancer. N Engl J Med (1994) 6.12
Validation of the Gail et al. model of breast cancer risk prediction and implications for chemoprevention. J Natl Cancer Inst (2001) 5.97
Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Proc Natl Acad Sci U S A (1986) 5.34
Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. J Natl Cancer Inst (2001) 5.33
Tubal ligation, hysterectomy, and risk of ovarian cancer. A prospective study. JAMA (1993) 5.31
Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum (2001) 5.24
Birthweight as a risk factor for breast cancer. Lancet (1996) 5.05
Postmenopausal hormone therapy and mortality. N Engl J Med (1997) 4.96
Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstet Gynecol (1997) 4.84
Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol (2000) 4.83
Dual effects of weight and weight gain on breast cancer risk. JAMA (1997) 4.81
Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up. JAMA (1992) 4.80
Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst (1998) 4.74
Alcohol and breast cancer in women: a pooled analysis of cohort studies. JAMA (1998) 4.65
Aggregation of cartilage proteoglycans. 3. Characteristics of the proteins isolated from trypsin digests of aggregates. J Biol Chem (1974) 4.61
A prospective study of pregravid determinants of gestational diabetes mellitus. JAMA (1997) 4.50
Aggregation of cartilage proteoglycans. I. The role of hyaluronic acid. J Biol Chem (1974) 4.39
OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage (2007) 4.34
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci U S A (1992) 4.27
Alcohol consumption and mortality among women. N Engl J Med (1995) 4.22
Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement. Ann Rheum Dis (2004) 3.95
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J (1994) 3.92
Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. J Natl Cancer Inst (1995) 3.88
Reproducibility and validity of maternal recall of pregnancy-related events. Epidemiology (1999) 3.86
Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science (1996) 3.82
Predictors of HIV-1 serostatus disclosure: a prospective study among HIV-infected pregnant women in Dar es Salaam, Tanzania. AIDS (2001) 3.81
Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon. Biochem J (1984) 3.81
Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Intern Med (1998) 3.73
Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet (1998) 3.69
The validity of recalled weight among younger women. Int J Obes Relat Metab Disord (1995) 3.68
Aggregation of cartilage proteoglycans. II. Oligosaccharide competitors of the proteoglycan-hyaluronic acid interaction. J Biol Chem (1974) 3.62
The "redisorganisation" of the NHS. BMJ (2001) 3.52
Influence of methotrexate, TNF blockers and prednisolone on antibody responses to pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis. Rheumatology (Oxford) (2005) 3.42
Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies. JAMA (2001) 3.37
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res (1997) 3.36
Silicone breast implants and the risk of connective-tissue diseases and symptoms. N Engl J Med (1995) 3.29
IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. J Immunol (1999) 3.15
Etanercept, infliximab, and leflunomide in established rheumatoid arthritis: clinical experience using a structured follow up programme in southern Sweden. Ann Rheum Dis (2002) 3.10
Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA (2001) 3.07
Distribution of keratan sulfate in cartilage proteoglycans. J Biol Chem (1977) 3.04
Dietary factors and the survival of women with breast carcinoma. Cancer (1999) 2.92
Osteopontin--a possible anchor of osteoclasts to bone. Proc Natl Acad Sci U S A (1990) 2.90
Epidemiology of interstitial cystitis: a population based study. J Urol (1999) 2.85
The incidence of HIV infection among women using family planning methods in Dar es Salaam, Tanzania. AIDS (1998) 2.80
Association of dietary intake of fat and fatty acids with risk of breast cancer. JAMA (1999) 2.80
Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum. Arthritis Rheum (1988) 2.77
Polydispersity of cartilage proteoglycans. Structural variations with size and buoyant density of the molecules. J Biol Chem (1977) 2.74
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J Immunol (1995) 2.72
Physical activity and breast cancer risk in a cohort of young women. J Natl Cancer Inst (1998) 2.67
The impact of arthritis in rural populations. Arthritis Care Res (1995) 2.63
A candidate gene approach to searching for low-penetrance breast and prostate cancer genes. Nat Rev Cancer (2005) 2.62
Evaluation of clinically relevant states in patient reported outcomes in knee and hip osteoarthritis: the patient acceptable symptom state. Ann Rheum Dis (2004) 2.60
Determination of serum creatinine by a direct colorimetric method. Clin Chim Acta (1973) 2.60
Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage. J Biol Chem (1992) 2.58
Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum (2006) 2.57
Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis (2008) 2.55
Isolation and characterization of two sialoproteins present only in bone calcified matrix. Biochem J (1985) 2.55
Radiographic osteoarthritis of the hip and bone mineral density. The Study of Osteoporotic Fractures Research Group. Arthritis Rheum (1995) 2.51
Leisure-time physical activity, body size, and colon cancer in women. Nurses' Health Study Research Group. J Natl Cancer Inst (1997) 2.46
Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists. Ann Rheum Dis (2005) 2.46
Family history, age, and risk of breast cancer. Prospective data from the Nurses' Health Study. JAMA (1993) 2.45
In vivo effects of intercalating drugs on the superhelix density of mitochondrial DNA isolated from human and mouse cells in culture. J Mol Biol (1971) 2.44
Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists. Ann Rheum Dis (2005) 2.43
Extraction, fractionation and characterization of proteoglycans from bovine tracheal cartilage. Biochim Biophys Acta (1972) 2.43
Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. Genes Dev (1991) 2.40
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage (2010) 2.39
Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon. J Biol Chem (1999) 2.38
A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum (2001) 2.37
Adolescent body mass index and infertility caused by ovulatory disorder. Am J Obstet Gynecol (1994) 2.37
Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. Arthritis Rheum (1999) 2.36
Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. Br J Rheumatol (1992) 2.32
A prospective study of cigarette smoking and the risk of pancreatic cancer. Arch Intern Med (1996) 2.31
Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis. Osteoarthritis Cartilage (2006) 2.29
Smoking cessation in relation to total mortality rates in women. A prospective cohort study. Ann Intern Med (1993) 2.27
Determinants of low birth weight among HIV-infected pregnant women in Tanzania. Am J Clin Nutr (2001) 2.26
The association of radiographic changes of osteoarthritis of the hand and hip in elderly women. J Rheumatol (1995) 2.25
Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomas. Ann Rheum Dis (2005) 2.25
Prognostic laboratory markers of joint damage in rheumatoid arthritis. Ann Rheum Dis (2004) 2.25
The relation between dietary intake and adipose tissue composition of selected fatty acids in US women. Am J Clin Nutr (1998) 2.24
Postmenopausal estrogen therapy and the risk for developing systemic lupus erythematosus. Ann Intern Med (1995) 2.22
Harvard report on cancer prevention volume 4: Harvard Cancer Risk Index. Risk Index Working Group, Harvard Center for Cancer Prevention. Cancer Causes Control (2000) 2.19
Occurrence of complex mitochondrial DNA in normal tissues. Nature (1968) 2.18