Published in Cell Metab on June 01, 2006
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature (2010) 4.07
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature (2008) 3.91
Molecular aspects of thyroid hormone actions. Endocr Rev (2010) 3.29
Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes (2009) 3.17
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J Clin Invest (2009) 2.80
Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature (2011) 2.63
Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab (2009) 1.78
Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology (2009) 1.71
Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection. Cardiovasc Res (2008) 1.41
Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab (2010) 1.36
Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus. Exp Diabetes Res (2011) 1.25
Oxidative stress and beta-cell dysfunction. Pflugers Arch (2010) 1.22
Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol (2013) 1.22
Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing. Am J Physiol Regul Integr Comp Physiol (2009) 1.21
G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization. Hum Mol Genet (2012) 1.21
Mitochondrial uncoupling protein-2 mediates steatotic liver injury following ischemia/reperfusion. J Biol Chem (2007) 1.19
UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17
The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta (2010) 1.17
Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes (2011) 1.13
UCP2 regulates the glucagon response to fasting and starvation. Diabetes (2013) 1.13
Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion. PLoS One (2008) 1.13
Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents. PLoS One (2010) 1.09
Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells. Islets (2011) 1.09
Leucine metabolism in regulation of insulin secretion from pancreatic beta cells. Nutr Rev (2010) 1.03
Physiological and pathological roles of mitochondrial SLC25 carriers. Biochem J (2013) 1.00
Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J (2010) 0.97
Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice. Am J Physiol Gastrointest Liver Physiol (2008) 0.96
Mitochondrial recoupling: a novel therapeutic strategy for cancer? Br J Cancer (2011) 0.95
Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacol Sin (2009) 0.94
Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart. PLoS One (2011) 0.94
Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. Diabetologia (2012) 0.93
Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion. J Biol Chem (2012) 0.89
A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis. Kidney Int (2013) 0.87
Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells. Acta Pharmacol Sin (2009) 0.87
Autoregulation of free radicals via uncoupling protein control in pancreatic beta-cell mitochondria. Biophys J (2010) 0.86
Role of uncoupling proteins in cancer. Cancers (Basel) (2010) 0.86
Genipin inhibits mitochondrial uncoupling protein 2 expression and ameliorates podocyte injury in diabetic mice. PLoS One (2012) 0.86
Fatty acid flippase activity of UCP2 is essential for its proton transport in mitochondria. Cell Metab (2014) 0.85
Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells. Acta Pharmacol Sin (2010) 0.85
Glucose sensing in the pancreatic beta cell: a computational systems analysis. Theor Biol Med Model (2010) 0.85
Genipin inhibits TNF-α-induced vascular smooth muscle cell proliferation and migration via induction of HO-1. PLoS One (2013) 0.84
UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. PLoS One (2012) 0.83
Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells. J Mol Med (Berl) (2008) 0.83
Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression. Sci Rep (2015) 0.83
Redox homeostasis in pancreatic β cells. Oxid Med Cell Longev (2012) 0.82
Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice. Mediators Inflamm (2016) 0.81
Asymmetric total synthesis of the iridoid beta-glucoside (+)-geniposide via phosphine organocatalysis. Org Lett (2009) 0.81
Peroxisome proliferator-activated receptor activating hypoglycemic effect of Gardenia jasminoides Ellis aqueous extract and improvement of insulin sensitivity in steroid induced insulin resistant rats. BMC Complement Altern Med (2014) 0.81
Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2. Cell Immunol (2015) 0.80
The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failure. Curr Diabetes Rev (2012) 0.80
Apoptosis induced by genipin in human leukemia K562 cells: involvement of c-Jun N-terminal kinase in G₂/M arrest. Acta Pharmacol Sin (2011) 0.79
Hypoglycemic Activity and the Potential Mechanism of the Flavonoid Rich Extract from Sophora tonkinensis Gagnep. in KK-Ay Mice. Front Pharmacol (2016) 0.79
Protection of long-term treatment with huang-lian-jie-du-tang on vascular endothelium in rats with type 2 diabetes mellitus. Curr Ther Res Clin Exp (2012) 0.78
The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale. J Biol Chem (2013) 0.78
Parkin suppresses Drp1-independent mitochondrial division. Biochem Biophys Res Commun (2016) 0.77
Overexpression of uncoupling protein 2 inhibits the high glucose-induced apoptosis of human umbilical vein endothelial cells. Int J Mol Med (2016) 0.77
Mitochondrial regulation of β-cell function: maintaining the momentum for insulin release. Mol Aspects Med (2015) 0.77
Overexpression of uncoupling protein-2 in cancer: metabolic and heat changes, inhibition and effects on drug resistance. Inflammopharmacology (2015) 0.77
Uncoupling protein 2 mediates resistance to gemcitabine-induced apoptosis in hepatocellular carcinoma cell lines. Biosci Rep (2015) 0.77
Effect of epigallocatechin gallate on uncoupling protein 2 in acute liver injury. Int J Clin Exp Pathol (2015) 0.76
RNA Sequencing Exposes Adaptive and Immune Responses to Intrauterine Growth Restriction in Fetal Sheep Islets. Endocrinology (2017) 0.76
Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine. J Endocrinol (2016) 0.75
The Hydroxyl at Position C1 of Genipin Is the Active Inhibitory Group that Affects Mitochondrial Uncoupling Protein 2 in Panc-1 Cells. PLoS One (2016) 0.75
Oleate induces KATP channel-dependent hyperpolarisation in mouse hypothalamic glucose-excited neurones without altering cellular energy charge. Neuroscience (2017) 0.75
Effects of Mitochondrial Uncoupling Protein 2 Inhibition by Genipin in Human Cumulus Cells. Biomed Res Int (2015) 0.75
Genipin cross-linked decellularized tracheal tubular matrix for tracheal tissue engineering applications. Sci Rep (2016) 0.75
A Mechanism for the Temporal Potentiation of Genipin to the Cytotoxicity of Cisplatin in Colon Cancer Cells. Int J Med Sci (2016) 0.75
Leishmania donovani restricts mitochondrial dynamics to enhance miRNP stability and target RNA repression in host macrophages. Mol Biol Cell (2017) 0.75
Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice. Mol Metab (2017) 0.75
Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species. Int J Biochem Cell Biol (2017) 0.75
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron (2004) 7.15
Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell (2005) 7.04
Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science (2007) 6.48
Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature (2012) 5.37
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron (2006) 5.27
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest (2011) 5.12
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron (2011) 4.88
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem (2004) 4.86
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature (2003) 4.80
Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A (2002) 4.77
betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (2002) 4.47
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature (2007) 4.20
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest (2005) 3.92
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci (2008) 3.90
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab (2011) 3.68
The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol (2005) 3.42
The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab (2005) 3.38
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab (2007) 3.02
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology (2007) 2.95
Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol (2005) 2.93
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (2013) 2.79
Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med (2008) 2.78
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest (2008) 2.77
Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging (2003) 2.68
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron (2010) 2.54
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest (2008) 2.40
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab (2006) 2.37
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci (2011) 2.36
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest (2003) 2.35
GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell (2012) 2.34
Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat Neurosci (2004) 2.31
N-cadherin mediates cortical organization in the mouse brain. Dev Biol (2006) 2.19
Representation facilitates reasoning: what natural frequencies are and what they are not. Cognition (2002) 2.18
Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron (2006) 2.16
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One (2009) 2.11
Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron (2012) 2.10
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci (2007) 2.05
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron (2008) 2.04
Discovery of chemical reactions through multidimensional screening. J Am Chem Soc (2007) 1.97
Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. J Neurosci (2009) 1.92
The conjunction fallacy and the many meanings of and. Cognition (2008) 1.81
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes (2002) 1.74
Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell (2013) 1.71
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell (2003) 1.71
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. Clin Exp Metastasis (2009) 1.71
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res (2012) 1.70
A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus. Dev Biol (2007) 1.69
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol (2005) 1.66
Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res (2006) 1.64
Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. Am J Hum Genet (2007) 1.62
PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab (2010) 1.57
Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab (2013) 1.56
An approach to skeletal diversity using functional group pairing of multifunctional scaffolds. Org Lett (2007) 1.56
Tankyrases as drug targets. FEBS J (2013) 1.55
A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci U S A (2001) 1.55
Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. J Biol Chem (2004) 1.46
Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. J Exp Med (2011) 1.45
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Recurrent network activity drives striatal synaptogenesis. Nature (2012) 1.44
Synthesis of the azaphilones using copper-mediated enantioselective oxidative dearomatization. J Am Chem Soc (2005) 1.43
Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro. Biochem Biophys Res Commun (2011) 1.42
Enantioselective synthesis of the complex rocaglate (-)-silvestrol. Angew Chem Int Ed Engl (2007) 1.40
Monitoring FoxO1 localization in chemically identified neurons. J Neurosci (2008) 1.39
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res (2011) 1.38
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res (2013) 1.38
Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab (2010) 1.36
Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds. J Org Chem (2009) 1.34
COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex (2007) 1.33
Enantioselective photocycloaddition mediated by chiral Brønsted acids: asymmetric synthesis of the rocaglamides. J Am Chem Soc (2006) 1.32
Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab (2013) 1.32
Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors. J Neurosci (2013) 1.30
Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One (2011) 1.30
Remodelling of the natural product fumagillol employing a reaction discovery approach. Nat Chem (2011) 1.30
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology (2008) 1.29
Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends. J Gene Med (2005) 1.29
Dearomatization strategies in the synthesis of complex natural products. Angew Chem Int Ed Engl (2011) 1.28
Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases. DNA Repair (Amst) (2008) 1.26
Rapid access to polyprenylated phloroglucinols via alkylative dearomatization-annulation: total synthesis of (+/-)-clusianone(1). J Am Chem Soc (2007) 1.24
Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis (2007) 1.22
Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain. Brain Res Dev Brain Res (2004) 1.22
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification. Nat Biotechnol (2009) 1.21
A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci (2010) 1.18
Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc Natl Acad Sci U S A (2010) 1.18
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci (2010) 1.15
Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4 + 2] dimerization cascade. J Am Chem Soc (2008) 1.15
Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling. Biol Psychiatry (2012) 1.14
Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade. J Am Chem Soc (2003) 1.13
Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1. J Am Chem Soc (2006) 1.13
Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5. J Biol Chem (2006) 1.13
UCP2 regulates the glucagon response to fasting and starvation. Diabetes (2013) 1.13
Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex. ACS Chem Biol (2013) 1.12
Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Rep (2012) 1.12