Published in Nature on August 21, 2003
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol (2011) 7.40
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. J Cell Biol (2006) 3.87
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. Biochem J (2004) 3.60
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol (2007) 3.51
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell (2005) 3.32
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2004) 3.00
Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene (2006) 2.96
Direct evidence for S-nitrosation of mitochondrial complex I. Biochem J (2006) 2.88
Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med (2008) 2.78
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J (2004) 2.77
Molecular physiology of mammalian glucokinase. Cell Mol Life Sci (2009) 2.66
Assessing the potential of glucokinase activators in diabetes therapy. Nat Rev Drug Discov (2009) 2.60
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol (2007) 2.45
For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer (2010) 2.26
Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol (2004) 2.19
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
Cancer metabolism: current perspectives and future directions. Cell Death Dis (2012) 2.07
BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures. Neuron (2012) 2.05
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc Natl Acad Sci U S A (2007) 1.83
Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr (2008) 1.73
Hypoglycemia leads to age-related loss of vision. Proc Natl Acad Sci U S A (2006) 1.59
Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell (2009) 1.58
The engine driving the ship: metabolic steering of cell proliferation and death. Nat Rev Mol Cell Biol (2010) 1.51
Multiple functions of BCL-2 family proteins. Cold Spring Harb Perspect Biol (2013) 1.51
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem (2010) 1.41
Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2. Dev Cell (2009) 1.41
Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia. J Neurosci (2010) 1.39
Mitochondria and endoplasmic reticulum: the lethal interorganelle cross-talk. J Bioenerg Biomembr (2005) 1.39
GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J Biol Chem (2009) 1.36
Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt. Mol Biol Cell (2004) 1.33
Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther (2010) 1.30
The mitochondrial death pathway: a promising therapeutic target in diseases. J Cell Mol Med (2009) 1.30
A surface groove essential for viral Bcl-2 function during chronic infection in vivo. PLoS Pathog (2005) 1.30
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. Proc Natl Acad Sci U S A (2008) 1.28
Mitochondria-associated hexokinases play a role in the control of programmed cell death in Nicotiana benthamiana. Plant Cell (2006) 1.28
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. J Biol Chem (2010) 1.27
Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends Neurosci (2013) 1.25
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment. Genes Cancer (2011) 1.23
Genetic evidence for a link between glycolysis and DNA replication. PLoS One (2007) 1.20
Mitochondria-mediated apoptosis in mammals. Protein Cell (2014) 1.19
Pharmacological manipulation of Bcl-2 family members to control cell death. J Clin Invest (2005) 1.19
The role of anti-alpha-enolase autoantibodies in pathogenicity of autoimmune-mediated retinopathy. J Clin Immunol (2007) 1.19
Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. J Biol Chem (2010) 1.19
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. EMBO J (2012) 1.17
Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis. Infect Immun (2005) 1.16
Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2. BMC Cell Biol (2005) 1.16
Sugar sensing and signaling. Arabidopsis Book (2008) 1.15
At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis. Biochem J (2009) 1.15
Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases. Pharmaceuticals (Basel) (2010) 1.13
Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood (2012) 1.13
WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells. Leukemia (2009) 1.12
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. J Biol Chem (2013) 1.11
Redox regulation of mitochondrial biogenesis. Free Radic Biol Med (2012) 1.11
Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. Biochim Biophys Acta (2012) 1.10
Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila. EMBO J (2005) 1.08
Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state. Proc Natl Acad Sci U S A (2012) 1.07
The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage. Cell Metab (2015) 1.05
A network of transcriptionally coordinated functional modules in Saccharomyces cerevisiae. Genome Res (2005) 1.04
Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine. J Biol Chem (2009) 1.03
Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics. Am J Physiol Endocrinol Metab (2011) 1.03
Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic β-cells. Diabetes (2012) 1.03
Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One (2009) 1.03
Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide. J Biol Chem (2009) 1.03
Functions of BCL-X L at the Interface between Cell Death and Metabolism. Int J Cell Biol (2013) 1.02
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development. Cell Death Differ (2010) 1.00
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Changing appetites: the adaptive advantages of fuel choice. Trends Cell Biol (2013) 1.00
The tangled circuitry of metabolism and apoptosis. Mol Cell (2013) 0.99
A role for F-actin in hexokinase-mediated glucose signaling. Plant Physiol (2007) 0.98
Assay of the multiple energy-producing pathways of mammalian cells. PLoS One (2011) 0.98
Channelopathy pathogenesis in autism spectrum disorders. Front Genet (2013) 0.97
Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? J Biol Chem (2012) 0.97
Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. J Biol Chem (2010) 0.96
Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J Biol Chem (2008) 0.96
Glucokinase activators for diabetes therapy: May 2010 status report. Diabetes Care (2011) 0.96
PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation. Nat Commun (2015) 0.95
BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J Biol Chem (2004) 0.94
Order-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase. PLoS Biol (2012) 0.94
How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions? Oncogene (2014) 0.93
Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. Mol Cell (2014) 0.93
Cell metabolism: an essential link between cell growth and apoptosis. Biochim Biophys Acta (2010) 0.92
Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. PLoS One (2011) 0.92
Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS One (2009) 0.91
Cell death in mammalian cell culture: molecular mechanisms and cell line engineering strategies. Cytotechnology (2010) 0.91
Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humans. J Biol Chem (2011) 0.91
Mitochondrial roles and cytoprotection in chronic liver injury. Biochem Res Int (2012) 0.90
Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization. J Biol Chem (2009) 0.90
The synergism of MCL1 and glycolysis on pediatric acute lymphoblastic leukemia cell survival and prednisolone resistance. Haematologica (2013) 0.90
Evolutionary diversification of plant shikimate kinase gene duplicates. PLoS Genet (2008) 0.90
A message emerging from development: the repression of mitochondrial beta-F1-ATPase expression in cancer. J Bioenerg Biomembr (2007) 0.90
Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis. PLoS Genet (2016) 0.89
SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. J Biol Chem (2013) 0.89
Regulation of hepatic energy metabolism and gluconeogenesis by BAD. Cell Metab (2014) 0.89
Targeting the Warburg effect in hematological malignancies: from PET to therapy. Curr Opin Oncol (2009) 0.89
Matched and mismatched metabolic fuels in lymphocyte function. Semin Immunol (2013) 0.88
Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein. Oncogene (2015) 0.88
Contribution of apoptosis-associated signaling pathways to epileptogenesis: lessons from Bcl-2 family knockouts. Front Cell Neurosci (2013) 0.87
Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle? J Bioenerg Biomembr (2005) 0.87
The impact of microRNAs on protein output. Nature (2008) 32.39
Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat Methods (2007) 25.29
Cell death: critical control points. Cell (2004) 22.56
An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature (2005) 22.40
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res (2008) 20.59
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet (2001) 13.79
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol (2006) 12.13
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome. J Proteome Res (2003) 11.96
Defining the human deubiquitinating enzyme interaction landscape. Cell (2009) 11.39
Network organization of the human autophagy system. Nature (2010) 11.38
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 11.09
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci U S A (2003) 10.82
Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A (2004) 10.78
A proteomics approach to understanding protein ubiquitination. Nat Biotechnol (2003) 10.51
A brain-specific microRNA regulates dendritic spine development. Nature (2006) 10.18
A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07
Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature (2008) 9.66
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science (2003) 9.55
A tissue-specific atlas of mouse protein phosphorylation and expression. Cell (2010) 8.65
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
Identifying autism loci and genes by tracing recent shared ancestry. Science (2008) 7.72
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell (2006) 7.72
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (2004) 7.63
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol (2011) 7.40
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron (2004) 7.15
Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell (2005) 7.04
Comprehensive proteomic analysis of the human spliceosome. Nature (2002) 6.85
Influenza-associated deaths among children in the United States, 2003-2004. N Engl J Med (2005) 6.83
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature (2003) 6.78
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77
Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations. Nat Methods (2005) 6.73
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell (2005) 6.71
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts. Nat Protoc (2007) 6.57
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron (2006) 6.50
Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science (2007) 6.48
Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A (2007) 6.08
An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets. Nat Biotechnol (2005) 5.93
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron (2012) 5.84
Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell (2010) 5.77
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (2011) 5.73
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol (2007) 5.48
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell (2002) 5.45
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science (2009) 5.37
Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature (2012) 5.37
OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A (2004) 5.34
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J (2007) 5.31
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron (2006) 5.27
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A (2004) 5.16
Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu Rev Neurosci (2008) 5.12
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest (2011) 5.12
The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry. Nat Protoc (2008) 5.10
Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature (2010) 5.08
Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A (2008) 5.08
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature (2009) 4.98
VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science (2003) 4.92
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron (2011) 4.88
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science (2002) 4.88
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem (2004) 4.86
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85
Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A (2002) 4.77
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science (2005) 4.75
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science (2006) 4.68
Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A (2005) 4.63
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (2002) 4.47
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46
Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell (2004) 4.34
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol (2006) 4.25
Optimization and use of peptide mass measurement accuracy in shotgun proteomics. Mol Cell Proteomics (2006) 4.25
The many forks in FOXO's road. Sci STKE (2003) 4.23
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem (2007) 4.22
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell (2004) 4.21
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature (2007) 4.20
Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis. Science (2008) 4.15
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Activity-dependent regulation of inhibitory synapse development by Npas4. Nature (2008) 4.10
From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. Neuron (2008) 4.02