Published in Methods Enzymol on January 01, 2006
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell (2009) 6.23
CD200 is induced by ERK and is a potential therapeutic target in melanoma. J Clin Invest (2007) 1.45
The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis (2011) 1.05
Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. J Steroid Biochem Mol Biol (2009) 1.02
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways. Int J Exp Pathol (2009) 1.00
The role of fibroblast Tiam1 in tumor cell invasion and metastasis. Oncogene (2010) 0.98
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms. J Biol Chem (2010) 0.96
The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector. Mol Cell Biol (2012) 0.95
Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation. Mol Cancer Ther (2013) 0.91
Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways. Cancer Growth Metastasis (2015) 0.82
The Kinase Mirk/dyrk1B: A Possible Therapeutic Target in Pancreatic Cancer. Cancers (Basel) (2010) 0.78
Constitutive IRAK4 Activation Underlies Poor Prognosis And Chemoresistance In Pancreatic Ductal Adenocarcinoma. Clin Cancer Res (2016) 0.75
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol (2005) 10.44
Oncogenically active MYD88 mutations in human lymphoma. Nature (2010) 7.34
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol (2004) 6.61
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res (2008) 5.34
Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol (2002) 4.91
The Ras superfamily at a glance. J Cell Sci (2005) 4.83
Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev (2002) 4.30
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev (2007) 4.25
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol (2003) 4.24
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell (2006) 3.66
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature (2003) 3.66
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2005) 3.64
Blood vessels engineered from human cells. Lancet (2005) 3.61
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer (2010) 3.59
Rho-family GTPases: it's not only Rac and Rho (and I like it). J Cell Sci (2004) 3.27
Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell (2005) 3.17
Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy? J Clin Oncol (2010) 2.70
Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. Nat Biotechnol (2002) 2.61
Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol (2006) 2.61
The dark side of Ras: regulation of apoptosis. Oncogene (2003) 2.60
Signaling interplay in Ras superfamily function. Curr Biol (2005) 2.59
Tumour maintenance is mediated by eNOS. Nature (2008) 2.52
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem (2003) 2.44
Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance. Cancer Cell (2005) 2.39
Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? Trends Cell Biol (2004) 2.32
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res (2007) 2.26
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem (2008) 2.22
KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer. Mol Cancer Ther (2009) 2.22
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem (2007) 2.20
Ras history: The saga continues. Small GTPases (2010) 2.18
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17
Ligand-dependent dynamics and intramolecular signaling in a PDZ domain. J Mol Biol (2004) 2.17
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat Struct Biol (2002) 2.14
Inhibition of Ras for cancer treatment: the search continues. Future Med Chem (2011) 2.14
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol (2002) 2.12
RALA and RALBP1 regulate mitochondrial fission at mitosis. Nat Cell Biol (2011) 2.03
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Curr Biol (2003) 1.84
Loss of hPot1 function leads to telomere instability and a cut-like phenotype. Curr Biol (2004) 1.79
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem (2002) 1.78
Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res (2004) 1.75
Ras family signaling: therapeutic targeting. Cancer Biol Ther (2003) 1.74
Rare codons regulate KRas oncogenesis. Curr Biol (2012) 1.74
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell (2007) 1.72
RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem (2002) 1.70
PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. Cancer Res (2006) 1.70
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog (2008) 1.67
Opinion: Searching for the elusive targets of farnesyltransferase inhibitors. Nat Rev Cancer (2003) 1.67
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene (2004) 1.66
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Res (2007) 1.62
Oncogenic Ras and its role in tumor cell invasion and metastasis. Semin Cancer Biol (2004) 1.62
A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies. Blood (2013) 1.56
Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry. Protein Sci (2005) 1.55
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A (2006) 1.54
Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. J Biol Chem (2003) 1.52
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol (2009) 1.51
Human arteries engineered in vitro. EMBO Rep (2003) 1.51
Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol (2004) 1.50
A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma. PLoS Med (2010) 1.46
C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. Mol Cell Biol (2002) 1.46
CD200 is induced by ERK and is a potential therapeutic target in melanoma. J Clin Invest (2007) 1.45
Genetic modeling of human rhabdomyosarcoma. Cancer Res (2005) 1.45
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. Mol Cell Biol (2002) 1.43
A network of genetic events sufficient to convert normal human cells to a tumorigenic state. Cancer Res (2005) 1.43
Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways. J Biol Chem (2001) 1.40
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling. J Biol Chem (2004) 1.39
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol (2006) 1.37
A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro. Methods Enzymol (2006) 1.36
Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032. Radiother Oncol (2011) 1.35
RKIP downregulates B-Raf kinase activity in melanoma cancer cells. Oncogene (2005) 1.35
MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest (2013) 1.34
The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery. Genes Cancer (2011) 1.32
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol Cell Biol (2007) 1.32
Oncogenic ras-induced expression of cytokines: a new target of anti-cancer therapeutics. Mol Interv (2008) 1.31
Molecular basis for Rho GTPase signaling specificity. Breast Cancer Res Treat (2004) 1.28
Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. Mol Cell Biol (2004) 1.27
A novel role for copper in Ras/mitogen-activated protein kinase signaling. Mol Cell Biol (2012) 1.24
The nucleolar localization domain of the catalytic subunit of human telomerase. J Biol Chem (2002) 1.24
Farnesyltransferase inhibitors: promises and realities. Curr Opin Pharmacol (2002) 1.24
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat Struct Mol Biol (2007) 1.22
Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. Mol Biol Cell (2008) 1.22
Similar nucleotide excision repair capacity in melanocytes and melanoma cells. Cancer Res (2010) 1.21
Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. J Clin Oncol (2003) 1.21
Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38. Mol Cell Biol (2002) 1.20
Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. J Biol Chem (2004) 1.20
Folate-targeted polymeric nanoparticle formulation of docetaxel is an effective molecularly targeted radiosensitizer with efficacy dependent on the timing of radiotherapy. ACS Nano (2011) 1.20