Published in Nat Struct Mol Biol on August 19, 2007
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Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein. Gene (2005) 1.35
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The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor. J Mol Biol (2006) 1.16
Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism. J Biol Chem (2006) 1.16
Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol Cell Biol (2006) 1.13
Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22. Biochem Biophys Res Commun (2000) 1.01
Asef is a Cdc42-specific guanine nucleotide exchange factor. Biol Chem (2007) 0.97
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Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev (2002) 4.30
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol (2003) 4.24
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2005) 3.64
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Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell (2005) 3.17
Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy? J Clin Oncol (2010) 2.70
Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol (2006) 2.61
The dark side of Ras: regulation of apoptosis. Oncogene (2003) 2.60
Signaling interplay in Ras superfamily function. Curr Biol (2005) 2.59
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem (2003) 2.44
Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? Trends Cell Biol (2004) 2.32
Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature (2002) 2.30
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res (2007) 2.26
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem (2008) 2.22
KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer. Mol Cancer Ther (2009) 2.22
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem (2007) 2.20
Ras history: The saga continues. Small GTPases (2010) 2.18
Ligand-dependent dynamics and intramolecular signaling in a PDZ domain. J Mol Biol (2004) 2.17
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat Struct Biol (2002) 2.14
Inhibition of Ras for cancer treatment: the search continues. Future Med Chem (2011) 2.14
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol (2002) 2.12
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J (2002) 2.07
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (2005) 1.98
The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation. Proc Natl Acad Sci U S A (2005) 1.94
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr Biol (2004) 1.87
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Curr Biol (2003) 1.84
Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex. Science (2010) 1.78
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem (2002) 1.78
Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res (2004) 1.75
Ras family signaling: therapeutic targeting. Cancer Biol Ther (2003) 1.74
Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. J Biol Chem (2003) 1.72
RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem (2002) 1.70
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog (2008) 1.67
Opinion: Searching for the elusive targets of farnesyltransferase inhibitors. Nat Rev Cancer (2003) 1.67
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene (2004) 1.66
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Res (2007) 1.62
Oncogenic Ras and its role in tumor cell invasion and metastasis. Semin Cancer Biol (2004) 1.62
General and versatile autoinhibition of PLC isozymes. Mol Cell (2008) 1.62
Crystal structure of Rac1 bound to its effector phospholipase C-beta2. Nat Struct Mol Biol (2006) 1.60
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A (2006) 1.54
Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat Struct Mol Biol (2008) 1.52
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol (2009) 1.51
Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol (2004) 1.50
Regulation of phospholipase C isozymes by ras superfamily GTPases. Annu Rev Pharmacol Toxicol (2006) 1.47
A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma. PLoS Med (2010) 1.46
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. Mol Cell Biol (2002) 1.43
A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Curr Biol (2005) 1.41
Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways. J Biol Chem (2001) 1.40
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling. J Biol Chem (2004) 1.39
Direct activation of phospholipase C-epsilon by Rho. J Biol Chem (2003) 1.39
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol (2006) 1.37
PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nat Struct Mol Biol (2004) 1.36
Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain. J Biol Chem (2007) 1.35
The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery. Genes Cancer (2011) 1.32
Structure of the claudin-binding domain of Clostridium perfringens enterotoxin. J Biol Chem (2007) 1.32
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol Cell Biol (2007) 1.32
The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac. J Biol Chem (2003) 1.31
Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. J Biol Chem (2004) 1.29
Type III effector activation via nucleotide binding, phosphorylation, and host target interaction. PLoS Pathog (2007) 1.29
Molecular basis for Rho GTPase signaling specificity. Breast Cancer Res Treat (2004) 1.28
Farnesyltransferase inhibitors: promises and realities. Curr Opin Pharmacol (2002) 1.24
A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. Nat Struct Biol (2002) 1.23
The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation. J Mol Biol (2007) 1.22
Crystal structures of the type III effector protein AvrPphF and its chaperone reveal residues required for plant pathogenesis. Structure (2004) 1.22
Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38. Mol Cell Biol (2002) 1.20
Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. J Biol Chem (2004) 1.20
Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proc Natl Acad Sci U S A (2013) 1.20
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J (2009) 1.19
RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. J Biol Chem (2002) 1.19
Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes. J Biol Chem (2010) 1.18
Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. J Biol Chem (2002) 1.18
Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J Biol Chem (2005) 1.18
Activation and involvement of Ral GTPases in colorectal cancer. Cancer Res (2011) 1.18
Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol (2008) 1.18
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J Biol Chem (2003) 1.16
Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. J Biol Chem (2002) 1.16
Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. J Biol Chem (2004) 1.16
Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding. J Mol Biol (2010) 1.14