Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: a novel marker of renal injury.

PubWeight™: 2.09‹?› | Rank: Top 2%

🔗 View Article (PMID 16773412)

Published in Pediatr Nephrol on June 01, 2006

Authors

Howard Trachtman1, Erica Christen, Avital Cnaan, Jilma Patrick, Volker Mai, Jaya Mishra, Aditya Jain, Nathan Bullington, Prasad Devarajan, Investigators of the HUS-SYNSORB Pk Multicenter Clinical Trial

Author Affiliations

1: Department of Pediatrics (Division of Nephrology), Schneider Children's Hospital of the North Shore-Long Island Jewish Medical Center, New Hyde Park, New York, NY, USA. trachtma@lij.edu

Articles citing this

Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol (2008) 4.56

Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care (2007) 3.19

Biomarkers of acute kidney injury. Annu Rev Pharmacol Toxicol (2008) 3.10

NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol (2007) 2.99

Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol (2009) 2.77

Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis (2012) 2.52

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36

Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med (2008) 2.32

Biomarkers for the early detection of acute kidney injury. Curr Opin Pediatr (2011) 2.01

Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury. Biomark Med (2010) 1.90

Urinary neutrophil gelatinase-associated lipocalin as a novel biomarker for disease activity in lupus nephritis. Rheumatology (Oxford) (2010) 1.88

Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. Scand J Clin Lab Invest Suppl (2008) 1.86

Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure. J Card Fail (2009) 1.75

Biomarkers for the early detection of acute kidney injury. Pediatr Nephrol (2007) 1.69

Neutrophil gelatinase-associated lipocalin is instrumental in the pathogenesis of antibody-mediated nephritis in mice. Arthritis Rheum (2012) 1.53

Biomarkers for lupus nephritis: a critical appraisal. J Biomed Biotechnol (2010) 1.42

Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol (2009) 1.36

Neutrophil gelatinase-associated lipocalin--an emerging troponin for kidney injury. Nephrol Dial Transplant (2008) 1.35

Biomarkers of acute kidney injury. Adv Chronic Kidney Dis (2008) 1.32

Neutrophil gelatinase-associated lipocalin: pathophysiology and clinical applications. Acta Physiol (Oxf) (2013) 1.26

Escherichia coli Shiga Toxin Mechanisms of Action in Renal Disease. Toxins (Basel) (2010) 1.26

Biomarkers of acute kidney injury in children: discovery, evaluation, and clinical application. Pediatr Nephrol (2010) 1.25

Emerging urinary biomarkers in the diagnosis of acute kidney injury. Expert Opin Med Diagn (2008) 1.15

Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of cyclosporine nephrotoxicity? Pediatr Nephrol (2010) 1.11

Proteomics for biomarker discovery in acute kidney injury. Semin Nephrol (2007) 1.11

Reference values of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants. Pediatr Res (2009) 1.10

Urinary biomarkers to detect acute kidney injury in the pediatric emergency center. Pediatr Nephrol (2010) 1.08

Acute kidney injury biomarkers: renal angina and the need for a renal troponin I. BMC Med (2011) 1.07

Neutrophil gelatinase-associated lipocalin: new paths for an old shuttle. Cancer Ther (2007) 1.05

Progression from acute kidney injury to chronic kidney disease: a pediatric perspective. Adv Chronic Kidney Dis (2008) 1.02

Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis. J Clin Immunol (2009) 0.97

Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2. Br J Pharmacol (2012) 0.95

Predictive performance of urine neutrophil gelatinase-associated lipocalin for dialysis requirement and death following cardiac surgery in neonates and infants. Clin J Am Soc Nephrol (2013) 0.90

Urinary neutrophil gelatinase-associated lipocalin levels in comparison with glomerular filtration rate for evaluation of renal function in patients with diabetic chronic kidney disease. Diabetes Metab J (2012) 0.89

Biomarkers in systemic lupus erythematosus: challenges and prospects for the future. Ther Adv Musculoskelet Dis (2013) 0.88

Urine biomarkers in juvenile-onset SLE nephritis. Pediatr Nephrol (2012) 0.88

Retracted Investigations of renal function using the level of neutrophil gelatinase-associated lipocalin associated with single-dose of cisplatin during chemotherapy. Diagn Pathol (2015) 0.87

Serum cystatin C and tubular urinary enzymes as biomarkers of renal dysfunction in type 2 diabetes mellitus. Clin Med Insights Endocrinol Diabetes (2013) 0.87

The future of pediatric acute kidney injury management--biomarkers. Semin Nephrol (2008) 0.86

Shiga toxin pathogenesis: kidney complications and renal failure. Curr Top Microbiol Immunol (2012) 0.86

Renal neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 expression in children with acute kidney injury and Henoch-Schönlein purpura nephritis. Exp Ther Med (2014) 0.86

Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury. Exp Ther Med (2011) 0.85

Normal-range albuminuria does not exclude nephropathy in diabetic children. Pediatr Nephrol (2010) 0.83

Urinary vascular cell adhesion molecule, but not neutrophil gelatinase-associated lipocalin, is associated with lupus nephritis. J Rheumatol (2012) 0.83

Emerging biomarkers and metabolomics for assessing toxic nephropathy and acute kidney injury (AKI) in neonatology. Biomed Res Int (2014) 0.81

Sepsis and AKI in Clinical Emergency Room Patients: The Role of Urinary NGAL. Biomed Res Int (2015) 0.80

Role of circulating fibroblast growth factor-2 in lipopolysaccharide-induced acute kidney injury in mice. Pediatr Nephrol (2011) 0.80

Podocytes express IL-6 and lipocalin 2/ neutrophil gelatinase-associated lipocalin in lipopolysaccharide-induced acute glomerular injury. Nephron Exp Nephrol (2012) 0.80

Role of Shiga/Vero toxins in pathogenesis. Microbiol Spectr (2014) 0.79

Therapeutic and predictive targets of AKI. Clin Nephrol (2008) 0.79

The importance of total kidney volume in evaluating progression of polycystic kidney disease. Nat Rev Nephrol (2016) 0.78

Effects of Shiga toxin type 2 on a bioengineered three-dimensional model of human renal tissue. Infect Immun (2014) 0.78

Predictive ability of urinary biomarkers for outcome in children with acute kidney injury. Pediatr Nephrol (2016) 0.77

Towards a biomarker panel for the assessment of AKI in children receiving intensive care. Pediatr Nephrol (2015) 0.77

Interleukin-18 and NGAL in assessment of ESWL treatment safety in children with urolithiasis. Cent Eur J Immunol (2014) 0.77

Accuracy of neutrophil gelatinase-associated lipocalin for acute kidney injury diagnosis in children: systematic review and meta-analysis. Pediatr Nephrol (2017) 0.77

Serum neutrophil gelatinase-associated lipocalin levels and aortic stiffness in noncritical coronary artery disease. Cardiorenal Med (2014) 0.76

Urinary neutrophil gelatinase-associated lipocalin: potential biomarker for late-onset sepsis. Pediatr Res (2015) 0.75

Expression and Function of Interleukin-1β-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells. PLoS One (2016) 0.75

Detection of early renal injury in children with solid tumors undergoing chemotherapy by urinary neutrophil gelatinase-associated lipocalin. Mol Clin Oncol (2015) 0.75

Role of plasma neutrophil gelatinase-associated lipocalin as an emerging biomarker of acute renal failure following kidney transplantation and its correlation with plasma creatinine. J Renal Inj Prev (2016) 0.75

Articles cited by this

Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet (2005) 13.77

Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet (2005) 9.78

Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol (2003) 9.08

Acute renal failure. Lancet (2005) 5.60

Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest (2005) 5.51

Hemolytic uremic syndrome. J Am Soc Nephrol (2005) 3.19

Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression. JAMA (2003) 2.97

Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol (2004) 2.96

Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome. Pediatr Nephrol (2001) 2.18

Effect of an oral Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: a randomized controlled trial. JAMA (2003) 2.04

The pathogenesis and treatment of hemolytic uremic syndrome. J Am Soc Nephrol (1998) 1.83

Spectrum of extrarenal involvement in postdiarrheal hemolytic-uremic syndrome. J Pediatr (1994) 1.72

Cytotoxic effect of Shiga toxin-1 on human proximal tubule cells. Kidney Int (1998) 1.70

Hemolytic uremic syndrome: epidemiology, pathophysiology, and therapy. Pediatr Nephrol (2002) 1.14

Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission. Clin Exp Immunol (2003) 1.13

Induction of apoptosis in normal human renal tubular epithelial cells by Escherichia coli Shiga toxins 1 and 2. J Infect Dis (1998) 1.06

Pathogenesis, treatment, and therapeutic trials in hemolytic uremic syndrome. Curr Opin Pediatr (1999) 1.04

Up-regulation of tissue factor activity on human proximal tubular epithelial cells in response to Shiga toxin. Kidney Int (2005) 0.96

Management of patients with hemolytic uremic syndrome demonstrating severe azotemia but not anuria. Pediatr Nephrol (1996) 0.87

Detection of apoptosis in kidney biopsies of patients with D+ hemolytic uremic syndrome. Pediatr Res (2001) 0.76

Articles by these authors

Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet (2005) 13.77

Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol (2003) 9.08

Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis (2009) 6.99

Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med (2008) 5.89

Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest (2005) 5.51

Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica (2004) 5.21

Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol (2007) 4.99

The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol (2011) 4.57

Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol (2008) 4.56

Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. JAMA (2007) 4.44

Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study. Crit Care Med (2009) 4.30

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med (2010) 3.86

ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia (2006) 3.69

Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol (2011) 3.53

Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care (2007) 3.29

The Ngal reporter mouse detects the response of the kidney to injury in real time. Nat Med (2011) 3.20

Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care (2007) 3.19

Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass. J Am Coll Cardiol (2011) 3.17

Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int (2008) 3.12

Diarrheagenic Escherichia coli infection in Baltimore, Maryland, and New Haven, Connecticut. Clin Infect Dis (2006) 3.06

Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int (2011) 3.05

Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol (2010) 3.03

NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol (2007) 2.99

Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study. J Am Coll Cardiol (2012) 2.97

Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol (2004) 2.96

Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med (2009) 2.94

Intestinal microbial ecology in premature infants assessed with non-culture-based techniques. J Pediatr (2010) 2.93

Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol (2004) 2.91

Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol (2011) 2.90

Inhaled nitric oxide in preterm infants undergoing mechanical ventilation. N Engl J Med (2006) 2.88

The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury. Nephrol Dial Transplant (2009) 2.73

Differential gene expression following early renal ischemia/reperfusion. Kidney Int (2003) 2.60

Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol (2006) 2.48

Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial. Crit Care Med (2009) 2.45

Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. Blood (2005) 2.45

IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation. J Am Soc Nephrol (2009) 2.43

Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number. Cancer Res (2006) 2.42

Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: a prospective multicenter study. Crit Care Med (2011) 2.41

Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens (2006) 2.34

Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med (2008) 2.32

Sex and race differences in right ventricular structure and function: the multi-ethnic study of atherosclerosis-right ventricle study. Circulation (2011) 2.30

Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus. Arthritis Rheum (2006) 2.27

NGAL distinguishes steroid sensitivity in idiopathic nephrotic syndrome. Pediatr Nephrol (2011) 2.19

Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults. Ann Thorac Surg (2009) 2.19

Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol (2006) 2.18

New biomarkers of acute kidney injury. Crit Care Med (2008) 2.11

A comparison of alternative risk-assessment strategies for predicting significant neonatal hyperbilirubinemia in term and near-term infants. Pediatrics (2008) 2.08

Enhancing their likelihood for a positive future: the perspective of inner-city youth. Pediatrics (2002) 2.06

Effect of an oral Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: a randomized controlled trial. JAMA (2003) 2.04

Acute kidney injury in childhood: should we be worried about progression to CKD? Pediatr Nephrol (2010) 2.00

Performance-based measures of everyday function in mild cognitive impairment. Am J Psychiatry (2010) 1.96

Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clin J Am Soc Nephrol (2012) 1.90

Early postoperative serum cystatin C predicts severe acute kidney injury following pediatric cardiac surgery. Kidney Int (2011) 1.88

A large-scale benchmark study of existing algorithms for taxonomy-independent microbial community analysis. Brief Bioinform (2011) 1.87

Tolerance of the human kidney to isolated controlled ischemia. J Am Soc Nephrol (2013) 1.82

Biomarkers in acute and chronic kidney disease. Curr Opin Nephrol Hypertens (2008) 1.81

Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea. J Clin Microbiol (2013) 1.79

Elevated serum concentrations of insulin and glucose increase risk of recurrent colorectal adenomas. Gastroenterology (2007) 1.75

Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model. ISME J (2009) 1.74

Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics. Mol Genet Metab (2003) 1.72

Non-enteropathic hemolytic uremic syndrome: causes and short-term course. Am J Kidney Dis (2004) 1.71

Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia (2013) 1.69

Biomarkers for the early detection of acute kidney injury. Pediatr Nephrol (2007) 1.69

Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr (2011) 1.66

The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods. BMC Nephrol (2010) 1.63

Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome. J Am Soc Nephrol (2002) 1.63

Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit Care (2009) 1.61

Cisplatin nephrotoxicity: molecular mechanisms. Cancer Ther (2003) 1.61

Screening for risk of persistent posttraumatic stress in injured children and their parents. JAMA (2003) 1.56

Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney Int (2012) 1.55

The cooperative international neuromuscular research group Duchenne natural history study: glucocorticoid treatment preserves clinically meaningful functional milestones and reduces rate of disease progression as measured by manual muscle testing and other commonly used clinical trial outcome measures. Muscle Nerve (2013) 1.55

Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy. Neurology (2013) 1.52

Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways. J Am Soc Nephrol (2002) 1.51

Advanced computational algorithms for microbial community analysis using massive 16S rRNA sequence data. Nucleic Acids Res (2010) 1.50

Treatment of posttraumatic stress symptoms in adolescent survivors of childhood cancer and their families: a randomized clinical trial. J Fam Psychol (2004) 1.49

Induction of proapoptotic Daxx following ischemic acute kidney injury. Kidney Int (2008) 1.49

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months. Epilepsia (2012) 1.49

Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. Clin J Am Soc Nephrol (2013) 1.48

The cooperative international neuromuscular research group Duchenne natural history study--a longitudinal investigation in the era of glucocorticoid therapy: design of protocol and the methods used. Muscle Nerve (2013) 1.48

Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status. Ann Clin Biochem (2014) 1.47

Semantic distance abnormalities in mild cognitive impairment: their nature and relationship to function. Am J Psychiatry (2012) 1.43

Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis. Pediatr Nephrol (2008) 1.42

Multiple courses of antenatal corticosteroids are associated with early severe lung disease in preterm neonates. J Perinatol (2002) 1.41

Epidemiology of human parvovirus B19 in children with sickle cell disease. Blood (2003) 1.40

Relation of cardiovascular risk factors to right ventricular structure and function as determined by magnetic resonance imaging (results from the multi-ethnic study of atherosclerosis). Am J Cardiol (2010) 1.40

Tubular proteinuria in acute kidney injury: a critical evaluation of current status and future promise. Ann Clin Biochem (2010) 1.36

Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activity. Arthritis Rheum (2009) 1.36

Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol (2009) 1.36

Neutrophil gelatinase-associated lipocalin--an emerging troponin for kidney injury. Nephrol Dial Transplant (2008) 1.35

Activation of mitochondrial apoptotic pathways in human renal allografts after ischemiareperfusion injury. Transplantation (2003) 1.35

Occupational health and safety policy and psychosocial risks in Europe: the role of stakeholders' perceptions. Health Policy (2010) 1.35

Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J Am Soc Nephrol (2011) 1.35

Urinary NGAL marks cystic disease in HIV-associated nephropathy. J Am Soc Nephrol (2009) 1.34