Published in Curr Biol on June 20, 2006
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle (2009) 3.05
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell (2012) 2.11
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J Hematol Oncol (2010) 1.92
Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals. Mol Cell (2011) 1.89
Strong negative feedback from Erk to Raf confers robustness to MAPK signalling. Mol Syst Biol (2011) 1.65
Mechanisms and pathways of growth failure in primordial dwarfism. Genes Dev (2011) 1.56
Regulation of primary response genes. Mol Cell (2011) 1.56
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer (2010) 1.43
Spatiotemporal regulation of ERK2 by dual specificity phosphatases. J Biol Chem (2008) 1.37
Erk1/2 MAP kinases are required for epidermal G2/M progression. J Cell Biol (2009) 1.32
A transcriptional program mediating entry into cellular quiescence. PLoS Genet (2007) 1.23
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Sci Signal (2011) 1.20
Mitochondrial regulation of cell cycle and proliferation. Antioxid Redox Signal (2012) 1.19
Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases. J Biol Chem (2008) 1.18
ERK activity and G1 phase progression: identifying dispensable versus essential activities and primary versus secondary targets. Mol Biol Cell (2007) 1.18
Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice. PLoS One (2010) 1.17
Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Mol Cell Biol (2010) 1.07
ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes. J Cell Biol (2010) 1.05
Kinetics of gene derepression by ERK signaling. Proc Natl Acad Sci U S A (2013) 1.02
Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression. Cell Death Dis (2013) 1.01
Non-stimulated, agonist-stimulated and store-operated Ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry. PLoS One (2012) 1.00
Cell cycle: sustained ERK signalling represses the inhibitors. Curr Biol (2006) 0.95
Timing-dependent actions of NGF required for cell differentiation. PLoS One (2010) 0.94
Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis. Eur J Cell Biol (2009) 0.94
Tumor promotion by γ and suppression by β non-muscle actin isoforms. Oncotarget (2015) 0.92
Endothelial cells isolated from caveolin-2 knockout mice display higher proliferation rate and cell cycle progression relative to their wild-type counterparts. Am J Physiol Cell Physiol (2009) 0.92
Differential activation of multiple signalling pathways dictates eNOS upregulation by FGF2 but not VEGF in placental artery endothelial cells. Placenta (2008) 0.91
Prostaglandin E2 increases cardiac fibroblast proliferation and increases cyclin D expression via EP1 receptor. Prostaglandins Leukot Essent Fatty Acids (2011) 0.91
Anterior pituitary adenomas: inherited syndromes, novel genes and molecular pathways. Expert Rev Endocrinol Metab (2010) 0.90
Hippocampal Erk mechanisms linking prediction error to fear extinction: roles of shock expectancy and contextual aversive valence. Learn Mem (2009) 0.89
Zinc and the ERK kinases in the developing brain. Neurotox Res (2011) 0.87
Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases. Cell Signal (2012) 0.87
Sustained ERK activation underlies reprogramming in regeneration-competent salamander cells and distinguishes them from their mammalian counterparts. Stem Cell Reports (2014) 0.86
A signature-based method for indexing cell cycle phase distribution from microarray profiles. BMC Genomics (2009) 0.86
ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene (2012) 0.86
The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res (2010) 0.86
Extracellular matrix collagen alters cell proliferation and cell cycle progression of human uterine leiomyoma smooth muscle cells. PLoS One (2013) 0.85
The control operated by the cell cycle machinery on MEF2 stability contributes to the downregulation of CDKN1A and entry into S phase. Mol Cell Biol (2015) 0.83
β-Arrestin1 mediates the endocytosis and functions of macrophage migration inhibitory factor. PLoS One (2011) 0.83
Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. Elife (2015) 0.83
From pathway to population--a multiscale model of juxtacrine EGFR-MAPK signalling. BMC Syst Biol (2008) 0.83
Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis. J Gastroenterol (2013) 0.82
Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice. Cancer Med (2016) 0.81
MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer. J Clin Invest (2015) 0.81
p53-Dependent transcriptional responses to interleukin-3 signaling. PLoS One (2012) 0.81
A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS. Cancer Biol Ther (2013) 0.80
Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M. J Biol Chem (2012) 0.80
Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis. Clin Immunol (2012) 0.80
Shoc2-tranduced ERK1/2 motility signals - Novel insights from functional genomics. Cell Signal (2016) 0.80
Zinc deficiency and neurodevelopment: the case of neurons. Biofactors (2010) 0.80
IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif (2014) 0.79
Fibroblast growth factor 2 causes G2/M cell cycle arrest in ras-driven tumor cells through a Src-dependent pathway. PLoS One (2013) 0.79
Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation? Int J Mol Sci (2015) 0.78
Stimulation of periodontal ligament stem cells by dentin matrix protein 1 activates mitogen-activated protein kinase and osteoblast differentiation. J Periodontol (2012) 0.76
Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation. J Biol Chem (2016) 0.76
Cell proliferation by silk gut incorporating FGF-2 protein microcrystals. Sci Rep (2015) 0.76
KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet (2015) 0.76
The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair. Cell Signal (2015) 0.75
MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway. Int J Clin Exp Pathol (2015) 0.75
Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells. Oncotarget (2015) 0.75
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo. Sci Rep (2017) 0.75
An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation. Sci Rep (2016) 0.75
Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth. PLoS One (2017) 0.75
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63
Ripples from neighbouring transcription. Nat Cell Biol (2008) 3.87
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene (2003) 3.53
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat Cell Biol (2002) 3.35
Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. J Biol Chem (2003) 3.30
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep (2001) 3.08
RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell (2009) 2.93
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev (2005) 2.81
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem (2006) 2.73
Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner. EMBO J (2007) 2.73
PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells. Dev Cell (2007) 2.45
The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity. J Cell Sci (2005) 2.40
Molecular recognitions in the MAP kinase cascades. Cell Signal (2003) 2.36
Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet (2012) 2.33
MAPK signalling: ERK5 versus ERK1/2. EMBO Rep (2006) 2.19
Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep (2002) 2.15
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature (2008) 2.14
Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells. Mol Cell Biol (2002) 2.13
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell (2008) 2.13
Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell (2004) 2.04
ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing. Curr Biol (2004) 2.00
A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling. EMBO J (2012) 1.81
XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation. Dev Cell (2006) 1.79
Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res (2006) 1.78
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J (2004) 1.76
Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport. Nat Struct Mol Biol (2009) 1.64
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol (2006) 1.57
Regulation of MAP kinases by MAP kinase phosphatases. Biochim Biophys Acta (2006) 1.54
CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol Cell Biol (2004) 1.44
Noninvasive method for assessing the human circadian clock using hair follicle cells. Proc Natl Acad Sci U S A (2010) 1.43
Docking interactions in the mitogen-activated protein kinase cascades. Pharmacol Ther (2002) 1.43
Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J Biol Chem (2002) 1.42
Temperature compensation and temperature resetting of circadian rhythms in mammalian cultured fibroblasts. Genes Cells (2003) 1.42
Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis. Arthritis Rheum (2005) 1.41
ERK MAP kinase in G cell cycle progression and cancer. Cancer Sci (2006) 1.41
Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells. J Leukoc Biol (2003) 1.40
FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr Biol (2008) 1.40
Regulatory mechanisms and function of ERK MAP kinases. J Biochem (2004) 1.34
Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1. J Biol Chem (2007) 1.33
Cutting edge: SR-PSOX/CXC chemokine ligand 16 mediates bacterial phagocytosis by APCs through its chemokine domain. J Immunol (2003) 1.30
The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT. J Immunol (2006) 1.25
Dual role of Cdc42 in spindle orientation control of adherent cells. Mol Cell Biol (2009) 1.24
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Hum Mol Genet (2002) 1.24
Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms. Sci Signal (2009) 1.21
Translocation of analogues of the antimicrobial peptides magainin and buforin across human cell membranes. J Biol Chem (2002) 1.20
ABL1 regulates spindle orientation in adherent cells and mammalian skin. Nat Commun (2012) 1.20
Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms. Mol Cell Biol (2006) 1.18
Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. J Biol Chem (2004) 1.18
Requirement for ERK MAP kinase in mouse preimplantation development. Development (2007) 1.17
Control of MAP kinase signaling to the nucleus. Chromosoma (2005) 1.16
The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Curr Biol (2002) 1.15
Regulatory mechanisms and functions of MAP kinase signaling pathways. IUBMB Life (2006) 1.15
Notch signaling suppresses p38 MAPK activity via induction of MKP-1 in myogenesis. J Biol Chem (2006) 1.15
Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma. Int J Cancer (2003) 1.15
ERK5 regulates muscle cell fusion through Klf transcription factors. Dev Cell (2011) 1.15
The polarity-inducing kinase Par-1 controls Xenopus gastrulation in cooperation with 14-3-3 and aPKC. EMBO J (2004) 1.14
Modular structure of a docking surface on MAPK phosphatases. J Biol Chem (2002) 1.14
Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. Mol Cell Biol (2009) 1.13
Critical role of p38 and GATA3 in natural helper cell function. J Immunol (2013) 1.11
Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Mol Cell Biol (2005) 1.10
The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression. Mol Biol Cell (2010) 1.10
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J Biol Chem (2010) 1.09
Revolving movement of a dynamic cluster of actin filaments during mitosis. J Cell Biol (2010) 1.08
Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Curr Biol (2003) 1.07
Regulation of c-Fos and Fra-1 by the MEK5-ERK5 pathway. Genes Cells (2003) 1.06
Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells. J Immunol (2007) 1.05
Distribution and kinetics of SR-PSOX/CXCL16 and CXCR6 expression on human dendritic cell subsets and CD4+ T cells. J Leukoc Biol (2005) 1.05
Identification of the Anti-proliferative protein Tob as a MAPK substrate. J Biol Chem (2002) 1.04
Scavenger receptors for oxidized lipoprotein in age-related macular degeneration. Invest Ophthalmol Vis Sci (2007) 1.04
Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB. Genes Cells (2006) 1.04
Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development (2005) 1.04
Nuclear translocation of plk1 mediated by its bipartite nuclear localization signal. J Biol Chem (2002) 1.01
CXCL16 is a novel angiogenic factor for human umbilical vein endothelial cells. Biochem Biophys Res Commun (2005) 1.00
Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling. Genes Cells (2008) 1.00
Spindle orientation in animal cell mitosis: roles of integrin in the control of spindle axis. J Cell Physiol (2007) 0.99
Upregulation of SR-PSOX/CXCL16 and recruitment of CD8+ T cells in cardiac valves during inflammatory valvular heart disease. Arterioscler Thromb Vasc Biol (2003) 0.99
Activation of a C-terminal transcriptional activation domain of ERK5 by autophosphorylation. J Biol Chem (2007) 0.98
Regulation of pluripotency in male germline stem cells by Dmrt1. Genes Dev (2013) 0.97
Optically tunable amino-functionalized graphene quantum dots. Adv Mater (2012) 0.97
Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT. EMBO J (2004) 0.97
FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. Oncogene (2003) 0.97
Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit. J Cell Biol (2008) 0.97
Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis. FEBS J (2007) 0.95
Cutting edge: critical role of CXCL16/CXCR6 in NKT cell trafficking in allograft tolerance. J Immunol (2005) 0.94
Elk-1, CREB, and MKP-1 regulate Egr-1 expression in gonadotropin-releasing hormone stimulated gonadotrophs. J Cell Biochem (2008) 0.94
A fasting-responsive signaling pathway that extends life span in C. elegans. Cell Rep (2013) 0.92
Global splicing pattern reversion during somatic cell reprogramming. Cell Rep (2013) 0.92
Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases. J Biol Chem (2005) 0.91
SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation. Gut (2011) 0.91
Contributions of mitogen-activated protein kinase and nuclear factor kappa B to N-(4-hydroxyphenyl)retinamide-induced apoptosis in prostate cancer cells. Mol Carcinog (2002) 0.90