Published in Proc Natl Acad Sci U S A on August 23, 2010
Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci U S A (2013) 1.94
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proc Natl Acad Sci U S A (2013) 1.63
Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station. PLoS One (2016) 1.40
Human blood metabolite timetable indicates internal body time. Proc Natl Acad Sci U S A (2012) 1.37
Control of skin cancer by the circadian rhythm. Proc Natl Acad Sci U S A (2011) 1.34
Chronopharmacology: new insights and therapeutic implications. Annu Rev Pharmacol Toxicol (2013) 1.02
Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin. FASEB J (2012) 0.97
Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology. Front Neurol (2015) 0.88
Early nocturnal meal skipping alters the peripheral clock and increases lipogenesis in mice. Nutr Metab (Lond) (2012) 0.86
The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity. J Biol Rhythms (2015) 0.85
Possible contribution of chronobiology to cardiovascular health. Front Physiol (2014) 0.85
Biologic rhythms derived from Siberian mammoths' hairs. PLoS One (2011) 0.84
Chronobiology of Melatonin beyond the Feedback to the Suprachiasmatic Nucleus-Consequences to Melatonin Dysfunction. Int J Mol Sci (2013) 0.83
A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock. J Invest Dermatol (2013) 0.83
Exploiting human and mouse transcriptomic data: Identification of circadian genes and pathways influencing health. Bioessays (2015) 0.83
Advanced Circadian Phase in Mania and Delayed Circadian Phase in Mixed Mania and Depression Returned to Normal after Treatment of Bipolar Disorder. EBioMedicine (2016) 0.82
An out-of-lab trial: a case example for the effect of intensive exercise on rhythms of human clock gene expression. J Circadian Rhythms (2013) 0.81
Circadian rhythms of liver physiology and disease: experimental and clinical evidence. Nat Rev Gastroenterol Hepatol (2016) 0.78
Investigation of a non-invasive method of assessing the equine circadian clock using hair follicle cells. J Circadian Rhythms (2012) 0.78
Diurnal rhythmicity in biological processes involved in bioavailability of functional food factors. J Clin Biochem Nutr (2013) 0.78
24-hour rhythm of aquaporin-3 function in the epidermis is regulated by molecular clocks. J Invest Dermatol (2014) 0.77
Comparative Analysis of Vertebrate Diurnal/Circadian Transcriptomes. PLoS One (2017) 0.77
Estimation methods for human circadian phase by use of peripheral tissues. Hypertens Res (2016) 0.77
Altered dynamics in the circadian oscillation of clock genes in dermal fibroblasts of patients suffering from idiopathic hypersomnia. PLoS One (2014) 0.77
Does evening sun increase the risk of skin cancer? Proc Natl Acad Sci U S A (2011) 0.77
Differential Phasing between Circadian Clocks in the Brain and Peripheral Organs in Humans. J Biol Rhythms (2016) 0.77
Molecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity. Sci Rep (2016) 0.77
Peripheral Skin Temperature and Circadian Biological Clock in Shift Nurses after a Day off. Int J Mol Sci (2016) 0.77
Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle. PLoS One (2015) 0.77
Diurnal Preference Predicts Phase Differences in Expression of Human Peripheral Circadian Clock Genes. J Circadian Rhythms (2015) 0.77
Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer. Int J Mol Sci (2016) 0.76
Long-lasting effect of perinatal exposure to L-tryptophan on circadian clock of primary cell lines established from male offspring born from mothers fed on dietary protein restriction. PLoS One (2013) 0.76
Machine learning identifies a compact gene set for monitoring the circadian clock in human blood. Genome Med (2017) 0.75
Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Mol Metab (2016) 0.75
Impact of the Circadian Clock on UV-Induced DNA Damage Response and Photocarcinogenesis. Photochem Photobiol (2016) 0.75
Biological Rhythms in the Skin. Int J Mol Sci (2016) 0.75
Positive association between physical activity and PER3 expression in older adults. Sci Rep (2017) 0.75
Molecular insights into chronotype and time-of-day effects on decision-making. Sci Rep (2016) 0.75
Effects of bright light exposure during daytime on peripheral clock gene expression in humans. Int J Biometeorol (2016) 0.75
A simple method using ex vivo culture of hair follicle tissue to investigate intrinsic circadian characteristics in humans. Sci Rep (2017) 0.75
Coordination of circadian timing in mammals. Nature (2002) 18.47
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
Obesity and metabolic syndrome in circadian Clock mutant mice. Science (2005) 12.66
Role of the CLOCK protein in the mammalian circadian mechanism. Science (1998) 10.03
Time zones: a comparative genetics of circadian clocks. Nat Rev Genet (2001) 8.98
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell (1999) 8.38
Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79
The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet (2008) 7.65
Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu Rev Genomics Hum Genet (2004) 7.50
A clockwork web: circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci (2003) 6.30
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (2001) 6.07
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell (2002) 6.05
The meter of metabolism. Cell (2008) 5.71
Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science (2000) 4.94
Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature (1997) 4.44
A web of circadian pacemakers. Cell (2002) 4.39
Health disorders of shift workers. Occup Med (Lond) (2003) 4.20
RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell (1997) 3.24
Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol (2000) 2.69
The period length of fibroblast circadian gene expression varies widely among human individuals. PLoS Biol (2005) 2.13
Molecular insights into human daily behavior. Proc Natl Acad Sci U S A (2008) 2.03
Circadian clock genes oscillate in human peripheral blood mononuclear cells. Blood (2003) 1.61
Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles. Proc Natl Acad Sci U S A (2004) 1.14
Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans. Eur J Neurosci (2006) 1.08
The thymus is similar to the testis in its pattern of circadian clock gene expression. J Biol Rhythms (2005) 0.95
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res (2014) 4.83
Ripples from neighbouring transcription. Nat Cell Biol (2008) 3.87
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med (2002) 3.74
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene (2003) 3.53
Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation. Circulation (2008) 3.48
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat Cell Biol (2002) 3.35
Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. J Biol Chem (2003) 3.30
Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol (2004) 3.18
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med (2002) 3.17
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep (2001) 3.08
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev (2005) 2.81
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
Effects of pitavastatin in Japanese patients with chronic heart failure: the Pitavastatin Heart Failure Study (PEARL Study). Circ J (2013) 2.75
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem (2006) 2.73
Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner. EMBO J (2007) 2.73
Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med (2008) 2.68
Physiological role of ROCKs in the cardiovascular system. Am J Physiol Cell Physiol (2006) 2.61
Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression. Curr Biol (2006) 2.59
CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest (2012) 2.55
Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids. Circ Res (2002) 2.53
PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells. Dev Cell (2007) 2.45
The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity. J Cell Sci (2005) 2.40
Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation (2002) 2.39
Endothelium-dependent effects of statins. Arterioscler Thromb Vasc Biol (2003) 2.39
Molecular recognitions in the MAP kinase cascades. Cell Signal (2003) 2.36
Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation (2003) 2.30
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Rho GTPases, statins, and nitric oxide. Circ Res (2005) 2.21
MAPK signalling: ERK5 versus ERK1/2. EMBO Rep (2006) 2.19
Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep (2002) 2.15
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature (2008) 2.14
Pleiotropic effects of statins. - Basic research and clinical perspectives -. Circ J (2010) 2.13
Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells. Mol Cell Biol (2002) 2.13
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke (2005) 2.13
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice. Circulation (2005) 2.09
Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell (2004) 2.04
Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. Circ Res (2008) 2.04
Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A (2002) 2.04
Requirement of Rac1 in the development of cardiac hypertrophy. Proc Natl Acad Sci U S A (2006) 2.02
ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing. Curr Biol (2004) 2.00
Transcriptional oscillation of canonical clock genes in mouse peripheral tissues. BMC Mol Biol (2004) 1.94
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. J Clin Invest (2008) 1.92
Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. Arch Biochem Biophys (2005) 1.91
Vascular inflammation and repair: implications for re-endothelialization, restenosis, and stent thrombosis. JACC Cardiovasc Interv (2011) 1.85
HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration. Nature (2013) 1.84
Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res (2006) 1.84
A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling. EMBO J (2012) 1.81
Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci U S A (2006) 1.79
XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation. Dev Cell (2006) 1.79
Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid-responsive element. J Biol Chem (2005) 1.77
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J (2004) 1.76
NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy. J Mol Cell Cardiol (2003) 1.75
Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis. Mol Cell Biol (2003) 1.75
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Circulation (2004) 1.73
Local release of C-reactive protein from vulnerable plaque or coronary arterial wall injured by stenting. J Am Coll Cardiol (2005) 1.68
RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. FASEB J (2010) 1.67
Long-term statin use and psychological well-being. J Am Coll Cardiol (2003) 1.66
Mobilization of CD34-positive bone marrow-derived cells after coronary stent implantation: impact on restenosis. Circulation (2007) 1.64
Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport. Nat Struct Mol Biol (2009) 1.64
FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1. Circ Res (2006) 1.63
Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol (2010) 1.62
Optical and electrical properties of three-dimensional interlinked gold nanoparticle assemblies. J Am Chem Soc (2004) 1.61
Targeting eNOS for stroke protection. Trends Neurosci (2004) 1.60
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep (2012) 1.60
Preservation of NO production by statins in the treatment of heart failure. Cardiovasc Res (2003) 1.59
Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58
Cilostazol inhibits leukocyte integrin Mac-1, leading to a potential reduction in restenosis after coronary stent implantation. J Am Coll Cardiol (2004) 1.55
Regulation of MAP kinases by MAP kinase phosphatases. Biochim Biophys Acta (2006) 1.54
Vascular failure: A new clinical entity for vascular disease. J Hypertens (2006) 1.52
Comparison of renal and vascular protective effects between telmisartan and amlodipine in hypertensive patients with chronic kidney disease with mild renal insufficiency. Hypertens Res (2008) 1.51
Irbesartan, an angiotensin receptor blocker, exhibits metabolic, anti-inflammatory and antioxidative effects in patients with high-risk hypertension. Hypertens Res (2013) 1.51
Increased Rho kinase activity in a Taiwanese population with metabolic syndrome. J Am Coll Cardiol (2007) 1.46
Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. Circulation (2005) 1.45
CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol Cell Biol (2004) 1.44
Docking interactions in the mitogen-activated protein kinase cascades. Pharmacol Ther (2002) 1.43
Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal (2009) 1.43
Postprandial hyperglycemia is a possible contributor to paroxysmal atrial fibrillation: a case report. J Cardiol (2006) 1.42
Temperature compensation and temperature resetting of circadian rhythms in mammalian cultured fibroblasts. Genes Cells (2003) 1.42
Molecular basis of restenosis and novel issues of drug-eluting stents. Circ J (2009) 1.42
Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice. FASEB J (2008) 1.41
Cloning of CYP2J2 gene and identification of functional polymorphisms. Mol Pharmacol (2002) 1.41
ERK MAP kinase in G cell cycle progression and cancer. Cancer Sci (2006) 1.41
Low-density lipoprotein subfractions and the prevalence of silent lacunar infarction in subjects with essential hypertension. Hypertens Res (2006) 1.41
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest (2010) 1.40
FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr Biol (2008) 1.40
Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest (2002) 1.40
Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation (2007) 1.39
Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study. J Hypertens (2015) 1.39
11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression. Bioorg Med Chem Lett (2003) 1.38
Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2. Circulation (2008) 1.36
Percutaneous CT-guided puncture and steroid injection for the treatment of lumbar discal cyst: a case report. Spine (Phila Pa 1976) (2003) 1.35
Endothelial dysfunction as a cellular mechanism for vascular failure. Am J Physiol Heart Circ Physiol (2011) 1.35