Published in Biochem Biophys Res Commun on June 08, 2006
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol (2010) 3.61
Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res (2007) 2.51
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. Dev Cell (2012) 1.53
The Notch effector Hey1 associates with myogenic target genes to repress myogenesis. J Biol Chem (2009) 1.11
Regulation of ocular angiogenesis by Notch signaling: implications in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci (2011) 1.00
BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II. Angiogenesis (2012) 0.95
USP11 regulates PML stability to control Notch-induced malignancy in brain tumours. Nat Commun (2014) 0.88
Regulation of blood vessel sprouting. Semin Cell Dev Biol (2011) 0.87
How blood vessel networks are made and measured. Cells Tissues Organs (2011) 0.84
Gamma-secretase inhibitor DAPT suppresses glioblastoma growth via uncoupling of tumor vessel density from vessel function. Clin Exp Med (2012) 0.79
Notch: A multi-functional integrating system of microenvironmental signals. Dev Biol (2016) 0.78
Endothelial sirtuin 1 inactivation enhances capillary rarefaction and fibrosis following kidney injury through Notch activation. Biochem Biophys Res Commun (2016) 0.77
The proangiogenic effect of iroquois homeobox transcription factor Irx3 in human microvascular endothelial cells. J Biol Chem (2014) 0.76
Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence. FASEB J (2017) 0.75
Of mice and not men: differences between mouse and human immunology. J Immunol (2004) 10.61
Hippo signaling: growth control and beyond. Development (2011) 5.25
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science (2011) 4.76
Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circ Res (2011) 2.99
Functional genetic analysis of mouse chromosome 11. Nature (2003) 2.87
Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. J Neurosci (2008) 2.81
Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity (2007) 2.71
Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc Res (2003) 2.61
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest (2003) 2.48
Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res (2008) 2.45
The effect of matrix density on the regulation of 3-D capillary morphogenesis. Biophys J (2007) 2.37
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Diffusion limits of an in vitro thick prevascularized tissue. Tissue Eng (2005) 2.15
Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue Eng Part A (2009) 2.14
Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc Res (2002) 2.10
Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell (2012) 2.06
Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A (2002) 2.04
Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A (2009) 2.00
Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation. Tissue Eng (2006) 1.98
Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci (2006) 1.92
Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB J (2005) 1.92
B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J Immunol (2002) 1.90
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A (2010) 1.84
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood (2008) 1.83
Hippo signaling impedes adult heart regeneration. Development (2013) 1.81
Rapid anastomosis of endothelial progenitor cell-derived vessels with host vasculature is promoted by a high density of cotransplanted fibroblasts. Tissue Eng Part A (2010) 1.79
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res (2008) 1.77
An optimized three-dimensional in vitro model for the analysis of angiogenesis. Methods Enzymol (2008) 1.73
The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation. Mol Biol Cell (2011) 1.70
Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci (2003) 1.70
Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell (2009) 1.67
Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem (2002) 1.60
Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58
Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. Arterioscler Thromb Vasc Biol (2004) 1.58
Genetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome population. Circ Cardiovasc Genet (2012) 1.57
In vitro perfused human capillary networks. Tissue Eng Part C Methods (2013) 1.57
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol (2005) 1.42
Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea. Dev Biol (2008) 1.35
The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes. J Clin Invest (2002) 1.32
Optimized fibrin gel bead assay for the study of angiogenesis. J Vis Exp (2007) 1.32
The spectrum of cardiovascular anomalies in CHF1/Hey2 deficient mice reveals roles in endocardial cushion, myocardial and vascular maturation. J Mol Cell Cardiol (2005) 1.29
Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling. Mech Dev (2004) 1.27
Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. J Neurosci (2007) 1.26
CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression. Circ Res (2007) 1.24
Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway. J Immunol (2002) 1.22
Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol (2012) 1.21
Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress. Cardiovasc Res (2011) 1.21
Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development (2006) 1.20
Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation (2004) 1.19
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development (2006) 1.19
Full range physiological mass transport control in 3D tissue cultures. Lab Chip (2012) 1.18
CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways. Biochem Biophys Res Commun (2007) 1.17
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers. Development (2011) 1.16
A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. Circ Res (2006) 1.16
Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res (2004) 1.16
Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc Res (2002) 1.14
Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia. Nat Commun (2012) 1.13
Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Development (2004) 1.12
Macrophages and angiogenesis: a role for Wnt signaling. Vasc Cell (2012) 1.12
TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. Gene (2009) 1.11
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma. Mol Cell Biol (2006) 1.11
Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am J Physiol Heart Circ Physiol (2006) 1.10
Interactions between dorsal-ventral patterning genes lmx1b, engrailed-1 and wnt-7a in the vertebrate limb. Int J Dev Biol (2002) 1.09
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors. J Neurosci (2011) 1.08
Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning. Dev Biol (2006) 1.07
Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development. BMC Dev Biol (2008) 1.07
VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model. Lab Invest (2003) 1.05
Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2. Arterioscler Thromb Vasc Biol (2013) 1.04
A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays. Lab Chip (2013) 1.04
Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo. Mol Cell Biol (2014) 1.02
A three-dimensional in vitro model of tumor cell intravasation. Integr Biol (Camb) (2014) 1.01
Isolation of human umbilical vein endothelial cells (HUVEC). J Vis Exp (2007) 0.98
Manifold functions of the Nail-Patella Syndrome gene Lmx1b in vertebrate development. Dev Growth Differ (2009) 0.96
Transforming growth factor-β signaling in myogenic cells regulates vascular morphogenesis, differentiation, and matrix synthesis. Arterioscler Thromb Vasc Biol (2011) 0.96
Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PLoS One (2009) 0.95
Longitudinal in vivo imaging to assess blood flow and oxygenation in implantable engineered tissues. Tissue Eng Part C Methods (2012) 0.95
BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II. Angiogenesis (2012) 0.95
Is it possible to transform cardiac scar tissue into beating heart muscle in humans? Regen Med (2012) 0.94
PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth. J Bone Miner Res (2013) 0.94
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol (2013) 0.93
Hesr, a mediator of the Notch signaling, functions in heart and vessel development. Trends Cardiovasc Med (2005) 0.93
Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA. Int Immunol (2005) 0.93
Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis. Arterioscler Thromb Vasc Biol (2013) 0.91
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Development (2011) 0.91
The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload. Am J Physiol Heart Circ Physiol (2010) 0.91
Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev (2013) 0.90
Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning. Development (2010) 0.90
Lmx1b-expressing cells in the mouse limb bud define a dorsal mesenchymal lineage compartment. Genesis (2009) 0.90
Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance. Cell Rep (2013) 0.89
CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6. Biochem Biophys Res Commun (2005) 0.88
CHF1/Hey2 promotes physiological hypertrophy in response to pressure overload through selective repression and activation of specific transcriptional pathways. OMICS (2009) 0.88
Angiogenic sprouting is regulated by endothelial cell expression of Slug. J Cell Sci (2014) 0.88
Transcription factor CHF1/Hey2 regulates the global transcriptional response to platelet-derived growth factor in vascular smooth muscle cells. Physiol Genomics (2007) 0.88
Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice. Hepatology (2011) 0.88
Transcription factor CHF1/Hey2 regulates coronary vascular maturation. Mech Dev (2010) 0.87
Inhalation of diesel exhaust does not exacerbate cardiac hypertrophy or heart failure in two mouse models of cardiac hypertrophy. Part Fibre Toxicol (2013) 0.86
Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT. J Interferon Cytokine Res (2005) 0.86