Published in Development on December 01, 2013
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 3.03
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell (2015) 2.31
ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nat Cell Biol (2015) 1.62
Multi-investigator letter on reproducibility of neonatal heart regeneration following apical resection. Stem Cell Reports (2014) 1.49
Hippo pathway deficiency reverses systolic heart failure after infarction. Nature (2017) 1.39
Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. Elife (2015) 1.34
Disease implications of the Hippo/YAP pathway. Trends Mol Med (2015) 1.32
Noncontact quantitative biomechanical characterization of cardiac muscle using shear wave imaging optical coherence tomography. Biomed Opt Express (2014) 1.25
Response to Sadek et al. and Kotlikoff et al. Stem Cell Reports (2014) 1.25
Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res (2014) 1.23
The extracellular matrix protein Agrin promotes heart regeneration in mice. Nature (2017) 1.09
Building and re-building the heart by cardiomyocyte proliferation. Development (2016) 1.09
Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity. Circ Res (2014) 1.08
Strategies for cardiac regeneration and repair. Sci Transl Med (2014) 1.08
Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. Dev Cell (2015) 1.04
Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res (2014) 1.01
A neonatal blueprint for cardiac regeneration. Stem Cell Res (2014) 1.01
Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation. Stem Cell Res (2014) 0.98
Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice. Sci Signal (2015) 0.95
Programming and reprogramming a human heart cell. EMBO J (2015) 0.92
Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature (2016) 0.92
The hippo pathway in heart development, regeneration, and diseases. Circ Res (2015) 0.91
Mechanisms of Cardiac Regeneration. Dev Cell (2016) 0.90
A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis. Cell Res (2015) 0.89
Macro advances in microRNAs and myocardial regeneration. Curr Opin Cardiol (2014) 0.88
The Hippo pathway in disease and therapy: cancer and beyond. Clin Transl Med (2014) 0.87
Overexpression of Tbx20 in Adult Cardiomyocytes Promotes Proliferation and Improves Cardiac Function After Myocardial Infarction. Circulation (2016) 0.86
Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. Stem Cell Res (2014) 0.83
Neonatal heart regeneration: mounting support and need for technical standards. J Am Heart Assoc (2015) 0.82
Acute inflammation stimulates a regenerative response in the neonatal mouse heart. Cell Res (2015) 0.82
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell (2016) 0.80
Cardiac Regeneration and Stem Cells. Physiol Rev (2015) 0.80
Hippo in the path to heart repair. Circ Res (2014) 0.78
The Hippo signal transduction network for exercise physiologists. J Appl Physiol (1985) (2016) 0.77
Multiobjective triclustering of time-series transcriptome data reveals key genes of biological processes. BMC Bioinformatics (2015) 0.77
Translational aspects of cardiac cell therapy. J Cell Mol Med (2015) 0.77
The hippo signaling pathway: implications for heart regeneration and disease. Clin Transl Med (2014) 0.76
Inferring dynamic gene regulatory networks in cardiac differentiation through the integration of multi-dimensional data. BMC Bioinformatics (2015) 0.76
Interplay between cardiac function and heart development. Biochim Biophys Acta (2016) 0.76
Cardiomyocyte Proliferation: Teaching an Old Dogma New Tricks. Circ Res (2017) 0.75
Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction. J Clin Invest (2017) 0.75
RNA mimics as therapeutics for cardiac regeneration: a paradigm shift. Mol Ther (2015) 0.75
Redirecting cardiac growth mechanisms for therapeutic regeneration. J Clin Invest (2017) 0.75
Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS One (2015) 0.75
Targeting NF2-Hippo/Yap signaling pathway for cardioprotection after ischemia/reperfusion injury. Ann Transl Med (2016) 0.75
Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy. Genes (Basel) (2016) 0.75
A growing role for the Hippo signaling pathway in the heart. J Mol Med (Berl) (2017) 0.75
Expression Analysis of the Hippo Cascade Indicates a Role in Pituitary Stem Cell Development. Front Physiol (2016) 0.75
A hippo "AKT" regulates cardiomyocyte proliferation. Circ Res (2015) 0.75
The Hippo pathway in tissue homeostasis and regeneration. Protein Cell (2017) 0.75
Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality. PLoS One (2016) 0.75
Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun (2017) 0.75
Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight (2017) 0.75
Direct Stimulation of Cardiogenesis: A New Paradigm for Treating Heart Disease. Circ Res (2017) 0.75
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway. Cell Death Differ (2017) 0.75
Hippo Pathway: An Emerging Regulator of Craniofacial and Dental Development. J Dent Res (2017) 0.75
A global double-fluorescent Cre reporter mouse. Genesis (2007) 17.86
Evidence for cardiomyocyte renewal in humans. Science (2009) 14.17
Transient regenerative potential of the neonatal mouse heart. Science (2011) 9.02
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res (2001) 6.15
Mammalian heart renewal by pre-existing cardiomyocytes. Nature (2012) 5.56
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science (2011) 4.76
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol (2011) 4.64
Functional screening identifies miRNAs inducing cardiac regeneration. Nature (2012) 4.39
MicroRNA-34a regulates cardiac ageing and function. Nature (2013) 4.03
MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. Circ Res (2012) 3.53
Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation (2012) 2.83
Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) 2.76
Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc Natl Acad Sci U S A (2012) 2.66
Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature (2013) 2.53
Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal (2011) 2.38
Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci U S A (2013) 2.16
Retracted Cardiomyogenesis in the aging and failing human heart. Circulation (2012) 2.16
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A (2012) 2.13
Anillin localization defect in cardiomyocyte binucleation. J Mol Cell Cardiol (2006) 1.78
Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol (2012) 1.70
Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res (2007) 1.66
Lats2 is a negative regulator of myocyte size in the heart. Circ Res (2008) 1.53
Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem (2012) 1.18
MIQuant--semi-automation of infarct size assessment in models of cardiac ischemic injury. PLoS One (2011) 0.88
Direct reprogramming for cardiac regeneration: from dream to reality. Circ Res (2012) 0.83
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med (2008) 43.36
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet (2009) 10.52
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation (2003) 8.61
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev (2002) 8.19
Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis (2002) 6.11
Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation (2003) 5.34
Hippo signaling: growth control and beyond. Development (2011) 5.25
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science (2011) 4.76
A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med (2009) 4.46
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A (2005) 4.25
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation (2003) 3.94
Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation (2005) 3.83
Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol (2007) 3.48
The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis. Circulation (2003) 3.45
Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest (2006) 3.22
Computer-assisted personalized sedation for upper endoscopy and colonoscopy: a comparative, multicenter randomized study. Gastrointest Endosc (2010) 2.96
Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development (2005) 2.92
Functional genetic analysis of mouse chromosome 11. Nature (2003) 2.87
Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. J Neurosci (2008) 2.81
A cluster of cholinergic premotor interneurons modulates mouse locomotor activity. Neuron (2009) 2.75
Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol (2004) 2.74
The role of periadventitial fat in atherosclerosis. Arch Pathol Lab Med (2007) 2.59
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. FEBS Lett (2003) 2.52
Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease. Am J Hum Genet (2009) 2.50
Distinct functions for Bmp signaling in lip and palate fusion in mice. Development (2005) 2.46
A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol (2005) 2.42
Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation (2003) 2.28
Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy. Circ Res (2012) 2.25
Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation (2003) 2.11
Bmp2 is critical for the murine uterine decidual response. Mol Cell Biol (2007) 2.09
Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip. Am J Hum Genet (2009) 2.07
Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell (2012) 2.06
Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation (2004) 2.05
Comparison of intracoronary and transendocardial delivery of allogeneic mesenchymal cells in a canine model of acute myocardial infarction. J Mol Cell Cardiol (2007) 2.04
Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A (2009) 2.00
Regulatory divergence modifies limb length between mammals. Genes Dev (2008) 1.96
C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol (2006) 1.96
Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A (2004) 1.93
Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci (2006) 1.92
Vulnerable atherosclerotic plaque: a multifocal disease. Circulation (2003) 1.84
Development of a network to test strategies in cardiovascular cell delivery: the NHLBI-sponsored Cardiovascular Cell Therapy Research Network (CCTRN). J Cardiovasc Transl Res (2010) 1.84
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A (2010) 1.84
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. Circ Cardiovasc Genet (2010) 1.83
Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities study. Circ Cardiovasc Genet (2009) 1.80
Coming of age of C-reactive protein: using inflammation markers in cardiology. Circulation (2003) 1.74
Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol (2007) 1.72
The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion. Proc Natl Acad Sci U S A (2008) 1.72
Five common gene variants identify elevated genetic risk for coronary heart disease. Genet Med (2007) 1.72
Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. Proc Natl Acad Sci U S A (2012) 1.72
Paired-related homeobox gene Prx1 is required for pulmonary vascular development. Circ Res (2004) 1.71
Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci (2003) 1.70
Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. J Am Coll Cardiol (2005) 1.67
Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell (2009) 1.67
Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease. Circulation (2003) 1.63
Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development (2002) 1.60
The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery. Dev Cell (2008) 1.60
A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science (2009) 1.58
Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development (2005) 1.57
Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development. Circ Res (2011) 1.57
Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation (2004) 1.55
Characterization of progenitor domains in the developing mouse thalamus. J Comp Neurol (2007) 1.55
E2F-1 regulates nuclear factor-kappaB activity and cell adhesion: potential antiinflammatory activity of the transcription factor E2F-1. Circulation (2002) 1.54
Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A (2008) 1.53
Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development (2003) 1.52
FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circ Res (2011) 1.52
Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. Circ Cardiovasc Genet (2010) 1.52
LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction. Tex Heart Inst J (2010) 1.52
Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy. Circ Res (2007) 1.51
Outcomes in patients with diabetes mellitus undergoing percutaneous coronary intervention in the current era: a report from the Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial. Circulation (2004) 1.51
Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol (2005) 1.50
Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell (2010) 1.49
Preoperative statin therapy decreases risk of postoperative renal insufficiency. Cardiovasc Ther (2010) 1.47
Nuclear plakoglobin is essential for differentiation of cardiac progenitor cells to adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res (2011) 1.47
Atorvastatin and cardiac hypertrophy and function in hypertrophic cardiomyopathy: a pilot study. Eur J Clin Invest (2010) 1.47
ACCF/AHA consensus conference report on professionalism and ethics. Circulation (2004) 1.47
Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34-positive cells into cardiomyocytes in vivo. Circulation (2004) 1.46
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol (2009) 1.46
Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER). Circ Cardiovasc Qual Outcomes (2009) 1.46
Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A (2007) 1.46
BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev Dyn (2008) 1.44
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol (2005) 1.42
Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development. Dev Biol (2004) 1.41
Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene. Mamm Genome (2004) 1.39
Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A (2008) 1.39
The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development. Mol Cell Biol (2004) 1.39
Adult stem cell therapy in perspective. Circulation (2003) 1.38
Preserved homograft function 32 years after surgery in a young patient. J Thorac Cardiovasc Surg (2010) 1.38
System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in mice. Dev Dyn (2008) 1.37
A randomized study of transendocardial injection of autologous bone marrow mononuclear cells and cell function analysis in ischemic heart failure (FOCUS-HF). Am Heart J (2011) 1.35
Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res (2005) 1.34
The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes. J Clin Invest (2002) 1.32