Published in DNA Repair (Amst) on June 19, 2006
Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell (2008) 3.31
Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination. PLoS One (2013) 1.46
APOBEC3B and AID have similar nuclear import mechanisms. J Mol Biol (2012) 1.22
How does DNA break during chromosomal translocations? Nucleic Acids Res (2011) 1.14
Mechanisms of leukemia translocations. Curr Opin Hematol (2008) 1.06
AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID. Mol Immunol (2008) 0.96
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Nat Methods (2016) 0.93
Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions. Mol Immunol (2010) 0.89
G-quadruplex recognition activities of E. Coli MutS. BMC Mol Biol (2012) 0.83
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination. Nat Commun (2017) 0.77
Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region. Eur J Immunol (2011) 0.77
Clonal expansion in B-CLL: fungal drivers or self-service? J Exp Med (2013) 0.76
Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32
The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell (2010) 3.88
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58
Targeting of somatic hypermutation. Nat Rev Immunol (2006) 2.42
Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc. Nat Immunol (2004) 2.00
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
Balancing AID and DNA repair during somatic hypermutation. Trends Immunol (2009) 1.86
Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell (2002) 1.73
Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments. Genes Dev (2003) 1.69
Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein. Mol Cancer Ther (2005) 1.59
Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination. Int Immunol (2004) 1.41
Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc Natl Acad Sci U S A (2005) 1.40
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol (2009) 1.40
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat Immunol (2010) 1.35
Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination. Genes Dev (2002) 1.35
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J Exp Med (2002) 1.34
B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5. Nat Immunol (2004) 1.34
Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination. J Exp Med (2010) 1.23
Ebf1-dependent control of the osteoblast and adipocyte lineages. Bone (2008) 1.23
A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol (2003) 1.21
Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood (2009) 1.19
Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2. EMBO J (2003) 1.19
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Mol Cell (2010) 1.18
Up-regulation of Hlx in immature Th cells induces IFN-gamma expression. J Immunol (2004) 1.18
Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J Exp Med (2006) 1.14
Mobilization of RAG-generated signal ends by transposition and insertion in vivo. Mol Cell Biol (2006) 1.12
Histone modifications associated with somatic hypermutation. Immunity (2005) 1.10
Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol (2007) 1.10
Strand-biased spreading of mutations during somatic hypermutation. Science (2007) 1.09
DNA mismatches and GC-rich motifs target transposition by the RAG1/RAG2 transposase. Nucleic Acids Res (2003) 1.05
Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells. Immunity (2003) 1.05
B cells and osteoblast and osteoclast development. Immunol Rev (2005) 1.02
Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitors. J Immunol (2004) 1.02
Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation. J Immunol (2006) 1.00
Targeting of AID-mediated sequence diversification by cis-acting determinants. Adv Immunol (2007) 0.98
RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy. J Biol Chem (2002) 0.96
Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions. Nat Immunol (2012) 0.95
The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements. J Exp Med (2013) 0.93
Immunology. One AID to unite them all. Science (2002) 0.93
Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way. Cancer Cell (2009) 0.92
Non-redundancy of cytidine deaminases in class switch recombination. Eur J Immunol (2004) 0.92
The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination. Mol Cell Biol (2007) 0.90
Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers. Cell Rep (2013) 0.90
AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. PLoS One (2012) 0.89
New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2. Immunol Rev (2004) 0.89
Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma. Blood (2012) 0.89
A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinase. J Biol Chem (2012) 0.89
Identification of core DNA elements that target somatic hypermutation. J Immunol (2012) 0.88
Origins of peripheral B cells in IL-7 receptor-deficient mice. Mol Immunol (2006) 0.87
Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex. Mol Cell Biol (2007) 0.87
Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination. Mol Cell Biol (2004) 0.86
Multiple transcription factor binding sites predict AID targeting in non-Ig genes. J Immunol (2013) 0.86
Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. Proc Natl Acad Sci U S A (2013) 0.85
Mutational analysis of terminal deoxynucleotidyltransferase-mediated N-nucleotide addition in V(D)J recombination. J Immunol (2004) 0.85
RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes. Nucleic Acids Res (2013) 0.84
Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. J Biol Chem (2007) 0.81
RNA AIDS DNA. Nat Immunol (2003) 0.80
Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” rule. Mol Cell Biol (2014) 0.80
A critical context-dependent role for E boxes in the targeting of somatic hypermutation. J Immunol (2013) 0.79
Cloning of apoptosis-related genes by representational difference analysis of cDNA. Methods Mol Biol (2004) 0.78
Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA. Nucleic Acids Res (2013) 0.78
Immunology. UNGstoppable switching. Science (2004) 0.77
Partial reconstitution of V(D)J rearrangement and lymphocyte development in RAG-deficient mice expressing inducible, tetracycline-regulated RAG transgenes. Mol Immunol (2004) 0.77
DNA deaminases converge on adaptive immunity. Nat Immunol (2007) 0.75
Inducible, reversible hair loss in transgenic mice. Transgenic Res (2002) 0.75
Pillars article: the V(D)J recombination activating gene, RAG-1. 1989. J Immunol (2008) 0.75