Published in J Exp Med on February 04, 2013
RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals. J Exp Med (2016) 1.12
RAG Represents a Widespread Threat to the Lymphocyte Genome. Cell (2015) 1.09
High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX. Cell Res (2015) 0.97
Tel1(ATM)-mediated interference suppresses clustered meiotic double-strand-break formation. Nature (2015) 0.91
Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. Proc Natl Acad Sci U S A (2013) 0.85
Lymphocyte lineage-specific and developmental stage specific mechanisms suppress cyclin D3 expression in response to DNA double strand breaks. Cell Cycle (2016) 0.85
Long-Range Regulation of V(D)J Recombination. Adv Immunol (2015) 0.84
Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes. Front Immunol (2014) 0.82
Mechanisms of central tolerance for B cells. Nat Rev Immunol (2017) 0.81
The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRβ and IgH allelic exclusion. J Immunol (2014) 0.80
Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining. J Immunol (2016) 0.76
Spatio-temporal regulation of RAG2 following genotoxic stress. DNA Repair (Amst) (2015) 0.76
MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA. Oncotarget (2016) 0.75
Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks. J Immunol (2017) 0.75
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
Clonal selection and learning in the antibody system. Nature (1996) 9.58
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell (2002) 6.34
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
Contribution of receptor editing to the antibody repertoire. Science (2001) 3.45
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
Recombination centres and the orchestration of V(D)J recombination. Nat Rev Immunol (2011) 3.12
Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity (2008) 2.72
V(D)J recombination: mechanisms of initiation. Annu Rev Genet (2011) 2.70
Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Cell (1980) 2.68
CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat Immunol (2008) 2.52
Receptor editing in lymphocyte development and central tolerance. Nat Rev Immunol (2006) 2.38
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol (2009) 2.05
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98
Asynchronous replication and allelic exclusion in the immune system. Nature (2001) 1.89
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
ATM controls meiotic double-strand-break formation. Nature (2011) 1.68
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
Antigen receptor allelic exclusion: an update and reappraisal. J Immunol (2010) 1.54
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Allelic exclusion of immunoglobulin genes: models and mechanisms. Immunol Rev (2010) 1.17
Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors. J Exp Med (1995) 1.09
Ig allotypic inclusion does not prevent B cell development or response. J Immunol (2007) 1.08
Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice. J Exp Med (2012) 0.96
RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J Exp Med (2011) 0.91
A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinase. J Biol Chem (2012) 0.89
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32
The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell (2010) 3.88
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58
Control of sister chromatid recombination by histone H2AX. Mol Cell (2004) 2.43
Targeting of somatic hypermutation. Nat Rev Immunol (2006) 2.42
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution. PLoS One (2011) 2.29
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol (2005) 2.19
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05
Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc. Nat Immunol (2004) 2.00
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88
Balancing AID and DNA repair during somatic hypermutation. Trends Immunol (2009) 1.86
Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci U S A (2005) 1.85
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol (2012) 1.82
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (2009) 1.75
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity (2002) 1.74
Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell (2002) 1.73
Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe (2007) 1.71
Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments. Genes Dev (2003) 1.69
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A (2006) 1.67
Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev (2007) 1.65
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein. Mol Cancer Ther (2005) 1.59
ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med (2003) 1.55
Antigen receptor allelic exclusion: an update and reappraisal. J Immunol (2010) 1.54
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci U S A (2009) 1.50
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proc Natl Acad Sci U S A (2003) 1.49
Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells. Mol Cancer (2006) 1.48
Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med (2009) 1.48
Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur J Immunol (2008) 1.48
Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A (2008) 1.42
Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination. Int Immunol (2004) 1.41
Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc Natl Acad Sci U S A (2005) 1.40
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol (2009) 1.40
Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol (2002) 1.39
Proteasome activator PA200 is required for normal spermatogenesis. Mol Cell Biol (2006) 1.38
Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. Mol Cell Biol (2008) 1.37
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol (2011) 1.36
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med (2010) 1.36
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat Immunol (2010) 1.35
Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination. Genes Dev (2002) 1.35
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J Exp Med (2002) 1.34
B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5. Nat Immunol (2004) 1.34
Allelic exclusion at the TCRbeta locus. Curr Opin Immunol (2002) 1.30
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J Exp Med (2007) 1.29
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol (2010) 1.28
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A (2006) 1.27
Regulation of cell differentiation by the DNA damage response. Trends Cell Biol (2011) 1.25
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci U S A (2009) 1.25
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination. J Exp Med (2010) 1.23
Ebf1-dependent control of the osteoblast and adipocyte lineages. Bone (2008) 1.23
Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol (2012) 1.23
A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol (2003) 1.21
Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood (2009) 1.19
Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2. EMBO J (2003) 1.19
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. J Exp Med (2003) 1.18
Up-regulation of Hlx in immature Th cells induces IFN-gamma expression. J Immunol (2004) 1.18
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Mol Cell (2010) 1.18
Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help. J Exp Med (2006) 1.17
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest (2010) 1.17
Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J Immunol (2006) 1.16
Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood (2009) 1.15
Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J Exp Med (2006) 1.14
Mobilization of RAG-generated signal ends by transposition and insertion in vivo. Mol Cell Biol (2006) 1.12
Intra- and inter-allelic ordering of T cell receptor beta chain gene assembly. Eur J Immunol (2005) 1.11
Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol (2007) 1.10
Histone modifications associated with somatic hypermutation. Immunity (2005) 1.10