Published in Methods Enzymol on January 01, 2006
Dynamic changes in histone acetylation regulate origins of DNA replication. Nat Struct Mol Biol (2010) 1.82
Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes. Cell (2012) 1.51
Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. EMBO J (2011) 1.49
Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3. Mol Biol Cell (2007) 1.44
SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination. Nat Struct Mol Biol (2009) 1.32
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol Cell Biol (2009) 1.26
Overcoming natural replication barriers: differential helicase requirements. Nucleic Acids Res (2011) 1.14
Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution. J Biol Chem (2010) 1.08
Quality control of DNA break metabolism: in the 'end', it's a good thing. EMBO J (2008) 1.08
Homologous recombination-dependent rescue of deficiency in the structural maintenance of chromosomes (Smc) 5/6 complex. J Biol Chem (2010) 1.05
Visualization of recombination-mediated damage bypass by template switching. Nat Struct Mol Biol (2014) 1.05
Friedreich's ataxia-associated GAA repeats induce replication-fork reversal and unusual molecular junctions. Nat Struct Mol Biol (2013) 1.03
Histone H3 lysine 56 acetylation and the response to DNA replication fork damage. Mol Cell Biol (2011) 0.97
A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes. PLoS One (2007) 0.94
Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability. J Virol (2013) 0.84
Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress. Cell Rep (2015) 0.82
Resolution by unassisted Top3 points to template switch recombination intermediates during DNA replication. J Biol Chem (2013) 0.78
Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse. Elife (2015) 0.77
Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes. Cell Cycle (2014) 0.77
Valproate inhibits MAP kinase signalling and cell cycle progression in S. cerevisiae. Sci Rep (2016) 0.75
Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats. Nucleic Acids Res (2017) 0.75
Mutation at a distance caused by homopolymeric guanine repeats in Saccharomyces cerevisiae. Sci Adv (2016) 0.75
Replication forks reverse at high frequency upon replication stress in Physarum polycephalum. Chromosoma (2014) 0.75
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature (2006) 11.18
Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science (2002) 7.46
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature (2004) 6.94
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell (2003) 5.45
Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol (2008) 5.10
Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell (2011) 4.83
Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol Cell (2006) 4.44
Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing. Cell (2003) 4.24
Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase. Mol Cell (2002) 3.76
Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks. Cell (2006) 3.60
Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus. Genes Dev (2002) 3.09
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev (2005) 2.91
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell (2011) 2.65
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nat Cell Biol (2009) 2.60
Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Mol Cell (2005) 2.47
Topoisomerase I poisoning results in PARP-mediated replication fork reversal. Nat Struct Mol Biol (2012) 2.44
The DNA damage response during DNA replication. Curr Opin Cell Biol (2005) 2.44
The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses. Mol Cell Biol (2007) 2.41
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol (2010) 2.40
DNA replication origins fire stochastically in fission yeast. Mol Biol Cell (2005) 2.35
The checkpoint response to replication stress. DNA Repair (Amst) (2009) 2.27
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol (2008) 2.18
SUMOylation regulates Rad18-mediated template switch. Nature (2008) 2.14
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev (2010) 1.98
Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites. Mol Cell (2011) 1.98
Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing. Oncogene (2004) 1.89
Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells. Mol Biol Cell (2007) 1.85
Interplay of replication checkpoints and repair proteins at stalled replication forks. DNA Repair (Amst) (2007) 1.84
Branch migrating sister chromatid junctions form at replication origins through Rad51/Rad52-independent mechanisms. Mol Cell (2003) 1.83
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. Proc Natl Acad Sci U S A (2011) 1.81
Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell (2009) 1.78
G-quadruplex-induced instability during leading-strand replication. EMBO J (2011) 1.77
Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation. Genes Dev (2007) 1.75
Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements. Mol Cell (2010) 1.74
Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Mol Cell Biol (2005) 1.69
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep (2009) 1.69
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol (2013) 1.67
Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes Dev (2004) 1.67
DNA replication origin interference increases the spacing between initiation events in human cells. Mol Biol Cell (2006) 1.66
Noncanonical mismatch repair as a source of genomic instability in human cells. Mol Cell (2012) 1.63
Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription. Mol Cell (2012) 1.59
The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation. Exp Cell Res (2006) 1.52
Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes. Cell (2012) 1.51
Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. EMBO J (2011) 1.49
Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription. Cell (2009) 1.48
Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA. Genes Dev (2007) 1.47
Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks. Mol Cancer Res (2007) 1.46
The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair. Mol Biol Cell (2009) 1.44
Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates. J Cell Biol (2013) 1.37
Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase. Cell Cycle (2010) 1.35
Human ribosomal RNA gene arrays display a broad range of palindromic structures. Genome Res (2005) 1.33
Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation. Mol Cell (2010) 1.33
The Hsk1(Cdc7) replication kinase regulates origin efficiency. Mol Biol Cell (2008) 1.29
Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair. EMBO J (2009) 1.29
Yeast Rad52 and Rad51 recombination proteins define a second pathway of DNA damage assessment in response to a single double-strand break. Mol Cell Biol (2003) 1.24
RecQ helicases queuing with Srs2 to disrupt Rad51 filaments and suppress recombination. Genes Dev (2007) 1.24
Kinetic model of DNA replication in eukaryotic organisms. J Mol Biol (2002) 1.19
New histone supply regulates replication fork speed and PCNA unloading. J Cell Biol (2013) 1.16
Genomic organization of amplified MYC genes suggests distinct mechanisms of amplification in tumorigenesis. Cancer Res (2005) 1.14
DNA replication origin plasticity and perturbed fork progression in human inverted repeats. Mol Cell Biol (2005) 1.13
Single DNA molecule analysis: applications of molecular combing. Brief Funct Genomic Proteomic (2003) 1.13
Template switching: from replication fork repair to genome rearrangements. Cell (2007) 1.10
Signal transduction: how rad53 kinase is activated. Curr Biol (2005) 1.09
Visualization and interpretation of eukaryotic DNA replication intermediates in vivo by electron microscopy. Methods Mol Biol (2014) 1.04
Friedreich's ataxia-associated GAA repeats induce replication-fork reversal and unusual molecular junctions. Nat Struct Mol Biol (2013) 1.03
Replication dynamics at common fragile site FRA6E. Chromosoma (2010) 1.01
Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template. Genes Dev (2013) 1.00
Identification of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae. Curr Biol (2002) 1.00
Combed single DNA molecules imaged by secondary ion mass spectrometry. Anal Chem (2011) 0.99
The DNA polymerase alpha-primase complex: multiple functions and interactions. ScientificWorldJournal (2003) 0.99
Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint. Cell Cycle (2007) 0.99
Persistence length of chromatin determines origin spacing in Xenopus early-embryo DNA replication: quantitative comparisons between theory and experiment. Cell Cycle (2004) 0.99
Characterization of the BUD31 gene of Saccharomyces cerevisiae. Biochem Biophys Res Commun (2004) 0.98
Preserving the genome by regulating chromatin association with the nuclear envelope. Trends Cell Biol (2012) 0.95
Global regulation of genome duplication in eukaryotes: an overview from the epifluorescence microscope. Chromosoma (2008) 0.94
Acetylation: a novel link between double-strand break repair and autophagy. Cancer Res (2012) 0.93
Introduction to molecular combing: genomics, DNA replication, and cancer. Methods Mol Biol (2009) 0.90
Spi-1/PU.1 oncogene accelerates DNA replication fork elongation and promotes genetic instability in the absence of DNA breakage. Cancer Res (2010) 0.90
A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A (2002) 0.89
Significant contribution of large BRCA1 gene rearrangements in 120 French breast and ovarian cancer families. Oncogene (2002) 0.89
Leaping forks at inverted repeats. Genes Dev (2010) 0.88
14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks. PLoS Genet (2011) 0.87
The emerging role of melatonin agonists in the treatment of major depression: focus on agomelatine. CNS Neurol Disord Drug Targets (2011) 0.86
Mechanisms controlling the integrity of replicating chromosomes in budding yeast. Cell Cycle (2003) 0.85
Characterisation of a 161 kb deletion extending from the NBR1 to the BRCA1 genes in a French breast-ovarian cancer family. Hum Mutat (2003) 0.85
Combing the genome for genomic instability. Trends Biotechnol (2002) 0.85
Molecular combing reveals allelic combinations in facioscapulohumeral dystrophy. Ann Neurol (2011) 0.85
Paroxysmal dyskinesias in childhood. Pediatr Neurol (2003) 0.85