Published in Am J Physiol Gastrointest Liver Physiol on October 28, 2010
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med (2012) 2.08
Ulcerative colitis patients in remission have an altered secretory capacity in the proximal colon despite macroscopically normal mucosa. Neurogastroenterol Motil (2012) 2.03
Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility. Dig Dis Sci (2012) 1.61
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe (2013) 1.61
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev (2013) 1.50
CFTR, mucins, and mucus obstruction in cystic fibrosis. Cold Spring Harb Perspect Med (2012) 1.15
Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. J Gen Physiol (2013) 1.07
Functional Cftr in crypt epithelium of organotypic enteroid cultures from murine small intestine. Am J Physiol Cell Physiol (2012) 1.01
The cystic fibrosis intestine. Cold Spring Harb Perspect Med (2013) 0.98
Physiology and pathophysiology of SLC12A1/2 transporters. Pflugers Arch (2013) 0.96
Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology (2015) 0.93
The electroneutral Na⁺:HCO₃⁻ cotransporter NBCn1 is a major pHi regulator in murine duodenum. J Physiol (2012) 0.88
Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes. J Cell Sci (2015) 0.88
Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Traffic (2012) 0.87
Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo. J Physiol (2013) 0.87
Essential role of the electroneutral Na+-HCO3- cotransporter NBCn1 in murine duodenal acid-base balance and colonic mucus layer build-up in vivo. J Physiol (2013) 0.85
Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport. Am J Physiol Gastrointest Liver Physiol (2013) 0.85
Identification of resveratrol oligomers as inhibitors of cystic fibrosis transmembrane conductance regulator by high-throughput screening of natural products from chinese medicinal plants. PLoS One (2014) 0.85
Luminal 5-HT stimulates colonic bicarbonate secretion in rats. Br J Pharmacol (2015) 0.83
Increased spinal cord Na⁺-K⁺-2Cl⁻ cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain. J Biol Chem (2014) 0.83
Characterization of CFTR High Expresser cells in the intestine. Am J Physiol Gastrointest Liver Physiol (2013) 0.81
Cell-specific effects of luminal acid, bicarbonate, cAMP, and carbachol on transporter trafficking in the intestine. Am J Physiol Gastrointest Liver Physiol (2012) 0.81
Normal mucus formation requires cAMP-dependent HCO3- secretion and Ca2+-mediated mucin exocytosis. J Physiol (2013) 0.80
Membrane protein profiling of human colon reveals distinct regional differences. Mol Cell Proteomics (2014) 0.79
Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes. Am J Physiol Cell Physiol (2013) 0.77
Carbachol-induced colonic mucus formation requires transport via NKCC1, K⁺ channels and CFTR. Pflugers Arch (2014) 0.77
Molecular motors and apical CFTR traffic in epithelia. Int J Mol Sci (2013) 0.77
The ethanol-induced stimulation of rat duodenal mucosal bicarbonate secretion in vivo is critically dependent on luminal Cl-. PLoS One (2014) 0.77
Impact of Hybrid and Complex N-Glycans on Cell Surface Targeting of the Endogenous Chloride Cotransporter Slc12a2. Int J Cell Biol (2015) 0.77
Localization and vasopressin regulation of the Na⁺-K⁺-2Cl⁻ cotransporter in the distal colonic epithelium. World J Gastroenterol (2014) 0.77
Endogenous and exogenous control of gastrointestinal epithelial function: building on the legacy of Bayliss and Starling. J Physiol (2016) 0.77
Differential expression of pancreatic protein and chemosensing receptor mRNAs in NKCC1-null intestine. World J Gastrointest Pathophysiol (2016) 0.76
Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR. Am J Physiol Cell Physiol (2013) 0.76
Bumetanide increases Cl--dependent short-circuit current in late distal colon: Evidence for the presence of active electrogenic Cl- absorption. PLoS One (2017) 0.75
Identification of intestinal ion transport defects in microvillus inclusion disease. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Defective small intestinal anion secretion, dipeptide absorption, and intestinal failure in suckling NBCe1-deficient mice. Pflugers Arch (2016) 0.75
Di- and tripeptide transport in vertebrates: the contribution of teleost fish models. J Comp Physiol B (2016) 0.75
The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Annu Rev Physiol (2017) 0.75
Improving structural integrity of cryosections for immunogold labeling. Histochem Cell Biol (1996) 4.73
The intestinal stem cell. Genes Dev (2008) 4.21
Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A (1994) 3.21
Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion. J Clin Invest (2009) 2.37
Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis. Lancet (2008) 2.33
Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line. J Clin Invest (1986) 2.24
Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol (2005) 1.99
In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator. Nature (1991) 1.90
Activation of the Na-K-Cl cotransporter NKCC1 detected with a phospho-specific antibody. J Biol Chem (2002) 1.86
Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization. J Clin Invest (1994) 1.86
A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects. Genome Res (2001) 1.86
NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. Am J Physiol (1996) 1.84
Antibodies to tumour necrosis factor alpha as treatment for Crohn's disease. Lancet (2000) 1.69
Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter. J Biol Chem (2006) 1.68
CFTR and its key role in in vivo resting and luminal acid-induced duodenal HCO3- secretion. Acta Physiol (Oxf) (2008) 1.65
The emerging role of PDZ adapter proteins for regulation of intestinal ion transport. Am J Physiol Gastrointest Liver Physiol (2006) 1.64
Distribution and diversity of Na-K-Cl cotransport proteins: a study with monoclonal antibodies. Am J Physiol (1995) 1.59
Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator. Am J Physiol Cell Physiol (2003) 1.45
An electrogenic Na(+)-HCO(-)(3) cotransporter (NBC) with a novel COOH-terminus, cloned from rat brain. Am J Physiol Cell Physiol (2000) 1.44
HCO(3)(-) secretion in the rat colonic crypt is closely linked to Cl(-) secretion. Gastroenterology (2000) 1.43
Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells. Mol Biol Cell (2009) 1.41
Revised immunolocalization of the Na+-D-glucose cotransporter SGLT1 in rat organs with an improved antibody. Am J Physiol Cell Physiol (2008) 1.38
Endocytic trafficking of CFTR in health and disease. J Cyst Fibros (2006) 1.36
Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3. Nat Genet (2003) 1.36
PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum. Am J Physiol Gastrointest Liver Physiol (2006) 1.33
The high affinity Na+/glucose cotransporter. Re-evaluation of function and distribution of expression. J Biol Chem (1994) 1.31
Defective CFTR apical endocytosis and enterocyte brush border in myosin VI-deficient mice. Traffic (2007) 1.31
Na+/H+ exchangers, NHE-1 and NHE-3, of rat intestine. Expression and localization. J Clin Invest (1994) 1.31
Human duodenal mucosal bicarbonate secretion. Evidence for basal secretion and stimulation by hydrochloric acid and a synthetic prostaglandin E1 analogue. Gastroenterology (1986) 1.31
Cl- secretion in epithelial monolayers of mucus-forming human colon cells (HT-29/B6). Am J Physiol (1991) 1.30
Membrane distribution of sodium-hydrogen and chloride-bicarbonate exchangers in crypt and villus cell membranes from rabbit ileum. J Clin Invest (1988) 1.30
Patterns of GI disease in adulthood associated with mutations in the CFTR gene. Gut (2007) 1.29
Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon. J Clin Invest (2010) 1.29
Regulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl. Am J Physiol (1996) 1.29
Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent. J Physiol (2004) 1.27
The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport. Ann N Y Acad Sci (2009) 1.26
Cellular localization of the cystic fibrosis transmembrane conductance regulator in mouse intestinal tract. Histochem Cell Biol (2000) 1.22
STa and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G. Am J Physiol Cell Physiol (2005) 1.21
Role of down-regulated in adenoma anion exchanger in HCO3- secretion across murine duodenum. Gastroenterology (2008) 1.21
CFTR mediates cAMP- and Ca2+-activated duodenal epithelial HCO3- secretion. Am J Physiol (1997) 1.17
Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium. J Physiol (2007) 1.16
Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes. Am J Physiol (1999) 1.15
cAMP-mediated regulation of murine intestinal/pancreatic Na+/HCO3- cotransporter subtype pNBC1. Am J Physiol Gastrointest Liver Physiol (2002) 1.13
Brunner's glands: a structural, histochemical and pathological profile. Prog Histochem Cytochem (2000) 1.13
A unique subset of rat and human intestinal villus cells express the cystic fibrosis transmembrane conductance regulator. Gastroenterology (1995) 1.11
Neurobiology of the intestinal mucosa. Gastroenterology (1986) 1.10
The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function. Am J Physiol Cell Physiol (2010) 1.08
A microelectrode study of responses to secretagogues by epithelial cells on villus and crypt of rat small intestine. Am J Physiol (1989) 1.07
Muscarinic receptor subtypes in the alimentary tract. J Physiol Pharmacol (2009) 1.06
Origin of cAMP-dependent Cl- secretion from both crypts and surface epithelia of rat intestine. Am J Physiol (1993) 1.04
The response of small intestinal villous and crypt epithelium to choleratoxin in rat and guinea pig. Evidence against a specific role of the crypt cells in choleragen-induced secretion. Biochim Biophys Acta (1975) 1.04
AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon. Am J Physiol Gastrointest Liver Physiol (2010) 1.04
Dynamic regulation of Na(+)-K(+)-2Cl(-) cotransporter surface expression by PKC-{epsilon} in Cl(-)--secretory epithelia. Am J Physiol Cell Physiol (2005) 1.04
cAMP inhibition of murine intestinal Na/H exchange requires CFTR-mediated cell shrinkage of villus epithelium. Gastroenterology (2003) 1.00
Na:K:2Cl cotransporter (NKCC) of intestinal epithelial cells. Surface expression in response to cAMP. J Biol Chem (1996) 0.99
Distribution of the SGLT1 Na+/glucose cotransporter and mRNA along the crypt-villus axis of rabbit small intestine. Biochem Biophys Res Commun (1991) 0.99
Abnormal jejunal potential difference in cystic fibrosis. Lancet (1989) 0.98
CFTR channel insertion to the apical surface in rat duodenal villus epithelial cells is upregulated by VIP in vivo. J Cell Sci (1999) 0.98
Cholinergic regulation of epithelial ion transport in the mammalian intestine. Br J Pharmacol (2006) 0.97
Na-K-2Cl cotransporter gene expression and function during enterocyte differentiation. Modulation of Cl- secretory capacity by butyrate. J Clin Invest (1998) 0.96
Subcellular distribution of CFTR in rat intestine supports a physiologic role for CFTR regulation by vesicle traffic. Histochem Cell Biol (2000) 0.96
Regulatory volume increase in mammalian jejunal villus cells is due to bumetanide-sensitive NaKCl2 cotransport. Am J Physiol (1990) 0.96
Expression and regulation of the Na+-K+-2Cl- cotransporter NKCC1 in the normal and CFTR-deficient murine colon. J Physiol (2003) 0.95
Carbachol increases Na+-HCO3- cotransport activity in murine colonic crypts in a M3-, Ca2+/calmodulin-, and PKC-dependent manner. Am J Physiol Gastrointest Liver Physiol (2006) 0.94
Intestinal bicarbonate secretion in cystic fibrosis mice. JOP (2001) 0.94
Expression of AE2 anion exchanger in mouse intestine. Am J Physiol (1999) 0.94
Secretion and absorption by colonic crypts. Annu Rev Physiol (2005) 0.93
Molecular and functional evidence for electrogenic and electroneutral Na(+)-HCO(3)(-) cotransporters in murine duodenum. Am J Physiol Gastrointest Liver Physiol (2001) 0.92
Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci U S A (2009) 0.89
Epithelial secretory response to inflammation. Ann N Y Acad Sci (1992) 0.88
Involvement of phosphatidylinositol 3-kinase in cAMP- and cGMP-induced duodenal epithelial CFTR activation in mice. Am J Physiol Cell Physiol (2009) 0.88
Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide in the Brunner's gland of the rat duodenum. Am J Physiol Gastrointest Liver Physiol (2005) 0.87
Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea. Am J Physiol Cell Physiol (2010) 0.87
Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells. Am J Physiol Cell Physiol (2008) 0.87
Secretagogue stimulation enhances NBCe1 (electrogenic Na(+)/HCO(3)(-) cotransporter) surface expression in murine colonic crypts. Am J Physiol Gastrointest Liver Physiol (2009) 0.86
Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini. World J Gastroenterol (2008) 0.84
Novel localization of Rab3D in rat intestinal goblet cells and Brunner's gland acinar cells suggests a role in early Golgi trafficking. Am J Physiol Gastrointest Liver Physiol (2007) 0.83
Na-K-Cl cotransport in villus and crypt cells from rat duodenum. Am J Physiol (1994) 0.82
Stimulation by carbachol of mucus gel thickness in rat stomach involves nitric oxide. Eur J Pharmacol (1994) 0.81
X-ray microanalysis of cell elements in normal and cystic fibrosis jejunum: evidence for chloride secretion in villi. Gastroenterology (1996) 0.80
Immunoreactivity for high-affinity choline transporter colocalises with VAChT in human enteric nervous system. Cell Tissue Res (2010) 0.78
Secretagogues stimulate electrogenic HCO3- secretion in the ileum of the brushtail possum, Trichosurus vulpecula: evidence for the role of a Na+/HCO3- cotransporter. J Exp Biol (2009) 0.77
Case report: acute unintentional carbachol intoxication. Crit Care (2006) 0.76
Higher proximal duodenal mucosal bicarbonate secretion is independent of Brunner's glands in rats and rabbits. Gastroenterology (1995) 0.76
Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility. Dig Dis Sci (2012) 1.61
Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression. Gut (2012) 1.13
Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Traffic (2012) 0.87
Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport. Am J Physiol Gastrointest Liver Physiol (2013) 0.85
Cell-specific effects of luminal acid, bicarbonate, cAMP, and carbachol on transporter trafficking in the intestine. Am J Physiol Gastrointest Liver Physiol (2012) 0.81
Characterization of CFTR High Expresser cells in the intestine. Am J Physiol Gastrointest Liver Physiol (2013) 0.81
Molecular motors and apical CFTR traffic in epithelia. Int J Mol Sci (2013) 0.77
Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR. Am J Physiol Cell Physiol (2013) 0.76