PubRank

R I Lechler

Author PubWeight™ 151.49‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998 7.36
2 Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med 1982 5.09
3 Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 2001 3.66
4 The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007 3.51
5 Splicing by overlap extension by PCR using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest. Gene 1997 3.28
6 Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 1999 2.48
7 Structural model of HLA-DR1 restricted T cell antigen recognition. Cell 1988 2.41
8 Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 2001 2.20
9 "Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. Proc Natl Acad Sci U S A 1985 1.93
10 Isolation of endothelial cells from murine tissue. J Immunol Methods 2000 1.81
11 Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans. Circulation 1998 1.79
12 Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis. J Clin Endocrinol Metab 2000 1.75
13 Thy-1+ dendritic epidermal cells belong to the T-cell lineage. Proc Natl Acad Sci U S A 1987 1.46
14 Nitric oxide-mediated expression of Bcl-2 and Bcl-xl and protection from tumor necrosis factor-alpha-mediated apoptosis in porcine endothelial cells after exposure to low concentrations of xenoreactive natural antibody. Transplantation 2001 1.46
15 Loss of direct and maintenance of indirect alloresponses in renal allograft recipients: implications for the pathogenesis of chronic allograft nephropathy. J Immunol 2001 1.43
16 Peptide analogues as a strategy to induce tolerance in T cells with indirect allospecificity. Transplantation 2000 1.43
17 Speculations on the specificity of suppression. Immunol Today 1989 1.43
18 Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins. J Thromb Haemost 2006 1.41
19 Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol 2009 1.37
20 MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. Arthritis Rheum 2005 1.32
21 Allorecognition. Am J Transplant 2001 1.30
22 Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cells. J Immunol 1985 1.26
23 Are primary alloresponses truly primary? Int Immunol 1990 1.21
24 Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males. Eur J Immunol 2001 1.21
25 The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. Int Immunol 2007 1.20
26 Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses. Am J Transplant 2006 1.19
27 Donor-specific indirect pathway analysis reveals a B-cell-independent signature which reflects outcomes in kidney transplant recipients. Am J Transplant 2011 1.18
28 Early genetic events in T cell development analyzed by in situ hybridization. J Exp Med 1987 1.16
29 Differential expression of CTLA-4 among T cell subsets. Clin Exp Immunol 2004 1.15
30 Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation. Am J Transplant 2013 1.14
31 Significant frequencies of T cells with indirect anti-donor specificity in heart graft recipients with chronic rejection. Circulation 2000 1.14
32 Antigen recognition influences transendothelial migration of CD4+ T cells. J Immunol 1999 1.10
33 Adult onset immunodeficiency caused by inherited adenosine deaminase deficiency. J Immunol 1994 1.06
34 Intercellular transfer of MHC and immunological molecules: molecular mechanisms and biological significance. Am J Transplant 2007 1.06
35 I-A-restricted T cell antigen recognition. Analysis of the roles of A alpha and A beta using DNA-mediated gene transfer. J Exp Med 1986 1.05
36 Allorecognition of DR1 by T cells from a DR4/DRw13 responder mimics self-restricted recognition of endogenous peptides. Proc Natl Acad Sci U S A 1989 1.05
37 Allorecognition and the alloresponse: clinical implications. Tissue Antigens 2007 1.05
38 Antigen presentation by parenchymal cells: a route to peripheral tolerance? Immunol Rev 1999 1.04
39 Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7. J Immunol 2000 1.00
40 Transplant accommodation in highly sensitized patients: a potential role for Bcl-xL and alloantibody. Am J Transplant 2001 1.00
41 Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells. J Exp Med 1996 1.00
42 Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient. J Exp Med 1982 0.99
43 The role of the allograft in the induction of donor-specific T cell hyporesponsiveness. Transplantation 2001 0.99
44 Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis. Clin Exp Immunol 2008 0.98
45 In Goodpasture's disease, CD4(+) T cells escape thymic deletion and are reactive with the autoantigen alpha3(IV)NC1. J Am Soc Nephrol 2001 0.97
46 Activated murine endothelial cells have reduced immunogenicity for CD8+ T cells: a mechanism of immunoregulation? J Immunol 2000 0.97
47 Co-recognition of endogenous antigens with HLA-DR1 by alloreactive human T cell clones. J Immunol 1989 0.96
48 Long-term sequelae of Helicobacter pylori gastritis. Lancet 1995 0.95
49 Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling. J Immunol 1997 0.95
50 HLA-G inhibits the transendothelial migration of human NK cells. Eur J Immunol 2000 0.95
51 Multiple Cladosporium brain abscesses in a renal transplant patient: aggressive management improves outcome. Transplantation 1997 0.94
52 Malignant disease in patients with long-term renal transplants. Transplantation 1995 0.93
53 Multiple sclerosis and HLA: is the susceptibility gene really HLA-DR or -DQ? Hum Immunol 1991 0.93
54 Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins. J Biol Chem 1997 0.92
55 Analysis of T cell responses to the autoantigen in Goodpasture's disease. Clin Exp Immunol 1995 0.92
56 Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells. J Exp Med 1992 0.90
57 A kinetic differentiation model for the action of altered TCR ligands. Immunol Today 1999 0.90
58 Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur J Immunol 1996 0.89
59 Role of alloantibodies in the pathogenesis of graft arteriosclerosis in cardiac transplantation. Am J Transplant 2006 0.89
60 Presentation and recognition of major and minor histocompatibility antigens. Transpl Immunol 1994 0.89
61 Position 71 in the alpha helix of the DR beta domain is predicted to influence peptide binding and plays a central role in allorecognition. Eur J Immunol 1993 0.89
62 Myoblasts fail to stimulate T cells but induce tolerance. Int Immunol 1994 0.88
63 Contribution of T-cell receptor-contacting and peptide-binding residues of the class II molecule HLA-DR4 Dw10 to serologic and antigen-specific T-cell recognition. Hum Immunol 1991 0.87
64 Improved protocol for colorimetric detection of complement-mediated cytotoxicity based on the measurement of cytoplasmic lactate dehydrogenase activity. J Immunol Methods 1996 0.87
65 Human T cells elicit IFN-alpha secretion from dendritic cells following cell to cell interactions. Eur J Immunol 2000 0.87
66 Renal transplantation following immunoadsorption in highly sensitized recipients. Transplantation 1993 0.87
67 The invariant chain inhibits presentation of endogenous antigens by a human fibroblast cell line. Eur J Immunol 1994 0.86
68 Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro. Int Immunol 1997 0.86
69 Detection of donor-specific hyporesponsiveness following late failure of human renal allografts. Kidney Int 1996 0.86
70 Direct evidence for a functional role of HLA-DRB1 and -DRB3 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T lymphocytes. Int Immunol 1990 0.86
71 The bioenergetics of the immune system. Science 2001 0.86
72 Individual variation in the frequency of HLA class II-specific cytotoxic T lymphocyte precursors. Eur J Immunol 1990 0.86
73 MHC class II molecular structure--permitted pairs? Immunol Today 1988 0.86
74 Rejection mechanisms in transplantation. Wien Klin Wochenschr 2001 0.86
75 Selective inhibition of beta-1,4- and alpha-1,3-galactosyltransferases: donor sugar-nucleotide based approach. Bioorg Med Chem 1999 0.85
76 The specificity of alloreactive T cells is determined by MHC polymorphisms which contact the T cell receptor and which influence peptide binding. Int Immunol 1991 0.85
77 The alloresponse. Rev Immunogenet 1999 0.85
78 Evidence that umbilical cord blood contains a higher frequency of HLA class II-specific alloreactive T cells than adult peripheral blood. A limiting dilution analysis. Transplantation 1992 0.85
79 Costimulatory blockade by the induction of an endogenous xenospecific antibody response. Nat Immunol 2000 0.85
80 A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation. Transplantation 1996 0.85
81 Inhibition of tissue factor-dependent and -independent coagulation by cell surface expression of novel anticoagulant fusion proteins. Transplantation 1999 0.84
82 Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins. Transplantation 1999 0.84
83 Transferrin receptor-mediated gene transfer to the corneal endothelium. Transplantation 2001 0.84
84 Interferon-alpha2a is sufficient for promoting dendritic cell immunogenicity. Clin Exp Immunol 2005 0.83
85 Helicobacter pylori induces in-vivo expansion of human regulatory T cells through stimulating interleukin-1β production by dendritic cells. Clin Exp Immunol 2012 0.83
86 Biased T-cell receptor usage is associated with allelic variation in the MHC class II peptide binding groove. Immunogenetics 1999 0.83
87 T cell-mediated xenograft rejection: specific tolerance is probably required for long term xenograft survival. Xenotransplantation 1998 0.83
88 Structural analysis of anti-DR1 allorecognition by using DR1/H-2Ek hybrid molecules. Influence of the beta 2-domain correlates with CD4 dependence. J Immunol 1991 0.82
89 Comparison of helper and cytotoxic antirecipient T cell frequencies in unrelated bone marrow transplantation. Transplantation 1994 0.82
90 Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation. Lancet 1993 0.82
91 Optimizing a limiting dilution culture system for quantifying the frequency of interleukin-2-producing alloreactive T helper lymphocytes. Transplantation 1997 0.82
92 Reversal of HLA restriction by a point mutation in an antigenic peptide. Int Immunol 1989 0.82
93 Structure and function of murine class II major histocompatibility complex genes. Mt Sinai J Med 1986 0.81
94 Role of donor and recipient antigen-presenting cells in priming and maintaining T cells with indirect allospecificity. Transplantation 1998 0.81
95 Induction of apoptosis following antigen presentation by T cells: anergy and apoptosis are two separate phenomena. Transplant Proc 1997 0.81
96 Human tissue factor pathway inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface. Thromb Haemost 1997 0.80
97 In vitro accommodation of immortalized porcine endothelial cells: resistance to complement mediated lysis and down-regulation of VCAM expression induced by low concentrations of polyclonal human IgG antipig antibodies. Transplantation 1996 0.80
98 Tolerance mechanisms and recent progress. Transplant Proc 2004 0.80
99 Allorecognition. Transfus Clin Biol 2001 0.80
100 Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells. J Immunol 1997 0.80
101 Binding of BCR/ABL junctional peptides to major histocompatibility complex (MHC) class I molecules: studies in antigen-processing defective cell lines. Leukemia 1994 0.80
102 Human CD4+ CD25+ T cells regulate CD8+ T-cell activation. Transplant Proc 2002 0.79
103 Differential effects of immunosuppressive drugs on T-cell motility. Am J Transplant 2006 0.79
104 Endogenous pathway of class II presentation. Biochem Soc Trans 1995 0.79
105 Differential role of naïve and memory CD4 T-cell subsets in primary alloresponses. Am J Transplant 2010 0.79
106 Prospects for xenografting. Curr Opin Immunol 1994 0.79
107 The prospects for xenotransplantation. QJM 1996 0.79
108 Lack of T cell proliferation without induction of nonresponsiveness after antigen presentation by endothelial cells. Transplantation 1999 0.79
109 Target specificity of immunoregulation by natural killer cells. Transplant Proc 1989 0.78
110 Antigen presentation by murine endothelial cells. Transplant Proc 2001 0.78
111 Fibrocytes mediate intimal hyperplasia post-vascular injury and are regulated by two tissue factor-dependent mechanisms. J Thromb Haemost 2013 0.78
112 Whole-body imaging of adoptively transferred T cells using magnetic resonance imaging, single photon emission computed tomography and positron emission tomography techniques, with a focus on regulatory T cells. Clin Exp Immunol 2013 0.78
113 Positive correlation of T cell sensitization with frequencies of alloreactive T helper cells in chronic renal failure patients. Transplantation 1992 0.78
114 Unusual chlamydial infection in a human renal allograft recipient. Br Med J 1978 0.78
115 Expression of alpha-1,3-galactose and other type 2 oligosaccharide structures in a porcine endothelial cell line transfected with human alpha-1,2-fucosyltransferase cDNA. J Biol Chem 1997 0.77
116 Individual variation in alloresponsiveness and the molecular basis of allorecognition. Hum Immunol 1990 0.77
117 Definition of sites on HLA-DR1 involved in the T cell response to staphylococcal enterotoxins E and C2. Eur J Immunol 1995 0.77
118 Significant primary indirect human T-cell anti-pig xenoresponses observed using immature porcine dendritic cells and SLA-class II-negative endothelial cells. Transplant Proc 1996 0.77
119 Adoptive cell therapy using in vitro generated human CD4+ CD25+ regulatory t cells with indirect allospecificity to promote donor-specific transplantation tolerance. Transplant Proc 2006 0.77
120 Improving the therapeutic monitoring of cyclosporin A. Clin Transplant 1999 0.77
121 Transfected murine cells expressing HLA class II can be used to generate alloreactive human T cell clones. J Immunol Methods 1994 0.77
122 Expression of hirudin fusion proteins in mammalian cells: a strategy for prevention of intravascular thrombosis. Circulation 1998 0.77
123 Cloning of porcine intercellular adhesion molecule-1 and characterization of its induction on endothelial cells by cytokines. Transplantation 2000 0.76
124 Dendritic cells prohibited by anergic T cells acquire tolerogenic properties. Transplant Proc 2002 0.76
125 Biased TCR gene usage in alloreactive T cells specific for a structurally dissimilar MHC alloantigen. Int Immunol 1994 0.76
126 Anergic T cells act as suppressor cells in vitro. Transplant Proc 1995 0.76
127 The role of T-cell anergy in the maintenance of donor-specific hyporesponsiveness in renal transplant recipients. Transplant Proc 2001 0.76
128 "Accomodated" pig endothelial cells promote nitric oxide-dependent Th-2 cytokine responses from human T cells. Transplantation 2001 0.76
129 Association between interleukin-4-producing T lymphocyte frequencies and reduced risk of graft-versus-host disease. Transplantation 1998 0.76
130 Quantitative but not qualitative variation in MHC class II alters CD4 interaction and influences T cell repertoire formation. Cell Immunol 1997 0.76
131 Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins. Xenotransplantation 2001 0.76
132 Leptin in intestinal inflammation: good and bad gut feelings. Gut 2004 0.76
133 Why MHC incompatible grafts induce strong primary alloimmunity. Transplant Proc 1982 0.76
134 In vitro accommodation of porcine endothelial cells by low dose human anti-pig antibody: reduced binding of human lymphocytes by accommodated cells associated with increased nitric oxide production. Xenotransplantation 1998 0.76
135 Co-expression of human T cell receptor chains with mouse CD3 on the cell surface of a mouse T cell hybridoma. J Immunol Methods 1992 0.76
136 NK cells inhibit T-cell responses: LFA3+ but not LFA3- T-cell responses are suppressed. Immunology 1991 0.75
137 Do functional assays have predictive value in sibling bone marrow transplantation? Transplantation 2000 0.75
138 Interactions between the amino-terminal domains of MHC class II molecules have a profound effect on serologic and T cell recognition: an analysis using recombinant HLA-DR/H-2E molecules. J Immunol 1991 0.75
139 A monoclonal antibody with broad anti-HLA-DR activity fails to bind to DRw11/Dw5: possible effect of a unique polymorphism on the beta 1 domain alpha-helix. Hum Immunol 1991 0.75
140 Induction of specific unresponsiveness in kidney transplant recipients. Proc Eur Dial Transplant Assoc 1981 0.75
141 Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis. Transplant Proc 2000 0.75
142 T cell receptor engagement can influence T cell motility. Transplant Proc 2001 0.75
143 Human anti-mouse xenorecognition. Provision of noncognate interactions reveals plasticity of T cell repertoire. J Immunol 1995 0.75
144 Recently activated T cells are costimulation-dependent in vitro. Cell Immunol 1999 0.75
145 HLA-DPB1 mismatch at position 69 is associated with high helper T lymphocyte precursor frequencies in unrelated bone marrow transplant pairs. Transplantation 1996 0.75
146 Primary Epstein-Barr virus infection associated with a rejection episode in a human renal allograft recipient. Clin Nephrol 1980 0.75
147 Glaxo/MRS Young Investigator Prize. Xenotransplantation: immune barriers beyond hyperacute rejection. Clin Sci (Lond) 1997 0.75
148 Customised immunosuppression. Bone Marrow Transplant 1994 0.75
149 Disease susceptibility, transplantation and the MHC. Immunol Today 1995 0.75
150 Tolerance induction in indirect alloresponses by analogs of HLA-derived peptides. Transplant Proc 2001 0.75
151 Could analysis of helper T-cell precursor frequencies be used as a predictive parameter in renal transplantation? Transplant Proc 1995 0.75
152 Endogenous peptides contribute to the ligand recognized by anti-DR1 human alloreactive T cells. Transplant Proc 1989 0.75
153 Inhibition of expression of the Galalpha1-3Gal epitope on porcine cells using an intracellular single-chain antibody directed against alpha1,3galactosyltransferase. J Immunol Methods 1999 0.75
154 Direct human T-cell anti-pig xenoresponses are vigorous but significantly weaker than direct alloresponses. Transplant Proc 1996 0.75
155 Helper T-lymphocyte precursor frequencies predict risks of graft-versus-host disease in bone marrow transplantation. Transplant Proc 1993 0.75
156 Structural analysis of human anti-mouse H-2E xenorecognition: T cell receptor bias and impaired CD4 interaction contribute to weak xenoresponses. Int Immunol 1992 0.75
157 Comparison of Neoral and Sandimmune preparations in renal transplant patients--improved pharmacokinetics with neoral. Transplant Proc 1996 0.75
158 Transplantation. Curr Opin Immunol 1995 0.75
159 Do cyclosporin profiles provide useful information in the management of renal transplant recipients? Nephrol Dial Transplant 1996 0.75
160 Immunosuppression of direct T-cell-mediated xenorecognition in vitro. Transplant Proc 2001 0.75
161 Reversible uraemia in normotensive nephrotic syndrome. Br Med J 1979 0.75
162 Establishing the optimal method to estimate the frequencies of alloreactive CD4+ T cells. Transplant Proc 2002 0.75
163 An allelic cluster of DQ alpha restriction fragments is associated with multiple sclerosis: evidence that a second haplotype may influence disease susceptibility. Hum Immunol 1989 0.75