Published in J Biol on January 01, 2006
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell (2010) 3.03
Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci (2008) 1.84
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev (2007) 1.81
The ERK Cascade: Distinct Functions within Various Subcellular Organelles. Genes Cancer (2011) 1.74
Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol (2007) 1.62
Sex affects bone morphogenetic protein type II receptor signaling in pulmonary artery smooth muscle cells. Am J Respir Crit Care Med (2015) 1.60
The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol (2008) 1.44
Erk1/2 MAP kinases are required for epidermal G2/M progression. J Cell Biol (2009) 1.32
Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer. Oncotarget (2013) 1.27
GnRH signaling, the gonadotrope and endocrine control of fertility. Front Neuroendocrinol (2010) 1.23
Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine. Biol Psychiatry (2009) 1.21
Erk1 positively regulates osteoclast differentiation and bone resorptive activity. PLoS One (2011) 1.19
Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. J Biol Chem (2009) 1.18
The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity. J Virol (2006) 1.15
Identification of the transcriptional response of human intestinal mucosa to Lactobacillus plantarum WCFS1 in vivo. BMC Genomics (2008) 1.12
Distinct functions for ERKs? J Biol (2006) 1.08
Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Mol Cell Biol (2010) 1.07
Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1. Mol Cell Biol (2009) 1.06
Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia. Proc Natl Acad Sci U S A (2010) 1.05
Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models. J Neurosci (2010) 1.04
Molecular mechanisms underlying memory consolidation of taste information in the cortex. Front Behav Neurosci (2012) 1.02
Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2. PLoS One (2014) 1.00
Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1. Mol Cancer Res (2011) 0.98
YB-1 is a Transcription/Translation Factor that Orchestrates the Oncogenome by Hardwiring Signal Transduction to Gene Expression. Transl Oncogenomics (2007) 0.96
Ras-ERK Signaling in Behavior: Old Questions and New Perspectives. Front Behav Neurosci (2011) 0.96
Raf-independent, PP2A-dependent MEK activation in response to ERK silencing. Biochem Biophys Res Commun (2009) 0.96
ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. BMC Genomics (2008) 0.95
Low ERK phosphorylation in cancer-associated fibroblasts is associated with tamoxifen resistance in pre-menopausal breast cancer. PLoS One (2012) 0.95
Requirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survival. J Neurosci (2008) 0.95
Dimerization in protein kinase signaling. J Biol (2006) 0.93
MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development (2013) 0.91
Growth arrest signaling of the Raf/MEK/ERK pathway in cancer. Front Biol (Beijing) (2014) 0.90
ERK2-dependent activation of c-Jun is required for nontypeable Haemophilus influenzae-induced CXCL2 upregulation in inner ear fibrocytes. J Immunol (2012) 0.89
ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy. PLoS One (2009) 0.89
Complexity of receptor tyrosine kinase signal processing. Cold Spring Harb Perspect Biol (2013) 0.89
Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount. Int J Mol Sci (2013) 0.89
Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3. Toxicol Appl Pharmacol (2008) 0.88
The N-terminal domain of ERK1 accounts for the functional differences with ERK2. PLoS One (2008) 0.88
ERK signaling regulates tumor promoter induced c-Jun recruitment at the Fra-1 promoter. Biochem Biophys Res Commun (2008) 0.88
Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation. Hum Mol Genet (2013) 0.84
Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa. PLoS One (2011) 0.84
Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions. Proteomics (2013) 0.84
Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos. Am J Respir Cell Mol Biol (2008) 0.83
Pharmacologic inhibition of MEK signaling prevents growth of canine hemangiosarcoma. Mol Cancer Ther (2013) 0.83
ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy? Front Cell Dev Biol (2016) 0.82
ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival. J Neurosci (2015) 0.81
Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs. Int J Mol Sci (2013) 0.81
Active ERK2 is sufficient to mediate growth arrest and differentiation signaling. FEBS J (2015) 0.81
Both ERK1 and ERK2 are required for enterovirus 71 (EV71) efficient replication. Viruses (2015) 0.81
Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. Mediators Inflamm (2013) 0.80
Down-regulation of Rab17 promotes tumourigenic properties of hepatocellular carcinoma cells via Erk pathway. Int J Clin Exp Pathol (2015) 0.80
Probiotic supplementation promotes calcification in Danio rerio larvae: a molecular study. PLoS One (2013) 0.80
Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M. J Biol Chem (2012) 0.80
U0126, an Inhibitor of MEK1/2, Increases Tumor Necrosis Factor-α-Induced Apoptosis, but not Interleukin-6 Induced Apoptosis in C-28/I2 Human Chondrocytes. J Autoimmune Disord (2015) 0.79
Effects of estrogens and bladder inflammation on mitogen-activated protein kinases in lumbosacral dorsal root ganglia from adult female rats. BMC Neurosci (2009) 0.79
P19 H-ras induces G1/S phase delay maintaining cells in a reversible quiescence state. PLoS One (2009) 0.79
Muscle-derived extracellular signal-regulated kinases 1 and 2 are required for the maintenance of adult myofibers and their neuromuscular junctions. Mol Cell Biol (2015) 0.79
Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1. J Biol Chem (2013) 0.79
Distinct roles for extracellular signal-regulated kinase 1 (ERK1) and ERK2 in the structure and production of a primate gammaherpesvirus. J Virol (2012) 0.79
MAP kinases have different functions in Dictyostelium G protein-mediated signaling. Cell Signal (2010) 0.79
Erk2 but not Erk1 regulates crosstalk between Met and EGFR in squamous cell carcinoma cell lines. Mol Cancer (2015) 0.79
ERK2-regulated TIMP1 induces hyperproliferation of K-Ras(G12D)-transformed pancreatic ductal cells. Neoplasia (2013) 0.79
LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cells. PLoS One (2014) 0.78
Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference. Mol Biotechnol (2008) 0.78
Monomeric and dimeric models of ERK2 in conjunction with studies on cellular localization, nuclear translocation, and in vitro analysis. Mol Cells (2012) 0.77
Peripheral serotonin regulates maternal calcium trafficking in mammary epithelial cells during lactation in mice. PLoS One (2014) 0.77
LPS-Induced G-CSF Expression in Macrophages Is Mediated by ERK2, but Not ERK1. PLoS One (2015) 0.77
Tracheal Morphologic and Protein Alterations FollowingShort-Term Cigarette Mainstream Smoke Exposure to Rats. J Toxicol Pathol (2012) 0.76
Redundancy in the World of MAP Kinases: All for One. Front Cell Dev Biol (2016) 0.76
Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway. Oncotarget (2015) 0.76
Hyperbaric Oxygen Reduces Production of Reactive Oxygen Species in Neutrophils from Polytraumatized Patients Yielding in the Inhibition of p38 MAP Kinase and Downstream Pathways. PLoS One (2016) 0.76
Substrate-Dependent Activity of ERK and MEK Proteins in Breast Cancer (MCF7), and Kidney Embryonic (Hek-293) Cell Lines, Cultured on Different Substrates. Iran J Cancer Prev (2015) 0.75
H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair. Oncotarget (2016) 0.75
Methotrexate-coupled nanoparticles and magnetic nanochemothermia for the relapse-free treatment of T24 bladder tumors. Int J Nanomedicine (2017) 0.75
Angiotensin II signaling in human preadipose cells: participation of ERK1,2-dependent modulation of Akt. PLoS One (2013) 0.75
ERK expression and its correlation with STAT1 in esophageal squamous cell carcinoma. Oncotarget (2017) 0.75
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
RNA interference. Nature (2002) 22.28
ras oncogenes in human cancer: a review. Cancer Res (1989) 22.03
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell (2004) 19.51
Mammalian MAP kinase signalling cascades. Nature (2001) 18.89
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02
Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem (1998) 13.93
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet (2003) 12.16
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (2001) 10.56
A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A (1995) 10.25
RAS oncogenes: the first 30 years. Nat Rev Cancer (2003) 8.61
The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (1999) 7.85
Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol (2006) 7.25
Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol (2005) 7.07
Essential role for oncogenic Ras in tumour maintenance. Nature (1999) 6.51
Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat Genet (2000) 6.12
Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer (2004) 6.07
A ras-related gene with transformation suppressor activity. Cell (1989) 5.81
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors (2006) 5.58
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell (2003) 5.17
Ancient pathways programmed by small RNAs. Science (2002) 4.94
NF1 tumor suppressor gene function: narrowing the GAP. Cell (2001) 4.11
CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell (1991) 4.11
RNA interference: listening to the sound of silence. Nat Struct Biol (2001) 4.05
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc Natl Acad Sci U S A (2000) 3.95
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science (1999) 3.85
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene (1999) 3.32
Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27
The role of erk1 and erk2 in multiple stages of T cell development. Immunity (2005) 2.96
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron (2002) 2.93
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr Biol (1999) 2.65
Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell (1998) 2.64
Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol (2002) 2.55
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep (2003) 2.52
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature (1995) 2.41
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc Natl Acad Sci U S A (2003) 2.25
RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat Rev Mol Cell Biol (2004) 2.24
A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature (1997) 2.16
RNA interference: the new somatic cell genetics? Cancer Cell (2002) 2.05
Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene (1997) 1.95
Does Rap1 deserve a bad Rap? Trends Biochem Sci (2003) 1.82
All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral. EMBO J (1998) 1.81
Is the Ras-MAPK signalling pathway necessary for long-term memory formation? Trends Neurosci (1999) 1.74
Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells (2003) 1.71
Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate. Biochemistry (1996) 1.51
Mek2 is dispensable for mouse growth and development. Mol Cell Biol (2003) 1.44
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Eur J Biochem (2003) 1.39
HIV-based vectors. Preparation and use. Methods Mol Med (2002) 1.39
Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development. Genes Dev (1997) 1.30
Protein-protein interactions in the regulation of the extracellular signal-regulated kinase. Mol Biotechnol (2005) 1.28
Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO J (1995) 1.28
Transduction of a gene expression cassette using advanced generation lentiviral vectors. Methods Enzymol (2002) 1.07
Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development. Mol Cell Biol (2002) 1.03
The mitogen-activated protein kinase signaling module as a therapeutic target in hematologic malignancies. Rev Clin Exp Hematol (2003) 0.97
The ERK cascade as a prototype of MAPK signaling pathways. Methods Mol Biol (2004) 0.94
Study of MAPK signaling using knockout mice. Methods Mol Biol (2004) 0.89