Published in Mol Biotechnol on January 01, 2005
ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially. J Biol (2006) 2.04
The ERK Cascade: Distinct Functions within Various Subcellular Organelles. Genes Cancer (2011) 1.74
Phosphorylation meets nuclear import: a review. Cell Commun Signal (2010) 1.49
Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis. Mol Cell Biol (2009) 1.36
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Nat Struct Mol Biol (2012) 1.30
ERK1c regulates Golgi fragmentation during mitosis. J Cell Biol (2006) 1.28
Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. J Biol Chem (2009) 1.18
Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation. Mol Cell Biol (2011) 1.17
Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma. J Clin Pathol (2005) 1.13
Thyroid hormone drives fetal cardiomyocyte maturation. FASEB J (2011) 1.09
Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity. J Biol Chem (2010) 1.03
PPARgamma and MEK Interactions in Cancer. PPAR Res (2008) 1.02
Calcium regulates ERK signaling by modulating its protein-protein interactions. Commun Integr Biol (2008) 0.99
How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members? Immunol Rev (2011) 0.94
How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches. Front Physiol (2012) 0.94
The nuclear translocation of ERK1/2 as an anticancer target. Nat Commun (2015) 0.93
Smooth muscle archvillin is an ERK scaffolding protein. J Biol Chem (2009) 0.92
A model of a MAPK•substrate complex in an active conformation: a computational and experimental approach. PLoS One (2011) 0.90
Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors. J Clin Invest (2013) 0.90
Dipyridamole prevents triple-negative breast-cancer progression. Clin Exp Metastasis (2012) 0.87
Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking. J Immunol (2013) 0.87
Stimulated nuclear import by β-like importins. F1000Prime Rep (2013) 0.85
Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M. J Biol Chem (2012) 0.80
REV, A BRET-Based Sensor of ERK Activity. Front Endocrinol (Lausanne) (2013) 0.79
Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation. Sci Rep (2016) 0.78
Tay bridge is a negative regulator of EGFR signalling and interacts with Erk and Mkp3 in the Drosophila melanogaster wing. PLoS Genet (2013) 0.77
Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes. Mol Cell Endocrinol (2015) 0.77
A 50-kDa ERK-like protein is up-regulated by a dual altered peptide ligand that suppresses myasthenia gravis-associated responses. Proc Natl Acad Sci U S A (2006) 0.76
Macrophage migration inhibitory factor activates inflammatory responses of astrocytes through interaction with CD74 receptor. Oncotarget (2016) 0.76
C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction. PLoS Genet (2016) 0.75
Endogenous, Regulatory Cysteine Sulfenylation of ERK Kinases in Response to Proliferative Signals. Free Radic Biol Med (2017) 0.75
The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis. Int J Mol Sci (2017) 0.75
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors (2006) 5.58
The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta (2006) 4.06
Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron (2005) 3.09
The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions. Methods Mol Biol (2010) 2.72
Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene (2002) 2.50
DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation. Mol Cell (2007) 2.48
The ERK cascade: a prototype of MAPK signaling. Mol Biotechnol (2005) 2.45
CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions. Nat Immunol (2011) 2.05
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Biochim Biophys Acta (2010) 1.85
The ERK Cascade: Distinct Functions within Various Subcellular Organelles. Genes Cancer (2011) 1.74
Identification and characterization of a general nuclear translocation signal in signaling proteins. Mol Cell (2008) 1.73
Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol (2006) 1.59
Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase. J Mol Biol (2006) 1.57
The mitogen-activated protein kinase signaling cascade: from bench to bedside. Isr Med Assoc J (2002) 1.44
Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. J Biol Chem (2002) 1.37
MAPK kinases as nucleo-cytoplasmic shuttles for PPARgamma. Cell Cycle (2007) 1.37
The subcellular localization of MEK and ERK--a novel nuclear translocation signal (NTS) paves a way to the nucleus. Mol Cell Endocrinol (2009) 1.37
Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. J Clin Invest (2005) 1.36
ERK1c regulates Golgi fragmentation during mitosis. J Cell Biol (2006) 1.28
Activation of MAPK cascades by GnRH: ERK and Jun N-terminal kinase are involved in basal and GnRH-stimulated activity of the glycoprotein hormone LHbeta-subunit promoter. Endocrinology (2002) 1.20
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci U S A (2007) 1.18
Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation. Mol Cell Biol (2011) 1.17
Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies. Biochem J (2007) 1.16
BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development (2010) 1.14
A positive role of the PI3-K/Akt signaling pathway in PC12 cell differentiation. Mol Cells (2004) 1.11
The ERK signaling cascade--views from different subcellular compartments. Biofactors (2009) 1.11
Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function. Mol Cell Biol (2004) 1.07
Extracellular signal-regulated kinase, Jun N-terminal kinase, p38, and c-Src are involved in gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone follicle-stimulating hormone beta-subunit promoter. Endocrinology (2004) 1.07
Retracted Regulation of p53: intricate loops and delicate balances. Biochem Pharmacol (2002) 1.05
Retracted Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases. J Biol Chem (2008) 1.04
PPARgamma and MEK Interactions in Cancer. PPAR Res (2008) 1.02
Regulation of p53: intricate loops and delicate balances. Ann N Y Acad Sci (2002) 1.01
Glycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer. Int J Cancer (2003) 1.00
Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits. Eur J Biochem (2002) 1.00
Calcium regulates ERK signaling by modulating its protein-protein interactions. Commun Integr Biol (2008) 0.99
Phosphomimetic mutants of pigment epithelium-derived factor with enhanced antiangiogenic activity as potent anticancer agents. Cancer Res (2010) 0.98
Manipulation of redox signaling in mammalian cells enabled by controlled photogeneration of reactive oxygen species. J Cell Sci (2005) 0.97
Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1. J Clin Endocrinol Metab (2003) 0.94
Activation of mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent. Mol Cell Endocrinol (2006) 0.94
The ERK cascade as a prototype of MAPK signaling pathways. Methods Mol Biol (2004) 0.94
ERK as a model for systems biology of enzyme kinetics in cells. Curr Biol (2013) 0.94
Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality. J Biol Chem (2008) 0.93
MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. J Cell Sci (2004) 0.93
Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor. Blood (2004) 0.92
Retracted c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells. J Biol Chem (2003) 0.91
Retracted Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest. J Biol Chem (2010) 0.91
Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade. Genes Dev (2009) 0.90
The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain. Mol Cell Biol (2011) 0.89
A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells. Mol Endocrinol (2009) 0.89
Extracellular signal-regulated kinase and c-Src, but not Jun N-terminal kinase, are involved in basal and gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone alpha-subunit promoter. Endocrinology (2003) 0.87
Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of extracellular signal-regulated kinase and Jun N-terminal kinase. Endocrinology (2010) 0.87
Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF. FEBS J (2008) 0.85
Retracted Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. J Biol Chem (2011) 0.85
Stimulated nuclear import by β-like importins. F1000Prime Rep (2013) 0.85
Gonadotropin-releasing hormone in apoptosis of prostate cancer cells. Cancer Lett (2005) 0.84
Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases. Mol Cell Biol (2013) 0.84
Variable phosphorylation states of pigment-epithelium-derived factor differentially regulate its function. Blood (2005) 0.84
Determination of ERK activity: anti-phospho-ERK antibodies and in vitro phosphorylation. Methods Mol Biol (2010) 0.81
Mxi2 sustains ERK1/2 phosphorylation in the nucleus by preventing ERK1/2 binding to phosphatases. Biochem J (2012) 0.80
ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage. Oncogene (2002) 0.80
Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction. PLoS One (2010) 0.80
ERK signaling in colorectal cancer: a preliminary report on the expression of phosphorylated ERK and the effects of radiation therapy. Am J Clin Oncol (2008) 0.80
Use of inhibitors in the study of MAPK signaling. Methods Mol Biol (2004) 0.79
Maturation-promoting factor governs mitogen-activated protein kinase activation and interphase suppression during meiosis of rat oocytes. Biol Reprod (2002) 0.79
Ligand interaction scan (LIScan) in the study of ERK8. Biochem Biophys Res Commun (2010) 0.79
Mechanisms of gonadotropin desensitization. Mol Cell Endocrinol (2002) 0.79
Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells: role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways. Cancer Res (2004) 0.79
Deletion of alloreactive T cells by veto cytotoxic T lymphocytes is mediated through extracellular signal-regulated kinase phosphorylation. Transplantation (2010) 0.78
Differential signaling of the GnRH receptor in pituitary gonadotrope cell lines and prostate cancer cell lines. Mol Cell Endocrinol (2013) 0.78
Role of non-phosphorylated activation loop residues in determining ERK2 dephosphorylation, activity, and subcellular localization. J Biol Chem (2007) 0.77
Determination of ERK activity: antiphospho-ERK antibodies, in vitro phosphorylation, and in-gel kinase assay. Methods Mol Biol (2004) 0.77
Nuclear localization of phosphorylated ERK1 and ERK2 as markers for the progression of ovarian cancer. Int J Oncol (2011) 0.77
The detection of MAPK signaling. Curr Protoc Mol Biol (2006) 0.76
A 50-kDa ERK-like protein is up-regulated by a dual altered peptide ligand that suppresses myasthenia gravis-associated responses. Proc Natl Acad Sci U S A (2006) 0.76
Ecto- and exo-protein kinases in Schistosoma mansoni: regulation of surface phosphorylation by acetylcholine and identification of the alpha subunit of CKII as a major secreted protein kinase. J Parasitol (2005) 0.76
Conjugates of gonadotropin releasing hormone (GnRH) with carminic acid: Synthesis, generation of reactive oxygen species (ROS) and biological evaluation. Bioorg Med Chem (2008) 0.76
SB203580 induces prolonged B-Raf activation and promotes neuronal differentiation upon EGF treatment of PC12 cells. Biochemistry (Mosc) (2004) 0.76
Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs. J Biol Chem (2017) 0.75
Two initiation sites of early detection of colon cancer revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of the tumor cells. Acta Histochem (2013) 0.75
c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells. J Biol Chem (2017) 0.75
Involvement of the activation loop of ERK in the detachment from cytosolic anchoring. J Biol Chem (2017) 0.75
The detection of MAPK signaling. Curr Protoc Cell Biol (2005) 0.75
Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases. J Biol Chem (2017) 0.75
Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone. J Biol Chem (2017) 0.75
Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest. J Biol Chem (2017) 0.75
ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK. J Biol Chem (2017) 0.75
Retracted Two initiation sites of early detection of colon cancer, revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of tumor cells. Int J Oncol (2011) 0.75
Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. J Biol Chem (2017) 0.75
Shmuel Shaltiel. FEBS Lett (2003) 0.75
The extra-cellular signal regulated kinases ERK1 and ERK2 segregate displaying distinct spatiotemporal characteristics in activated mast cells. Biochim Biophys Acta (2013) 0.75
The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis. J Biol Chem (2017) 0.75