Development and characterization of a small-scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings.

PubWeight™: 0.93‹?›

🔗 View Article (PMID 16807928)

Published in Biotechnol Bioeng on December 20, 2006

Authors

Stephanie Schmitmeier1, Angelika Langsch, Inka Jasmund, Augustinus Bader

Author Affiliations

1: Biotechnological-Biomedical Center, Cell Techniques and Applied Stem Cell Biology, University of Leipzig, Deutscher Platz 5, 04103 Leipzig, Germany. stephaine.schmitmeier@bbz.uni-leipzig.de

Articles citing this

A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Lab Chip (2008) 1.30

Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach. J Cell Mol Med (2010) 0.99

A microfluidic hepatic coculture platform for cell-based drug metabolism studies. Biochem Pharmacol (2009) 0.99

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human. Biochem Pharmacol (2009) 0.98

Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro. J Cell Mol Med (2009) 0.87

Encapsulation of Huh-7 cells within alginate-poly(ethylene glycol) hybrid microspheres. J Mater Sci Mater Med (2011) 0.83

Real-time in situ viability assessment in a 3D bioreactor with liver cells using resazurin assay. Cytotechnology (2012) 0.83

Isolation and Expansion of Hepatic Stem-like Cells from a Healthy Rat Liver and their Efficient Hepatic Differentiation of under Well-defined Vivo Hepatic like Microenvironment in a Multiwell Bioreactor. J Clin Exp Hepatol (2015) 0.77

Nanostructured self-assembling peptides as a defined extracellular matrix for long-term functional maintenance of primary hepatocytes in a bioartificial liver modular device. Int J Nanomedicine (2013) 0.77

Morphological and Functional Analysis of Hepatocyte Spheroids Generated on Poly-HEMA-Treated Surfaces under the Influence of Fetal Calf Serum and Nonparenchymal Cells. Biomolecules (2013) 0.76

Articles by these authors

Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study. Lancet (2012) 4.54

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. Drug Metab Dispos (2003) 2.01

Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model. Am J Sports Med (2010) 1.81

Multilineage differentiation potential of human dermal skin-derived fibroblasts. Exp Dermatol (2008) 1.44

Quantum dots for human mesenchymal stem cells labeling. A size-dependent autophagy activation. Nano Lett (2006) 1.43

Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes. Eur Biophys J (2007) 1.25

Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. J Thorac Cardiovasc Surg (2009) 1.06

New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures. Drug Metab Rev (2003) 1.04

Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system. Biomaterials (2007) 1.03

Quantitative real-time polymerase chain reaction: methodical analysis and mathematical model. J Biomol Tech (2004) 0.99

Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year. Am J Sports Med (2011) 0.99

Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs. Arthritis Res Ther (2010) 0.96

Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor. Tissue Eng Part A (2009) 0.92

Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2. J Biochem Mol Toxicol (2003) 0.92

Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS. Anal Bioanal Chem (2008) 0.92

Porcine endogenous retrovirus released by a bioartificial liver infects primary human cells. Liver Int (2009) 0.92

Evaluation of cell behaviour related to physico-chemical properties of polymeric membranes to be used in bioartificial organs. Biomaterials (2002) 0.91

Detoxification and endothelialization of glutaraldehyde-fixed bovine pericardium with titanium coating: a new technology for cardiovascular tissue engineering. Circulation (2009) 0.91

Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs. Biotechnol Bioeng (2008) 0.90

Cultivation of primary porcine hepatocytes in an OXY-HFB for use as a bioartificial liver device. Biotechnol Prog (2002) 0.89

Identification of human cells in brain xenografts and in neural co-cultures of rat by in situ hybridisation with Alu probe. J Neurosci Methods (2003) 0.89

A bioartificial liver support system using primary hepatocytes: a preclinical study in a new porcine hepatectomy model. Surgery (2004) 0.87

RGD-dependent integrins are mechanotransducers in dynamically compressed tissue-engineered cartilage constructs. J Biomech (2009) 0.87

Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro. J Cell Mol Med (2009) 0.87

Long-term maintenance of human hepatocytes in oxygen-permeable membrane bioreactor. Biomaterials (2006) 0.85

The concept of in vivo airway tissue engineering. Biomaterials (2012) 0.84

Thrombopoietin is a growth factor for rat hepatic progenitors. Eur J Gastroenterol Hepatol (2008) 0.84

Human hepatocyte functions in a crossed hollow fiber membrane bioreactor. Biomaterials (2009) 0.84

Determination of pore size distribution at the cell-hydrogel interface. J Nanobiotechnology (2011) 0.83

Determination of the decay rate constant for hepatocytes immobilized in alginate microcapsules. J Microencapsul (2010) 0.82

Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages. Expert Opin Drug Metab Toxicol (2010) 0.82

Gel entrapment culture of rat hepatocytes for investigation of tetracycline-induced toxicity. Toxicol Appl Pharmacol (2009) 0.82

Improved preclinical safety assessment using micro-BAL devices: the potential impact on human discovery and drug attrition. Drug Discov Today (2011) 0.82

A simple non-destructive method for the fixation and immunostaining of cultured cells encapsulated in alginate. Biotechnol Appl Biochem (2006) 0.82

Interspecies difference in liver-specific functions and biotransformation of testosterone of primary rat, porcine and human hepatocyte in an organotypical sandwich culture. Toxicol Lett (2009) 0.81

Preclinical characterization of primary porcine hepatocytes in a clinically relevant flat membrane bioreactor. Biomaterials (2009) 0.81

Three dimensional cultures of rat liver cells using a natural self-assembling nanoscaffold in a clinically relevant bioreactor for bioartificial liver construction. J Cell Physiol (2012) 0.81

Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes. Toxicol Lett (2006) 0.80

Formation of three-dimensional fetal myocardial tissue cultures from rat for long-term cultivation. Dev Dyn (2006) 0.80

The cardiovascular tissue-reactor: a novel device for the engineering of heart valves. Artif Organs (2006) 0.80

Vascular guidance: microstructural scaffold patterning for inductive neovascularization. Stem Cells Int (2010) 0.80

Timing and targeting of cell-based VEGF165 gene expression in ischemic tissue. J Surg Res (2008) 0.79

A multi-center study on the regenerative effects of erythropoietin in burn and scalding injuries: study protocol for a randomized controlled trial. Trials (2013) 0.79

Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin. Eur J Biochem (2002) 0.79

Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes. Fundam Clin Pharmacol (2011) 0.79

Enrichment of human beta 1 bri/alpha 6 bri/CD71 dim keratinocytes after culture in defined media. Cells Tissues Organs (2008) 0.79

Present and Future Developments in Hepatic Tissue Engineering for Liver Support Systems : State of the art and future developments of hepatic cell culture techniques for the use in liver support systems. Cytotechnology (2006) 0.79

Mesenchymal stem cells restore lung function by recruiting resident and nonresident proteins. Cell Transplant (2011) 0.79

Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes. Toxicol Appl Pharmacol (2008) 0.78

Recombinant human erythropoietin plays a pivotal role as a topical stem cell activator to reverse effects of damage to the skin in aging and trauma. Rejuvenation Res (2010) 0.78

Bioreactor developments for tissue engineering applications by the example of the bioartificial liver. Adv Biochem Eng Biotechnol (2002) 0.77

Improved functions of human hepatocytes on NH3 plasma-grafted PEEK-WC-PU membranes. Biomaterials (2009) 0.77

Nanostructured self-assembling peptides as a defined extracellular matrix for long-term functional maintenance of primary hepatocytes in a bioartificial liver modular device. Int J Nanomedicine (2013) 0.77

Tuning liver stiffness against tumours: an in vitro study using entrapped cells in tumour-like microcapsules. J Mech Behav Biomed Mater (2012) 0.77

Biodegradable and synthetic membranes for the expansion and functional differentiation of rat embryonic liver cells. Acta Biomater (2010) 0.76

Erythropoietin enhances cell proliferation and survival of human fetal neuronal progenitors in normoxia. Brain Res (2012) 0.76

Telomerase activity and hepatic functions of rat embryonic liver progenitor cell in nanoscaffold-coated model bioreactor. Mol Cell Biochem (2009) 0.76

Intracellular nucleotide pools and ratios as tools for monitoring dedifferentiation of primary porcine hepatocytes in culture. Cytotechnology (2006) 0.76

Rat embryonic liver cell expansion and differentiation on NH3 plasma-grafted PEEK-WC-PU membranes. Biomaterials (2009) 0.76

Analysis of extracellular matrix production in artificial cartilage constructs by histology, immunocytochemistry, mass spectrometry, and NMR spectroscopy. J Nanosci Nanotechnol (2006) 0.76

Isolation and Characterization of CD271⁺ Stem Cells Derived from Sheep Dermal Skin. Cells Tissues Organs (2015) 0.76

Detection of nanolevel drug metabolites in an organotypic culture of primary human hepatocytes and porcine hepatocytes with special reference to a two-compartment model. Int J Nanomedicine (2012) 0.75

Devices for stem cell isolation and delivery: current need for drug discovery and cell therapy. Expert Rev Med Devices (2014) 0.75

The influence of oxygen supply on metabolism of neural cells cultured on a gas-permeable PTFE foil. Biotechnol Prog (2010) 0.75

Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes. J Tissue Eng Regen Med (2011) 0.75

Cryopreservation of primary porcine liver cells in an organotypical sandwich model in a clinically relevant flat membrane bioreactor. Biotechnol Lett (2010) 0.75

The first self-endothelialized titanium-coated glutaraldehyde-fixed heart valve prosthesis within systemic circulation. J Thorac Cardiovasc Surg (2009) 0.75

Evaluation of liver support systems for preclinical testing by animal trials. Artif Organs (2006) 0.75

Differential regulation of CYP3A4 and CYP3A7 by dimethylsulfoxide in primary human hepatocytes. Basic Clin Pharmacol Toxicol (2004) 0.75