Published in Arthritis Res Ther on May 12, 2010
Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build. Cell Mol Life Sci (2013) 2.14
Role of NF-κB in the skeleton. Cell Res (2010) 1.45
Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments. Osteoarthritis Cartilage (2015) 0.78
Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes. Arthritis Res Ther (2015) 0.78
Low oxygen tension increased fibronectin fragment induced catabolic activities--response prevented with biomechanical signals. Arthritis Res Ther (2013) 0.76
Osteoarthritis, a disease bridging development and regeneration. Bonekey Rep (2012) 0.76
Functional significance of nerve growth factor and its receptor (TrkA) in inflammatory arthritis. Arthritis Res Ther (2010) 0.76
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res (2002) 28.38
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest (1997) 4.31
Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum (2002) 2.66
The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage (2003) 2.27
Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering. Tissue Eng (2003) 2.18
The role of mechanical loading in the onset and progression of osteoarthritis. Exerc Sport Sci Rev (2005) 2.09
The role of biomechanics and inflammation in cartilage injury and repair. Clin Orthop Relat Res (2004) 1.89
Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Arthritis Rheum (2002) 1.81
The futility of current approaches to chondroprotection. Arthritis Rheum (2007) 1.79
Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage. J Biol Chem (1991) 1.79
Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J Orthop Res (1997) 1.74
Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide. Arthritis Rheum (2006) 1.71
NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol (2005) 1.68
Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. J Biol Chem (2004) 1.56
Disease modification in osteoarthritis: are drugs the answer? Arthritis Rheum (2005) 1.49
FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage (2007) 1.40
Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression. Arthritis Rheum (2004) 1.38
Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. J Biomech (2004) 1.37
Integrin-dependent signal cascades in chondrocyte mechanotransduction. Ann Biomed Eng (2004) 1.37
Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid. Osteoarthritis Cartilage (1998) 1.32
Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines. Biochem J (1997) 1.26
Fibronectin fragments in osteoarthritic synovial fluid. J Rheumatol (1992) 1.25
Time, stress, and location dependent chondrocyte death and collagen damage in cyclically loaded articular cartilage. J Orthop Res (2003) 1.25
Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture. J Biol Chem (1992) 1.21
Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading. Scand J Med Sci Sports (2009) 1.20
A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage. Osteoarthritis Cartilage (2005) 1.18
Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments. Front Biosci (1999) 1.11
Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun (2001) 1.10
Cyclic compression of articular cartilage explants is associated with progressive consolidation and altered expression pattern of extracellular matrix proteins. Matrix Biol (1999) 1.10
Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys (2003) 1.10
Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis. Matrix Biol (2004) 1.08
Cartilage destruction by matrix degradation products. Mod Rheumatol (2006) 1.08
Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration. J Orthop Res (1999) 1.07
Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation. Matrix Biol (2006) 1.07
Cartilage chondrolysis by fibronectin fragments is associated with release of several proteinases: stromelysin plays a major role in chondrolysis. Arch Biochem Biophys (1994) 1.06
Mechanical and physicochemical regulation of the action of insulin-like growth factor-I on articular cartilage. Arch Biochem Biophys (2000) 1.04
Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods Mol Med (2004) 1.03
Matrix loss and synthesis following a single impact load on articular cartilage in vitro. Biochim Biophys Acta (1997) 1.02
Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment. J Biol Chem (2001) 1.02
Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs. Osteoarthritis Cartilage (2003) 1.02
Characterization of synovial fluid fibronectin from patients with rheumatic inflammatory diseases and healthy subjects. Arthritis Rheum (1984) 1.01
Mechanical regulation of matrix metalloproteinases. Front Biosci (2007) 1.01
Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression. Arch Biochem Biophys (1998) 1.00
Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis. Pathobiology (2004) 1.00
A critical role for collagen II in cartilage matrix degradation: collagen II induces pro-inflammatory cytokines and MMPs in primary human chondrocytes. J Orthop Res (2009) 1.00
An immunohistochemical study of fibronectin in human osteoarthritic and disease free articular cartilage. Ann Rheum Dis (1987) 1.00
Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes. J Orthop Res (2006) 0.98
Association of proteoglycan degradation with catabolic cytokine and stromelysin release from cartilage cultured with fibronectin fragments. Arch Biochem Biophys (1996) 0.94
The effects of collagen fragments on the extracellular matrix metabolism of bovine and human chondrocytes. Connect Tissue Res (2001) 0.93
Fibronectin fragments mediate matrix metalloproteinase upregulation and cartilage damage through proline rich tyrosine kinase 2, c-src, NF-kappaB and protein kinase Cdelta. Osteoarthritis Cartilage (2009) 0.91
Antisense oligonucleotides to the integrin receptor subunit alpha(5) decrease fibronectin fragment mediated cartilage chondrolysis. Osteoarthritis Cartilage (2002) 0.90
Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs. Biotechnol Bioeng (2008) 0.90
Telopeptides of type II collagen upregulate proteinases and damage cartilage but are less effective than highly active fibronectin fragments. Inflamm Res (2009) 0.89
Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression. Ann Biomed Eng (2009) 0.88
Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs. Methods Mol Biol (2011) 0.86
Fibronectin fragments alter matrix protein synthesis in cartilage tissue cultured in vitro. Arch Biochem Biophys (1993) 0.85
The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology (2003) 0.85
Fibronectin fragments elevate nitric oxide (NO) and inducible NO synthetase (iNOS) levels in bovine cartilage and iNOS inhibitors block fibronectin fragment mediated damage and promote repair. Inflamm Res (2004) 0.83
COOH-terminal heparin-binding fibronectin fragment induces nitric oxide production in rheumatoid cartilage through CD44. Rheumatology (Oxford) (2004) 0.82
Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs. Biomech Model Mechanobiol (2008) 0.82
The effect of continuously applied cyclic mechanical loading on the fibronectin metabolism of articular cartilage explants. Res Exp Med (Berl) (1999) 0.81
Type II collagen peptide release from rabbit articular cartilage. Ann N Y Acad Sci (1999) 0.81
N-telopeptide of type II collagen interacts with annexin V on human chondrocytes. Connect Tissue Res (2003) 0.81
Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study. Lancet (2012) 4.54
Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. Drug Metab Dispos (2003) 2.01
Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model. Am J Sports Med (2010) 1.81
Multilineage differentiation potential of human dermal skin-derived fibroblasts. Exp Dermatol (2008) 1.44
Quantum dots for human mesenchymal stem cells labeling. A size-dependent autophagy activation. Nano Lett (2006) 1.43
Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes. Eur Biophys J (2007) 1.25
Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. J Thorac Cardiovasc Surg (2009) 1.06
New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures. Drug Metab Rev (2003) 1.04
Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system. Biomaterials (2007) 1.03
Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year. Am J Sports Med (2011) 0.99
Quantitative real-time polymerase chain reaction: methodical analysis and mathematical model. J Biomol Tech (2004) 0.99
Development and characterization of a small-scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings. Biotechnol Bioeng (2006) 0.93
Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor. Tissue Eng Part A (2009) 0.92
Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2. J Biochem Mol Toxicol (2003) 0.92
Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS. Anal Bioanal Chem (2008) 0.92
Porcine endogenous retrovirus released by a bioartificial liver infects primary human cells. Liver Int (2009) 0.92
Evaluation of cell behaviour related to physico-chemical properties of polymeric membranes to be used in bioartificial organs. Biomaterials (2002) 0.91
Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs. Biotechnol Bioeng (2008) 0.90
Cultivation of primary porcine hepatocytes in an OXY-HFB for use as a bioartificial liver device. Biotechnol Prog (2002) 0.89
Identification of human cells in brain xenografts and in neural co-cultures of rat by in situ hybridisation with Alu probe. J Neurosci Methods (2003) 0.89
Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro. J Cell Mol Med (2009) 0.87
RGD-dependent integrins are mechanotransducers in dynamically compressed tissue-engineered cartilage constructs. J Biomech (2009) 0.87
A bioartificial liver support system using primary hepatocytes: a preclinical study in a new porcine hepatectomy model. Surgery (2004) 0.87
Long-term maintenance of human hepatocytes in oxygen-permeable membrane bioreactor. Biomaterials (2006) 0.85
The concept of in vivo airway tissue engineering. Biomaterials (2012) 0.84
Thrombopoietin is a growth factor for rat hepatic progenitors. Eur J Gastroenterol Hepatol (2008) 0.84
A single blunt impact on cartilage promotes fibronectin fragmentation and upregulates cartilage degrading stromelysin-1/matrix metalloproteinase-3 in a bovine ex vivo model. J Orthop Res (2014) 0.84
Human hepatocyte functions in a crossed hollow fiber membrane bioreactor. Biomaterials (2009) 0.84
Determination of pore size distribution at the cell-hydrogel interface. J Nanobiotechnology (2011) 0.83
Determination of the decay rate constant for hepatocytes immobilized in alginate microcapsules. J Microencapsul (2010) 0.82
Gel entrapment culture of rat hepatocytes for investigation of tetracycline-induced toxicity. Toxicol Appl Pharmacol (2009) 0.82
A simple non-destructive method for the fixation and immunostaining of cultured cells encapsulated in alginate. Biotechnol Appl Biochem (2006) 0.82
Improved preclinical safety assessment using micro-BAL devices: the potential impact on human discovery and drug attrition. Drug Discov Today (2011) 0.82
Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages. Expert Opin Drug Metab Toxicol (2010) 0.82
Three dimensional cultures of rat liver cells using a natural self-assembling nanoscaffold in a clinically relevant bioreactor for bioartificial liver construction. J Cell Physiol (2012) 0.81
Interspecies difference in liver-specific functions and biotransformation of testosterone of primary rat, porcine and human hepatocyte in an organotypical sandwich culture. Toxicol Lett (2009) 0.81
Preclinical characterization of primary porcine hepatocytes in a clinically relevant flat membrane bioreactor. Biomaterials (2009) 0.81
Vascular guidance: microstructural scaffold patterning for inductive neovascularization. Stem Cells Int (2010) 0.80
Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes. Toxicol Lett (2006) 0.80
Formation of three-dimensional fetal myocardial tissue cultures from rat for long-term cultivation. Dev Dyn (2006) 0.80
The cardiovascular tissue-reactor: a novel device for the engineering of heart valves. Artif Organs (2006) 0.80
Timing and targeting of cell-based VEGF165 gene expression in ischemic tissue. J Surg Res (2008) 0.79
Mesenchymal stem cells restore lung function by recruiting resident and nonresident proteins. Cell Transplant (2011) 0.79
Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes. Fundam Clin Pharmacol (2011) 0.79
Present and Future Developments in Hepatic Tissue Engineering for Liver Support Systems : State of the art and future developments of hepatic cell culture techniques for the use in liver support systems. Cytotechnology (2006) 0.79
A multi-center study on the regenerative effects of erythropoietin in burn and scalding injuries: study protocol for a randomized controlled trial. Trials (2013) 0.79
Enrichment of human beta 1 bri/alpha 6 bri/CD71 dim keratinocytes after culture in defined media. Cells Tissues Organs (2008) 0.79
Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin. Eur J Biochem (2002) 0.79
Recombinant human erythropoietin plays a pivotal role as a topical stem cell activator to reverse effects of damage to the skin in aging and trauma. Rejuvenation Res (2010) 0.78
Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes. Toxicol Appl Pharmacol (2008) 0.78
Improved functions of human hepatocytes on NH3 plasma-grafted PEEK-WC-PU membranes. Biomaterials (2009) 0.77
Bioreactor developments for tissue engineering applications by the example of the bioartificial liver. Adv Biochem Eng Biotechnol (2002) 0.77
Tuning liver stiffness against tumours: an in vitro study using entrapped cells in tumour-like microcapsules. J Mech Behav Biomed Mater (2012) 0.77
Nanostructured self-assembling peptides as a defined extracellular matrix for long-term functional maintenance of primary hepatocytes in a bioartificial liver modular device. Int J Nanomedicine (2013) 0.77
Intracellular nucleotide pools and ratios as tools for monitoring dedifferentiation of primary porcine hepatocytes in culture. Cytotechnology (2006) 0.76
Analysis of extracellular matrix production in artificial cartilage constructs by histology, immunocytochemistry, mass spectrometry, and NMR spectroscopy. J Nanosci Nanotechnol (2006) 0.76
Rat embryonic liver cell expansion and differentiation on NH3 plasma-grafted PEEK-WC-PU membranes. Biomaterials (2009) 0.76
Biodegradable and synthetic membranes for the expansion and functional differentiation of rat embryonic liver cells. Acta Biomater (2010) 0.76
Isolation and Characterization of CD271⁺ Stem Cells Derived from Sheep Dermal Skin. Cells Tissues Organs (2015) 0.76
Erythropoietin enhances cell proliferation and survival of human fetal neuronal progenitors in normoxia. Brain Res (2012) 0.76
Telomerase activity and hepatic functions of rat embryonic liver progenitor cell in nanoscaffold-coated model bioreactor. Mol Cell Biochem (2009) 0.76
Detection of nanolevel drug metabolites in an organotypic culture of primary human hepatocytes and porcine hepatocytes with special reference to a two-compartment model. Int J Nanomedicine (2012) 0.75
The influence of oxygen supply on metabolism of neural cells cultured on a gas-permeable PTFE foil. Biotechnol Prog (2010) 0.75
Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes. J Tissue Eng Regen Med (2011) 0.75
Evaluation of liver support systems for preclinical testing by animal trials. Artif Organs (2006) 0.75
Differential regulation of CYP3A4 and CYP3A7 by dimethylsulfoxide in primary human hepatocytes. Basic Clin Pharmacol Toxicol (2004) 0.75
Cryopreservation of primary porcine liver cells in an organotypical sandwich model in a clinically relevant flat membrane bioreactor. Biotechnol Lett (2010) 0.75
Devices for stem cell isolation and delivery: current need for drug discovery and cell therapy. Expert Rev Med Devices (2014) 0.75