Published in Intensive Care Med on June 30, 2006
Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis. Crit Care (2011) 1.23
Soluble CD40L (CD154) is increased in patients with shock. Inflamm Res (2010) 0.99
Platelets and infections - complex interactions with bacteria. Front Immunol (2015) 0.90
Protective effect of resin adsorption on septic plasma-induced tubular injury. Crit Care (2010) 0.87
Lipopolysaccharide induces sCD40L release through human platelets TLR4, but not TLR2 and TLR9. Intensive Care Med (2006) 0.86
Microvascular thrombosis and CD40/CD40L signaling. J Thromb Haemost (2011) 0.81
Metalloproteinases regulate CD40L shedding from platelets and pulmonary recruitment of neutrophils in abdominal sepsis. Inflamm Res (2012) 0.79
Rac1 regulates platelet shedding of CD40L in abdominal sepsis. Lab Invest (2014) 0.77
Role of platelet TLR4 expression in pathogensis of septic thrombocytopenia. World J Emerg Med (2011) 0.75
Mortality after fluid bolus in African children with severe infection. N Engl J Med (2011) 10.99
Transfusion strategies for patients in pediatric intensive care units. N Engl J Med (2007) 7.21
Clinical recognition of meningococcal disease in children and adolescents. Lancet (2006) 6.27
The likelihood of an indeterminate test result from a whole-blood interferon-gamma release assay for the diagnosis of Mycobacterium tuberculosis infection in children correlates with age and immune status. Pediatr Infect Dis J (2009) 3.86
Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis. N Engl J Med (2016) 3.59
Hyperventilation in severe diabetic ketoacidosis. Pediatr Crit Care Med (2005) 3.50
Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies. Lancet (2004) 2.90
The role of healthcare delivery in the outcome of meningococcal disease in children: case-control study of fatal and non-fatal cases. BMJ (2005) 2.52
A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. PLoS Genet (2009) 2.45
Response to volume resuscitation in children with severe malaria. Pediatr Crit Care Med (2003) 2.39
Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries. Medicine (Baltimore) (2010) 2.33
Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet (2010) 2.32
The unique contribution of manual chest compression-vibrations to airflow during physiotherapy in sedated, fully ventilated children. Pediatr Crit Care Med (2012) 2.31
CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res (2003) 2.27
Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis (2008) 2.20
Diagnosis of childhood tuberculosis and host RNA expression in Africa. N Engl J Med (2014) 2.12
A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chem Biol (2011) 2.07
Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma. J Clin Invest (2005) 2.06
Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One (2009) 2.03
WHO guidelines on fluid resuscitation in children: missing the FEAST data. BMJ (2014) 2.00
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet (2011) 1.97
Endothelial dysfunction in childhood infection. Circulation (2005) 1.97
Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study. PLoS Med (2013) 1.91
Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle. Cell Cycle (2009) 1.88
Increased incidence and severity of the systemic inflammatory response syndrome in patients deficient in mannose-binding lectin. Intensive Care Med (2004) 1.86
Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans. Clin Infect Dis (2012) 1.82
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A (2003) 1.78
ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans. Mol Ther (2012) 1.76
Coagulation abnormalities in dengue hemorrhagic Fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome. Clin Infect Dis (2002) 1.73
Dissecting interferon-induced transcriptional programs in human peripheral blood cells. PLoS One (2010) 1.73
Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing. Am J Respir Crit Care Med (2006) 1.72
Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study. BMJ (2006) 1.69
Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates. Development (2006) 1.68
Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care. Crit Care Med (2002) 1.68
H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration. Development (2007) 1.67
Role of membrane potential in the regulation of cell proliferation and differentiation. Stem Cell Rev (2009) 1.66
Genomewide analysis of the host response to malaria in Kenyan children. J Infect Dis (2005) 1.66
Randomized trial of group interventions to reduce HIV/STD risk and change theoretical mediators among detained adolescents. J Consult Clin Psychol (2009) 1.65
Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. Dev Biol (2009) 1.62
Role of functional plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism in susceptibility, severity, and outcome of meningococcal disease in Caucasian children. Crit Care Med (2003) 1.61
Size and charge characteristics of the protein leak in dengue shock syndrome. J Infect Dis (2004) 1.60
Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis. Pediatrics (2004) 1.60
Open, aware, and active: contextual approaches as an emerging trend in the behavioral and cognitive therapies. Annu Rev Clin Psychol (2011) 1.59
Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia. Science (2013) 1.57
Intestinal injury and endotoxemia in children undergoing surgery for congenital heart disease. Am J Respir Crit Care Med (2011) 1.57
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med (2013) 1.57
Emergency management of meningococcal disease: eight years on. Arch Dis Child (2007) 1.57
Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet (2004) 1.56
Impact of rapid leukodepletion on the outcome of severe clinical pertussis in young infants. Pediatrics (2010) 1.55
Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial. PLoS Clin Trials (2006) 1.55
Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation (2005) 1.54
Investigation of childhood central nervous system vasculitis: magnetic resonance angiography versus catheter cerebral angiography. Dev Med Child Neurol (2010) 1.53
Swine-origin influenza virus H1N1, seasonal influenza virus, and critical illness in children. Lancet (2009) 1.53
Apoptosis is required during early stages of tail regeneration in Xenopus laevis. Dev Biol (2006) 1.52
Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus. J Immunol (2002) 1.52
Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease. Clin Infect Dis (2006) 1.51
Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med (2002) 1.50
Endothelial response to childhood infection: the role of mannose-binding lectin (MBL). Atherosclerosis (2009) 1.48
Endothelial injury in childhood stroke with cerebral arteriopathy: a cross-sectional study. Neurology (2012) 1.47
Transforming growth factor-beta signaling pathway in patients with Kawasaki disease. Circ Cardiovasc Genet (2010) 1.45
Low-molecular-weight polyethylene glycol improves survival in experimental sepsis. Crit Care Med (2010) 1.45
Weight-for-age distribution and case-mix adjusted outcomes of 14,307 paediatric intensive care admissions. Intensive Care Med (2014) 1.44
Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. Clin Infect Dis (2005) 1.44
The effect of atropine on rhythm and conduction disturbances during 322 critical care intubations. Pediatr Crit Care Med (2013) 1.44
Use of recombinant tissue plasminogen activator in children with meningococcal purpura fulminans: a retrospective study. Crit Care Med (2004) 1.42
Empirical antibiotics for suspected early neonatal sepsis. Arch Dis Child Fetal Neonatal Ed (2011) 1.42
Intracranial pressure and cerebral perfusion pressure responses to head elevation changes in pediatric traumatic brain injury. Pediatr Crit Care Med (2012) 1.42
Transcriptional instability during evolving sepsis may limit biomarker based risk stratification. PLoS One (2013) 1.41
Genetic variability in complement activation modulates the systemic inflammatory response syndrome in children. Pediatr Crit Care Med (2010) 1.41
Suboptimal patterns of provider initiated HIV testing and counselling, antiretroviral therapy eligibility assessment and referral in primary health clinic attendees in Blantyre, Malawi. Trop Med Int Health (2012) 1.41
Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. Curr Biol (2005) 1.40
Changes in the interleukin-6/soluble interleukin-6 receptor axis in meningococcal septic shock. Crit Care Med (2005) 1.40
Reconstitution of antimycobacterial immune responses in HIV-infected children receiving HAART. AIDS (2006) 1.40
A Novel Method to Identify the Start and End of the Winter Surge in Demand for Pediatric Intensive Care in Real Time. Pediatr Crit Care Med (2015) 1.38
Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells. PLoS One (2008) 1.37
Interleukin-10 and its role in clinical immunoparalysis following pediatric cardiac surgery. Crit Care Med (2006) 1.35
Gene regulatory networks. Proc Natl Acad Sci U S A (2005) 1.35
Gamma interferon-based immunodiagnosis of tuberculosis: comparison between whole-blood and enzyme-linked immunospot methods. J Clin Microbiol (2004) 1.32
Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest (2010) 1.32
Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration. Dev Biol (2005) 1.30
Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection. J Biol Chem (2006) 1.30
Declining serotype coverage of new pneumococcal conjugate vaccines relating to the carriage of Streptococcus pneumoniae in young children. Vaccine (2011) 1.28
Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells. Proc Natl Acad Sci U S A (2005) 1.28
Putative vaccine antigens from Neisseria meningitidis recognized by serum antibodies of young children convalescing after meningococcal disease. J Infect Dis (2004) 1.27
Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock (2006) 1.26
Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis. Development (2011) 1.23
Induction of vertebrate regeneration by a transient sodium current. J Neurosci (2010) 1.23
smedinx-11 is a planarian stem cell gap junction gene required for regeneration and homeostasis. Development (2007) 1.23
Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion. Br J Haematol (2005) 1.23
Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways. Hum Mol Genet (2011) 1.22
Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.22
Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients. Scand J Infect Dis (2006) 1.20
Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children. Antimicrob Agents Chemother (2010) 1.18