Published in Crit Care Med on February 01, 2010
Peripheral neural detection of danger-associated and pathogen-associated molecular patterns. Crit Care Med (2013) 0.79
Therapeutic interventions in sepsis: current and anticipated pharmacological agents. Br J Pharmacol (2014) 0.78
Polymer therapeutics move into the sepsis space. Crit Care Med (2010) 0.75
Polyethylene glycol restores axonal conduction after corpus callosum transection. Neural Regen Res (2017) 0.75
Hydrocortisone therapy for patients with septic shock. N Engl J Med (2008) 15.85
Trial of early, goal-directed resuscitation for septic shock. N Engl J Med (2015) 8.24
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA (2013) 7.23
Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet (2005) 6.33
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med (2008) 5.30
Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study. Lancet (2005) 5.01
Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet (2002) 4.42
The likelihood of an indeterminate test result from a whole-blood interferon-gamma release assay for the diagnosis of Mycobacterium tuberculosis infection in children correlates with age and immune status. Pediatr Infect Dis J (2009) 3.86
Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. Eur Heart J (2005) 3.50
The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med (2009) 3.30
The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases. Hypertension (2012) 3.07
Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med (2007) 2.79
Statin use and mortality in the bacteremic critically ill patient. Crit Care Med (2006) 2.57
Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med (2010) 2.48
The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis. Crit Care Med (2007) 2.45
Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections. Crit Care Med (2015) 2.37
Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients. Intensive Care Med (2012) 2.33
Mechanisms of sepsis-induced organ dysfunction. Crit Care Med (2007) 2.30
CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res (2003) 2.27
The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals. Crit Care Med (2011) 2.23
Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit. Crit Care (2005) 2.03
Understanding the benefits and harms of oxygen therapy. Intensive Care Med (2015) 2.00
Terlipressin for norepinephrine-resistant septic shock. Lancet (2002) 1.99
Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting? Crit Care Med (2009) 1.99
Endothelial dysfunction in childhood infection. Circulation (2005) 1.97
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol Regul Integr Comp Physiol (2003) 1.95
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
Increased incidence and severity of the systemic inflammatory response syndrome in patients deficient in mannose-binding lectin. Intensive Care Med (2004) 1.86
Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med (2005) 1.83
Connexin hemichannel-mediated CO2-dependent release of ATP in the medulla oblongata contributes to central respiratory chemosensitivity. J Physiol (2010) 1.81
Microvascular effects of heart rate control with esmolol in patients with septic shock: a pilot study. Crit Care Med (2013) 1.81
Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms. Exp Physiol (2012) 1.80
Variability in management of early severe sepsis. Emerg Med J (2010) 1.76
Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices. Intensive Care Med (2009) 1.76
Adrenal function in sepsis: the retrospective Corticus cohort study. Crit Care Med (2007) 1.74
Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages. Am J Physiol Regul Integr Comp Physiol (2004) 1.74
H1N1 pneumonitis treated with intravenous zanamivir. Lancet (2009) 1.73
A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing. J Neurosci (2008) 1.69
Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat. J Physiol (2012) 1.69
Endothelial NO synthase activity in nucleus tractus solitarii contributes to hypertension in spontaneously hypertensive rats. Hypertension (2006) 1.68
Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care. Crit Care Med (2002) 1.68
Platelet and soluble CD40L in meningococcal sepsis. Intensive Care Med (2006) 1.67
Potential metabolic consequences of statins in sepsis. Crit Care Med (2011) 1.64
Clinical review: Update on hemodynamic monitoring--a consensus of 16. Crit Care (2011) 1.62
Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration. J Neurosci (2010) 1.62
Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci (2003) 1.59
Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis. Crit Care Med (2007) 1.58
Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation (2005) 1.54
Temporal changes in tissue cardiorespiratory function during faecal peritonitis. Intensive Care Med (2011) 1.54
Investigation of childhood central nervous system vasculitis: magnetic resonance angiography versus catheter cerebral angiography. Dev Med Child Neurol (2010) 1.53
Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus. J Immunol (2002) 1.52
Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. Shock (2011) 1.52
Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease. Clin Infect Dis (2006) 1.51
Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis. Crit Care Med (2007) 1.50
Post hoc insights from PAC-Man--the U.K. pulmonary artery catheter trial. Crit Care Med (2008) 1.48
The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage. Intensive Care Med (2009) 1.48
Endothelial response to childhood infection: the role of mannose-binding lectin (MBL). Atherosclerosis (2009) 1.48
Endothelial injury in childhood stroke with cerebral arteriopathy: a cross-sectional study. Neurology (2012) 1.47
Critical care: advances and future perspectives. Lancet (2010) 1.44
Intensive care and emergency medicine: progress over the past 25 years. Chest (2006) 1.43
The FTc is not an accurate marker of left ventricular preload. Intensive Care Med (2006) 1.42
Genetic variability in complement activation modulates the systemic inflammatory response syndrome in children. Pediatr Crit Care Med (2010) 1.41
Multicenter, randomized, placebo-controlled phase III study of pyridoxalated hemoglobin polyoxyethylene in distributive shock (PHOENIX). Crit Care Med (2015) 1.40
In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent. BMC Microbiol (2009) 1.40
Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis. Crit Care Med (2012) 1.38
The validity of trans-esophageal Doppler ultrasonography as a measure of cardiac output in critically ill adults. Intensive Care Med (2004) 1.37
Interleukin-10 and its role in clinical immunoparalysis following pediatric cardiac surgery. Crit Care Med (2006) 1.35
Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability. Circulation (2005) 1.33
Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection. J Biol Chem (2006) 1.30
Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure. Crit Care (2006) 1.30
Mitochondrial Dysfunction in Sepsis. Curr Infect Dis Rep (2003) 1.30
Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats. Crit Care Med (2010) 1.30
Cellular energetic metabolism in sepsis: the need for a systems approach. Biochim Biophys Acta (2008) 1.28
Vasopressin: mechanisms of action on the vasculature in health and in septic shock. Crit Care Med (2007) 1.28
Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. J Endocrinol (2009) 1.27
Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med (2012) 1.27
TREM-1 promotes survival during septic shock in mice. Eur J Immunol (2007) 1.27
Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock (2006) 1.26
Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones. Cardiovasc Res (2012) 1.23
Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication. Crit Care (2010) 1.22
Contribution of p16(INK4a) to replicative senescence of human fibroblasts. Exp Cell Res (2004) 1.22
Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children. Antimicrob Agents Chemother (2010) 1.18
British HIV Association and British Infection Association guidelines for the treatment of opportunistic infection in HIV-seropositive individuals 2011. HIV Med (2011) 1.17
Intestinal innate immunity to Campylobacter jejuni results in induction of bactericidal human beta-defensins 2 and 3. Infect Immun (2005) 1.16
The heart in sepsis: from basic mechanisms to clinical management. Curr Vasc Pharmacol (2013) 1.16
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med (2017) 1.15
Mannose-binding lectin binds to two major outer membrane proteins, opacity protein and porin, of Neisseria meningitidis. J Immunol (2004) 1.13
Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles. J Am Soc Nephrol (2011) 1.11
A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni. Cell Microbiol (2007) 1.11
Vagal Modulation of Atrial Fibrillation. J Am Coll Cardiol (2015) 1.07
Tissue oxygen and hemodynamics in renal medulla, cortex, and corticomedullary junction during hemorrhage-reperfusion. Am J Physiol Renal Physiol (2006) 1.07
Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata. Cardiovasc Res (2011) 1.06
Hazard Ratios and Hazardous Carbapenemase-Producing Enterobacteriaceae. Crit Care Med (2015) 1.06
Signalling properties of inorganic polyphosphate in the mammalian brain. Nat Commun (2013) 1.05
Hyperglycemia in critical illness: a review. J Diabetes Sci Technol (2009) 1.04
Rapid adenosine release in the nucleus tractus solitarii during defence response in rats: real-time measurement in vivo. J Physiol (2002) 1.04
The nature of colitis in chronic granulomatous disease. J Pediatr Gastroenterol Nutr (2003) 1.04