Myotubularin phosphatases: policing 3-phosphoinositides.

Endosome maturation. EMBO J (2011) 5.22

Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21

Centronuclear (myotubular) myopathy. Orphanet J Rare Dis (2008) 2.53

Signaling by the phosphoinositide 3-kinase family in immune cells. Annu Rev Immunol (2013) 2.09

Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy. EMBO J (2009) 2.07

PIKfyve: Partners, significance, debates and paradoxes. Cell Biol Int (2008) 1.87

Host cell factors and functions involved in vesicular stomatitis virus entry. J Virol (2008) 1.83

T-tubule disorganization and defective excitation-contraction coupling in muscle fibers lacking myotubularin lipid phosphatase. Proc Natl Acad Sci U S A (2009) 1.83

The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. J Cell Biol (2007) 1.67

Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut (2012) 1.66

MTM1 mutation associated with X-linked myotubular myopathy in Labrador Retrievers. Proc Natl Acad Sci U S A (2010) 1.64

Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. PLoS Biol (2012) 1.57

Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology (Bethesda) (2009) 1.56

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy. Ann Transl Med (2015) 1.45

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis. Hum Mol Genet (2008) 1.44

Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy. Sci Transl Med (2014) 1.32

Evolutionary radiation pattern of novel protein phosphatases revealed by analysis of protein data from the completely sequenced genomes of humans, green algae, and higher plants. Plant Physiol (2007) 1.30

Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle. J Clin Invest (2010) 1.21

Phosphoinositides and vesicular membrane traffic. Biochim Biophys Acta (2012) 1.14

The role of PI3P phosphatases in the regulation of autophagy. FEBS Lett (2010) 1.13

Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions. J Cell Biol (2010) 1.09

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis. Aging (Albany NY) (2010) 1.08

Structural basis for the glucan phosphatase activity of Starch Excess4. Proc Natl Acad Sci U S A (2010) 1.08

Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet (2009) 1.07

Zebrafish MTMR14 is required for excitation-contraction coupling, developmental motor function and the regulation of autophagy. Hum Mol Genet (2010) 1.07

Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res (2010) 1.05

Phosphoinositide phosphatases in a network of signalling reactions. Pflugers Arch (2007) 1.03

Structural insights into glucan phosphatase dynamics using amide hydrogen-deuterium exchange mass spectrometry. Biochemistry (2009) 1.00

Conservation of the glucan phosphatase laforin is linked to rates of molecular evolution and the glucan metabolism of the organism. BMC Evol Biol (2009) 0.99

Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice. Proc Natl Acad Sci U S A (2008) 0.98

Defective autophagy and mTORC1 signaling in myotubularin null mice. Mol Cell Biol (2012) 0.95

Pathogenic mechanisms in centronuclear myopathies. Front Aging Neurosci (2014) 0.94

Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice. PLoS Genet (2012) 0.93

Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate. J Biol Chem (2011) 0.92

Phosphoinositide phosphatases and disease. J Lipid Res (2008) 0.92

Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models. Dis Model Mech (2012) 0.92

The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. Biochem J (2010) 0.91

Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. Proc Natl Acad Sci U S A (2012) 0.91

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation. Front Physiol (2014) 0.90

The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling. J Cell Mol Med (2011) 0.89

The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought. Plant Signal Behav (2009) 0.89

Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Proc Natl Acad Sci U S A (2014) 0.89

Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. J Biol Chem (2012) 0.89

The myotubularin family of lipid phosphatases in disease and in spermatogenesis. Biochem J (2011) 0.88

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Mol Biol Cell (2012) 0.87

Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87

Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and protein kinase B AKT signaling. Proc Natl Acad Sci U S A (2013) 0.87

Gene expression in blood of subjects with Duchenne muscular dystrophy. Neurogenetics (2008) 0.86

Expanding the MTM1 mutational spectrum: novel variants including the first multi-exonic duplication and development of a locus-specific database. Eur J Hum Genet (2012) 0.85

Clinical phenotype of X-linked myotubular myopathy in Labrador Retriever puppies. J Vet Intern Med (2015) 0.83

The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. Biochem J (2009) 0.83

Function of Arabidopsis hexokinase-like1 as a negative regulator of plant growth. J Exp Bot (2009) 0.82

Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans. J Cell Biochem (2008) 0.82

Charcot-Marie-Tooth disease and intracellular traffic. Prog Neurobiol (2012) 0.81

Functional diversity of voltage-sensing phosphatases in two urodele amphibians. Physiol Rep (2014) 0.81

Murine Fig4 is dispensable for muscle development but required for muscle function. Skelet Muscle (2013) 0.81

The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death. Adv Biol Regul (2012) 0.80

Gene therapy in myotubular myopathy: promising progress and future directions. Ann Transl Med (2015) 0.79

MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation. Proc Natl Acad Sci U S A (2015) 0.79

The CMT4B disease-causing phosphatases Mtmr2 and Mtmr13 localize to the Schwann cell cytoplasm and endomembrane compartments, where they depend upon each other to achieve wild-type levels of protein expression. Hum Mol Genet (2013) 0.79

Gene therapy for inherited muscle diseases: where genetics meets rehabilitation medicine. Am J Phys Med Rehabil (2014) 0.78

Bell-shaped and ultrasensitive dose-response in phosphorylation-dephosphorylation cycles: the role of kinase-phosphatase complex formation. BMC Syst Biol (2012) 0.78

AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects. Autophagy (2016) 0.78

A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis. BMC Genomics (2010) 0.78

The yeast vacuolar ABC transporter Ybt1p regulates membrane fusion through Ca2+ transport modulation. Biochem J (2012) 0.77

Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans. BMC Cell Biol (2012) 0.77

Novel findings associated with MTM1 suggest a higher number of female symptomatic carriers. Neuromuscul Disord (2016) 0.77

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission. Mol Cell Proteomics (2015) 0.77

Biochemistry and structure of phosphoinositide phosphatases. BMB Rep (2013) 0.77

Metabolism and roles of phosphatidylinositol 3-phosphate in pollen development and pollen tube growth in Arabidopsis. Plant Signal Behav (2012) 0.77

Crystallization and preliminary X-ray crystallographic analysis of human myotubularin-related protein 1. Acta Crystallogr F Struct Biol Commun (2015) 0.76

The role of autophagy in Crohn's disease. Cells (2012) 0.76

A phylogenetic survey of myotubularin genes of eukaryotes: distribution, protein structure, evolution, and gene expression. BMC Evol Biol (2010) 0.76

MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. PLoS One (2014) 0.76

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep (2017) 0.75

Crystallization and preliminary X-ray crystallographic analysis of the PH-GRAM domain of human MTMR4. Acta Crystallogr F Struct Biol Commun (2014) 0.75

Expression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3. Acta Crystallogr F Struct Biol Commun (2014) 0.75

Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity. PLoS One (2016) 0.75

MTMR4 Is Required for the Stability of the Salmonella-Containing Vacuole. Front Cell Infect Microbiol (2016) 0.75

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99

Cleavage of Arabidopsis PBS1 by a bacterial type III effector. Science (2003) 3.81

Identification of a bacterial type III effector family with G protein mimicry functions. Cell (2006) 3.47

Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A (2008) 3.20

Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector. Science (2002) 3.10

Sorting out the cellular functions of sorting nexins. Nat Rev Mol Cell Biol (2002) 2.93

Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A (2003) 2.92

Widespread dynamic DNA methylation in response to biotic stress. Proc Natl Acad Sci U S A (2012) 2.90

A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell (2002) 2.75

The fic domain: regulation of cell signaling by adenylylation. Mol Cell (2009) 2.73

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Science (2012) 2.55

Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell (2005) 2.36

MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A (2007) 2.28

Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation. Cell Host Microbe (2008) 2.21

MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A (2007) 2.19

Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15

Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem (2006) 2.04

Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab (2011) 1.97

Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci U S A (2005) 1.90

A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2008) 1.85

Mitochondrial modulation: reversible phosphorylation takes center stage? Trends Biochem Sci (2005) 1.81

A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Proc Natl Acad Sci U S A (2007) 1.80

Secreted protein kinases. Trends Biochem Sci (2012) 1.79

A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen. J Biol Chem (2001) 1.78

The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem (2007) 1.72

Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell (2006) 1.71

The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. J Cell Biol (2007) 1.67

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem (2001) 1.66

The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66

PTEN. Annu Rev Biochem (2014) 1.62

PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol (2002) 1.62

The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases. J Biol Chem (2003) 1.61

Functions of the Yersinia effector proteins in inhibiting host immune responses. Curr Opin Microbiol (2005) 1.57

Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). J Biol Chem (2007) 1.57

Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. Proc Natl Acad Sci U S A (2003) 1.54

Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. Proc Natl Acad Sci U S A (2003) 1.53

Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. J Biol Chem (2009) 1.50

Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci (2009) 1.50

Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome. Mol Cell (2003) 1.46

Structural basis of Fic-mediated adenylylation. Nat Struct Mol Biol (2010) 1.44

Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal Biochem (2009) 1.38

The crystal structure of Pseudomonas avirulence protein AvrPphB: a papain-like fold with a distinct substrate-binding site. Proc Natl Acad Sci U S A (2003) 1.38

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. Proc Natl Acad Sci U S A (2014) 1.35

Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease. J Biol Chem (2001) 1.35

Interactions of bacterial effector proteins with host proteins. Curr Opin Immunol (2007) 1.33

A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev (2007) 1.32

Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci U S A (2006) 1.30

Identification of a molecular target for the Yersinia protein kinase A. Mol Cell (2007) 1.29

A PTEN-like phosphatase with a novel substrate specificity. J Biol Chem (2004) 1.26

Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem (2010) 1.25

Yersinia effectors target mammalian signalling pathways. Cell Microbiol (2002) 1.23

Voltage-sensing phosphatase: its molecular relationship with PTEN. Physiology (Bethesda) (2011) 1.20

The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease. J Biol Chem (2005) 1.18

Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem (2011) 1.17

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. J Biol Chem (2011) 1.15

A family of bacterial cysteine protease type III effectors utilizes acylation-dependent and -independent strategies to localize to plasma membranes. J Biol Chem (2009) 1.12

UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Proc Natl Acad Sci U S A (2011) 1.09

The structure and regulation of myotubularin phosphatases. Curr Opin Struct Biol (2005) 1.08

Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem (2012) 1.08

PTEN and myotubularins: families of phosphoinositide phosphatases. Methods Enzymol (2003) 1.07

The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production. Proc Natl Acad Sci U S A (2002) 1.04

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med (2013) 1.04

Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice. Proc Natl Acad Sci U S A (2008) 0.98

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc Natl Acad Sci U S A (2011) 0.98

Cloning, expression, and characterization of the Galalpha 1,3Gal high affinity lectin from the mushroom Marasmius oreades. J Biol Chem (2002) 0.98

Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem (2008) 0.97

Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1. J Mol Biol (2011) 0.97

Crystal structure of the Golgi casein kinase. Proc Natl Acad Sci U S A (2013) 0.97

Phosphoinositide phosphatases: emerging roles as voltage sensors? Mol Interv (2005) 0.95

Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci (2010) 0.94

A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem (2003) 0.92

Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J Pharmacol Exp Ther (2010) 0.92

Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem (2001) 0.91

Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Genes Dev (2014) 0.86

The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers. Mol Cancer (2006) 0.86

Chapter 13 Localization and function of the 2Fe-2S outer mitochondrial membrane protein mitoNEET. Methods Enzymol (2009) 0.85

Distinguishing mitochondrial inner membrane orientation of dual specific phosphatase 18 and 21. Methods Enzymol (2009) 0.85

YopT is a cysteine protease cleaving Rho family GTPases. Adv Exp Med Biol (2003) 0.84

Analysis of Rho-GTPase mimicry by a family of bacterial type III effector proteins. Methods Enzymol (2008) 0.83

Phosphorylation of substrates destined for secretion by the Fam20 kinases. Biochem Soc Trans (2013) 0.83

Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. Biochem J (2002) 0.83

Microbiology. Bacteria seize control by acetylating host proteins. Science (2006) 0.82

Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. FEBS Lett (2005) 0.82

Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN. FEBS Lett (2004) 0.82

The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron (2013) 0.81

Assaying phosphoinositide phosphatases. Methods Mol Biol (2004) 0.80

Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1. Plant Physiol (2013) 0.80

Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. Mol Cell Proteomics (2014) 0.78

RNA interference in cultured Drosophila cells. Curr Protoc Mol Biol (2004) 0.78

Subversion of myosin function by E. coli. Dev Cell (2008) 0.77

Response to Wang et al.: Secreted protein kinases? Trends Biochem Sci (2013) 0.77

Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica. J Biol Chem (2013) 0.76

Glycogen synthase: an old enzyme with a new trick. Cell Metab (2011) 0.75