Canonical Wnt signaling in osteoblasts is required for osteoclast differentiation.

Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo. Blood (2007) 1.75

Msx2 exerts bone anabolism via canonical Wnt signaling. J Biol Chem (2008) 1.43

SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling. J Biol Chem (2008) 1.34

Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling. PLoS One (2008) 1.20

Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr (2009) 1.11

WNT/beta-catenin signaling is involved in regulation of osteoclast differentiation by human immunodeficiency virus protease inhibitor ritonavir: relationship to human immunodeficiency virus-linked bone mineral loss. Am J Pathol (2008) 1.09

In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma. Bone (2013) 0.94

Noncanonical Wnt signaling promotes osteoclast differentiation and is facilitated by the human immunodeficiency virus protease inhibitor ritonavir. Biochem Biophys Res Commun (2011) 0.90

Effects of HIV infection and antiretroviral therapy with ritonavir on induction of osteoclast-like cells in postmenopausal women. Osteoporos Int (2010) 0.89

The role of midkine in skeletal remodelling. Br J Pharmacol (2014) 0.84

SPARC functions as an inhibitor of adipogenesis. J Cell Commun Signal (2009) 0.82

Secondary osteoporosis in collagen-induced arthritis rats. J Bone Miner Metab (2015) 0.78

Teriparatide and denosumab combination therapy and skeletal metabolism. Osteoporos Int (2016) 0.76

Alcohol-related deficient fracture healing is associated with activation of FoxO transcription factors in mice. J Orthop Res (2016) 0.75

Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations. Biochim Biophys Acta (2015) 0.75

Endocrine regulation of energy metabolism by the skeleton. Cell (2007) 10.41

p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64

Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature (2005) 6.43

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20

Leptin regulates bone formation via the sympathetic nervous system. Cell (2002) 5.95

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell (2004) 5.80

A twist code determines the onset of osteoblast differentiation. Dev Cell (2004) 5.40

ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell (2004) 5.27

Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell (2010) 5.08

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03

Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A (2008) 4.77

SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell (2006) 4.01

The molecular clock mediates leptin-regulated bone formation. Cell (2005) 3.88

WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 3.44

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev (2005) 3.38

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell (2009) 3.28

Endocrine regulation of male fertility by the skeleton. Cell (2011) 3.20

Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol (2004) 2.90

ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest (2009) 2.46

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis. Nat Med (2010) 2.32

Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum (2006) 2.19

PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development (2002) 2.19

miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol (2012) 2.15

The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14

Maternal and offspring pools of osteocalcin influence brain development and functions. Cell (2013) 2.00

Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell (2006) 1.95

Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem (2005) 1.91

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol (2005) 1.86

An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice. J Bone Miner Res (2013) 1.85

Efficacy of serotonin inhibition in mouse models of bone loss. J Bone Miner Res (2011) 1.84

Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest (2013) 1.81

Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol (2004) 1.74

The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest (2009) 1.73

The osteoblast: an insulin target cell controlling glucose homeostasis. J Bone Miner Res (2011) 1.70

Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ. Mol Cell Biol (2003) 1.69

Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a. Diabetes (2013) 1.68

Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med (2002) 1.67

A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms. Mol Cell Endocrinol (2009) 1.64

In vivo analysis of Wnt signaling in bone. Endocrinology (2007) 1.61

Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J Biol Chem (2001) 1.57

ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells. J Biol Chem (2004) 1.55

Polymorphisms in the osteopontin promoter affect its transcriptional activity. Physiol Genomics (2004) 1.54

Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background. J Clin Invest (2003) 1.53

Reciprocal regulation of bone and energy metabolism. Trends Endocrinol Metab (2008) 1.52

Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev (2006) 1.52

Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev (2003) 1.51

Anabolic action of parathyroid hormone regulated by the β2-adrenergic receptor. Proc Natl Acad Sci U S A (2012) 1.50

PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Dev Biol (2006) 1.50

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation. J Cell Biol (2010) 1.49

Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification. Genes Dev (2008) 1.46

Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell (2005) 1.44

MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLoS Genet (2013) 1.42

Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblasts. Clin Cancer Res (2003) 1.42

Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo. Proc Natl Acad Sci U S A (2008) 1.34

Transcription factors in bone: developmental and pathological aspects. Trends Mol Med (2002) 1.30

An ELISA-based method to quantify osteocalcin carboxylation in mice. Biochem Biophys Res Commun (2010) 1.29

Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system. J Biol Chem (2005) 1.27

Molecular bases of the sympathetic regulation of bone mass. Bone (2008) 1.21

Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2/Cbfal. J Bone Miner Res (2002) 1.21

Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab (2013) 1.19

Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone. J Biol Chem (2005) 1.19

Regulation of bone formation and vision by LRP5. N Engl J Med (2002) 1.19

Optical imaging of hydroxyapatite in the calcified vasculature of transgenic animals. Arterioscler Thromb Vasc Biol (2006) 1.17

Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual. J Exp Med (2011) 1.16

Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP gene. Connect Tissue Res (2002) 1.15

Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway. Curr Top Dev Biol (2006) 1.15

A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts. Genes Dev (2013) 1.15

Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). J Biol Chem (2012) 1.14

Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest (2014) 1.13

An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci (2009) 1.13

CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes Dev (2010) 1.09

The two faces of serotonin in bone biology. J Cell Biol (2010) 1.05

Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation. Mol Cell Biol (2009) 1.05

Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency. Endocrinology (2006) 1.05

Osteopontin upregulation and polymerization by transglutaminase 2 in calcified arteries of Matrix Gla protein-deficient mice. J Histochem Cytochem (2006) 1.04

Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab (2012) 1.02

An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoter. J Bone Miner Res (2005) 1.02

Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications. J Exp Med (2010) 1.01

Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab (2013) 1.00

Sympathetic control of bone mass regulated by osteopontin. Proc Natl Acad Sci U S A (2011) 0.99

Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin. J Bone Miner Res (2010) 0.98

Parathyroid hormone regulates fetal-placental mineral homeostasis. J Bone Miner Res (2010) 0.97

Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner. J Cell Biol (2007) 0.96

Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity. Cell Metab (2010) 0.96

Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis. Mol Cell Biol (2014) 0.96

The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease. Arthritis Rheum (2008) 0.95

Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice. Endocrinology (2003) 0.95

Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice. Dev Biol (2004) 0.94

Vitamin D receptor in osteoblasts is a negative regulator of bone mass control. Endocrinology (2013) 0.94

In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice. Mol Metab (2013) 0.94

A new insight into the formation of osteolytic lesions in multiple myeloma. N Engl J Med (2003) 0.93

Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule. Endocrinology (2008) 0.92

Common endocrine control of body weight, reproduction, and bone mass. Annu Rev Nutr (2003) 0.92

Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass. Endocrinology (2003) 0.90

Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology (2014) 0.90

Leptin-dependent co-regulation of bone and energy metabolism. Aging (Albany NY) (2009) 0.89

FGF-21 and skeletal remodeling during and after lactation in C57BL/6J mice. Endocrinology (2014) 0.88