Published in J Exp Med on March 28, 2011
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The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice. Br J Pharmacol (2012) 0.80
Bone health and associated metabolic complications in neuromuscular diseases. Phys Med Rehabil Clin N Am (2012) 0.80
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ATF3 controls proliferation of osteoclast precursor and bone remodeling. Sci Rep (2016) 0.76
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Impaired osteoblast and osteoclast function characterize the osteoporosis of Snyder - Robinson syndrome. Orphanet J Rare Dis (2015) 0.75
Clonidine increases bone resorption in humans. Osteoporos Int (2015) 0.75
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Chronic stress, sympathetic activation and skeletal metastasis of breast cancer cells. Bonekey Rep (2015) 0.75
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Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93
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Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell (2010) 5.08
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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity (2001) 4.09
Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast. Dev Dyn (2002) 4.01
The molecular clock mediates leptin-regulated bone formation. Cell (2005) 3.88
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell (2009) 3.28
Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab (2006) 2.93
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14
Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A (2004) 1.99
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest (2009) 1.73
PTH and PTHrP signaling in osteoblasts. Cell Signal (2009) 1.69
Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo. Proc Natl Acad Sci U S A (2008) 1.34
New treatments for reflex sympathetic dystrophy. N Engl J Med (2000) 1.27
Bone embedding in pure methyl methacrylate at low temperature preserves enzyme activities. Acta Histochem (1987) 1.16
CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes Dev (2010) 1.09
Low dose beta-blocker prevents ovariectomy-induced bone loss in rats without affecting heart functions. J Cell Physiol (2008) 1.04
C-myc as a modulator of renal stem/progenitor cell population. Dev Dyn (2009) 1.01
Endocrine regulation of energy metabolism by the skeleton. Cell (2007) 10.41
p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature (2005) 6.43
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20
Leptin regulates bone formation via the sympathetic nervous system. Cell (2002) 5.95
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell (2004) 5.80
A twist code determines the onset of osteoblast differentiation. Dev Cell (2004) 5.40
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell (2004) 5.27
De novo cardiomyocytes from within the activated adult heart after injury. Nature (2011) 5.17
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell (2010) 5.08
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03
Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A (2008) 4.77
Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc (2006) 4.41
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet (2016) 4.29
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell (2006) 4.01
The molecular clock mediates leptin-regulated bone formation. Cell (2005) 3.88
Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell (2011) 3.56
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 3.44
The TLR4 gene polymorphisms and susceptibility to cancer: a systematic review and meta-analysis. Eur J Cancer (2012) 3.41
Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev (2005) 3.38
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell (2009) 3.28
Endocrine regulation of male fertility by the skeleton. Cell (2011) 3.20
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol (2004) 2.90
Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature (2010) 2.85
Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell (2012) 2.71
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol (2006) 2.70
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest (2009) 2.46
Engineering anatomically shaped human bone grafts. Proc Natl Acad Sci U S A (2009) 2.37
Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis. Nat Med (2010) 2.32
Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol (2006) 2.30
Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone. J Bone Miner Res (2006) 2.21
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum (2006) 2.19
PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development (2002) 2.19
Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human. Nat Med (2003) 2.17
miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol (2012) 2.15
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A (2012) 2.13
Mechano-electrochemical properties of articular cartilage: their inhomogeneities and anisotropies. Annu Rev Biomed Eng (2002) 2.04
The contribution of bone to whole-organism physiology. Nature (2012) 2.03
Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer. Dis Markers (2009) 2.02
High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone. J Bone Miner Res (2010) 2.01
Maternal and offspring pools of osteocalcin influence brain development and functions. Cell (2013) 2.00
Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell (2006) 1.95
Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology (2011) 1.95
Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem (2005) 1.91
Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism. J Bone Miner Res (2011) 1.89
Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone. J Bone Miner Res (2008) 1.89
Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol (2008) 1.88
Developmental expression of LC3alpha and beta: absence of fibronectin or autophagy phenotype in LC3beta knockout mice. Dev Dyn (2008) 1.88
Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study. J Clin Endocrinol Metab (2013) 1.88
Differences in bone microarchitecture between postmenopausal Chinese-American and white women. J Bone Miner Res (2011) 1.86
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol (2005) 1.86
In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin Cancer Res (2011) 1.85
An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice. J Bone Miner Res (2013) 1.85
Efficacy of serotonin inhibition in mouse models of bone loss. J Bone Miner Res (2011) 1.84
Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest (2014) 1.82
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest (2013) 1.81
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell (2012) 1.79
Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. J Bone Miner Res (2010) 1.78
Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res (2008) 1.76
Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol (2004) 1.74
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest (2009) 1.73
FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab (2010) 1.72
The osteoblast: an insulin target cell controlling glucose homeostasis. J Bone Miner Res (2011) 1.70
Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ. Mol Cell Biol (2003) 1.69
Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a. Diabetes (2013) 1.68
Prospective evaluation of whole-body cancer screening with multiple modalities including [18F]fluorodeoxyglucose positron emission tomography in a healthy population: a preliminary report. J Clin Oncol (2009) 1.68
Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med (2002) 1.67
Anatomically shaped osteochondral constructs for articular cartilage repair. J Biomech (2003) 1.64
A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms. Mol Cell Endocrinol (2009) 1.64
Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One (2008) 1.61
In vivo analysis of Wnt signaling in bone. Endocrinology (2007) 1.61
Bone microarchitecture and stiffness in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab (2009) 1.61
Therapeutic potential of human umbilical cord derived stem cells in a rat myocardial infarction model. Ann Thorac Surg (2007) 1.57
Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J Biol Chem (2001) 1.57
ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells. J Biol Chem (2004) 1.55
Application of serum SELDI proteomic patterns in diagnosis of lung cancer. BMC Cancer (2005) 1.55
Polymorphisms in the osteopontin promoter affect its transcriptional activity. Physiol Genomics (2004) 1.54