Published in Mol Pharmacol on July 11, 2006
Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction. Biochem Pharmacol (2009) 1.76
Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission. Br J Pharmacol (2007) 1.69
Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. AAPS J (2009) 1.68
Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors. Neuropharmacology (2010) 1.37
Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function. Mol Pharmacol (2008) 1.30
α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease. Pharmacol Rev (2011) 1.29
Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers. Mol Pharmacol (2010) 1.28
Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum. J Neurosci (2012) 1.17
Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders. Biochem Pharmacol (2011) 1.12
Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms. J Neurosci (2012) 1.12
Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. J Gen Physiol (2014) 1.07
GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptors. Brain Res (2010) 1.04
Myasthenia gravis and the tops and bottoms of AChRs: antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains. Ann N Y Acad Sci (2008) 0.99
Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward. J Neurosci (2016) 0.97
Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells. Biochem Pharmacol (2011) 0.93
Structural answers and persistent questions about how nicotinic receptors work. Front Biosci (2008) 0.93
Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists. Br J Pharmacol (2011) 0.92
Progress and challenges in the study of α6-containing nicotinic acetylcholine receptors. Biochem Pharmacol (2011) 0.90
Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation. Biochem Pharmacol (2007) 0.89
Inside-out neuropharmacology of nicotinic drugs. Neuropharmacology (2015) 0.89
Acute activation, desensitization and smoldering activation of human acetylcholine receptors. PLoS One (2013) 0.88
Modulation of gain-of-function α6*-nicotinic acetylcholine receptor by β3 subunits. J Biol Chem (2012) 0.88
Nicotinic acetylcholine receptor subunits in rhesus monkey retina. Invest Ophthalmol Vis Sci (2008) 0.87
Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. Genes Brain Behav (2015) 0.84
Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland. FASEB J (2011) 0.83
Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex. FASEB J (2012) 0.83
Mutations of cytosolic loop residues impair assembly and maturation of alpha7 nicotinic acetylcholine receptors. J Neurochem (2009) 0.83
Efficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunits. PLoS One (2014) 0.80
Elucidation of molecular impediments in the α6 subunit for in vitro expression of functional α6β4* nicotinic acetylcholine receptors. J Biol Chem (2013) 0.80
The Nicotine Metabolite, Cotinine, Alters the Assembly and Trafficking of a Subset of Nicotinic Acetylcholine Receptors. J Biol Chem (2015) 0.79
Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs. PLoS One (2013) 0.79
Nicotine withdrawal. Curr Top Behav Neurosci (2015) 0.78
Subtype-specific mechanisms for functional interaction between α6β4* nicotinic acetylcholine receptors and P2X receptors. Mol Pharmacol (2014) 0.77
Roles for N-terminal extracellular domains of nicotinic acetylcholine receptor (nAChR) β3 subunits in enhanced functional expression of mouse α6β2β3- and α6β4β3-nAChRs. J Biol Chem (2014) 0.77
Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. Transl Psychiatry (2016) 0.75
Nicotinic Acetylcholine Receptors as Targets for Tobacco Cessation Therapeutics: Cutting-Edge Methodologies to Understand Receptor Assembly and Trafficking. Neuromethods (2016) 0.75
Retrieval of crystallographically-derived molecular geometry information. J Chem Inf Comput Sci (2004) 74.81
Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors. Mol Pharmacol (2003) 3.22
Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nat Biotechnol (2008) 3.04
SIFTS: Structure Integration with Function, Taxonomy and Sequences resource. Nucleic Acids Res (2012) 2.61
Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer Res (2006) 2.47
Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron (2011) 2.42
Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol (2008) 2.18
Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function. Mol Pharmacol (2010) 2.02
Human alpha4beta2 acetylcholine receptors formed from linked subunits. J Neurosci (2003) 1.86
Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors. Mol Pharmacol (2004) 1.84
Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol (2009) 1.82
Activated cholinergic signaling provides a target in squamous cell lung carcinoma. Cancer Res (2008) 1.76
Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts. EMBO J (2006) 1.74
A multilevel adaptive finite element algorithm for bioluminescence tomography. Opt Express (2006) 1.71
Is "seronegative" MG explained by autoantibodies to MuSK? Neurology (2004) 1.66
Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. J Biol Chem (2002) 1.60
Specific immunotherapy of experimental myasthenia gravis by a novel mechanism. Ann Neurol (2010) 1.53
Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma. Clin Cancer Res (2009) 1.43
Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology (2004) 1.42
Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors. J Neurosci (2003) 1.34
Tumor cyclooxygenase 2-dependent suppression of dendritic cell function. Clin Cancer Res (2003) 1.33
Biophysical mechanisms of MRI signal frequency contrast in multiple sclerosis. Proc Natl Acad Sci U S A (2012) 1.32
IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis. J Clin Invest (2002) 1.29
Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers. Mol Pharmacol (2010) 1.28
COX-2-dependent stabilization of survivin in non-small cell lung cancer. FASEB J (2003) 1.24
Characterization of ganglionic acetylcholine receptor autoantibodies. J Neuroimmunol (2008) 1.21
Pigmented paraganglioma of the kidney: a case report. Diagn Pathol (2012) 1.18
Cyclooxygenase-2-dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer. Cancer Res (2004) 1.17
Proinflammatory mediators upregulate snail in head and neck squamous cell carcinoma. Clin Cancer Res (2009) 1.17
Endothelial cells enhance prostate cancer metastasis via IL-6→androgen receptor→TGF-β→MMP-9 signals. Mol Cancer Ther (2013) 1.10
Novel hydroxycinnamoyl-coenzyme A quinate transferase genes from artichoke are involved in the synthesis of chlorogenic acid. Plant Physiol (2010) 1.09
Comparative genomics of parasitic silkworm microsporidia reveal an association between genome expansion and host adaptation. BMC Genomics (2013) 1.07
New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells. J Mol Cell Biol (2012) 1.07
Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors. PLoS One (2011) 1.06
Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events. Stem Cell Res (2012) 1.05
Genetic analysis of the metabolome exemplified using a rice population. Proc Natl Acad Sci U S A (2013) 1.04
Biocidal efficacy, biofilm-controlling function, and controlled release effect of chloromelamine-based bioresponsive fibrous materials. Biomaterials (2006) 1.03
Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. Am J Respir Cell Mol Biol (2008) 1.03
Overexpressing the glucocorticoid receptor in forebrain causes an aging-like neuroendocrine phenotype and mild cognitive dysfunction. J Neurosci (2007) 1.02
EGFR signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells. Am J Respir Cell Mol Biol (2007) 1.02
Voxel spread function method for correction of magnetic field inhomogeneity effects in quantitative gradient-echo-based MRI. Magn Reson Med (2012) 1.01
A transcriptomic network underlies microstructural and physiological responses to cadmium in Populus x canescens. Plant Physiol (2013) 0.99
Myasthenia gravis and the tops and bottoms of AChRs: antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains. Ann N Y Acad Sci (2008) 0.99
Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity. J Neurosci (2009) 0.99
Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis. J Biol Chem (2012) 0.98
A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: application in the study of rice metabolomics. Mol Plant (2013) 0.98
In vivo quantitative evaluation of brain tissue damage in multiple sclerosis using gradient echo plural contrast imaging technique. Neuroimage (2010) 0.97
Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer. J Biol Chem (2013) 0.97
Computer-aided diagnosis and quantification of cirrhotic livers based on morphological analysis and machine learning. Comput Math Methods Med (2013) 0.96
Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth. Mol Cancer Ther (2010) 0.96
New insight into the antifibrotic effects of praziquantel on mice in infection with Schistosoma japonicum. PLoS One (2011) 0.95
Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis. Hepatology (2013) 0.95
Overexpression of CCL-21/secondary lymphoid tissue chemokine in human dendritic cells augments chemotactic activities for lymphocytes and antigen presenting cells. Mol Cancer (2003) 0.94
RPB2 gene phylogeny in flowering plants, with particular emphasis on asterids. Mol Phylogenet Evol (2004) 0.94
First and second transmembrane segments of alpha3, alpha4, beta2, and beta4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine. Mol Pharmacol (2002) 0.93
N-fertilization has different effects on the growth, carbon and nitrogen physiology, and wood properties of slow- and fast-growing Populus species. J Exp Bot (2012) 0.93
Comparative study on polymer light-emitting devices based on blends of polyfluorene and 4,7-di-2-thienyl-2,1,3-benzothiadiazole with devices based on copolymer of the same composition. J Phys Chem B (2007) 0.93
Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy. Bioorg Med Chem Lett (2013) 0.93
Inhibition of retinal neovascularization by siRNA targeting VEGF(165). Mol Vis (2008) 0.93
Enhanced homing of mesenchymal stem cells to the ischemic myocardium by ultrasound-targeted microbubble destruction. Ultrasonics (2011) 0.91
The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling. EMBO Mol Med (2012) 0.90
Structural and functional characterization of herpes simplex virus 1 immediate-early protein infected-cell protein 22. J Biochem (2006) 0.90
The role of ZEB1 in the inflammation-induced promotion of EMT in HNSCC. Otolaryngol Head Neck Surg (2010) 0.90
UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. J Neurosci (2009) 0.90
Polymorphisms of base-excision repair genes hOGG1 326cys and XRCC1 280His increase hepatocellular carcinoma risk. Dig Dis Sci (2012) 0.90
Theoretical studies on the mechanisms and dynamics of OH radicals with CH(2)FCF(2)OCHF(2) and CH(2)FOCH(2)F. J Phys Chem A (2010) 0.89
Alcohol modulation of neuronal nicotinic acetylcholine receptors is alpha subunit dependent. Alcohol Clin Exp Res (2002) 0.89
Acute activation, desensitization and smoldering activation of human acetylcholine receptors. PLoS One (2013) 0.88
Asymmetric catalysis with chiral primary amine-based organocatalysts. Chem Commun (Camb) (2009) 0.88
Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-α. J Exp Clin Cancer Res (2011) 0.88
Should patients with symptomatic Hashimoto's thyroiditis pursue surgery? J Surg Res (2011) 0.87
A role of cell apoptosis in lipopolysaccharide (LPS)-induced nonlethal liver injury in D-galactosamine (D-GalN)-sensitized rats. Dig Dis Sci (2007) 0.87
Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure. Cell Tissue Res (2005) 0.87
The application of loop-mediated isothermal amplification (LAMP) in food testing for bacterial pathogens and fungal contaminants. Food Microbiol (2013) 0.87
Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR. Biochim Biophys Acta (2013) 0.86
Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in non-small cell lung cancer. J Transl Med (2008) 0.86
Anti-hepatitis B virus active lactones from the traditional Chinese herb: Swertia mileensis. Chemistry (2011) 0.86
Increased PrLZ-mediated androgen receptor transactivation promotes prostate cancer growth at castration-resistant stage. Carcinogenesis (2012) 0.85
The biofilm-controlling functions of rechargeable antimicrobial N-halamine dental unit waterline tubing. J Clin Dent (2011) 0.85
Effects of electroconvulsive stimulation on long-term potentiation and synaptophysin in the hippocampus of rats with depressive behavior. J ECT (2012) 0.84
Non-small cell lung cancer-derived soluble mediators enhance apoptosis in activated T lymphocytes through an I kappa B kinase-dependent mechanism. Cancer Res (2003) 0.84
Loss of nicotinic acetylcholine receptor subunits alpha4 and alpha7 in the cerebral cortex of Parkinson patients. Parkinsonism Relat Disord (2003) 0.84
Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. J Neurochem (2013) 0.84
Combination of taxanes, cisplatin and fluorouracil as induction chemotherapy for locally advanced head and neck cancer: a meta-analysis. PLoS One (2012) 0.84
An effective docking strategy for virtual screening based on multi-objective optimization algorithm. BMC Bioinformatics (2009) 0.83
Gene profile of chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9/10 on liver non-parenchymal cells. PLoS One (2012) 0.83
Mutations of cytosolic loop residues impair assembly and maturation of alpha7 nicotinic acetylcholine receptors. J Neurochem (2009) 0.83
Negative regulation of transcription coactivator p300 by orphan receptor TR3. Nucleic Acids Res (2007) 0.83
Concise review: androgen receptor differential roles in stem/progenitor cells including prostate, embryonic, stromal, and hematopoietic lineages. Stem Cells (2014) 0.83
Lingzhiols, unprecedented rotary door-shaped meroterpenoids as potent and selective inhibitors of p-Smad3 from Ganoderma lucidum. Org Lett (2013) 0.83
Leisingera nanhaiensis sp. nov., isolated from marine sediment. Int J Syst Evol Microbiol (2009) 0.83
Direct asymmetric aldol reactions between aldehydes and ketones catalyzed by L-tryptophan in the presence of water. Org Biomol Chem (2010) 0.83
Index-ion triggered MS2 ion quantification: a novel proteomics approach for reproducible detection and quantification of targeted proteins in complex mixtures. Mol Cell Proteomics (2010) 0.83
Myasthenogenicity of the main immunogenic region and endogenous muscle nicotinic acetylcholine receptors. Autoimmunity (2011) 0.82