Published in Endocrinology on February 05, 2004
Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol (2008) 3.39
Integrative control of the lower urinary tract: preclinical perspective. Br J Pharmacol (2006) 1.94
Activated cholinergic signaling provides a target in squamous cell lung carcinoma. Cancer Res (2008) 1.76
Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res (2006) 1.69
Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer. Cancer Prev Res (Phila) (2011) 1.61
Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual. Proc Natl Acad Sci U S A (2012) 1.56
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
The airway sensory impact of nicotine contributes to the conditioned reinforcing effects of individual puffs from cigarettes. Pharmacol Biochem Behav (2005) 1.25
The epithelial cholinergic system of the airways. Histochem Cell Biol (2008) 1.17
The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells. J Cancer Res Clin Oncol (2006) 1.16
Life-long programming implications of exposure to tobacco smoking and nicotine before and soon after birth: evidence for altered lung development. Int J Environ Res Public Health (2011) 1.11
TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle. Biochim Biophys Acta (2013) 1.08
Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epithelium. Am J Respir Cell Mol Biol (2010) 1.07
Ion transport by pulmonary epithelia. J Biomed Biotechnol (2011) 1.05
Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. Am J Respir Cell Mol Biol (2008) 1.03
Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir Res (2006) 0.96
Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation. PLoS One (2011) 0.95
Brain-derived neurotrophic factor in the airways. Pharmacol Ther (2014) 0.94
Muscarinic receptor agonists and antagonists: effects on cancer. Handb Exp Pharmacol (2012) 0.94
Early manifestations of NNK-induced lung cancer: role of lung immunity in tumor susceptibility. Am J Respir Cell Mol Biol (2006) 0.92
alpha3alpha5beta2-Nicotinic acetylcholine receptor contributes to the wound repair of the respiratory epithelium by modulating intracellular calcium in migrating cells. Am J Pathol (2006) 0.92
Nicotinic acetylcholine receptors mediate lung cancer growth. Front Physiol (2013) 0.91
CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression. Carcinogenesis (2011) 0.88
Muscarinic receptors and their antagonists in COPD: anti-inflammatory and antiremodeling effects. Mediators Inflamm (2012) 0.87
Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo. J Allergy Clin Immunol (2012) 0.86
Cholinergic regulation of airway inflammation and remodelling. J Allergy (Cairo) (2012) 0.86
mAChRs activation induces epithelial-mesenchymal transition on lung epithelial cells. BMC Pulm Med (2014) 0.85
Epithelium integrity is crucial for the relaxant activity of brain natriuretic peptide in human isolated bronchi. Br J Pharmacol (2011) 0.84
Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. J Neurochem (2013) 0.84
Muscarinic receptor antagonists: effects on pulmonary function. Handb Exp Pharmacol (2012) 0.83
TTF-1 regulates α5 nicotinic acetylcholine receptor (nAChR) subunits in proximal and distal lung epithelium. Respir Res (2010) 0.82
Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Cancer Biol Ther (2015) 0.81
A novel muscarinic antagonist R2HBJJ inhibits non-small cell lung cancer cell growth and arrests the cell cycle in G0/G1. PLoS One (2012) 0.80
Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors. BMC Cancer (2015) 0.80
Non-neuronal cholinergic system in airways and lung cancer susceptibility. Transl Lung Cancer Res (2013) 0.79
Cholinergic Targets in Lung Cancer. Curr Pharm Des (2016) 0.79
Systematic Review of Pharmacological Properties of the Oligodendrocyte Lineage. Front Cell Neurosci (2016) 0.78
Pharmacological profile of Ascaris suum ACR-16, a new homomeric nicotinic acetylcholine receptor widely distributed in Ascaris tissues. Br J Pharmacol (2016) 0.78
Tiotropium in asthma: what is the evidence and how does it fit in? World Allergy Organ J (2016) 0.77
Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study. J Vet Intern Med (2015) 0.77
Local small airway epithelial injury induces global smooth muscle contraction and airway constriction. J Appl Physiol (1985) (2011) 0.76
Nicotine exposure during differentiation causes inhibition of N-myc expression. Respir Res (2013) 0.76
Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC). Oncotarget (2015) 0.75
Pulmonary inflammation is regulated by the levels of the vesicular acetylcholine transporter. PLoS One (2015) 0.75
(S)-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu-ACR-16 receptor. Int J Parasitol Drugs Drug Resist (2016) 0.75
M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation. World Allergy Organ J (2013) 0.75
Mitochondrial Transplantation Attenuates Airway Hyperresponsiveness by Inhibition of Cholinergic Hyperactivity. Theranostics (2016) 0.75
Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium. Int Immunopharmacol (2015) 0.75
Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors. Mol Pharmacol (2003) 3.22
A transient placental source of serotonin for the fetal forebrain. Nature (2011) 2.71
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Am J Hum Genet (2005) 2.44
Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors. Am J Respir Cell Mol Biol (2002) 2.22
Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol (2008) 2.18
The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology (2006) 2.12
Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. J Biol Chem (2005) 2.03
Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function. Mol Pharmacol (2010) 2.02
Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2002) 2.01
Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A (2005) 1.98
Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta). BMC Genomics (2007) 1.87
Human alpha4beta2 acetylcholine receptors formed from linked subunits. J Neurosci (2003) 1.86
Targeting cell surface receptors with ligand-conjugated nanocrystals. J Am Chem Soc (2002) 1.82
Activated cholinergic signaling provides a target in squamous cell lung carcinoma. Cancer Res (2008) 1.76
Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts. EMBO J (2006) 1.74
p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. J Biol Chem (2005) 1.71
Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein. J Neurochem (2003) 1.70
Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation. Mol Pharmacol (2005) 1.67
Is "seronegative" MG explained by autoantibodies to MuSK? Neurology (2004) 1.66
Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res (2003) 1.61
Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I. J Biol Chem (2003) 1.60
Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Mol Pharmacol (2004) 1.57
Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest (2008) 1.57
Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer. J Thorac Oncol (2014) 1.55
Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Proc Natl Acad Sci U S A (2005) 1.53
Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. PLoS Biol (2007) 1.48
Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc Natl Acad Sci U S A (2012) 1.48
Dopamine transporters depolarize neurons by a channel mechanism. Proc Natl Acad Sci U S A (2004) 1.46
Vesicular localization and activity-dependent trafficking of presynaptic choline transporters. J Neurosci (2003) 1.45
Vigorous motor activity in Caenorhabditis elegans requires efficient clearance of dopamine mediated by synaptic localization of the dopamine transporter DAT-1. J Neurosci (2007) 1.43
Anomalous dopamine release associated with a human dopamine transporter coding variant. J Neurosci (2008) 1.41
Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Proc Natl Acad Sci U S A (2009) 1.38
A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. J Neurosci (2003) 1.35
Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies. Proteins (2009) 1.32
Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload. Circ Res (2009) 1.32
Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice. Proc Natl Acad Sci U S A (2004) 1.29
Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis. Neuropsychopharmacology (2005) 1.29
Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers. Mol Pharmacol (2010) 1.28
Enhanced activity of human serotonin transporter variants associated with autism. Philos Trans R Soc Lond B Biol Sci (2009) 1.25
Going with the flow: trafficking-dependent and -independent regulation of serotonin transport. Traffic (2008) 1.25
Beta3 subunits promote expression and nicotine-induced up-regulation of human nicotinic alpha6* nicotinic acetylcholine receptors expressed in transfected cell lines. Mol Pharmacol (2006) 1.23
A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder. Proc Natl Acad Sci U S A (2006) 1.23
Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. J Biol Chem (2006) 1.23
Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation. Mol Pharmacol (2005) 1.23
M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res (2007) 1.23
Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology (2010) 1.22
The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration. Annu Rev Pharmacol Toxicol (2002) 1.22
The choline transporter resurfaces: new roles for synaptic vesicles? Mol Interv (2004) 1.22
Characterization of ganglionic acetylcholine receptor autoantibodies. J Neuroimmunol (2008) 1.21
Binding and transport in norepinephrine transporters. Real-time, spatially resolved analysis in single cells using a fluorescent substrate. J Biol Chem (2002) 1.21
Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission. Proc Natl Acad Sci U S A (2008) 1.21
The functional impact of SLC6 transporter genetic variation. Annu Rev Pharmacol Toxicol (2007) 1.20
A dialogue between the immune system and brain, spoken in the language of serotonin. ACS Chem Neurosci (2012) 1.20
Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. J Neurosci (2010) 1.19
Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex. J Neurosci (2006) 1.18
Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles. J Neurosci (2006) 1.16
Networking in autism: leveraging genetic, biomarker and model system findings in the search for new treatments. Neuropsychopharmacology (2011) 1.15
A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. J Neurosci (2003) 1.15
Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation. J Neurosci (2012) 1.14
Leveraging human genomic information to identify nonhuman primate sequences for expression array development. BMC Genomics (2005) 1.13
Developing novel treatments for mood disorders: accelerating discovery. Biol Psychiatry (2002) 1.13
Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. Neuropsychopharmacology (2005) 1.12
Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals. J Comp Neurol (2003) 1.11
Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Cardiovasc Res (2004) 1.09
Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area. Synapse (2004) 1.08
Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epithelium. Am J Respir Cell Mol Biol (2010) 1.07
Getting the message across: a recent transporter structure shows the way. Neuron (2006) 1.07
The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics. FASEB J (2005) 1.07
Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes. Mol Pharmacol (2006) 1.06
Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors. PLoS One (2011) 1.06
Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J Neurochem (2009) 1.06
Choline transporter gene variation is associated with attention-deficit hyperactivity disorder. J Neurodev Disord (2009) 1.06
Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys. Am J Respir Crit Care Med (2005) 1.06
Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation. J Neurosci (2012) 1.04
Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Neuropharmacology (2005) 1.04
Defective presynaptic choline transport underlies hereditary motor neuropathy. Am J Hum Genet (2012) 1.03
Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. Am J Respir Cell Mol Biol (2008) 1.03
Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proc Natl Acad Sci U S A (2011) 1.03
Intercenter reliability and validity of the rhesus macaque GeneChip. BMC Genomics (2007) 1.02
A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking. J Neurochem (2005) 1.02
The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch (2013) 1.02
Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. J Neurosci (2010) 1.01
Dopamine signaling architecture in Caenorhabditis elegans. Cell Mol Neurobiol (2006) 1.01
The presynaptic choline transporter imposes limits on sustained cortical acetylcholine release and attention. J Neurosci (2013) 1.00
Hereditary spastic paraplegia-associated mutations in the NIPA1 gene and its Caenorhabditis elegans homolog trigger neural degeneration in vitro and in vivo through a gain-of-function mechanism. J Neurosci (2008) 1.00
Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304). J Pharmacol Exp Ther (2003) 1.00