Published in Science on July 14, 2006
Viral membrane fusion. Nat Struct Mol Biol (2008) 8.54
Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme. Crit Rev Biochem Mol Biol (2008) 5.26
Mechanics of membrane fusion. Nat Struct Mol Biol (2008) 4.79
Fusing structure and function: a structural view of the herpesvirus entry machinery. Nat Rev Microbiol (2011) 2.86
Structural basis of viral invasion: lessons from paramyxovirus F. Curr Opin Struct Biol (2007) 2.82
PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell (2008) 2.49
Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL. Nat Struct Mol Biol (2010) 2.45
Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion. Proc Natl Acad Sci U S A (2007) 2.43
Membranes of the world unite! J Cell Biol (2006) 2.06
Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B. Proc Natl Acad Sci U S A (2009) 2.05
Herpes virus fusion and entry: a story with many characters. Viruses (2012) 2.05
Cascade of events governing cell-cell fusion induced by herpes simplex virus glycoproteins gD, gH/gL, and gB. J Virol (2010) 1.91
Cryo-EM model of the bullet-shaped vesicular stomatitis virus. Science (2010) 1.90
The cell biology of rabies virus: using stealth to reach the brain. Nat Rev Microbiol (2010) 1.86
Native 3D intermediates of membrane fusion in herpes simplex virus 1 entry. Proc Natl Acad Sci U S A (2008) 1.81
Mutational evidence of internal fusion loops in herpes simplex virus glycoprotein B. J Virol (2007) 1.79
Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex. Proc Natl Acad Sci U S A (2010) 1.75
Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion. J Virol (2010) 1.70
Protein-driven membrane stresses in fusion and fission. Trends Biochem Sci (2010) 1.69
Herpes simplex virus glycoprotein B associates with target membranes via its fusion loops. J Virol (2009) 1.65
Class III viral membrane fusion proteins. Curr Opin Struct Biol (2009) 1.64
Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus. J Virol (2007) 1.59
Crystal Structure of the Human Cytomegalovirus Glycoprotein B. PLoS Pathog (2015) 1.58
Ebolavirus glycoprotein structure and mechanism of entry. Future Virol (2009) 1.56
Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions. J Virol (2007) 1.56
Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain. J Biol Chem (2009) 1.45
Viral membrane fusion. Virology (2015) 1.40
Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A (2011) 1.40
Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody. Proc Natl Acad Sci U S A (2010) 1.38
Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein. J Virol (2006) 1.38
Characterization of a structural intermediate of flavivirus membrane fusion. PLoS Pathog (2007) 1.37
Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B. Proc Natl Acad Sci U S A (2007) 1.35
Viral and developmental cell fusion mechanisms: conservation and divergence. Dev Cell (2008) 1.32
Molecular gymnastics at the herpesvirus surface. EMBO Rep (2006) 1.29
Lipids as modulators of membrane fusion mediated by viral fusion proteins. Eur Biophys J (2007) 1.29
Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity. J Virol (2007) 1.28
Molecular engineering of viral gene delivery vehicles. Annu Rev Biomed Eng (2008) 1.28
Cell entry of enveloped viruses. Curr Opin Virol (2011) 1.18
Functional and evolutionary insight from the crystal structure of rubella virus protein E1. Nature (2013) 1.16
Low pH-induced conformational change in herpes simplex virus glycoprotein B. J Virol (2010) 1.16
Identification of a small-molecule entry inhibitor for filoviruses. J Virol (2011) 1.14
Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1. J Virol (2010) 1.14
N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function. J Virol (2007) 1.14
Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins. Virology (2007) 1.13
Molecular and cellular aspects of rhabdovirus entry. Viruses (2012) 1.12
Biochemistry. Viral glycoproteins and an evolutionary conundrum. Science (2006) 1.08
Regulation of herpes simplex virus gB-induced cell-cell fusion by mutant forms of gH/gL in the absence of gD and cellular receptors. MBio (2013) 1.07
Capturing the herpes simplex virus core fusion complex (gB-gH/gL) in an acidic environment. J Virol (2011) 1.07
Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein H. J Biol Chem (2008) 1.05
Distinct structural rearrangements of the VSV glycoprotein drive membrane fusion. J Cell Biol (2010) 1.04
Glycoprotein B switches conformation during murid herpesvirus 4 entry. J Gen Virol (2008) 1.03
Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection. Antimicrob Agents Chemother (2008) 1.00
Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function. Chem Rev (2014) 1.00
The structure of herpesvirus fusion glycoprotein B-bilayer complex reveals the protein-membrane and lateral protein-protein interaction. Structure (2013) 1.00
Enhanced growth of influenza vaccine seed viruses in vero cells mediated by broadening the optimal pH range for virus membrane fusion. J Virol (2011) 1.00
The Murid Herpesvirus-4 gL regulates an entry-associated conformation change in gH. PLoS One (2008) 0.99
Insertion mutations in herpes simplex virus 1 glycoprotein H reduce cell surface expression, slow the rate of cell fusion, or abrogate functions in cell fusion and viral entry. J Virol (2009) 0.98
Characterization of monomeric intermediates during VSV glycoprotein structural transition. PLoS Pathog (2012) 0.98
Syncytial phenotype of C-terminally truncated herpes simplex virus type 1 gB is associated with diminished membrane interactions. J Virol (2010) 0.98
Crystal structure of the Marburg virus GP2 core domain in its postfusion conformation. Biochemistry (2012) 0.98
A spatio-temporal analysis of matrix protein and nucleocapsid trafficking during vesicular stomatitis virus uncoating. PLoS Pathog (2010) 0.97
Characterization of Durham virus, a novel rhabdovirus that encodes both a C and SH protein. Virus Res (2010) 0.97
E1 mutants identify a critical region in the trimer interface of the Semliki forest virus fusion protein. J Virol (2009) 0.97
Marburg virus glycoprotein GP2: pH-dependent stability of the ectodomain α-helical bundle. Biochemistry (2012) 0.97
Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus. Proc Natl Acad Sci U S A (2010) 0.96
Assembly and architecture of the EBV B cell entry triggering complex. PLoS Pathog (2014) 0.96
Systemic delivery of fusogenic membrane glycoprotein-expressing neural stem cells to selectively kill tumor cells. Mol Ther (2013) 0.96
Low-pH-dependent changes in the conformation and oligomeric state of the prefusion form of herpes simplex virus glycoprotein B are separable from fusion activity. J Virol (2011) 0.95
Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form. J Mol Biol (2013) 0.95
Reevaluating herpes simplex virus hemifusion. J Virol (2010) 0.95
Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry. Curr Opin Virol (2012) 0.95
Role of electrostatic repulsion in controlling pH-dependent conformational changes of viral fusion proteins. Structure (2013) 0.95
Niakha virus: a novel member of the family Rhabdoviridae isolated from phlebotomine sandflies in Senegal. Virology (2013) 0.94
Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesis. J Virol (2008) 0.94
Receptor binding and low pH coactivate oncogenic retrovirus envelope-mediated fusion. J Virol (2009) 0.93
Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae. Virol J (2013) 0.93
A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion. J Virol (2011) 0.92
Interferon response and viral evasion by members of the family rhabdoviridae. Viruses (2009) 0.92
Mechanism of neutralization of herpes simplex virus by antibodies directed at the fusion domain of glycoprotein B. J Virol (2013) 0.92
The P2 capsid protein of the nonenveloped rice dwarf phytoreovirus induces membrane fusion in insect host cells. Proc Natl Acad Sci U S A (2007) 0.91
A pH-sensitive heparin-binding sequence from Baculovirus gp64 protein is important for binding to mammalian cells but not to Sf9 insect cells. J Virol (2011) 0.91
Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 contain reduced cysteine residues essential for virus entry. J Biol Chem (2011) 0.91
Bovine herpesvirus type 4 glycoprotein L is nonessential for infectivity but triggers virion endocytosis during entry. J Virol (2011) 0.91
Fusion-deficient insertion mutants of herpes simplex virus type 1 glycoprotein B adopt the trimeric postfusion conformation. J Virol (2009) 0.91
The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein H. J Biol Chem (2010) 0.90
Clathrin-mediated endocytosis in living host cells visualized through quantum dot labeling of infectious hematopoietic necrosis virus. J Virol (2011) 0.90
An antibody directed against the fusion peptide of Junin virus envelope glycoprotein GPC inhibits pH-induced membrane fusion. J Virol (2010) 0.89
Site-specific proteolytic cleavage of the amino terminus of herpes simplex virus glycoprotein K on virion particles inhibits virus entry. J Virol (2011) 0.89
Biophysical characterization and membrane interaction of the two fusion loops of glycoprotein B from herpes simplex type I virus. PLoS One (2012) 0.89
Modulation of Epstein-Barr virus glycoprotein B (gB) fusion activity by the gB cytoplasmic tail domain. MBio (2013) 0.89
A novel membrane fusion protein family in Flaviviridae? Trends Microbiol (2014) 0.88
A mechanistic basis for potent, glycoprotein B-directed gammaherpesvirus neutralization. J Gen Virol (2011) 0.88
The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein. J Virol (2011) 0.88
Proteomics computational analyses suggest that baculovirus GP64 superfamily proteins are class III penetrenes. Virol J (2008) 0.88
Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody. Nat Commun (2015) 0.88
The three lives of viral fusion peptides. Chem Phys Lipids (2014) 0.87
Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. PLoS Med (2006) 11.14
Virus membrane-fusion proteins: more than one way to make a hairpin. Nat Rev Microbiol (2006) 4.16
Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation. EMBO J (2004) 4.05
Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus. Nature (2004) 4.02
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity. Cell Host Microbe (2010) 3.48
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor. Nat Struct Mol Biol (2005) 3.07
Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G. Science (2007) 2.97
Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography. Nature (2010) 2.90
Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science (2009) 2.71
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J Virol (2002) 2.61
The birnavirus crystal structure reveals structural relationships among icosahedral viruses. Cell (2005) 2.44
The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule. PLoS Pathog (2010) 2.28
Structure and interactions at the viral surface of the envelope protein E1 of Semliki Forest virus. Structure (2006) 2.05
Virus membrane fusion. FEBS Lett (2007) 2.03
Visualization of the target-membrane-inserted fusion protein of Semliki Forest virus by combined electron microscopy and crystallography. Cell (2003) 1.67
Structural basis of potent Zika-dengue virus antibody cross-neutralization. Nature (2016) 1.52
Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death. Structure (2011) 1.46
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest (2009) 1.46
Functional characterization of Negri bodies (NBs) in rabies virus-infected cells: Evidence that NBs are sites of viral transcription and replication. J Virol (2009) 1.43
Characterization of the equilibrium between the native and fusion-inactive conformation of rabies virus glycoprotein indicates that the fusion complex is made of several trimers. Virology (2002) 1.39
Characterization of a structural intermediate of flavivirus membrane fusion. PLoS Pathog (2007) 1.37
Crystal structure of vesicular stomatitis virus matrix protein. EMBO J (2002) 1.34
Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein. Proc Natl Acad Sci U S A (2011) 1.32
X-ray structure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformation. Proc Natl Acad Sci U S A (2011) 1.27
Fossil rhabdoviral sequences integrated into arthropod genomes: ontogeny, evolution, and potential functionality. Mol Biol Evol (2011) 1.22
Nucleocytoplasmic shuttling of the rabies virus P protein requires a nuclear localization signal and a CRM1-dependent nuclear export signal. Virology (2005) 1.20
Characterization of a membrane-associated trimeric low-pH-induced Form of the class II viral fusion protein E from tick-borne encephalitis virus and its crystallization. J Virol (2004) 1.19
Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. J Gen Virol (2007) 1.17
Structural and functional analysis of hepatitis C virus strain JFH1 polymerase. J Virol (2009) 1.17
Functional and evolutionary insight from the crystal structure of rubella virus protein E1. Nature (2013) 1.16
Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J Biol Chem (2010) 1.14
Molecular and cellular aspects of rhabdovirus entry. Viruses (2012) 1.12
Membrane deformations induced by the matrix protein of vesicular stomatitis virus in a minimal system. J Gen Virol (2005) 1.11
Capsid protein identification and analysis of mature Triatoma virus (TrV) virions and naturally occurring empty particles. Virology (2010) 1.11
The picobirnavirus crystal structure provides functional insights into virion assembly and cell entry. EMBO J (2009) 1.10
A comprehensive structure-function comparison of hepatitis C virus strain JFH1 and J6 polymerases reveals a key residue stimulating replication in cell culture across genotypes. J Virol (2011) 1.07
High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells. Protein Eng Des Sel (2011) 1.06
Distinct structural rearrangements of the VSV glycoprotein drive membrane fusion. J Cell Biol (2010) 1.04
Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein. Virology (2005) 1.01
Characterization of monomeric intermediates during VSV glycoprotein structural transition. PLoS Pathog (2012) 0.98
The respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid. J Gen Virol (2013) 0.98
Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates. J Mol Biol (2005) 0.97
Dermal-type macrophages expressing CD209/DC-SIGN show inherent resistance to dengue virus growth. PLoS Negl Trop Dis (2008) 0.97
Crystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 Fc reveals a novel epitope and evidence for affinity maturation. J Mol Biol (2007) 0.96
An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors. J Mol Biol (2011) 0.93
Phenotypes of vesicular stomatitis virus mutants with mutations in the PSAP motif of the matrix protein. J Gen Virol (2011) 0.93
Structure of the Triatoma virus capsid. Acta Crystallogr D Biol Crystallogr (2013) 0.93
Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology (2011) 0.91
Crystal structure of an Aquabirnavirus particle: insights into antigenic diversity and virulence determinism. J Virol (2009) 0.91
Intermediate conformations during viral fusion glycoprotein structural transition. Curr Opin Virol (2013) 0.91
Evidence that rabies virus forms different kinds of fusion machines with different pH thresholds for fusion. J Virol (2004) 0.90
Crystal structure of the pestivirus envelope glycoprotein E(rns) and mechanistic analysis of its ribonuclease activity. Structure (2012) 0.88
In praise of impurity: 30S ribosomal S15 protein-assisted crystallization of turnip yellow mosaic virus proteinase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.88
A compact viral processing proteinase/ubiquitin hydrolase from the OTU family. PLoS Pathog (2013) 0.87
Two crucial early steps in RNA synthesis by the hepatitis C virus polymerase involve a dual role of residue 405. J Virol (2012) 0.86
The matrix protein of vesicular stomatitis virus binds dynamin for efficient viral assembly. J Virol (2010) 0.86
Rabies virus glycoprotein (RVG) is a trimeric ligand for the N-terminal cysteine-rich domain of the mammalian p75 neurotrophin receptor. J Biol Chem (2002) 0.86
Differential stability and fusion activity of Lyssavirus glycoprotein trimers. Virus Res (2003) 0.85
Rabies virus glycoprotein can fold in two alternative, antigenically distinct conformations depending on membrane-anchor type. J Gen Virol (2002) 0.85
Scaffolds for protein crystallisation. Acta Crystallogr D Biol Crystallogr (2002) 0.84
Alphavirus structure: activation for entry at the target cell surface. Curr Opin Virol (2013) 0.84
Unusual self-assembly properties of Norovirus Newbury2 virus-like particles. Arch Biochem Biophys (2013) 0.84
Norovirus capsid proteins self-assemble through biphasic kinetics via long-lived stave-like intermediates. J Am Chem Soc (2013) 0.84
Structure and working of viral fusion machinery. Curr Top Membr (2011) 0.81
Spectroscopic characterization of two peptides derived from the stem of rabies virus glycoprotein. Virus Res (2003) 0.81
Prevalence and phylogenetic analysis of tick-borne encephalitis virus (TBEV) in field-collected ticks (Ixodes ricinus) in southern Switzerland. Parasit Vectors (2014) 0.79
Crystallization and preliminary X-ray analysis of Chandipura virus glycoprotein G. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.78
Purification, crystallization and preliminary X-ray analysis of Triatoma virus (TrV) from Triatoma infestans. Acta Crystallogr D Biol Crystallogr (2004) 0.76
Erratum: Structural basis of potent Zika-dengue virus antibody cross-neutralization. Nature (2016) 0.76
Virology: One protein, many functions. Nature (2010) 0.75
Pathway of virus-induced membrane fusion studied with liposomes. Methods Enzymol (2003) 0.75
Virus/host interactions: a strong force driving the diversification of cellular organisms. Curr Opin Microbiol (2011) 0.75
Macromolecular assemblies. Curr Opin Struct Biol (2009) 0.75