Published in J Biol Chem on July 13, 2006
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. Neurobiol Learn Mem (2011) 1.63
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. EMBO J (2011) 1.13
Structural and hydration properties of the partially unfolded states of the prion protein. Biophys J (2007) 0.99
Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria. PLoS One (2010) 0.98
Human apolipoprotein A-I-derived amyloid: its association with atherosclerosis. PLoS One (2011) 0.98
Aggregation of prion protein with insertion mutations is proportional to the number of inserts. Biochem J (2007) 0.90
Misfolded PrP and a novel mechanism of proteasome inhibition. Prion (2012) 0.83
Observing fibrillar assemblies on scrapie-infected cells. Pflugers Arch (2008) 0.81
Unique Properties of the Rabbit Prion Protein Oligomer. PLoS One (2016) 0.75
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. J Clin Invest (2012) 2.33
Monoclonal antibodies that target pathological assemblies of Abeta. J Neurochem (2006) 2.32
Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J (2007) 2.25
Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases. IUBMB Life (2007) 1.81
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. Cell Metab (2013) 1.74
Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria. J Biol Chem (2004) 1.59
Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts. Prog Neurobiol (2007) 1.37
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization. FASEB J (2004) 1.35
Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS Drugs (2013) 1.30
Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus. FEBS Lett (2005) 1.27
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem (2008) 1.20
N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers. J Neurochem (2010) 1.10
Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein. J Mol Biol (2006) 1.07
Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity. Int J Biochem Cell Biol (2008) 1.07
Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity. J Biol Chem (2006) 1.06
Closed conformation of the active site loop of rabbit muscle triosephosphate isomerase in the absence of substrate: evidence of conformational heterogeneity. J Mol Biol (2003) 1.02
Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria. PLoS One (2010) 0.98
Formation of amyloid aggregates from human lysozyme and its disease-associated variants using hydrostatic pressure. FASEB J (2004) 0.97
Amyloid-beta oligomers increase the localization of prion protein at the cell surface. J Neurochem (2011) 0.97
Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration. J Neurochem (2007) 0.97
Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers. J Biol Chem (2012) 0.96
Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers. J Biol Chem (2010) 0.94
Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers. J Neurosci (2013) 0.93
Amyloid-β oligomers induce differential gene expression in adult human brain slices. J Biol Chem (2012) 0.91
Folding intermediates of the prion protein stabilized by hydrostatic pressure and low temperature. J Biol Chem (2003) 0.88
Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons. Neuropharmacology (2005) 0.88
Amyloidogenicity and cytotoxicity of recombinant mature human islet amyloid polypeptide (rhIAPP). J Biol Chem (2004) 0.87
Solution studies and structural model of the extracellular domain of the human amyloid precursor protein. Biophys J (2002) 0.86
Small molecule inhibitors of lysozyme amyloid aggregation. Cell Biochem Biophys (2006) 0.86
Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease. Cell Mol Neurobiol (2002) 0.86
Peptide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by amyloid beta. J Biol Chem (2005) 0.85
Neuritogenesis and neuronal differentiation promoted by 2,4-dinitrophenol, a novel anti-amyloidogenic compound. FASEB J (2005) 0.84
Folding of a de novo designed native-like four-helix bundle protein. J Biol Chem (2002) 0.82
Protein folding, misfolding and aggregation: evolving concepts and conformational diseases. Protein Pept Lett (2005) 0.82
Heparin-binding sites in granulocyte-macrophage colony-stimulating factor. Localization and regulation by histidine ionization. J Biol Chem (2005) 0.82
Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: up-regulation of cAMP signaling genes. Neurotox Res (2009) 0.82
Functional properties of purified vicilins from cowpea (Vigna unguiculata) and pea (Pisum sativum) and cowpea protein isolate. J Agric Food Chem (2003) 0.81
Inhibition of yeast glutathione reductase by trehalose: possible implications in yeast survival and recovery from stress. Int J Biochem Cell Biol (2004) 0.81
Predissociated dimers and molten globule monomers in the equilibrium unfolding of yeast glutathione reductase. Biophys J (2003) 0.81
Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease. Curr Alzheimer Res (2007) 0.81
Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus. IUBMB Life (2006) 0.80
Folding and stability of the extracellular domain of the human amyloid precursor protein. J Biol Chem (2003) 0.80
Metastable, partially folded states in the productive folding and in the misfolding and amyloid aggregation of proteins. Cell Biochem Biophys (2006) 0.78
Acid- and pressure-induced (un)folding of yeast glutathione reductase: competition between protein oligomerization and aggregation. Int J Biochem Cell Biol (2005) 0.78
Folding and stability of a coiled-coil investigated using chemical and physical denaturing agents: comparative analysis of polymerized and non-polymerized forms of alpha-tropomyosin. Int J Biochem Cell Biol (2005) 0.77
2,4-Dinitrophenol blocks neurodegeneration and preserves sciatic nerve function after trauma. J Neurotrauma (2010) 0.77
Neuroprotection against Abeta and glutamate toxicity by melatonin: are GABA receptors involved? Neurotox Res (2003) 0.77
Identification of a neurofilament-like protein in the protocerebral tract of the crab Ucides cordatus. Cell Tissue Res (2004) 0.77
Secreted human amyloid precursor protein binds semaphorin 3a and prevents semaphorin-induced growth cone collapse. PLoS One (2011) 0.77
Equilibrium unfolding and conformational plasticity of troponin I and T. Eur J Biochem (2002) 0.77
Amyloid-β decreases nitric oxide production in cultured retinal neurons: a possible mechanism for synaptic dysfunction in Alzheimer's disease? Neurochem Res (2010) 0.76
Long-lived conformational isomerism of protein dimers: the role of the free energy of subunit association. Biophys J (2006) 0.75
Interrogating global gene expression in rat neuronal cultures using SAGE. Neurotox Res (2007) 0.75
Redesigning the folding energetics of a model three-helix bundle protein by site-directed mutagenesis. J Biol Chem (2003) 0.75
Reductive inactivation of yeast glutathione reductase by Fe(II) and NADPH. Comp Biochem Physiol A Mol Integr Physiol (2007) 0.75
Conformational plasticity of DM43, a metalloproteinase inhibitor from Didelphis marsupialis: chemical and pressure-induced equilibrium (un)folding studies. Biochim Biophys Acta (2009) 0.75