Published in J Phys Chem B on October 20, 2005
Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. Science (2009) 3.85
Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions. Chem Rev (2006) 2.16
Rate theories for biologists. Q Rev Biophys (2010) 1.44
Stochastic fluctuations in metabolic pathways. Proc Natl Acad Sci U S A (2007) 1.39
Use of pathway information in molecular epidemiology. Hum Genomics (2009) 1.22
Initiation of transcription-coupled repair characterized at single-molecule resolution. Nature (2012) 1.10
Modelling reaction kinetics inside cells. Essays Biochem (2008) 1.05
Coupling of pressure-induced structural shifts to spectral changes in a yellow fluorescent protein. Biophys J (2009) 0.96
Utilizing the information content in two-state trajectories. Proc Natl Acad Sci U S A (2006) 0.96
Extending the absorbing boundary method to fit dwell-time distributions of molecular motors with complex kinetic pathways. Proc Natl Acad Sci U S A (2007) 0.93
The Goldbeter-Koshland switch in the first-order region and its response to dynamic disorder. PLoS One (2008) 0.90
Electrochemical tunnelling sensors and their potential applications. Nat Commun (2012) 0.89
Mechanistic constraints from the substrate concentration dependence of enzymatic fluctuations. Proc Natl Acad Sci U S A (2010) 0.88
Stochastic focusing coupled with negative feedback enables robust regulation in biochemical reaction networks. J R Soc Interface (2015) 0.87
Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments. BMC Syst Biol (2009) 0.87
Statistics and Related Topics in Single-Molecule Biophysics. Annu Rev Stat Appl (2014) 0.84
Quantitative interpretation of the randomness in single enzyme turnover times. Biophys J (2011) 0.81
Role of substrate unbinding in Michaelis-Menten enzymatic reactions. Proc Natl Acad Sci U S A (2014) 0.81
Modelling non-Markovian dynamics in biochemical reactions. BMC Syst Biol (2015) 0.80
Dynamic disorder and the energetic costs of information transduction. J Chem Phys (2014) 0.80
Enzymatic turnover of macromolecules generates long-lasting protein-water-coupled motions beyond reaction steady state. Proc Natl Acad Sci U S A (2014) 0.79
Single-molecule enzymatic conformational dynamics: spilling out the product molecules. J Phys Chem B (2014) 0.79
Correlation Analysis of Enzymatic Reaction of a Single Protein Molecule. Ann Appl Stat (2012) 0.79
Stepping and crowding of molecular motors: statistical kinetics from an exclusion process perspective. Biophys J (2014) 0.78
Michaelis-Menten relations for complex enzymatic networks. J Chem Phys (2011) 0.78
Variance-corrected Michaelis-Menten equation predicts transient rates of single-enzyme reactions and response times in bacterial gene-regulation. Sci Rep (2015) 0.78
smFRET studies of the 'encounter' complexes and subsequent intermediate states that regulate the selectivity of ligand binding. FEBS Lett (2014) 0.78
Three-state kinetic mechanism for scaffold-mediated signal transduction. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 0.77
A queueing approach to multi-site enzyme kinetics. Interface Focus (2014) 0.76
Mfd as a central partner of transcription coupled repair. Transcription (2013) 0.75
Stochastic dynamic study of optical transition properties of single GFP-like molecules. J Biol Phys (2016) 0.75
Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS. Proc Natl Acad Sci U S A (2016) 0.75
A model for single-substrate trimolecular enzymatic kinetics. Biophys J (2010) 0.75
Activator-induced dynamic disorder and molecular memory in human two-pore domain hTREK1 K channel. J Chem Biol (2011) 0.75
Quantifying protein diffusion and capture on filaments. Biophys J (2015) 0.75
Nonparametric Inference of Doubly Stochastic Poisson Process Data via the Kernel Method. Ann Appl Stat (2010) 0.75
Stationary distribution of self-organized states and biological information generation. Sci Rep (2013) 0.75
Dynamic disorder in simple enzymatic reactions induces stochastic amplification of substrate. J R Soc Interface (2017) 0.75
Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science (2010) 11.37
Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science (2008) 10.19
Stochastic protein expression in individual cells at the single molecule level. Nature (2006) 8.00
Probing gene expression in live cells, one protein molecule at a time. Science (2006) 7.21
Probing transcription factor dynamics at the single-molecule level in a living cell. Science (2007) 6.85
Protein conformational dynamics probed by single-molecule electron transfer. Science (2003) 6.48
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A (2005) 5.96
Genome-wide detection of single-nucleotide and copy-number variations of a single human cell. Science (2012) 5.50
Coherent anti-stokes Raman scattering microscopy: chemical imaging for biology and medicine. Annu Rev Anal Chem (Palo Alto Calif) (2008) 5.13
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A (2006) 4.60
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. Nat Chem Biol (2005) 4.24
Linking stochastic dynamics to population distribution: an analytical framework of gene expression. Phys Rev Lett (2006) 4.06
DNA primase acts as a molecular brake in DNA replication. Nature (2006) 3.66
A stochastic single-molecule event triggers phenotype switching of a bacterial cell. Science (2008) 3.46
Video-rate molecular imaging in vivo with stimulated Raman scattering. Science (2010) 3.30
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder. Science (2003) 3.22
Central dogma at the single-molecule level in living cells. Nature (2011) 3.00
Probing allostery through DNA. Science (2013) 2.92
Imaging chromophores with undetectable fluorescence by stimulated emission microscopy. Nature (2009) 2.74
Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy. J Lipid Res (2003) 2.59
Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes. Proc Natl Acad Sci U S A (2012) 2.59
Observation of individual microtubule motor steps in living cells with endocytosed quantum dots. J Phys Chem B (2005) 2.55
Nonspecifically bound proteins spin while diffusing along DNA. Nat Struct Mol Biol (2009) 2.43
Chromosome organization by a nucleoid-associated protein in live bacteria. Science (2011) 2.41
Fluctuating enzymes: lessons from single-molecule studies. Acc Chem Res (2005) 2.33
Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med (2013) 2.31
High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy. Opt Lett (2006) 2.27
Laser-scanning coherent anti-Stokes Raman scattering microscopy and applications to cell biology. Biophys J (2002) 2.26
Single-molecule imaging of transcription factor binding to DNA in live mammalian cells. Nat Methods (2013) 2.22
Coherent nonlinear optical imaging: beyond fluorescence microscopy. Annu Rev Phys Chem (2011) 2.22
Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Science (2012) 2.14
Fluorogenic DNA sequencing in PDMS microreactors. Nat Methods (2011) 2.13
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients. Proc Natl Acad Sci U S A (2013) 2.09
Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase. Proc Natl Acad Sci U S A (2007) 2.06
Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging. Opt Lett (2006) 1.96
Observation of a power-law memory kernel for fluctuations within a single protein molecule. Phys Rev Lett (2005) 1.91
RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods (2011) 1.82
Nonperturbative chemical imaging of organelle transport in living cells with coherent anti-stokes Raman scattering microscopy. Biophys J (2006) 1.75
Generalized Langevin equation with fractional Gaussian noise: subdiffusion within a single protein molecule. Phys Rev Lett (2004) 1.70
Chemically-selective imaging of brain structures with CARS microscopy. Opt Express (2007) 1.62
High-resolution near-field Raman microscopy of single-walled carbon nanotubes. Phys Rev Lett (2003) 1.55
Organelle tracking in a living cell with microsecond time resolution and nanometer spatial precision. Chemphyschem (2008) 1.41
Coherent anti-stokes raman scattering spectral interferometry: determination of the real and imaginary components of nonlinear susceptibility chi(3) for vibrational microscopy. Opt Lett (2004) 1.40
Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy. Proc Natl Acad Sci U S A (2013) 1.36
Diffusion constant of a nonspecifically bound protein undergoing curvilinear motion along DNA. J Phys Chem B (2008) 1.33
Ordering of water molecules between phospholipid bilayers visualized by coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A (2003) 1.33
Highly specific label-free molecular imaging with spectrally tailored excitation stimulated Raman scattering (STE-SRS) microscopy. Nat Photonics (2011) 1.32
Label-free, real-time monitoring of biomass processing with stimulated Raman scattering microscopy. Angew Chem Int Ed Engl (2010) 1.30
Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA. Nat Methods (2007) 1.29
Coherent Raman scanning fiber endoscopy. Opt Lett (2011) 1.28
Direct visualization of lipid phase segregation in single lipid bilayers with coherent anti-Stokes Raman scattering microscopy. Chemphyschem (2005) 1.27
Two-dimensional reaction free energy surfaces of catalytic reaction: effects of protein conformational dynamics on enzyme catalysis. J Phys Chem B (2007) 1.25
Probing dynein and kinesin stepping with mechanical manipulation in a living cell. Chemphyschem (2009) 1.24
Multicolored stain-free histopathology with coherent Raman imaging. Lab Invest (2012) 1.22
Coordinated production and utilization of FADH2 by NAD(P)H-flavin oxidoreductase and 4-hydroxyphenylacetate 3-monooxygenase. Biochemistry (2003) 1.21
Label-free live-cell imaging of nucleic acids using stimulated Raman scattering microscopy. Chemphyschem (2012) 1.20
When does the Michaelis-Menten equation hold for fluctuating enzymes? J Phys Chem B (2006) 1.15
Imaging drug delivery to skin with stimulated Raman scattering microscopy. Mol Pharm (2011) 1.15
High-power picosecond fiber source for coherent Raman microscopy. Opt Lett (2009) 1.12
Dynamic distance disorder in proteins is caused by trapping. J Phys Chem B (2006) 1.10
Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy. Proc Natl Acad Sci U S A (2013) 1.09
Generalized Haldane equation and fluctuation theorem in the steady-state cycle kinetics of single enzymes. Phys Rev E Stat Nonlin Soft Matter Phys (2006) 1.07
Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. Virology (2009) 1.05
Super-resolution laser scanning microscopy through spatiotemporal modulation. Nano Lett (2009) 1.05
Peroxisome proliferator-activated receptor alpha antagonism inhibits hepatitis C virus replication. Chem Biol (2006) 1.04
Single-molecule study of DNA polymerization activity of HIV-1 reverse transcriptase on DNA templates. J Mol Biol (2009) 1.03
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates. J Biol Chem (2012) 1.03
Multicolor stimulated Raman scattering microscopy with a rapidly tunable optical parametric oscillator. Opt Lett (2013) 1.03
Synchronized time-lens source for coherent Raman scattering microscopy. Opt Express (2010) 1.02
Multicolor stimulated Raman scattering (SRS) microscopy. Mol Phys (2012) 1.02
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction. J Biol Chem (2012) 1.00
Label-free imaging of lipid dynamics using Coherent Anti-stokes Raman Scattering (CARS) and Stimulated Raman Scattering (SRS) microscopy. Curr Opin Genet Dev (2011) 1.00
Positive allosteric feedback regulation of the stringent response enzyme RelA by its product. EMBO Rep (2012) 0.99
Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice. J Biomed Opt (2011) 0.99
Reliable cell segmentation based on spectral phasor analysis of hyperspectral stimulated Raman scattering imaging data. Anal Chem (2014) 0.99
Intracavity wavelength modulation of an optical parametric oscillator for coherent Raman microscopy. Opt Express (2009) 0.96
Multicolor live-cell chemical imaging by isotopically edited alkyne vibrational palette. J Am Chem Soc (2014) 0.92
Dynamics of chain closure: approximate treatment of nonlocal interactions. J Chem Phys (2004) 0.92
Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies. Chembiochem (2006) 0.92
Protein-flexibility mediated coupling between photoswitching kinetics and surrounding viscosity of a photochromic fluorescent protein. Proc Natl Acad Sci U S A (2012) 0.91
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA AND to hexon of the precursor to protein VI, pVI, of human adenovirus. J Biol Chem (2012) 0.90
Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40. Sci Rep (2011) 0.90
Nonequilibrium steady state of a nanometric biochemical system: determining the thermodynamic driving force from single enzyme turnover time traces. Nano Lett (2005) 0.89
Rare event of histone demethylation can initiate singular gene expression of olfactory receptors. Proc Natl Acad Sci U S A (2013) 0.89
FAD is a preferred substrate and an inhibitor of Escherichia coli general NAD(P)H:flavin oxidoreductase. J Biol Chem (2002) 0.86
High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice. Cancer Lett (2006) 0.86
Role of conformational dynamics in kinetics of an enzymatic cycle in a nonequilibrium steady state. J Chem Phys (2009) 0.86
Tracking surface glycans on live cancer cells with single-molecule sensitivity. Angew Chem Int Ed Engl (2014) 0.85
Stochastic switching in gene networks can occur by a single-molecule event or many molecular steps. J Mol Biol (2009) 0.85
Near-degenerate four-wave-mixing microscopy. Nano Lett (2009) 0.85