Published in Nat Methods on June 12, 2011
PEG-labeled nucleotides and nanopore detection for single molecule DNA sequencing by synthesis. Sci Rep (2012) 1.16
Points of view: arrows. Nat Methods (2011) 1.03
Scalable microfluidics for single-cell RNA printing and sequencing. Genome Biol (2015) 1.02
Reconfigurable microfluidics combined with antibody microarrays for enhanced detection of T-cell secreted cytokines. Biomicrofluidics (2013) 0.93
PyroHMMsnp: an SNP caller for Ion Torrent and 454 sequencing data. Nucleic Acids Res (2013) 0.91
Fluorogenic pyrosequencing in microreactors. Nat Methods (2011) 0.90
Lab-on-a-chip technologies for single-molecule studies. Lab Chip (2013) 0.85
An Automated Microwell Platform for Large-Scale Single Cell RNA-Seq. Sci Rep (2016) 0.82
The Sequencing Bead Array (SBA), a next-generation digital suspension array. PLoS One (2013) 0.78
Lignocellulose-based analytical devices: bamboo as an analytical platform for chemical detection. Sci Rep (2015) 0.76
ATP-Releasing Nucleotides: Linking DNA Synthesis to Luciferase Signaling. Angew Chem Int Ed Engl (2016) 0.75
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
Real-time DNA sequencing from single polymerase molecules. Science (2008) 29.53
Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science (2009) 21.24
Accurate multiplex polony sequencing of an evolved bacterial genome. Science (2005) 20.91
Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding. Genome Res (2009) 15.15
Real-time DNA sequencing using detection of pyrophosphate release. Anal Biochem (1996) 12.94
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. Proc Natl Acad Sci U S A (2003) 12.91
Single-molecule DNA sequencing of a viral genome. Science (2008) 11.66
Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. Acc Chem Res (2002) 7.35
Whole-genome molecular haplotyping of single cells. Nat Biotechnol (2010) 6.77
Alta-Cyclic: a self-optimizing base caller for next-generation sequencing. Nat Methods (2008) 5.70
Microdroplet-based PCR enrichment for large-scale targeted sequencing. Nat Biotechnol (2009) 4.80
Microfluidic single-cell mRNA isolation and analysis. Anal Chem (2006) 2.47
Microfabricated arrays of femtoliter chambers allow single molecule enzymology. Nat Biotechnol (2005) 1.63
The autofluorescence of plastic materials and chips measured under laser irradiation. Lab Chip (2005) 1.56
Long, processive enzymatic DNA synthesis using 100% dye-labeled terminal phosphate-linked nucleotides. Nucleosides Nucleotides Nucleic Acids (2008) 1.52
Terminal phosphate labeled nucleotides: synthesis, applications, and linker effect on incorporation by DNA polymerases. Nucleosides Nucleotides Nucleic Acids (2005) 1.38
Stochastic inhibitor release and binding from single-enzyme molecules. Proc Natl Acad Sci U S A (2007) 1.14
Terminal phosphate-labeled nucleotides with improved substrate properties for homogeneous nucleic acid assays. J Am Chem Soc (2005) 1.08
Plasma stencilling methods for cell patterning. Anal Bioanal Chem (2009) 1.03
Immobilization of DNA onto poly(dimethylsiloxane) surfaces and application to a microelectrochemical enzyme-amplified DNA hybridization assay. Langmuir (2004) 1.03
Synthesis and properties of a new fluorescent analog of ATP: adenosine-5'-triphosphoro-gamma-1-(5-sulfonic acid) napthylamidate. Biochem Biophys Res Commun (1978) 1.02
Rolling circle amplification of DNA immobilized on solid surfaces and its application to multiplex mutation detection. Genet Anal (1999) 0.92
A novel design method of ratiometric fluorescent probes based on fluorescence resonance energy transfer switching by spectral overlap integral. Chemistry (2003) 0.90
Homogeneous fluorescent assay for RNA polymerase. Anal Biochem (2005) 0.89
Cramming more sequencing reactions onto microreactor chips. Chem Rev (2007) 0.84
ATP gamma-anilidate; a substrate of DNA-dependent RNA-polymerase of Escherichia coli. FEBS Lett (1974) 0.84
Investigation of the phenylalanyl-tRNA synthetase modification with gamma-(p-azidoanilide-)-ATP. FEBS Lett (1975) 0.83
Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science (2010) 11.37
Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science (2008) 10.19
Stochastic protein expression in individual cells at the single molecule level. Nature (2006) 8.00
Probing gene expression in live cells, one protein molecule at a time. Science (2006) 7.21
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat Methods (2013) 7.06
Probing transcription factor dynamics at the single-molecule level in a living cell. Science (2007) 6.85
Protein conformational dynamics probed by single-molecule electron transfer. Science (2003) 6.48
Direct observation of base-pair stepping by RNA polymerase. Nature (2005) 6.29
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A (2005) 5.96
Genome-wide detection of single-nucleotide and copy-number variations of a single human cell. Science (2012) 5.50
Coherent anti-stokes Raman scattering microscopy: chemical imaging for biology and medicine. Annu Rev Anal Chem (Palo Alto Calif) (2008) 5.13
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A (2006) 4.60
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. Nat Chem Biol (2005) 4.24
Linking stochastic dynamics to population distribution: an analytical framework of gene expression. Phys Rev Lett (2006) 4.06
DNA primase acts as a molecular brake in DNA replication. Nature (2006) 3.66
A stochastic single-molecule event triggers phenotype switching of a bacterial cell. Science (2008) 3.46
Video-rate molecular imaging in vivo with stimulated Raman scattering. Science (2010) 3.30
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder. Science (2003) 3.22
Central dogma at the single-molecule level in living cells. Nature (2011) 3.00
Probing allostery through DNA. Science (2013) 2.92
Imaging chromophores with undetectable fluorescence by stimulated emission microscopy. Nature (2009) 2.74
Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy. J Lipid Res (2003) 2.59
Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes. Proc Natl Acad Sci U S A (2012) 2.59
Observation of individual microtubule motor steps in living cells with endocytosed quantum dots. J Phys Chem B (2005) 2.55
Applied force reveals mechanistic and energetic details of transcription termination. Cell (2008) 2.45
Nonspecifically bound proteins spin while diffusing along DNA. Nat Struct Mol Biol (2009) 2.43
Chromosome organization by a nucleoid-associated protein in live bacteria. Science (2011) 2.41
Fluctuating enzymes: lessons from single-molecule studies. Acc Chem Res (2005) 2.33
Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med (2013) 2.31
High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy. Opt Lett (2006) 2.27
Laser-scanning coherent anti-Stokes Raman scattering microscopy and applications to cell biology. Biophys J (2002) 2.26
Single-molecule imaging of transcription factor binding to DNA in live mammalian cells. Nat Methods (2013) 2.22
Coherent nonlinear optical imaging: beyond fluorescence microscopy. Annu Rev Phys Chem (2011) 2.22
Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Science (2012) 2.14
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients. Proc Natl Acad Sci U S A (2013) 2.09
Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase. Proc Natl Acad Sci U S A (2007) 2.06
Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging. Opt Lett (2006) 1.96
Observation of a power-law memory kernel for fluctuations within a single protein molecule. Phys Rev Lett (2005) 1.91
RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods (2011) 1.82
Single-molecule Michaelis-Menten equations. J Phys Chem B (2005) 1.80
Single-molecule studies of RNA polymerase: motoring along. Annu Rev Biochem (2008) 1.80
Nonperturbative chemical imaging of organelle transport in living cells with coherent anti-stokes Raman scattering microscopy. Biophys J (2006) 1.75
Generalized Langevin equation with fractional Gaussian noise: subdiffusion within a single protein molecule. Phys Rev Lett (2004) 1.70
Chemically-selective imaging of brain structures with CARS microscopy. Opt Express (2007) 1.62
High-resolution near-field Raman microscopy of single-walled carbon nanotubes. Phys Rev Lett (2003) 1.55
ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide. Curr Protoc Mol Biol (2015) 1.44
Organelle tracking in a living cell with microsecond time resolution and nanometer spatial precision. Chemphyschem (2008) 1.41
Coherent anti-stokes raman scattering spectral interferometry: determination of the real and imaginary components of nonlinear susceptibility chi(3) for vibrational microscopy. Opt Lett (2004) 1.40
Diffusion constant of a nonspecifically bound protein undergoing curvilinear motion along DNA. J Phys Chem B (2008) 1.33
Ordering of water molecules between phospholipid bilayers visualized by coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A (2003) 1.33
Highly specific label-free molecular imaging with spectrally tailored excitation stimulated Raman scattering (STE-SRS) microscopy. Nat Photonics (2011) 1.32
Label-free, real-time monitoring of biomass processing with stimulated Raman scattering microscopy. Angew Chem Int Ed Engl (2010) 1.30
Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA. Nat Methods (2007) 1.29
Coherent Raman scanning fiber endoscopy. Opt Lett (2011) 1.28
Direct visualization of lipid phase segregation in single lipid bilayers with coherent anti-Stokes Raman scattering microscopy. Chemphyschem (2005) 1.27
Two-dimensional reaction free energy surfaces of catalytic reaction: effects of protein conformational dynamics on enzyme catalysis. J Phys Chem B (2007) 1.25
Probing dynein and kinesin stepping with mechanical manipulation in a living cell. Chemphyschem (2009) 1.24
Multicolored stain-free histopathology with coherent Raman imaging. Lab Invest (2012) 1.22
Coordinated production and utilization of FADH2 by NAD(P)H-flavin oxidoreductase and 4-hydroxyphenylacetate 3-monooxygenase. Biochemistry (2003) 1.21
Label-free live-cell imaging of nucleic acids using stimulated Raman scattering microscopy. Chemphyschem (2012) 1.20
When does the Michaelis-Menten equation hold for fluctuating enzymes? J Phys Chem B (2006) 1.15
Imaging drug delivery to skin with stimulated Raman scattering microscopy. Mol Pharm (2011) 1.15
High-power picosecond fiber source for coherent Raman microscopy. Opt Lett (2009) 1.12
Dynamic distance disorder in proteins is caused by trapping. J Phys Chem B (2006) 1.10
Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy. Proc Natl Acad Sci U S A (2013) 1.09
Generalized Haldane equation and fluctuation theorem in the steady-state cycle kinetics of single enzymes. Phys Rev E Stat Nonlin Soft Matter Phys (2006) 1.07
Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. Virology (2009) 1.05
Peroxisome proliferator-activated receptor alpha antagonism inhibits hepatitis C virus replication. Chem Biol (2006) 1.04
Multicolor stimulated Raman scattering microscopy with a rapidly tunable optical parametric oscillator. Opt Lett (2013) 1.03
Single-molecule study of DNA polymerization activity of HIV-1 reverse transcriptase on DNA templates. J Mol Biol (2009) 1.03
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates. J Biol Chem (2012) 1.03
Synchronized time-lens source for coherent Raman scattering microscopy. Opt Express (2010) 1.02
Multicolor stimulated Raman scattering (SRS) microscopy. Mol Phys (2012) 1.02
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction. J Biol Chem (2012) 1.00
Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice. J Biomed Opt (2011) 0.99
Reliable cell segmentation based on spectral phasor analysis of hyperspectral stimulated Raman scattering imaging data. Anal Chem (2014) 0.99
Intracavity wavelength modulation of an optical parametric oscillator for coherent Raman microscopy. Opt Express (2009) 0.96
Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies. Chembiochem (2006) 0.92
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA AND to hexon of the precursor to protein VI, pVI, of human adenovirus. J Biol Chem (2012) 0.90
Nonequilibrium steady state of a nanometric biochemical system: determining the thermodynamic driving force from single enzyme turnover time traces. Nano Lett (2005) 0.89
Assembly of magnetic nanospheres into one-dimensional nanostructured carbon hybrid materials. Langmuir (2010) 0.89
Rare event of histone demethylation can initiate singular gene expression of olfactory receptors. Proc Natl Acad Sci U S A (2013) 0.89
Digital polymerase chain reaction in an array of femtoliter polydimethylsiloxane microreactors. Anal Chem (2012) 0.86
FAD is a preferred substrate and an inhibitor of Escherichia coli general NAD(P)H:flavin oxidoreductase. J Biol Chem (2002) 0.86
Role of conformational dynamics in kinetics of an enzymatic cycle in a nonequilibrium steady state. J Chem Phys (2009) 0.86
Near-degenerate four-wave-mixing microscopy. Nano Lett (2009) 0.85
Stochastic switching in gene networks can occur by a single-molecule event or many molecular steps. J Mol Biol (2009) 0.85
Development and evaluation of a trehalose-contained solution formula to preserve hUC-MSCs at 4°C. J Cell Physiol (2012) 0.83
Optical heterodyne-detected Raman-induced Kerr effect (OHD-RIKE) microscopy. J Phys Chem B (2011) 0.83
Molecule by molecule, the physics and chemistry of life: SMB 2007. Nat Chem Biol (2007) 0.82
Multiple time scale dynamics of distance fluctuations in a semiflexible polymer: a one-dimensional generalized Langevin equation treatment. J Chem Phys (2005) 0.82
One step cascade synthesis of 4,5-disubstituted-1,2,3-(NH)-triazoles. Org Lett (2008) 0.81
Fiber optical parametric oscillator for coherent anti-Stokes Raman scattering microscopy. Opt Lett (2013) 0.81
Modeling spatial correlation of DNA deformation: DNA allostery in protein binding. J Phys Chem B (2013) 0.81
Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice. Planta Med (2009) 0.80
Coherent Raman imaging techniques and biomedical applications. J Biomed Opt (2011) 0.80
1,2,3-Triazole-boranes: stable and efficient reagents for ketone and aldehyde reductive amination in organic solvents or in water. Chem Commun (Camb) (2009) 0.80
Hydrogen production coupled to hydrocarbon oxygenation from photocatalytic water splitting. Angew Chem Int Ed Engl (2011) 0.80
Picosecond-pulse amplification with an external passive optical cavity. Opt Lett (2003) 0.80
Effects of adenovirus-mediated delivery of the human hepatocyte growth factor gene in experimental radiation-induced heart disease. Int J Radiat Oncol Biol Phys (2009) 0.80