PubRank

David A Brenner

Author PubWeight™ 269.00‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Liver fibrosis. J Clin Invest 2005 17.27
2 TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 2007 9.77
3 Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008 5.06
4 Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 2007 4.06
5 Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A 2012 3.90
6 Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008 3.72
7 NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest 2003 3.69
8 CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest 2009 3.62
9 Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010 3.52
10 Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 2003 3.51
11 A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology 2004 3.42
12 Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol 2006 3.42
13 Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006 3.16
14 Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 2010 3.10
15 Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem 2005 2.74
16 Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology 2010 2.73
17 Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A 2009 2.68
18 Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med 2010 2.65
19 Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology 2012 2.58
20 Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology 2003 2.51
21 CCR2 promotes hepatic fibrosis in mice. Hepatology 2009 2.35
22 Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 2010 2.32
23 Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. J Hepatol 2012 2.28
24 Mechanisms of fibrogenesis. Exp Biol Med (Maywood) 2008 2.26
25 Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology 2010 2.23
26 Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest 2005 2.20
27 Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol 2002 2.17
28 A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology 2012 2.15
29 DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology 2003 2.10
30 Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol 2003 2.07
31 Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal 2002 2.03
32 Anandamide induces necrosis in primary hepatic stellate cells. Hepatology 2005 1.98
33 Identification of small molecule activators of cryptochrome. Science 2012 1.95
34 Toll-like receptor signaling in the liver. Gastroenterology 2006 1.94
35 Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol 2007 1.88
36 c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 2003 1.87
37 In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol 2004 1.84
38 Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology 2009 1.83
39 Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest 2014 1.82
40 Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 2008 1.81
41 Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology 2006 1.81
42 Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology 2008 1.79
43 Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology 2013 1.78
44 Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol 2006 1.77
45 The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem 2002 1.77
46 Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J 2004 1.76
47 Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol 2008 1.76
48 Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 2004 1.73
49 Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol 2004 1.72
50 Anti-fibrogenic strategies and the regression of fibrosis. Best Pract Res Clin Gastroenterol 2011 1.70
51 Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A 2009 1.69
52 Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem 2005 1.61
53 c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology 2009 1.59
54 TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 2014 1.58
55 Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 2011 1.55
56 Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology 2008 1.53
57 Fibrogenesis of parenchymal organs. Proc Am Thorac Soc 2008 1.53
58 Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology 2004 1.51
59 What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis. J Gastroenterol Hepatol 2012 1.50
60 Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology 2012 1.49
61 Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology 2013 1.48
62 Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Lab Invest 2002 1.47
63 CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology 2010 1.46
64 Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology 2009 1.45
65 Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Front Biosci 2003 1.42
66 JNK mediates hepatic ischemia reperfusion injury. J Hepatol 2005 1.42
67 The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology 2007 1.40
68 Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Nat Immunol 2012 1.38
69 Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res 2011 1.37
70 Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Gastroenterol Res Pract 2011 1.37
71 High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology 2008 1.37
72 Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology 2003 1.34
73 Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology 2005 1.34
74 The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology 2011 1.33
75 Liver fibrogenesis: a new role for the renin-angiotensin system. Antioxid Redox Signal 2005 1.31
76 NOX in liver fibrosis. Arch Biochem Biophys 2007 1.29
77 Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med (Maywood) 2005 1.27
78 Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Am J Physiol Gastrointest Liver Physiol 2003 1.27
79 Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Hepatology 2006 1.25
80 NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Gastroenterology 2006 1.22
81 What is the potential role of antifibrotic agents for the treatment of liver disease? Nat Clin Pract Gastroenterol Hepatol 2008 1.21
82 Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Gastroenterology 2010 1.20
83 Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Gastroenterology 2012 1.20
84 Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. J Biol Chem 2004 1.20
85 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. J Biol Chem 2002 1.19
86 M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol 2013 1.19
87 Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology 2015 1.18
88 Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology 2010 1.18
89 Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol 2009 1.17
90 Migration of fibrocytes in fibrogenic liver injury. Am J Pathol 2011 1.17
91 Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. Proc Natl Acad Sci U S A 2012 1.16
92 From quiescence to activation: Gene regulation in hepatic stellate cells. Gastroenterology 2004 1.15
93 Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology 2007 1.15
94 TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology 2002 1.14
95 Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol 2003 1.13
96 NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Korean J Hepatol 2011 1.13
97 Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest 2008 1.12
98 Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. J Gastroenterol Hepatol 2008 1.12
99 The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem 2005 1.11
100 TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Biochem Biophys Res Commun 2008 1.11
101 Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation 2006 1.11
102 Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal 2014 1.10
103 Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis 2005 1.09
104 Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Curr Pathobiol Rep 2013 1.08
105 Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology 2010 1.08
106 Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol 2005 1.08
107 An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Blood 2002 1.05
108 Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig Dis Sci 2007 1.05
109 Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. J Biol Chem 2002 1.05
110 Recent advances in liver stem cell therapy. Curr Opin Gastroenterol 2010 1.05
111 Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation 2003 1.05
112 Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Lab Invest 2006 1.04
113 Clinical syndromes of alcoholic liver disease. Dig Dis 2005 1.04
114 The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Hepatol 2011 1.04
115 Inactivation of myofibroblasts during regression of liver fibrosis. Cell Cycle 2013 1.04
116 c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Hepatology 2009 1.03
117 Information assimilation and distribution challenges and goals for real and virtual journals. J Clin Gastroenterol 2005 1.02
118 Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med (Berl) 2011 1.02
119 Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res 2005 1.01
120 Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Infect Immun 2002 1.01
121 Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Hepatology 2002 1.00
122 TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol 2004 0.99
123 Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology 2005 0.98
124 Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2006 0.97
125 c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation 2004 0.96
126 Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver Int 2009 0.95
127 Akt activation protects rat liver from ischemia/reperfusion injury. J Surg Res 2004 0.94
128 Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cells. J Biol Chem 2014 0.94
129 Diagnosis and management of patients with α1-antitrypsin (A1AT) deficiency. Clin Gastroenterol Hepatol 2011 0.94
130 Matrix metalloproteinase gene delivery for liver fibrosis. Pharm Res 2007 0.94
131 NF-kappaB activation in Kupffer cells after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol 2005 0.94
132 Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol 2003 0.92
133 Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl 2010 0.91
134 Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int 2006 0.90
135 Is it the end of the line for the EMT? Hepatology 2011 0.90
136 Mutation of the 5'-untranslated region stem-loop structure inhibits α1(I) collagen expression in vivo. J Biol Chem 2010 0.90
137 Genomics of liver fibrosis and cirrhosis. Semin Liver Dis 2007 0.89
138 Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Gastroenterology 2007 0.89
139 Recommendations for Probiotic Use-2015 Update: Proceedings and Consensus Opinion. J Clin Gastroenterol 2015 0.89
140 Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Clin Gastroenterol Hepatol 2011 0.88
141 Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. J Hepatol 2007 0.88
142 Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Gastroenterology 2007 0.88
143 Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol 2006 0.88
144 Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci 2003 0.87
145 Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J 2010 0.86
146 Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. J Gastroenterol Hepatol 2007 0.86
147 Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis. Am J Pathol 2013 0.85
148 Aging and liver disease. Curr Opin Gastroenterol 2015 0.84
149 Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochem Biophys Res Commun 2005 0.84
150 The genetics of nonalcoholic fatty liver disease. Ann Hepatol 2007 0.84
151 What goes up must come down: the emerging role of microRNA in fibrosis. Hepatology 2011 0.84
152 Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Neurology 2014 0.84
153 Nuclear factor-kappaB in the liver: friend or foe? Gastroenterology 2007 0.83
154 The enteropathy of prostaglandin deficiency. J Gastroenterol 2009 0.83
155 Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Am J Physiol Cell Physiol 2002 0.82
156 Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. PLoS One 2013 0.82
157 p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology 2003 0.81
158 Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver Int 2003 0.80
159 The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol 2007 0.79
160 Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. J Hepatol 2003 0.79
161 Hepatic progenitors for liver disease: current position. Stem Cells Cloning 2010 0.78
162 Alteration of interferon-α/β receptors in chronic hepatitis B patients. J Clin Immunol 2011 0.78
163 New Developments on the Treatment of Liver Fibrosis. Dig Dis 2016 0.77
164 Liver inflammation and fibrosis. J Clin Invest 2017 0.77
165 Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Surgery 2002 0.76
166 Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl 2006 0.76
167 TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Surgery 2004 0.76
168 Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Gut 2012 0.75
169 Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest 2017 0.75
170 Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Gastroenterology 2006 0.75
171 The future of gastroenterology and gastroenterology. Gastroenterology 2006 0.75
172 Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Gastroenterology 2013 0.75
173 Data from arrays: an embarrassment of riches. Gastroenterology 2004 0.75
174 Kenji Fujiwara, MD, PhD. Gastroenterology 2013 0.75
175 MELD and the practicing gastroenterologist. Gastroenterology 2003 0.75
176 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int 2011 0.75
177 Joint statement on missions and submissions of papers to AGA journals. Gastroenterology 2002 0.75