Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins.

PubWeight™: 1.20‹?› | Rank: Top 10%

🔗 View Article (PMC 3038676)

Published in Gastroenterology on June 09, 2010

Authors

Rohit Loomba1, Fangwen Rao, Lian Zhang, Srikrishna Khandrika, Michael G Ziegler, David A Brenner, Daniel T O'Connor

Author Affiliations

1: Department of Medicine, University of California at San Diego, La Jolla, California, USA.

Articles citing this

The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol (2013) 3.51

Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol (2014) 2.39

Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology (2012) 2.10

Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment. Curr Pharm Des (2013) 1.16

Commentary: dissecting the PNPLA3 association with liver fat and stiffness, and interaction with diet. Aliment Pharmacol Ther (2014) 1.12

Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease. Radiology (2014) 1.02

Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology (2015) 1.00

Predicting total, abdominal, visceral and hepatic adiposity with circulating biomarkers in Caucasian and Japanese American women. PLoS One (2012) 0.97

Serum γ-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. J Clin Exp Hepatol (2013) 0.92

The genetic architecture of liver enzyme levels: GGT, ALT and AST. Behav Genet (2013) 0.91

Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls. Gastroenterol Res Pract (2013) 0.88

Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study. Gut (2015) 0.88

Genetic background in nonalcoholic fatty liver disease: A comprehensive review. World J Gastroenterol (2015) 0.84

Serum γ-glutamyl transferase levels, insulin resistance and liver fibrosis in patients with chronic liver diseases. PLoS One (2012) 0.82

β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. PLoS One (2014) 0.79

Cardiovascular risk assessment in the treatment of nonalcoholic steatohepatitis: a secondary analysis of the MOZART trial. Therap Adv Gastroenterol (2016) 0.79

Endobiogeny: a global approach to systems biology (part 1 of 2). Glob Adv Health Med (2013) 0.78

Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology (2016) 0.76

Gamma glutamyl transferase: A novel cardiovascular outfit for an old liver test. Indian J Med Res (2016) 0.75

Articles cited by this

Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet (2008) 10.87

Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A (2000) 10.27

The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med (2007) 8.77

Haplotype reconstruction from genotype data using Imperfect Phylogeny. Bioinformatics (2004) 6.02

Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69

High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci U S A (2001) 4.31

Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study. Arterioscler Thromb Vasc Biol (2006) 3.48

Gamma glutamyl transferase. Crit Rev Clin Lab Sci (2001) 3.34

Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome. JAMA (2005) 3.16

Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a controlled study. N Engl J Med (1981) 3.13

Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem (2003) 2.49

Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis. Gastroenterology (2008) 2.33

Characterization of the human patatin-like phospholipase family. J Lipid Res (2006) 2.21

C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens (2007) 2.19

Genetic covariation between serum gamma-glutamyltransferase activity and cardiovascular risk factors. Clin Chem (2002) 2.06

Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J Clin Invest (1998) 1.94

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo. Circulation (2007) 1.91

Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol (2002) 1.85

Evidence for a substantial genetic influence on biochemical liver function tests: results from a population-based Danish twin study. Clin Chem (2001) 1.77

Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state. J Clin Endocrinol Metab (2007) 1.54

SERUM GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY IN HEPATOBILIARY PANCREATIC DISEASE. Gastroenterology (1963) 1.52

Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins. Physiol Genomics (2004) 1.51

Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Semin Liver Dis (2007) 1.49

Hepatic fibrogenesis requires sympathetic neurotransmitters. Gut (2004) 1.42

Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int (2006) 1.34

Propranolol in the prevention of first upper gastrointestinal tract hemorrhage in patients with cirrhosis of the liver and esophageal varices. N Engl J Med (1987) 1.34

A method for the colorimetric determination of gamma-glutamyl transpeptidase in human serum; enzymatic activity in health and disease. Gastroenterology (1963) 1.30

Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis. Am J Physiol Endocrinol Metab (2007) 1.29

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. J Clin Invest (2007) 1.25

Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome. Atherosclerosis (2006) 1.23

Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement. Obes Surg (2006) 1.21

Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. Hepatology (2004) 1.20

Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells. Biochem Biophys Res Commun (2003) 1.15

Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact. J Biol Chem (2003) 1.15

Epidemiology and genetic epidemiology of the liver function test proteins. PLoS One (2009) 1.07

Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function. Hypertension (2005) 1.05

Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury. Hepatology (2003) 1.05

Butyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity. Clin Chem (2006) 1.03

Arterial compliance by cuff sphygmomanometer. Application to hypertension and early changes in subjects at genetic risk. Hypertension (1996) 1.03

Insulin and counterregulatory hormones influence acute-phase protein production in human hepatocytes. Am J Physiol (1995) 1.03

Serum gamma-glutamyl transferase activity predicts future development of metabolic syndrome defined by 2 different criteria. Clin Chim Acta (2009) 1.01

Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice. Biochem Biophys Res Commun (2003) 0.99

Association of hypertension with beta2- and alpha2c10-adrenergic receptor genotype. Hypertension (1996) 0.97

Gln27Glu beta2-adrenergic receptor variant is associated with hypertriglyceridemia and the development of fatty liver. Clin Chim Acta (2001) 0.97

Gamma-glutamyltransferase and its isoenzymes: progress and problems. Clin Chem (1985) 0.96

Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis. Clin Chim Acta (2008) 0.93

Beta 2 adrenergic receptor 5' haplotypes influence promoter activity. Br J Pharmacol (2002) 0.89

The beta2 adrenergic receptor Gln27Glu polymorphism affects insulin resistance in patients with heart failure: possible modulation by choice of beta blocker. J Cardiovasc Pharmacol (2008) 0.89

Serum gamma-glutamyl transpeptidase level and blood pressure in nondrinkers: a possible pathogenetic role of fatty liver in obesity-related hypertension. J Hum Hypertens (1994) 0.89

Adrenergic blockade prevents endotoxin-induced increases in glucose metabolism. Am J Physiol (1988) 0.86

Hepatic expression of gamma-glutamyltranspeptidase in the human liver of patients with alcoholic liver disease. Hepatol Res (2007) 0.82

Influence of beta-2 adrenergic receptor gene polymorphism on the hemodynamic response to propranolol in patients with cirrhosis. Hepatology (2006) 0.81

Heritability of serum gamma-glutamyltransferase level: genetic analysis from the Framingham Offspring Study. Liver Int (2009) 0.81

Genetics of common obesity and nonalcoholic fatty liver disease. Gastroenterology (2009) 0.80

Beta-2-adrenergic receptor polymorphisms and changes in lipids induced by metoprolol. Pharmacology (2007) 0.80

Serum gamma-glutamyl transpeptidase levels and hypertension in non-drinkers: a possible role of fatty liver in the pathogenesis of obesity related hypertension. Obes Res (1993) 0.78

The adrenergic control of hepatic glucose and FFA metabolism in rainbow trout (Oncorhynchus mykiss): increased sensitivity to adrenergic stimulation with fasting. Gen Comp Endocrinol (2005) 0.78

Articles by these authors

Liver fibrosis. J Clin Invest (2005) 17.27

TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med (2007) 9.77

Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol (2008) 5.06

The chromogranin-secretogranin family. N Engl J Med (2003) 4.28

Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology (2007) 4.06

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A (2012) 3.90

Toll-like receptors and adaptor molecules in liver disease: update. Hepatology (2008) 3.72

NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest (2003) 3.69

CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest (2009) 3.62

Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology (2010) 3.52

Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology (2003) 3.51

A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology (2004) 3.42

Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol (2006) 3.42

Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst (2006) 3.36

Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol (2006) 3.16

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology (2010) 3.10

Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem (2005) 2.74

Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology (2010) 2.73

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A (2009) 2.68

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med (2010) 2.65

Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology (2012) 2.58

Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology (2003) 2.51

Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production. Cell Host Microbe (2010) 2.39

Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17. Curr Biol (2006) 2.36

CCR2 promotes hepatic fibrosis in mice. Hepatology (2009) 2.35

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A (2010) 2.32

Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. J Hepatol (2012) 2.28

Mechanisms of fibrogenesis. Exp Biol Med (Maywood) (2008) 2.26

Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology (2010) 2.23

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest (2005) 2.20

Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest (2005) 2.19

C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens (2007) 2.19

Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol (2002) 2.17

A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology (2012) 2.15

DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology (2003) 2.10

Decreased slow wave sleep increases risk of developing hypertension in elderly men. Hypertension (2011) 2.09

Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol (2003) 2.07

Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Kidney Int (2013) 2.05

Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal (2002) 2.03

Anandamide induces necrosis in primary hepatic stellate cells. Hepatology (2005) 1.98

Effects of continuous positive airway pressure versus supplemental oxygen on 24-hour ambulatory blood pressure. Hypertension (2006) 1.97

Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol (2007) 1.97

Effects of nasal continuous positive airway pressure and oxygen supplementation on norepinephrine kinetics and cardiovascular responses in obstructive sleep apnea. J Appl Physiol (1985) (2006) 1.96

Identification of small molecule activators of cryptochrome. Science (2012) 1.95

Toll-like receptor signaling in the liver. Gastroenterology (2006) 1.94

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo. Circulation (2007) 1.91

Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst (2012) 1.88

Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol (2007) 1.88

c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology (2003) 1.87

In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol (2004) 1.84

Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology (2009) 1.83

Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest (2014) 1.82

Feasibility of ultrasound-guided high intensity focused ultrasound ablating uterine fibroids with hyperintense on T2-weighted MR imaging. Eur J Radiol (2012) 1.81

Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology (2008) 1.81

Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology (2006) 1.81

Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology (2008) 1.79

The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury. J Invest Dermatol (2008) 1.79

Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology (2013) 1.78

Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol (2006) 1.77

The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem (2002) 1.77

Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J (2004) 1.76

Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol (2008) 1.76

Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology (2004) 1.73

Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol (2004) 1.72

Anti-fibrogenic strategies and the regression of fibrosis. Best Pract Res Clin Gastroenterol (2011) 1.70

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A (2009) 1.69

Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum. Proc Natl Acad Sci U S A (2013) 1.69

Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol (2008) 1.68

G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. Am J Hypertens (2009) 1.66

Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer. PLoS One (2012) 1.66

Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension. J Hypertens (2002) 1.65

Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension (2006) 1.64

Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem (2005) 1.61

Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension (2006) 1.61

The effects of ethnic discrimination and socioeconomic status on endothelin-1 among blacks and whites. Am J Hypertens (2009) 1.61

Autonomic and hemodynamic origins of pre-hypertension: central role of heredity. J Am Coll Cardiol (2012) 1.59

c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology (2009) 1.59

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest (2014) 1.58

Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. Am J Hum Genet (2004) 1.58

Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population. Carcinogenesis (2004) 1.57

Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol (2011) 1.55

Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol (2009) 1.55

Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens (2010) 1.54