Published in J Clin Invest on November 01, 2003
Liver fibrosis. J Clin Invest (2005) 17.27
Cellular and molecular mechanisms of fibrosis. J Pathol (2008) 14.01
Mechanisms of hepatic fibrogenesis. Gastroenterology (2008) 11.98
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev (2008) 10.28
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology (2010) 4.11
CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest (2009) 3.62
CCR2 promotes hepatic fibrosis in mice. Hepatology (2009) 2.35
p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases. Exp Mol Med (2009) 2.09
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. Proc Natl Acad Sci U S A (2006) 1.96
Myocardial repair/remodelling following infarction: roles of local factors. Cardiovasc Res (2008) 1.88
Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology (2009) 1.83
Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology (2009) 1.73
Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci U S A (2014) 1.71
Anti-fibrogenic strategies and the regression of fibrosis. Best Pract Res Clin Gastroenterol (2011) 1.70
Pathogenesis and management issues for non-alcoholic fatty liver disease. World J Gastroenterol (2007) 1.59
Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology (2012) 1.49
The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci U S A (2008) 1.49
Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis. Cell Metab (2016) 1.39
Role of free radicals in liver diseases. Hepatol Int (2009) 1.36
Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol Gastrointest Liver Physiol (2011) 1.35
The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology (2011) 1.33
Redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogenesis Tissue Repair (2008) 1.30
NOX in liver fibrosis. Arch Biochem Biophys (2007) 1.29
New pharmacological treatments for improving renal outcomes in diabetes. Nat Rev Nephrol (2010) 1.29
Inflammation and fibrogenesis in steatohepatitis. J Gastroenterol (2012) 1.21
Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo. Gastroenterology (2010) 1.18
Treatment of non-alcoholic fatty liver disease. Ther Clin Risk Manag (2007) 1.18
NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease. J Pathol (2011) 1.18
NADPH oxidase-derived reactive oxygen species in cardiac pathophysiology. Philos Trans R Soc Lond B Biol Sci (2005) 1.17
Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol (2009) 1.17
Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis. Hepatology (2009) 1.17
NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Korean J Hepatol (2011) 1.13
Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12
Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells. Hepatology (2010) 1.11
Role of NADPH oxidases in liver fibrosis. Antioxid Redox Signal (2014) 1.10
Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. Gastroenterology (2012) 1.09
Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology (2010) 1.08
Animal models for the study of liver fibrosis: new insights from knockout mouse models. Am J Physiol Gastrointest Liver Physiol (2011) 1.08
Kidney fibrosis in hypertensive rats: role of oxidative stress. Am J Nephrol (2008) 1.07
Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. Free Radic Biol Med (2009) 1.07
Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. J Hepatol (2008) 1.06
Lipid raft redox signaling: molecular mechanisms in health and disease. Antioxid Redox Signal (2011) 1.06
Recent advances in the pathogenesis and diagnosis of liver fibrosis. J Gastroenterol (2008) 1.02
Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect. Hepatology (2012) 1.01
Molecular therapy for hepatic injury and fibrosis: where are we? World J Gastroenterol (2006) 1.01
The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies. Front Pharmacol (2014) 1.01
Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice. Toxicol Appl Pharmacol (2010) 0.99
Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells. Pancreatology (2007) 0.99
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. Hepatology (2009) 0.99
Cell signals influencing hepatic fibrosis. Int J Hepatol (2012) 0.98
Obstructive sleep apnea and non-alcoholic Fatty liver disease: is the liver another target? Front Neurol (2012) 0.97
Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Hepatology (2014) 0.96
The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A (2014) 0.96
Mitochondria and redox signaling in steatohepatitis. Antioxid Redox Signal (2011) 0.96
Steatosis and insulin resistance in hepatitis C: a way out for the virus? World J Gastroenterol (2009) 0.96
Clinical features of nonalcoholic steatohepatitis in Japan: Evidence from the literature. J Gastroenterol (2006) 0.94
Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma. Free Radic Biol Med (2014) 0.94
The effects of angiotensin blocking agents on the progression of liver fibrosis in the HALT-C Trial cohort. Dig Dis Sci (2010) 0.93
Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol (2014) 0.93
Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells. J Gastroenterol (2008) 0.92
The effects of N-acetylcysteine on bile duct ligation-induced liver fibrosis in rats. Dig Dis Sci (2007) 0.92
Role of innate immune response in non-alcoholic Fatty liver disease: metabolic complications and therapeutic tools. Front Immunol (2014) 0.92
A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits. Am J Pathol (2010) 0.92
TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells. Comp Hepatol (2007) 0.91
Alcoholic pancreatitis: lessons from the liver. World J Gastroenterol (2010) 0.90
Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice. Am J Pathol (2009) 0.90
Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. J Biol Chem (2009) 0.88
Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease. PLoS One (2013) 0.88
Plasminogen activator inhibitor-1 deficient mice are protected from angiotensin II-induced fibrosis. Arch Biochem Biophys (2011) 0.87
Angiotensin II participates in hepatic inflammation and fibrosis through MCP-1 expression. Dig Dis Sci (2005) 0.87
The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Front Physiol (2016) 0.86
NADPH Oxidases in Chronic Liver Diseases. Adv Hepatol (2014) 0.86
Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro. PLoS One (2013) 0.86
A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. Drug Des Devel Ther (2015) 0.86
Renin-angiotensin system activation in congenital hepatic fibrosis in the PCK rat model of autosomal recessive polycystic kidney disease. J Pediatr Gastroenterol Nutr (2010) 0.85
Involvement of DNA damage response pathways in hepatocellular carcinoma. Biomed Res Int (2014) 0.84
The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis. Front Physiol (2015) 0.84
The role of redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogenesis Tissue Repair (2012) 0.84
Effects of angiotensin II receptor antagonist, Losartan on the apoptosis, proliferation and migration of the human pancreatic stellate cells. World J Gastroenterol (2005) 0.84
MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. PLoS One (2015) 0.83
Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Cell Death Differ (2013) 0.83
The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase pathway. Antioxid Redox Signal (2014) 0.83
Genetic resistance to liver fibrosis on A/J mouse chromosome 17. Alcohol Clin Exp Res (2013) 0.83
Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells. Med Sci Monit (2011) 0.82
Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet. PLoS One (2013) 0.81
The protective effect of Nigella sativa against liver injury: a review. Iran J Basic Med Sci (2014) 0.81
Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy. Hepatol Int (2008) 0.81
Oxidative stress-induced 1, N6-ethenodeoxyadenosine adduct formation contributes to hepatocarcinogenesis. Oncol Rep (2013) 0.81
Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats. Exp Mol Med (2011) 0.81
Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects. Int J Mol Sci (2015) 0.81
Effects of TGF-β and b-FGF on the potential of peripheral blood-borne stem cells and bone marrow-derived stem cells in wound healing in a murine model. Inflammation (2012) 0.81
Translating an understanding of the pathogenesis of hepatic fibrosis to novel therapies. Clin Gastroenterol Hepatol (2013) 0.80
Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells. BMC Gastroenterol (2015) 0.80
p47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney Int (2015) 0.80
Potential role of NADPH oxidase in pathogenesis of pancreatitis. World J Gastrointest Pathophysiol (2014) 0.80
Triplex forming oligonucleotides against type α1(I) collagen attenuates liver fibrosis induced by bile duct ligation. Biochem Pharmacol (2010) 0.79
NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents. Arch Dermatol Res (2013) 0.79
Comparative study of three angiotensin II type 1 receptor antagonists in preventing liver fibrosis in diabetic rats: stereology, histopathology, and electron microscopy. J Mol Histol (2012) 0.79
Activation of nuclear factor kappa B in the hepatic stellate cells of mice with schistosomiasis japonica. PLoS One (2014) 0.79
Liver fibrosis -- from bench to bedside. J Hepatol (2003) 5.80
The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med (1995) 4.25
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene (2001) 3.97
The neutrophil NADPH oxidase. Arch Biochem Biophys (2002) 3.71
Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension (2002) 3.23
The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell Mol Life Sci (2002) 3.22
Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis (2001) 2.98
Oxidative stress-related molecules and liver fibrosis. J Hepatol (2001) 2.75
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest (2000) 2.67
Angiotensin II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology (2000) 2.57
Host genetic factors influence disease progression in chronic hepatitis C. Hepatology (2000) 2.26
Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol (2002) 2.17
Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol (2002) 2.17
S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol (1999) 2.14
Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept (2000) 2.11
Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration. Am J Pathol (1998) 2.01
The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology (2001) 1.88
Angiotensin II and renal fibrosis. Hypertension (2001) 1.87
Hepatic fibrosis. Pathogenesis and principles of therapy. Clin Liver Dis (2001) 1.78
The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med (2001) 1.69
Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology (1998) 1.55
CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. J Immunol (2001) 1.54
Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver. Gastroenterology (2002) 1.50
The regulatory role of AT 1 receptor on activated HSCs in hepatic fibrogenesis:effects of RAS inhibitors on hepatic fibrosis induced by CCl(4). World J Gastroenterol (2000) 1.43
Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Hepatology (2002) 1.40
N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity. J Biol Chem (2001) 1.39
Heme oxygenase-1: redox regulation and role in the hepatic response to oxidative stress. Antioxid Redox Signal (2002) 1.37
Differential activation of mitogen-activated protein kinases in smooth muscle cells by angiotensin II: involvement of p22phox and reactive oxygen species. Arterioscler Thromb Vasc Biol (2000) 1.36
Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis. J Hepatol (2001) 1.35
TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Hepatology (2001) 1.34
Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension. J Hepatol (2002) 1.32
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol (2001) 1.32
Hydrogen peroxide: a link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells. Hepatology (2000) 1.31
Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Am J Physiol Gastrointest Liver Physiol (2003) 1.27
Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide. Hepatology (1997) 1.27
Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB. Ann Clin Lab Sci (2001) 1.23
Alcoholic liver disease: new insights in pathogenesis lead to new treatments. J Hepatol (2000) 1.20
Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis. J Gastroenterol Hepatol (1995) 1.14
The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression. Free Radic Biol Med (2002) 1.14
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver (2001) 1.10
Effect of losartan, an angiotensin II antagonist, on secondary biliary cirrhosis. Hepatogastroenterology (2002) 1.08
Role of superoxide anion in regulating pressor and vascular hypertrophic response to angiotensin II. Am J Physiol Heart Circ Physiol (2002) 1.08
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. J Hepatol (2002) 1.08
Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants. Biochem Biophys Res Commun (1998) 1.07
Progression of hepatic stellate cell activation is associated with the level of oxidative stress rather than cytokines during CCl4-induced fibrogenesis. Mol Cells (2000) 1.07
Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Hepatology (2001) 1.02
Assessment of the renin-angiotensin system in cirrhotic patients. Comparison between plasma renin activity and direct measurement of immunoreactive renin. J Hepatol (1992) 1.02
Arginine vasopressin induces contraction and stimulates growth of cultured human hepatic stellate cells. Gastroenterology (1997) 0.99
Viral gene delivery of superoxide dismutase attenuates experimental cholestasis-induced liver fibrosis in the rat. Gene Ther (2002) 0.96
Redox signals that regulate the vascular response to injury. Thromb Haemost (1999) 0.92
Mechanisms linking angiotensin II and atherogenesis. Curr Opin Lipidol (2002) 0.92
Immunohistochemical detection of 4-hydroxy-2-nonenal-modified-protein adducts in human alcoholic liver diseases. Alcohol Clin Exp Res (1998) 0.91
Effects of chronic ethanol treatment on the angiotensin II-mediated p42/p44 mitogen-activated protein kinase and phosphorylase a activation in rat hepatocytes. Alcohol (2003) 0.89
Activation of rat hepatic stellate cells leads to loss of glutathione S-transferases and their enzymatic activity against products of oxidative stress. Hepatology (1999) 0.85
Nox response to injury. Arterioscler Thromb Vasc Biol (2002) 0.84
International network of cancer genome projects. Nature (2010) 20.35
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Liver fibrosis. J Clin Invest (2005) 17.27
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA (2004) 11.52
TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med (2007) 9.77
Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila) (2008) 5.82
Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol (2008) 5.06
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell (2012) 4.98
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci U S A (2006) 4.84
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology (2007) 4.83
Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis. Rev Med Virol (2005) 4.47
Mechanisms of hepatotoxicity. Toxicol Sci (2002) 4.13
Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology (2007) 4.06
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A (2012) 3.90
Toll-like receptors and adaptor molecules in liver disease: update. Hepatology (2008) 3.72
CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest (2009) 3.62
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology (2010) 3.52
Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology (2006) 3.52
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology (2003) 3.51
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology (2004) 3.42
Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol (2006) 3.42
NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol (2011) 3.28
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology (2003) 3.21
Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol (2006) 3.16
Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology (2010) 3.10
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology (2004) 2.92
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest (2008) 2.89
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem (2005) 2.74
Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology (2010) 2.73
Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A (2009) 2.68
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med (2010) 2.65
Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun (2003) 2.58
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology (2012) 2.58
Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology (2003) 2.51
A prospective nationwide study of drug-induced liver injury in Korea. Am J Gastroenterol (2012) 2.43
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2005) 2.41
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy (2006) 2.37
CCR2 promotes hepatic fibrosis in mice. Hepatology (2009) 2.35
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A (2010) 2.32
Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors. Nat Struct Mol Biol (2010) 2.30
Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. J Hepatol (2012) 2.28
Mechanisms of fibrogenesis. Exp Biol Med (Maywood) (2008) 2.26
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology (2009) 2.25
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol (2009) 2.23
Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology (2010) 2.23
Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology (2008) 2.22
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest (2005) 2.20
Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol (2002) 2.17
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology (2012) 2.15
DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology (2003) 2.10
Glaucoma-like optic neuropathy in patients with intracranial tumours. Acta Ophthalmol (2011) 2.08
Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett (2002) 2.08
Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2006) 2.08
Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci (2004) 2.07
Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol (2003) 2.07
Photoreceptor apoptosis in human retinal detachment. Am J Ophthalmol (2005) 2.03
Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest (2007) 2.03
Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal (2002) 2.03
Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol (2004) 2.01
Hepatitis C virus genotype distribution in China: predominance of closely related subtype 1b isolates and existence of new genotype 6 variants. J Med Virol (2005) 1.98
Anandamide induces necrosis in primary hepatic stellate cells. Hepatology (2005) 1.98
Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron (2012) 1.97
Identification of small molecule activators of cryptochrome. Science (2012) 1.95
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells. Gastroenterology (2005) 1.95
Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol (2002) 1.95
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci (2006) 1.94
Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem (2008) 1.94
Toll-like receptor signaling in the liver. Gastroenterology (2006) 1.94
Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells. Biophys J (2004) 1.91
In vivo MR imaging tracking of magnetic iron oxide nanoparticle labeled, engineered, autologous bone marrow mesenchymal stem cells following intra-articular injection. Joint Bone Spine (2008) 1.91
Smoothened is a master regulator of adult liver repair. J Clin Invest (2013) 1.89
Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim Biophys Acta (2008) 1.89
Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer. Cancer Lett (2011) 1.88
Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol (2007) 1.88
c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology (2003) 1.87
Cyclophilin D as a drug target. Curr Med Chem (2003) 1.87
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol (2004) 1.84
Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology (2008) 1.84
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2010) 1.84
Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology (2009) 1.83
Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest (2014) 1.82
Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology (2008) 1.81
MethyCancer: the database of human DNA methylation and cancer. Nucleic Acids Res (2007) 1.81
Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81
Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology (2006) 1.81