Published in Am J Physiol Heart Circ Physiol on July 21, 2006
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest (2009) 2.98
CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol (2011) 2.65
CaMKII determines mitochondrial stress responses in heart. Nature (2012) 2.63
Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res (2009) 2.12
Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis. Am J Physiol Heart Circ Physiol (2007) 2.01
MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death. J Clin Invest (2012) 1.90
With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure. J Mol Cell Cardiol (2008) 1.74
Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest (2011) 1.68
CaMKII in the cardiovascular system: sensing redox states. Physiol Rev (2011) 1.67
Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. J Clin Invest (2008) 1.65
Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol (2009) 1.65
Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias. Circ Res (2012) 1.61
Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest (2009) 1.56
Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms. Circ Res (2010) 1.52
Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta (2007) 1.45
Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res (2013) 1.37
CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circ Res (2009) 1.33
The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury. J Mol Cell Cardiol (2010) 1.31
Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate. Circ Res (2010) 1.24
Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circ Res (2011) 1.23
Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling. Circ Res (2012) 1.20
Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol (2009) 1.17
New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Circulation (2012) 1.16
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes. J Biol Chem (2008) 1.15
CaMKII and a failing strategy for growth in heart. J Clin Invest (2009) 1.13
Sudden cardio arrest: oxidative stress irritates the heart. Nat Med (2010) 1.12
CaMKII-induced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling study. Biophys J (2009) 1.08
CaMKII in cerebral ischemia. Acta Pharmacol Sin (2011) 1.04
Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. Circulation (2014) 1.00
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy. J Biol Chem (2009) 0.98
Programmed cell death in cardiac myocytes: strategies to maximize post-ischemic salvage. Heart Fail Rev (2008) 0.94
CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation. J Mol Cell Cardiol (2015) 0.92
CaMKII-dependent responses to ischemia and reperfusion challenges in the heart. Front Pharmacol (2014) 0.89
Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease. J Physiol (2016) 0.89
S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ. J Biol Chem (2015) 0.85
Chasing cardiac physiology and pathology down the CaMKII cascade. Am J Physiol Heart Circ Physiol (2015) 0.83
Is CaMKII a link between inflammation and hypertrophy in heart? J Mol Med (Berl) (2011) 0.83
CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol (2014) 0.82
Chronic CaMKII inhibition blunts the cardiac contractile response to exercise training. Eur J Appl Physiol (2011) 0.82
CaMKII and stress mix it up in mitochondria. Front Pharmacol (2014) 0.81
CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury. EMBO Mol Med (2014) 0.81
Oxidized CaMKII: a "heart stopper" for the sinus node? J Clin Invest (2011) 0.80
PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban. J Clin Invest (2015) 0.79
Ca2+/calmodulin-dependent protein kinase II-γ (CaMKIIγ) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling. FASEB J (2015) 0.79
Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal. Cardiovasc Res (2016) 0.79
Transcriptional responses of olive flounder (Paralichthys olivaceus) to low temperature. PLoS One (2014) 0.78
Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease. Drug Discov Today Ther Strateg (2012) 0.76
Interaction of β1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling. JCI Insight (2016) 0.76
CaMKII is a nodal signal for multiple programmed cell death pathways in heart. J Mol Cell Cardiol (2016) 0.75
CaMKII plays a part in the chondrogenesis of bone marrow-derived mesenchymal stem cells. Int J Clin Exp Pathol (2015) 0.75
Increased Na⁺/Ca²⁺ exchanger expression/activity constitutes a point of inflection in the progression to heart failure of hypertensive rats. PLoS One (2014) 0.75
Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor. PLoS One (2014) 0.75
Calcium-calmodulin dependent protein kinase mediates the intracellular signaling pathways of cardiac apoptosis in mice with impaired glucose tolerance. J Physiol (2017) 0.75
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16
Calmodulin kinase II inhibition protects against structural heart disease. Nat Med (2005) 5.87
Metabolite identification via the Madison Metabolomics Consortium Database. Nat Biotechnol (2008) 5.12
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
Concern Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation (2002) 4.16
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96
Ice age terminations. Science (2009) 3.68
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature (2012) 3.63
T-tubule remodeling during transition from hypertrophy to heart failure. Circ Res (2010) 3.57
Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. Biochem Biophys Res Commun (2009) 3.49
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest (2009) 3.45
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res (2006) 3.42
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest (2003) 3.15
Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. Antimicrob Agents Chemother (2008) 3.10
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation (2010) 2.94
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82
Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol (2004) 2.75
Effect of aging and physical activity on left ventricular compliance. Circulation (2004) 2.68
CaMKII determines mitochondrial stress responses in heart. Nature (2012) 2.63
Performance of high-risk human papillomavirus DNA testing as a primary screen for cervical cancer: a pooled analysis of individual patient data from 17 population-based studies from China. Lancet Oncol (2010) 2.61
Retracted L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII. Mol Cell (2006) 2.49
Persistent sympathetic activation during chronic antihypertensive therapy: a potential mechanism for long term morbidity? Hypertension (2005) 2.48
Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res (2005) 2.45
MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation (2010) 2.35
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet (2011) 2.27
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Sci Transl Med (2012) 2.27
PAI-1 in tissue fibrosis. J Cell Physiol (2012) 2.26
Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Stem Cells Dev (2013) 2.24
New bioinformatics resources for metabolomics. Pac Symp Biocomput (2007) 2.19
Proarrhythmic defects in Timothy syndrome require calmodulin kinase II. Circulation (2008) 2.16
Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway. J Cell Biol (2008) 2.08
Established and emerging plasma biomarkers in the prediction of first atherothrombotic events. Circulation (2004) 2.07
A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. J Clin Invest (2010) 2.04
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circ Res (2007) 1.98
Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20. Circ Res (2003) 1.98
Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A (2009) 1.95
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics (2004) 1.95
Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ Res (2006) 1.94
Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism. Hypertension (2006) 1.91
Cardiac ion channels. Annu Rev Physiol (2002) 1.90
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J (2004) 1.88
PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS One (2009) 1.86
Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ Res (2004) 1.85
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A (2006) 1.85
Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes (2004) 1.85
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation (2006) 1.85
Plasmid-mediated carbapenem-hydrolysing beta-lactamase KPC-2 in carbapenem-resistant Serratia marcescens isolates from Hangzhou, China. J Antimicrob Chemother (2007) 1.84
A calcium sensor in the sodium channel modulates cardiac excitability. Nature (2002) 1.83
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. Mol Pharmacol (2008) 1.78
Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem (2007) 1.77
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science (2013) 1.76
Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence. Circulation (2013) 1.76
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer (2011) 1.75
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res (2010) 1.74
Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells. Proc Natl Acad Sci U S A (2006) 1.74
Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease. Proc Natl Acad Sci U S A (2008) 1.72
Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression. Mamm Genome (2007) 1.71
Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. J Biol Chem (2006) 1.70
Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Circ Res (2005) 1.70
Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res (2011) 1.69
Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest (2011) 1.68
Skin cooling maintains cerebral blood flow velocity and orthostatic tolerance during tilting in heated humans. J Appl Physiol (1985) (2002) 1.67
CaMKII in the cardiovascular system: sensing redox states. Physiol Rev (2011) 1.67
Metabolic syndrome and the risk of cardiovascular disease in older adults. J Am Coll Cardiol (2006) 1.66
Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression. Circ Res (2006) 1.66
Heat stress reduces cerebral blood velocity and markedly impairs orthostatic tolerance in humans. Am J Physiol Regul Integr Comp Physiol (2006) 1.65
Hemodynamics of orthostatic intolerance: implications for gender differences. Am J Physiol Heart Circ Physiol (2003) 1.65
Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Circ Res (2007) 1.65
Echocardiographic evaluation of ventricular function in mice. Echocardiography (2007) 1.64
Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy. Circulation (2009) 1.63
Calmodulin kinase II activity is required for normal atrioventricular nodal conduction. Heart Rhythm (2005) 1.63
CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm (2012) 1.63
Small-animal PET imaging of human epidermal growth factor receptor type 2 expression with site-specific 18F-labeled protein scaffold molecules. J Nucl Med (2008) 1.63
Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. Cancer Biol Ther (2009) 1.61
Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis. J Biol Chem (2007) 1.61