Published in Nat Med on March 27, 2005
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72
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Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest (2009) 3.45
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Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest (2009) 2.98
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82
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CaMKII determines mitochondrial stress responses in heart. Nature (2012) 2.63
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32
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Signaling effectors underlying pathologic growth and remodeling of the heart. J Clin Invest (2013) 2.06
A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. J Clin Invest (2010) 2.04
Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis. Am J Physiol Heart Circ Physiol (2007) 2.01
Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A (2009) 1.95
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Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol (2006) 1.82
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Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy. Eur Heart J (2012) 1.76
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Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest (2013) 1.53
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Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells. J Biol Chem (2007) 1.36
Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. J Neurosci (2013) 1.35
beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation. J Cell Biol (2010) 1.35
CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circ Res (2009) 1.33
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. J Mol Cell Cardiol (2010) 1.31
Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease. Circulation (2012) 1.31
The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circ Res (2010) 1.29
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation (2013) 1.29
Role of activated CaMKII in abnormal calcium homeostasis and I(Na) remodeling after myocardial infarction: insights from mathematical modeling. J Mol Cell Cardiol (2008) 1.27
Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circ Res (2011) 1.23
Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise. J Physiol (2006) 1.21
Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models. Am J Physiol Heart Circ Physiol (2009) 1.21
Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling. Circ Res (2012) 1.20
Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70. Circ Res (2009) 1.18
There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling. J Biomed Biotechnol (2010) 1.17
Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol (2009) 1.17
New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Circulation (2012) 1.16
Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure. J Biol Chem (2008) 1.16
Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy. Nat Rev Cardiol (2012) 1.15
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes. J Biol Chem (2008) 1.15
Rad GTPase deficiency leads to cardiac hypertrophy. Circulation (2007) 1.15
Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis. PLoS Comput Biol (2009) 1.14
CaMKII and a failing strategy for growth in heart. J Clin Invest (2009) 1.13
Sudden cardio arrest: oxidative stress irritates the heart. Nat Med (2010) 1.12
Synergy between CaMKII substrates and β-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling. Biophys J (2010) 1.12
The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol (2010) 1.09
MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction. J Mol Cell Cardiol (2012) 1.09
CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med (2016) 1.09
Ca2+/Calmodulin-dependent protein kinase II δ mediates myocardial ischemia/reperfusion injury through nuclear factor-κB. Circ Res (2013) 1.08
Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy. Am J Physiol Heart Circ Physiol (2009) 1.07
Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res (2014) 1.06
β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction. FASEB J (2012) 1.06
Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. PLoS One (2014) 1.05
Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias. J Mol Cell Cardiol (2011) 1.05
CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle. Am J Physiol Endocrinol Metab (2010) 1.05
Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II. J Clin Invest (2006) 1.05
Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy. Circulation (2010) 1.03
X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i. J Mol Cell Cardiol (2012) 1.03
CaMKII oxidative activation and the pathogenesis of cardiac disease. J Mol Cell Cardiol (2014) 1.02
Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res (2011) 1.02
Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart. J Biol Chem (2012) 1.01
Computational models reduce complexity and accelerate insight into cardiac signaling networks. Circ Res (2011) 1.00
Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice. Circ Res (2010) 1.00
Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. Circulation (2014) 1.00
Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta (2013) 0.99
Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem (2011) 0.98
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy. J Biol Chem (2009) 0.98
Atrial fibrillation therapy now and in the future: drugs, biologicals, and ablation. Circ Res (2014) 0.97
Diabetic cardiomyopathy: signaling defects and therapeutic approaches. Expert Rev Cardiovasc Ther (2010) 0.97
'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failure. Cardiovasc Res (2013) 0.96
Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm (2012) 0.95
From two competing oscillators to one coupled-clock pacemaker cell system. Front Physiol (2015) 0.95
Catecholamine-independent heart rate increases require Ca2+/calmodulin-dependent protein kinase II. Circ Arrhythm Electrophysiol (2011) 0.95
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