T-tubule remodeling during transition from hypertrophy to heart failure.

PubWeight™: 3.57‹?› | Rank: Top 1%

🔗 View Article (PMC 2927862)

Published in Circ Res on June 24, 2010

Authors

Sheng Wei1, Ang Guo, Biyi Chen, William Kutschke, Yu-Ping Xie, Kathy Zimmerman, Robert M Weiss, Mark E Anderson, Heping Cheng, Long-Sheng Song

Author Affiliations

1: Institute of Molecular Medicine, Peking University, Beijing, China.

Articles citing this

(truncated to the top 100)

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med (2014) 3.23

Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation (2011) 2.21

Ultrastructural remodelling of Ca(2+) signalling apparatus in failing heart cells. Cardiovasc Res (2012) 1.65

Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention. Trends Cardiovasc Med (2014) 1.46

t-tubule disease: Relationship between t-tubule organization and regional contractile performance in human dilated cardiomyopathy. J Mol Cell Cardiol (2015) 1.45

Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy. Circ Res (2012) 1.44

Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res (2013) 1.37

Emerging mechanisms of T-tubule remodelling in heart failure. Cardiovasc Res (2013) 1.35

Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension. Hypertension (2011) 1.27

The structure and function of cardiac t-tubules in health and disease. Proc Biol Sci (2011) 1.23

Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circ Heart Fail (2012) 1.23

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res (2013) 1.22

T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases. Skelet Muscle (2011) 1.22

Action potential propagation in transverse-axial tubular system is impaired in heart failure. Proc Natl Acad Sci U S A (2012) 1.15

Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat Med (2014) 1.14

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout. Proc Natl Acad Sci U S A (2012) 1.09

Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca(2+)-induced Ca(2+)release in a rodent model of heart failure. Eur J Heart Fail (2012) 1.08

In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice. Circ Res (2013) 1.07

Mir-24 regulates junctophilin-2 expression in cardiomyocytes. Circ Res (2012) 1.07

β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction. FASEB J (2012) 1.06

Early development of intracellular calcium cycling defects in intact hearts of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol (2010) 1.05

Ultrastructural and cellular basis for the development of abnormal myocardial mechanics during the transition from hypertension to heart failure. Am J Physiol Heart Circ Physiol (2013) 1.05

PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes. PLoS One (2011) 1.03

Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress. Proc Natl Acad Sci U S A (2014) 1.03

Superresolution modeling of calcium release in the heart. Biophys J (2014) 1.02

Differential regulation of EHD3 in human and mammalian heart failure. J Mol Cell Cardiol (2012) 1.02

Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation (2014) 1.02

Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1). Circ Res (2014) 1.01

Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovasc Res (2013) 0.99

Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta (2013) 0.99

Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure. Proc Natl Acad Sci U S A (2014) 0.99

The mechanisms of calcium cycling and action potential dynamics in cardiac alternans. Circ Res (2014) 0.96

Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ Res (2011) 0.96

Computational modeling and numerical methods for spatiotemporal calcium cycling in ventricular myocytes. Front Physiol (2012) 0.95

Heart failure with preserved ejection fraction. Glob Cardiol Sci Pract (2012) 0.94

Beyond the cardiac myofilament: hypertrophic cardiomyopathy- associated mutations in genes that encode calcium-handling proteins. Curr Mol Med (2012) 0.94

The transverse-axial tubular system of cardiomyocytes. Cell Mol Life Sci (2013) 0.93

A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart. Hum Mol Genet (2012) 0.93

AutoTT: automated detection and analysis of T-tubule architecture in cardiomyocytes. Biophys J (2014) 0.93

Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes. J Physiol (2013) 0.91

Calsequestrin accumulation in rough endoplasmic reticulum promotes perinuclear Ca2+ release. J Biol Chem (2012) 0.91

Calcium alternans in cardiac myocytes: order from disorder. J Mol Cell Cardiol (2012) 0.91

Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes. Biophys J (2012) 0.91

The interaction of Ca2+ with sarcomeric proteins: role in function and dysfunction of the heart. Am J Physiol Heart Circ Physiol (2011) 0.90

Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest (2013) 0.90

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels. J Biol Chem (2010) 0.89

Strain transfer in ventricular cardiomyocytes to their transverse tubular system revealed by scanning confocal microscopy. Biophys J (2011) 0.89

Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure. J Am Heart Assoc (2014) 0.88

Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts. J Mol Cell Cardiol (2015) 0.87

Targeting cardiomyocyte Ca2+ homeostasis in heart failure. Curr Pharm Des (2015) 0.87

Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses. Cardiovasc Res (2013) 0.87

Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1. J Mol Cell Cardiol (2013) 0.87

Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases. Cardiovasc Res (2014) 0.86

Structural phenotyping of stem cell-derived cardiomyocytes. Stem Cell Reports (2015) 0.86

Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes. J Biol Chem (2013) 0.85

Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase Cα in Cardiomyocytes. J Biol Chem (2015) 0.85

Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1. J Biol Chem (2012) 0.85

Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis. Circ Res (2014) 0.84

Ca²⁺ microdomains organized by junctophilins. Cell Calcium (2015) 0.84

Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes. Circulation (2015) 0.84

Dynamic changes in sarcoplasmic reticulum structure in ventricular myocytes. J Biomed Biotechnol (2011) 0.83

Mechanisms underlying the impaired contractility of diabetic cardiomyopathy. World J Cardiol (2014) 0.83

Spatial variability in T-tubule and electrical remodeling of left ventricular epicardium in mouse hearts with transgenic Gαq overexpression-induced pathological hypertrophy. J Mol Cell Cardiol (2012) 0.83

T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling. J Mol Cell Cardiol (2014) 0.82

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes. J Biol Chem (2015) 0.82

Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules, and Ca2+ Sparks Produced by Dyssynchronous Heart Failure. Circ Heart Fail (2015) 0.81

Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure. Biochem J (2015) 0.81

Palmitate diet-induced loss of cardiac caveolin-3: a novel mechanism for lipid-induced contractile dysfunction. PLoS One (2013) 0.81

Electromechanical coupling in the cardiac myocyte; stretch-arrhythmia feedback. Pflugers Arch (2011) 0.81

In situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused hearts. Front Physiol (2015) 0.81

Metabolic stress in isolated mouse ventricular myocytes leads to remodeling of t tubules. Am J Physiol Heart Circ Physiol (2011) 0.80

Hypoinnervation is an early event in experimental myocardial remodelling induced by pressure overload. J Anat (2013) 0.80

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release. Int J Cardiol (2016) 0.80

Cardiomyocyte Ca2+ handling and structure is regulated by degree and duration of mechanical load variation. J Cell Mol Med (2012) 0.79

Spatial control of the βAR system in heart failure: the transverse tubule and beyond. Cardiovasc Res (2013) 0.79

Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol (2014) 0.79

Nanoscale three-dimensional imaging of the human myocyte. J Struct Biol (2014) 0.79

Calcium signalling in developing cardiomyocytes: implications for model systems and disease. J Physiol (2015) 0.78

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis. Cardiovasc Res (2016) 0.78

Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency. PLoS One (2013) 0.78

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response. Biochem J (2013) 0.78

MicroRNA: a toolkit fine-tuning the dyadic "fuzzy space"? Circ Res (2012) 0.78

Revealing T-Tubules in Striated Muscle with New Optical Super-Resolution Microscopy Techniquess. Eur J Transl Myol (2014) 0.78

Cardiomyocyte transverse tubule loss leads the way to heart failure. Future Cardiol (2011) 0.78

Regional distribution of T-tubule density in left and right atria in dogs. Heart Rhythm (2016) 0.78

The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice. Biochem J (2014) 0.77

Myofibrillar misalignment correlated to triad disappearance of mdx mouse gastrocnemius muscle probed by SHG microscopy. Biomed Opt Express (2014) 0.77

Advances in exploring the role of microRNAs in the pathogenesis, diagnosis and therapy of cardiac diseases in China. Br J Pharmacol (2015) 0.77

Heterogeneity of T-Tubules in Pig Hearts. PLoS One (2016) 0.77

Myofilament dysfunction as an emerging mechanism of volume overload heart failure. Pflugers Arch (2014) 0.77

Chronic heart failure: Ca(2+), catabolism, and catastrophic cell death. Biochim Biophys Acta (2016) 0.77

Ca(2+) homeostasis in sealed t-tubules of mouse ventricular myocytes. J Mol Cell Cardiol (2014) 0.76

Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury. PLoS One (2016) 0.76

The growing importance of mitochondrial calcium in health and disease. Proc Natl Acad Sci U S A (2015) 0.76

Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. J Cell Sci (2016) 0.76

Recovery of the failing heart: emerging approaches and mechanisms in excitation-contraction coupling. F1000Prime Rep (2014) 0.75

BIN1 regulates dynamic t-tubule membrane. Biochim Biophys Acta (2015) 0.75

Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model. Acta Pharmacol Sin (2016) 0.75

T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure. Cardiovasc Res (2017) 0.75

Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues. Biomaterials (2015) 0.75

Articles cited by this

Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol (2003) 6.99

Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles. Biophys J (1999) 5.37

Junctophilins: a novel family of junctional membrane complex proteins. Mol Cell (2000) 4.45

Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A (2006) 3.99

Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature (2001) 3.79

Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques. Circ Res (1999) 3.42

Reduction in density of transverse tubules and L-type Ca(2+) channels in canine tachycardia-induced heart failure. Cardiovasc Res (2001) 3.39

Reduced synchrony of Ca2+ release with loss of T-tubules-a comparison to Ca2+ release in human failing cardiomyocytes. Cardiovasc Res (2004) 3.10

Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle. J Cell Biol (1995) 2.88

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A (2006) 2.81

Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc Natl Acad Sci U S A (2009) 2.61

T-tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarction. J Physiol (2006) 2.50

T-tubule function in mammalian cardiac myocytes. Circ Res (2003) 2.44

Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties. Circ Res (2007) 2.38

Altered cardiac myocyte Ca regulation in heart failure. Physiology (Bethesda) (2006) 2.29

Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circ Res (2003) 2.28

Quantitative electron microscopic description of heart muscle cells. Application to normal, hypertrophied and thyroxin-stimulated hearts. Am J Cardiol (1973) 2.03

Remodeling of T-tubules and reduced synchrony of Ca2+ release in myocytes from chronically ischemic myocardium. Circ Res (2007) 2.00

Depletion of T-tubules and specific subcellular changes in sarcolemmal proteins in tachycardia-induced heart failure. Cardiovasc Res (2003) 1.91

Is depressed myocyte contractility centrally involved in heart failure? Circ Res (2003) 1.88

Altered intracellular Ca2+ handling in heart failure. J Clin Invest (2005) 1.70

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol (2007) 1.70

Intermolecular failure of L-type Ca2+ channel and ryanodine receptor signaling in hypertrophy. PLoS Biol (2007) 1.70

Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun (2004) 1.69

Alterations in early action potential repolarization causes localized failure of sarcoplasmic reticulum Ca2+ release. Circ Res (2005) 1.55

Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure. Circ Heart Fail (2009) 1.52

Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes. Biophys J (2006) 1.48

Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images. Biophys J (2008) 1.47

The internal and external protein scaffold of the T-tubular system in cardiomyocytes. Cell Tissue Res (1998) 1.46

Progression of heart failure after myocardial infarction in the rat. Am J Physiol Regul Integr Comp Physiol (2001) 1.45

Spatiotemporal characteristics of SR Ca(2+) uptake and release in detubulated rat ventricular myocytes. J Mol Cell Cardiol (2005) 1.42

Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy. J Hum Genet (2007) 1.40

Distinct patterns of dystrophin organization in myocyte sarcolemma and transverse tubules of normal and diseased human myocardium. Circulation (2000) 1.37

Excitation-contraction coupling changes during postnatal cardiac development. J Mol Cell Cardiol (2009) 1.36

Molecular evolution of the junctophilin gene family. Physiol Genomics (2009) 1.31

Effect of changes in action potential spike configuration, junctional sarcoplasmic reticulum micro-architecture and altered t-tubule structure in human heart failure. J Muscle Res Cell Motil (2006) 1.29

Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failure. Physiol Genomics (2002) 1.27

Calcium biology of the transverse tubules in heart. Ann N Y Acad Sci (2005) 1.22

Crosstalk between L-type Ca2+ channels and the sarcoplasmic reticulum: alterations during cardiac remodelling. Cardiovasc Res (2007) 1.20

beta-adrenergic stimulation restores the Ca transient of ventricular myocytes lacking t-tubules. J Mol Cell Cardiol (2004) 1.17

Cardiac myocyte remodeling in hypertrophy and progression to failure. J Card Fail (2002) 1.15

Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol Heart Circ Physiol (2003) 1.15

Towards computational modeling of excitation-contraction coupling in cardiac myocytes: reconstruction of structures and proteins from confocal imaging. Pac Symp Biocomput (2009) 0.99

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling. J Mol Cell Cardiol (1999) 0.96

Reduced abundance of transverse tubules and L-type calcium channels: another cause of defective contractility in failing ventricular myocytes. Cardiovasc Res (2001) 0.89

Does the loss of transverse tubules contribute to dyssynchronous Ca2+ release during heart failure? Cardiovasc Res (2004) 0.84

Articles by these authors

A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature (2003) 5.94

Calmodulin kinase II inhibition protects against structural heart disease. Nat Med (2005) 5.87

Metabolite identification via the Madison Metabolomics Consortium Database. Nat Biotechnol (2008) 5.12

Concern Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation (2002) 4.16

Superoxide flashes in single mitochondria. Cell (2008) 4.08

Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A (2006) 3.99

ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest (2009) 3.45

High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res (2006) 3.42

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A (2002) 3.27

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR). Proc Natl Acad Sci U S A (2004) 3.25

Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest (2003) 3.15

Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Nat Cell Biol (2005) 3.14

Calcium flickers steer cell migration. Nature (2008) 3.01

Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation (2010) 2.94

Sarcolemma-localized nNOS is required to maintain activity after mild exercise. Nature (2008) 2.87

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82

CaMKII determines mitochondrial stress responses in heart. Nature (2012) 2.63

Ca2+ blinks: rapid nanoscopic store calcium signaling. Proc Natl Acad Sci U S A (2005) 2.56

Retracted L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII. Mol Cell (2006) 2.49

A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity. Proc Natl Acad Sci U S A (2007) 2.36

Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32

Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Sci Transl Med (2012) 2.27

Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation (2009) 2.20

New bioinformatics resources for metabolomics. Pac Symp Biocomput (2007) 2.19

Proarrhythmic defects in Timothy syndrome require calmodulin kinase II. Circulation (2008) 2.16

Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway. J Cell Biol (2008) 2.08

Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science (2003) 2.05

A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. J Clin Invest (2010) 2.04

Central gene transfer of interleukin-10 reduces hypothalamic inflammation and evidence of heart failure in rats after myocardial infarction. Circ Res (2007) 2.04

Dysfunction of store-operated calcium channel in muscle cells lacking mg29. Nat Cell Biol (2002) 2.03

Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circ Res (2007) 1.98

Putting out the fire: what terminates calcium-induced calcium release in cardiac muscle? Cell Calcium (2004) 1.96

Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A (2009) 1.95

Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ Res (2006) 1.94

Does aldosterone upregulate the brain renin-angiotensin system in rats with heart failure? Hypertension (2008) 1.94

The quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array in cardiac cells. Proc Natl Acad Sci U S A (2004) 1.91

Cardiac ion channels. Annu Rev Physiol (2002) 1.90

Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med (2011) 1.88

Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J (2004) 1.88

Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury. J Clin Invest (2007) 1.88

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A (2006) 1.87

Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo. Am J Physiol Heart Circ Physiol (2006) 1.86

Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure. Circ Res (2005) 1.86

Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ Res (2004) 1.85

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A (2006) 1.85

Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation (2006) 1.85

A calcium sensor in the sodium channel modulates cardiac excitability. Nature (2002) 1.83

Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks. Biophys J (2002) 1.80

1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit. Cancer Cell (2013) 1.79

Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats. Hypertension (2008) 1.78

Neural regulation of the proinflammatory cytokine response to acute myocardial infarction. Am J Physiol Heart Circ Physiol (2004) 1.76

Quarky calcium release in the heart. Circ Res (2010) 1.75

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74

Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res (2010) 1.74

Brain perivascular macrophages and the sympathetic response to inflammation in rats after myocardial infarction. Hypertension (2010) 1.74

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease. Proc Natl Acad Sci U S A (2008) 1.72

Calcific aortic valve stenosis: methods, models, and mechanisms. Circ Res (2011) 1.70

Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. J Biol Chem (2006) 1.70

Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Circ Res (2005) 1.70

Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res (2011) 1.69

Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop. Circulation (2007) 1.68

Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest (2011) 1.68

Hypersensitivity of BKCa to Ca2+ sparks underlies hyporeactivity of arterial smooth muscle in shock. Circ Res (2007) 1.67

CaMKII in the cardiovascular system: sensing redox states. Physiol Rev (2011) 1.67

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm (2012) 1.63

Calmodulin kinase II activity is required for normal atrioventricular nodal conduction. Heart Rhythm (2005) 1.63

Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis. J Biol Chem (2007) 1.61

Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias. Circ Res (2012) 1.61

Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol (2008) 1.60

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability. Nat Struct Mol Biol (2004) 1.59

Local recovery of Ca2+ release in rat ventricular myocytes. J Physiol (2005) 1.58

Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function. J Biol Chem (2002) 1.57

Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes. Circulation (2002) 1.57

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res (2006) 1.56