Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Structure of an agonist-bound human A2A adenosine receptor.
|
Science
|
2011
|
6.21
|
2
|
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.
|
Science
|
2010
|
5.86
|
3
|
Structure of the human κ-opioid receptor in complex with JDTic.
|
Nature
|
2012
|
5.18
|
4
|
Crystal structure of a lipid G protein-coupled receptor.
|
Science
|
2012
|
3.78
|
5
|
Serial femtosecond crystallography of G protein-coupled receptors.
|
Science
|
2013
|
3.58
|
6
|
Structure of the human histamine H1 receptor complex with doxepin.
|
Nature
|
2011
|
3.48
|
7
|
Structural basis for allosteric regulation of GPCRs by sodium ions.
|
Science
|
2012
|
3.40
|
8
|
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.
|
Science
|
2013
|
3.17
|
9
|
Structure of the human smoothened receptor bound to an antitumour agent.
|
Nature
|
2013
|
3.08
|
10
|
Structure of the human glucagon class B G-protein-coupled receptor.
|
Nature
|
2013
|
2.86
|
11
|
Structural features for functional selectivity at serotonin receptors.
|
Science
|
2013
|
2.60
|
12
|
Structural basis for molecular recognition at serotonin receptors.
|
Science
|
2013
|
1.86
|
13
|
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
|
Science
|
2014
|
1.81
|
14
|
Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold.
|
Proteins
|
2006
|
1.51
|
15
|
An unusual sugar conformation in the structure of an RNA/DNA decamer of the polypurine tract may affect recognition by RNase H.
|
J Mol Biol
|
2003
|
1.41
|
16
|
Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity.
|
J Biol Chem
|
2006
|
1.40
|
17
|
The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases.
|
Structure
|
2005
|
1.33
|
18
|
Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
1.28
|
19
|
Structural basis of murein peptide specificity of a gamma-D-glutamyl-l-diamino acid endopeptidase.
|
Structure
|
2009
|
1.23
|
20
|
Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 A resolution.
|
Proteins
|
2009
|
1.14
|
21
|
Crystal structure of soluble MD-1 and its interaction with lipid IVa.
|
Proc Natl Acad Sci U S A
|
2010
|
1.09
|
22
|
Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA.
|
Proteins
|
2007
|
1.09
|
23
|
Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.
|
Proteins
|
2007
|
1.04
|
24
|
Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution.
|
Proteins
|
2006
|
1.03
|
25
|
Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair.
|
J Mol Biol
|
2010
|
1.01
|
26
|
Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria.
|
Mol Genet Metab
|
2005
|
1.00
|
27
|
Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution.
|
Proteins
|
2008
|
0.99
|
28
|
Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold.
|
Proteins
|
2005
|
0.99
|
29
|
Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.98
|
30
|
Metal ions and phosphate binding in the H-N-H motif: crystal structures of the nuclease domain of ColE7/Im7 in complex with a phosphate ion and different divalent metal ions.
|
Protein Sci
|
2002
|
0.97
|
31
|
The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor.
|
Structure
|
2013
|
0.95
|
32
|
Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 Å resolution.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.95
|
33
|
The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.94
|
34
|
The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.94
|
35
|
Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes.
|
J Biol Chem
|
2012
|
0.91
|
36
|
Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.89
|
37
|
Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.89
|
38
|
Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p.
|
Proteins
|
2006
|
0.87
|
39
|
A structural basis for the regulatory inactivation of DnaA.
|
J Mol Biol
|
2008
|
0.87
|
40
|
Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold.
|
Proteins
|
2005
|
0.86
|
41
|
Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.86
|
42
|
Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 angstroms resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases.
|
Proteins
|
2007
|
0.85
|
43
|
Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold.
|
Proteins
|
2005
|
0.85
|
44
|
The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.85
|
45
|
Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 A resolution.
|
Proteins
|
2007
|
0.85
|
46
|
Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 A resolution.
|
Proteins
|
2005
|
0.85
|
47
|
Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen.
|
Blood
|
2011
|
0.85
|
48
|
Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain.
|
J Mol Biol
|
2009
|
0.85
|
49
|
Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution.
|
Proteins
|
2005
|
0.84
|
50
|
Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.84
|
51
|
Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold.
|
Proteins
|
2006
|
0.84
|
52
|
A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 Å resolution.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.84
|
53
|
Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution.
|
Proteins
|
2008
|
0.83
|
54
|
Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes.
|
J Biol Chem
|
2009
|
0.83
|
55
|
Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.83
|
56
|
Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus.
|
J Mol Biol
|
2009
|
0.83
|
57
|
Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution.
|
Proteins
|
2006
|
0.82
|
58
|
Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility.
|
Biochemistry
|
2011
|
0.82
|
59
|
Crystal structure of a novel archaeal AAA+ ATPase SSO1545 from Sulfolobus solfataricus.
|
Proteins
|
2009
|
0.81
|
60
|
Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.
|
Proteins
|
2012
|
0.80
|
61
|
Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold.
|
Proteins
|
2005
|
0.80
|
62
|
Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold.
|
Proteins
|
2008
|
0.80
|
63
|
Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution.
|
Proteins
|
2006
|
0.79
|
64
|
Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 angstroms resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate.
|
Proteins
|
2007
|
0.79
|
65
|
Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 A resolution.
|
Proteins
|
2009
|
0.79
|
66
|
The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.79
|
67
|
The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.78
|
68
|
Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution reveals molecular details of its transcription repressor function.
|
Proteins
|
2007
|
0.78
|
69
|
The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.78
|
70
|
Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.77
|
71
|
Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold.
|
Proteins
|
2005
|
0.77
|
72
|
The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.77
|
73
|
Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 Å resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.76
|
74
|
Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.76
|
75
|
The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu.
|
Protein Sci
|
2010
|
0.76
|
76
|
Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2010
|
0.75
|